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Items: 1 to 20 of 104

1.
Phenotypic and Genetic Factors Associated with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA Carriers
Esteban A. Lopera-Maya, Shuang Li, Remco de Brouwer, Ilja M. Nolte, Justin van Breen, The Netherlands A. C. M./P. L. N. Registry, Lifelines Cohort Study, Jan D. H. Jongbloed, Morris A. Swertz, Harold Snieder, Lude Franke, Cisca Wijmenga, Rudolf A. de Boer, Patrick Deelen, Paul A. van der Zwaag, Serena Sanna
J Cardiovasc Transl Res. 2023; 16(6): 1251–1266. Published online 2023 Jan 9. doi: 10.1007/s12265-022-10347-5
PMCID:
PMC10721704
AbstractArticlePDF–1.3M
2.
Assessment of community efforts to advance network-based prediction of protein–protein interactions
Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P. Wytock, István A. Kovács, Olivér M. Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A. Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K. Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu
Nat Commun. 2023; 14: 1582. Published online 2023 Mar 22. doi: 10.1038/s41467-023-37079-7
PMCID:
PMC10033937
AbstractArticlePDF–1.5M
3.
Generation of two induced pluripotent stem cell lines carrying the phospholamban R14del mutation for modeling ARVD/C
Carlos D. Vera, Amit Manhas, Sushma P. Shenoy, Matthew T. Wheeler, Karim Sallam, Joseph C. Wu
Stem Cell Res. Author manuscript; available in PMC 2022 Sep 15.
Published in final edited form as: Stem Cell Res. 2022 Aug; 63: 102834. Published online 2022 Jun 6. doi: 10.1016/j.scr.2022.102834
PMCID:
PMC9476586
AbstractArticlePDF–907K
4.
Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca2+ Handling and Arrhythmogenesis
Elizabeth Vafiadaki, Kobra Haghighi, Demetrios A. Arvanitis, Evangelia G. Kranias, Despina Sanoudou
Int J Mol Sci. 2022 Jul; 23(13): 6947. Published online 2022 Jun 22. doi: 10.3390/ijms23136947
PMCID:
PMC9266971
AbstractArticlePDF–3.3M
5.
Inhibitory and stimulatory micropeptides preferentially bind to different conformations of the cardiac calcium pump
Sean R. Cleary, Xuan Fang, Ellen E. Cho, Marsha P. Pribadi, Jaroslava Seflova, Jordan R. Beach, Peter M. Kekenes-Huskey, Seth L. Robia
J Biol Chem. 2022 Jul; 298(7): 102060. Published online 2022 May 20. doi: 10.1016/j.jbc.2022.102060
PMCID:
PMC9218510
AbstractArticlePDF–1.9M
6.
Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM
Ljubica Perisic Matic, Urszula Rykaczewska, Anton Razuvaev, Maria Sabater-Lleal, Mariette Lengquist, Clint L. Miller, Ida Ericsson, Samuel Röhl, Malin Kronqvist, Silvia Aldi, Joelle Magné, Valentina Paloschi, Mattias Vesterlund, Yuhuang Li, Hong Jin, Maria Gonzalez Diez, Joy Roy, Damiano Baldassarre, Fabrizio Veglia, Steve E. Humphries, Ulf de Faire, Elena Tremoli, Jacob Odeberg, Vladana Vukojević, Janne Lehtiö, Lars Maegdefessel, Ewa Ehrenborg, Gabrielle Paulsson-Berne, Göran K. Hansson, Jan H.N. Lindeman, Per Eriksson, Thomas Quertermous, Anders Hamsten, Ulf Hedin
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2022 Apr 8.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9): 1947–1961. Published online 2016 Jul 28. doi: 10.1161/ATVBAHA.116.307893
PMCID:
PMC8991816
AbstractArticlePDF–3.9M
7.
Characterization of the PLN p.Arg14del Mutation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Beatrice Badone, Carlotta Ronchi, Francesco Lodola, Anika E. Knaust, Arne Hansen, Thomas Eschenhagen, Antonio Zaza
Int J Mol Sci. 2021 Dec; 22(24): 13500. Published online 2021 Dec 16. doi: 10.3390/ijms222413500
PMCID:
PMC8709382
AbstractArticlePDF–3.0M
8.
The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy
Dries A.M. Feyen, Isaac Perea-Gil, Renee G.C. Maas, Magdalena Harakalova, Alexandra A. Gavidia, Jennifer Arthur Ataam, Ting-Hsuan Wu, Aryan Vink, Jiayi Pei, Nirmal Vadgama, Albert J. Suurmeijer, Wouter P. te Rijdt, Michelle Vu, Prashila L. Amatya, Maricela Prado, Yuan Zhang, Logan Dunkenberger, Joost P.G. Sluijter, Karim Sallam, Folkert W. Asselbergs, Mark Mercola, Ioannis Karakikes
Circulation. Author manuscript; available in PMC 2022 Aug 3.
Published in final edited form as: Circulation. 2021 Aug 3; 144(5): 382–392. Published online 2021 Apr 30. doi: 10.1161/CIRCULATIONAHA.120.049844
PMCID:
PMC8667423
AbstractArticlePDF–1.6M
9.
Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy
S. M. Kamel, C. J. M. van Opbergen, C. D. Koopman, A. O. Verkerk, B. J. D. Boukens, B. de Jonge, Y. L. Onderwater, E. van Alebeek, S. Chocron, C. Polidoro Pontalti, W. J. Weuring, M. A. Vos, T. P. de Boer, T. A. B. van Veen, J. Bakkers
Nat Commun. 2021; 12: 7151. Published online 2021 Dec 9. doi: 10.1038/s41467-021-27461-8
PMCID:
PMC8660846
AbstractArticlePDF–2.5M
10.
Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy due to Phospholamban R14del Mutation
Nour Raad, Philip Bittihn, Marine Cacheux, Dongtak Jeong, Zeki Ilkan, Delaine Ceholski, Erik Kohlbrenner, Lu Zhang, Chen-Leng Cai, Evangelia G. Kranias, Roger J. Hajjar, Francesca Stillitano, Fadi G. Akar
Circulation. Author manuscript; available in PMC 2022 Aug 10.
Published in final edited form as: Circulation. 2021 Aug 10; 144(6): 441–454. Published online 2021 May 24. doi: 10.1161/CIRCULATIONAHA.119.043502
PMCID:
PMC8456417
AbstractArticlePDF–2.5M
11.
An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation
Eduarde Rohner, Nevin Witman, Jesper Sohlmer, Erwin De Genst, William E. Louch, Makoto Sahara, Kenneth R. Chien
Mol Med. 2021; 27: 102. Published online 2021 Sep 8. doi: 10.1186/s10020-021-00362-8
PMCID:
PMC8425124
AbstractArticlePDF–2.8M
12.
Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers
Daniel Koch, Alexander Alexandrovich, Florian Funk, Ay Lin Kho, Joachim P. Schmitt, Mathias Gautel
Cell Rep. 2021 Jul 27; 36(4): 109448. Published online 2021 Jul 27. doi: 10.1016/j.celrep.2021.109448
PMCID:
PMC8333238
AbstractArticle
13.
Prediction of ventricular arrhythmia in phospholamban p.Arg14del mutation carriers–reaching the frontiers of individual risk prediction
Tom E Verstraelen, Freyja H M van Lint, Laurens P Bosman, Remco de Brouwer, Virginnio M Proost, Bob G S Abeln, Karim Taha, Aeilko H Zwinderman, Cathelijne Dickhoff, Toon Oomen, Bas A Schoonderwoerd, Gerardus P Kimman, Arjan C Houweling, Juan R Gimeno-Blanes, Folkert W Asselbergs, Paul A van der Zwaag, Rudolf A de Boer, Maarten P van den Berg, J Peter van Tintelen, Arthur A M Wilde
Eur Heart J. 2021 Aug 1; 42(29): 2842–2850. Published online 2021 Jun 11. doi: 10.1093/eurheartj/ehab294
PMCID:
PMC8325776
AbstractArticlePDF–1.4M
14.
When is an obscurin variant pathogenic? The impact of Arg4344Gln and Arg4444Trp variants on protein–protein interactions and protein stability
Atsushi Fukuzawa, Daniel Koch, Sarah Grover, Martin Rees, Mathias Gautel
Hum Mol Genet. 2021 Jun 15; 30(12): 1131–1141. Published online 2021 Jan 12. doi: 10.1093/hmg/ddab010
PMCID:
PMC8188405
AbstractArticlePDF–1.3M
15.
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation
Friederike Cuello, Anika E Knaust, Umber Saleem, Malte Loos, Janice Raabe, Diogo Mosqueira, Sandra Laufer, Michaela Schweizer, Petra van der Kraak, Frederik Flenner, Bärbel M Ulmer, Ingke Braren, Xiaoke Yin, Konstantinos Theofilatos, Jorge Ruiz‐Orera, Giannino Patone, Birgit Klampe, Thomas Schulze, Angelika Piasecki, Yigal Pinto, Aryan Vink, Norbert Hübner, Sian Harding, Manuel Mayr, Chris Denning, Thomas Eschenhagen, Arne Hansen
EMBO Mol Med. 2021 Jun 8; 13(6): e13074. Published online 2021 May 16. doi: 10.15252/emmm.202013074
PMCID:
PMC8185541
AbstractArticlePDF–2.6M
16.
Discovering and Visualizing Disease-Specific Electrocardiogram Features Using Deep Learning: Proof-of-Concept in Phospholamban Gene Mutation Carriers
Rutger R. van de Leur, Karim Taha, Max N. Bos, Jeroen F. van der Heijden, Deepak Gupta, Maarten J. Cramer, Rutger J. Hassink, Pim van der Harst, Pieter A. Doevendans, Folkert W. Asselbergs, René van Es
Circ Arrhythm Electrophysiol. 2021 Feb; 14(2): e009056. Published online 2021 Jan 5. doi: 10.1161/CIRCEP.120.009056
PMCID:
PMC7892204
AbstractArticlePDF–793K
17.
Atomistic Structure and Dynamics of the Ca2+-ATPase Bound to Phosphorylated Phospholamban
Rodrigo Aguayo-Ortiz, L. Michel Espinoza-Fonseca
Int J Mol Sci. 2020 Oct; 21(19): 7261. Published online 2020 Oct 1. doi: 10.3390/ijms21197261
PMCID:
PMC7583845
AbstractArticlePDF–3.2M
18.
Therapeutic Molecular Phenotype of β-blocker Associated Reverse-remodeling in Nonischemic Dilated Cardiomyopathy
David Kao, Brian Lowes, Edward Gilbert, Wayne Minobe, L Elaine Epperson, Leslie Meyer, Debra Ferguson, Kirk Volkman, Ronald Zolty, Alastair Robertson, Douglas Borg, Robert Quaife, Michael Bristow
Circ Cardiovasc Genet. Author manuscript; available in PMC 2020 May 7.
Published in final edited form as: Circ Cardiovasc Genet. 2015 Apr; 8(2): 270–283. Published online 2015 Jan 30. doi: 10.1161/CIRCGENETICS.114.000767
PMCID:
PMC7205443
AbstractArticlePDF–815K
19.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
20.
Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs
Daniel R. Stroik, Delaine K. Ceholski, Philip A. Bidwell, Justyna Mleczko, Paul F. Thanel, Forum Kamdar, Joseph M. Autry, Razvan L. Cornea, David D. Thomas
J Mol Cell Cardiol. Author manuscript; available in PMC 2021 Jan 1.
Published in final edited form as: J Mol Cell Cardiol. 2020 Jan; 138: 59–65. Published online 2019 Nov 18. doi: 10.1016/j.yjmcc.2019.11.147
PMCID:
PMC7035975
AbstractArticlePDF–1007K

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