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Select item 110823691.

Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules

Bruno A. Cisterna, Kristen Skruber, Makenzie L. Jane, Caleb I. Camesi, Ivan D. Nguyen, Tatiana M. Liu, Peyton V. Warp, Joseph B. Black, Mitchell T. Butler, James E. Bear, Danielle E. Mor, Tracy-Ann Read, Eric A. Vitriol

J Cell Biol. 2024 Jul 1; 223(7): e202309097. Published online 2024 May 9. doi: 10.1083/jcb.202309097

PMCID:: PMC11082369

Abstract Article PDF–5.3M

Select item 109546942.

Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

Salome Funes, Jonathan Jung, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Shankaracharya, Matthew Unger, Karly Stallworth, Debra Cameron, Melissa S. Rotunno, Pepper Dawes, Megan Fowler-Magaw, Pamela J. Keagle, Justin A. McDonough, Sivakumar Boopathy, Miguel Sena-Esteves, Jeffrey A. Nickerson, Cathleen Lutz, William C. Skarnes, Elaine T. Lim, Dorothy P. Schafer, Francesca Massi, John E. Landers, Daryl A. Bosco

Nat Commun. 2024; 15: 2497. Published online 2024 Mar 20. doi: 10.1038/s41467-024-46695-w

PMCID:: PMC10954694

Abstract Article PDF–4.6M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107211564.

Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases

Xuefei Tian, Christopher E. Pedigo, Ke Li, Xiaotao Ma, Patricia Bunda, John Pell, Angela Lek, Jianlei Gu, Yan Zhang, Paulina X. Medina Rangel, Wei Li, Eike Schwartze, Soichiro Nagata, Gabriel Lerner, Sudhir Perincheri, Anupama Priyadarshini, Hongyu Zhao, Monkol Lek, Madhav C. Menon, Rongguo Fu, Shuta Ishibe

J Clin Invest. 2023 Dec 15; 133(24): e171237. Published online 2023 Dec 15. doi: 10.1172/JCI171237

PMCID:: PMC10721156

Abstract Article PDF–8.1M

Select item 104328065.

Vascular endothelial profilin-1 drives a protumorigenic tumor microenvironment and tumor progression in renal cancer

David Gau, Andrew Daoud, Abigail Allen, Marion Joy, April Sagan, Sanghoon Lee, Peter C. Lucas, Stefan Duensing, David Boone, Hatice U. Osmanbeyoglu, Partha Roy

J Biol Chem. 2023 Aug; 299(8): 105044. Published online 2023 Jul 13. doi: 10.1016/j.jbc.2023.105044

PMCID:: PMC10432806

Abstract Article PDF–5.5M

Select item 98133766.

Profilin 1 deficiency drives mitotic defects and reduces genome stability

Federica Scotto di Carlo, Sharon Russo, Francesc Muyas, Maria Mangini, Lorenza Garribba, Laura Pazzaglia, Rita Genesio, Flavia Biamonte, Anna Chiara De Luca, Stefano Santaguida, Katia Scotlandi, Isidro Cortés-Ciriano, Fernando Gianfrancesco

Commun Biol. 2023; 6: 9. Published online 2023 Jan 4. doi: 10.1038/s42003-022-04392-8

PMCID:: PMC9813376

Abstract Article PDF–3.0M

Select item 96038607.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 94819338.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 91435299.

The Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis

Elisa Teyssou, Laura Chartier, Delphine Roussel, Nirma D. Perera, Ivan Nemazanyy, Dominique Langui, Mélanie Albert, Thierry Larmonier, Safaa Saker, François Salachas, Pierre-François Pradat, Vincent Meininger, Philippe Ravassard, Francine Côté, Christian S. Lobsiger, Séverine Boillée, Bradley J. Turner, Danielle Seilhean, Stéphanie Millecamps

Int J Mol Sci. 2022 May; 23(10): 5694. Published online 2022 May 19. doi: 10.3390/ijms23105694

PMCID:: PMC9143529

Abstract Article PDF–1.6M

Select item 860599910.

The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair

Wei-Ting Kuo, Li Zuo, Matthew A. Odenwald, Shariq Madha, Gurminder Singh, Christine B. Gurniak, Clara Abraham, Jerrold R. Turner

Gastroenterology. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Gastroenterology. 2021 Dec; 161(6): 1924–1939. Published online 2021 Aug 31. doi: 10.1053/j.gastro.2021.08.047

PMCID:: PMC8605999

Abstract Article PDF–3.7M

Select item 846706811.

Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure

Marina Di Domenico, Melanie Jokwitz, Walter Witke, Pietro Pilo Boyl

Cells. 2021 Sep; 10(9): 2310. Published online 2021 Sep 3. doi: 10.3390/cells10092310

PMCID:: PMC8467068

Abstract Article PDF–2.9M

Select item 831323912.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 826661713.

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P Maurer

Nucleic Acids Res. 2021 Jul 9; 49(12): 6702–6721. Published online 2021 Jun 16. doi: 10.1093/nar/gkab490

PMCID:: PMC8266617

Abstract Article PDF–4.0M

Select item 825153814.

Mutations in Profilin 1 Cause Early‐Onset Paget's Disease of Bone With Giant Cell Tumors

Zhe Wei, Shanshan Li, Xiaohui Tao, Guoying Zhu, Zhenkui Sun, Zhanying Wei, Qiong Jiao, Huizhen Zhang, Lin Chen, Baojie Li, Zhenlin Zhang, Hua Yue

J Bone Miner Res. 2021 Jun; 36(6): 1088–1103. Published online 2021 Mar 10. doi: 10.1002/jbmr.4275

PMCID:: PMC8251538

Abstract Article PDF–3.3M

Select item 793877015.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 766853116.

The actin regulator profilin 1 is functionally associated with the mammalian centrosome

Michaela Nejedlá, Anastasiya Klebanovych, Vadym Sulimenko, Tetyana Sulimenko, Eduarda Dráberová, Pavel Dráber, Roger Karlsson

Life Sci Alliance. 2021 Jan; 4(1): e202000655. Published online 2020 Nov 12. doi: 10.26508/lsa.202000655

PMCID:: PMC7668531

Abstract Article PDF–1.2M

Select item 764535217.

Knockdown of CK2α reduces P-cresol-induced fibrosis in human renal proximal tubule epithelial cells via the downregulation of profilin-1

Yeo Min Yoon, Gyeongyun Go, Chul Won Yun, Ji Ho Lim, Sang Hun Lee

Int J Med Sci. 2020; 17(17): 2850–2860. Published online 2020 Oct 16. doi: 10.7150/ijms.48429

PMCID:: PMC7645352

Abstract Article PDF–2.2M

Select item 741599118.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 736314619.

Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization

David Gau, Lucile Vignaud, Abigail Allen, Zhijian Guo, Jose Sahel, David Boone, David Koes, Xavier Guillonneau, Partha Roy

J Biol Chem. 2020 Jul 10; 295(28): 9618–9629. Published online 2020 May 22. doi: 10.1074/jbc.RA120.012613

PMCID:: PMC7363146

Abstract Article PDF–2.3M

Select item 710890420.

Profilin 1 delivery tunes cytoskeletal dynamics toward CNS axon regeneration

Rita Pinto-Costa, Sara C. Sousa, Sérgio C. Leite, Joana Nogueira-Rodrigues, Tiago Ferreira da Silva, Diana Machado, Joana Marques, Ana Catarina Costa, Márcia A. Liz, Francesca Bartolini, Pedro Brites, Mercedes Costell, Reinhard Fässler, Mónica M. Sousa

J Clin Invest. 2020 Apr 1; 130(4): 2024–2040. Published online 2020 Mar 16. doi: 10.1172/JCI125771

PMCID:: PMC7108904

Abstract Article PDF–18M

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