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Items: 1 to 20 of 78

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway
Huiyu Chen, Huafen Liu, Dishiwen Liu, Yuntao Fu, Yajun Yao, Zhen Cao, Zhibin Peng, Mei Yang, Qingyan Zhao
Mol Med Rep. 2024 Apr; 29(4): 55. Published online 2024 Feb 8. doi: 10.3892/mmr.2024.13179
PMCID:
PMC10877089
AbstractArticlePDF–8.1M
3.
Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes
Sarah Saxena, Vincent Nuyens, Christopher Rodts, Kristina Jamar, Adelin Albert, Laurence Seidel, Mustapha Cherkaoui-Malki, Jean G. Boogaerts, Heike Wulff, Mervyn Maze, Véronique Kruys, Joseph Vamecq
BMC Anesthesiol. 2023; 23: 80. Published online 2023 Mar 16. doi: 10.1186/s12871-023-02030-2
PMCID:
PMC10018926
AbstractArticlePDF–1.4M
4.
Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
Patrick Vigneault, Sandrine Parent, Pushpinder Kanda, Connor Michie, Darryl R. Davis, Stanley Nattel
Nat Commun. 2021; 12: 4963. Published online 2021 Aug 16. doi: 10.1038/s41467-021-25180-8
PMCID:
PMC8368210
AbstractArticlePDF–2.6M
5.
Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease
Génesis Vega, Anita Guequén, Amber R. Philp, Ambra Gianotti, Llilian Arzola, Manuel Villalón, Olga Zegarra-Moran, Luis J.V. Galietta, Marcus A. Mall, Carlos A. Flores
JCI Insight. 2020 Aug 20; 5(16): e140076. Published online 2020 Aug 20. doi: 10.1172/jci.insight.140076
PMCID:
PMC7455130
AbstractArticlePDF–17M
6.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
7.
Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis
Javier Lozano-Gerona, Aida Oliván-Viguera, Pablo Delgado-Wicke, Vikrant Singh, Brandon M. Brown, Elena Tapia-Casellas, Esther Pueyo, Marta Sofía Valero, Ángel-Luis Garcia-Otín, Pilar Giraldo, Edgar Abarca-Lachen, Joaquín C. Surra, Jesús Osada, Kirk L. Hamilton, Siba P. Raychaudhuri, Miguel Marigil, Ángeles Juarranz, Heike Wulff, Hiroto Miura, Yolanda Gilaberte, Ralf Köhler
PLoS One. 2020; 15(3): e0222619. Published online 2020 Mar 9. doi: 10.1371/journal.pone.0222619
PMCID:
PMC7062274
AbstractArticlePDF–3.2M
8.
Adipose-derived stem cells overexpressing SK4 calcium-activated potassium channel generate biological pacemakers
Mei Yang, Qingyan Zhao, Hongyi Zhao, Ankang Yang, Fengyuan Wang, Xi Wang, Yanhong Tang, Congxin Huang
Int J Mol Med. 2019 Dec; 44(6): 2103–2112. Published online 2019 Oct 16. doi: 10.3892/ijmm.2019.4374
PMCID:
PMC6844603
AbstractArticlePDF–1.0M
9.
Macrophages facilitate post myocardial infarction arrhythmias: roles of gap junction and KCa3.1
Yu-Dong Fei, Qian Wang, Jian-Wen Hou, Wei Li, Xing-Xing Cai, Yu-Li Yang, Liu-Hui Zhang, Zhi-Xing Wei, Tai-Zhong Chen, Yue-Peng Wang, Yi-Gang Li
Theranostics. 2019; 9(22): 6396–6411. Published online 2019 Aug 14. doi: 10.7150/thno.34801
PMCID:
PMC6771231
AbstractArticlePDF–2.7M
10.
Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.
Boris E. Shmukler, Alicia Rivera, Parul Bhargava, Katherine Nishimura, Ann Hsu, Edward H. Kim, Marie Trudel, Marco B. Rust, Christian A. Hubner, Carlo Brugnara, Seth L. Alper
Blood Cells Mol Dis. Author manuscript; available in PMC 2020 Nov 1.
Published in final edited form as: Blood Cells Mol Dis. 2019 Nov; 79: 102346. Published online 2019 Jul 17. doi: 10.1016/j.bcmd.2019.102346
Correction in:
Blood Cells Mol Dis. 2020 Jan 10; 81: 102390.
PMCID:
PMC6744291
AbstractArticlePDF–1.4M
11.
KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility
Marta Sofía Valero, Mariano Ramón-Gimenez, Javier Lozano-Gerona, Pablo Delgado-Wicke, Pilar Calmarza, Aida Oliván-Viguera, Víctor López, Ángel-Luis Garcia-Otín, Salvador Valero, Esther Pueyo, Kirk L. Hamilton, Hiroto Miura, Ralf Köhler
Int J Mol Sci. 2019 Mar; 20(5): 1193. Published online 2019 Mar 8. doi: 10.3390/ijms20051193
PMCID:
PMC6429421
AbstractArticlePDF–5.2M
12.
KCa3.1 constitutes a pharmacological target for astrogliosis associated with Alzheimer’s disease
Mengni Yi, Panpan Yu, Qin Lu, Herbert M. Geller, Zhihua Yu, Hongzhuan Chen
Mol Cell Neurosci. Author manuscript; available in PMC 2019 Jan 21.
Published in final edited form as: Mol Cell Neurosci. 2016 Oct; 76: 21–32. Published online 2016 Aug 24. doi: 10.1016/j.mcn.2016.08.008
PMCID:
PMC6340298
AbstractArticlePDF–3.1M
13.
Caveolae facilitate TRPV4-mediated Ca2+ signaling and the hierarchical activation of Ca2+-activated K+ channels in K+-secreting renal collecting duct cells
Yue Li, Hongxiang Hu, Roger G. O’Neil
Am J Physiol Renal Physiol. 2018 Dec 1; 315(6): F1626–F1636. Published online 2018 Sep 12. doi: 10.1152/ajprenal.00076.2018
PMCID:
PMC6336997
AbstractArticle
14.
Ca2+-activated K+ channels modulate microglia affecting motor neuron survival in hSOD1G93A mice
Germana Cocozza, Maria Amalia di Castro, Laura Carbonari, Alfonso Grimaldi, Fabrizio Antonangeli, Stefano Garofalo, Alessandra Porzia, Michele Madonna, Fabrizio Mainiero, Angela Santoni, Francesca Grassi, Heike Wulff, Giuseppina D’Alessandro, Cristina Limatola
Brain Behav Immun. Author manuscript; available in PMC 2019 Oct 1.
Published in final edited form as: Brain Behav Immun. 2018 Oct; 73: 584–595. Published online 2018 Jul 3. doi: 10.1016/j.bbi.2018.07.002
PMCID:
PMC6129409
AbstractArticlePDF–1.4M
15.
Supervised learning reveals circulating biomarker levels diagnostic of hepatocellular carcinoma in a clinically relevant model of non-alcoholic steatohepatitis; An OAD to NASH
Anne Hwang, Christopher Shi, Edward Zhu, Farha Naaz, Ping Zhou, Zainab Rasheed, Michelle Liu, Lindsey S. Jung, Bin Duan, Jingsong Li, Kai Jiang, Latha Paka, Satishkumar V. Gadhiya, Dibyendu Dana, Quaisar Ali, Michael A. Yamin, Itzhak D. Goldberg, Prakash Narayan
PLoS One. 2018; 13(6): e0198937. Published online 2018 Jun 26. doi: 10.1371/journal.pone.0198937
PMCID:
PMC6019748
AbstractArticlePDF–5.7M
16.
Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse
Amber R. Philp, Texia T. Riquelme, Pamela Millar-Büchner, Rodrigo González, Francisco V. Sepúlveda, L. Pablo Cid, Carlos A. Flores
Sci Rep. 2018; 8: 9320. Published online 2018 Jun 18. doi: 10.1038/s41598-018-27465-3
PMCID:
PMC6006244
AbstractArticlePDF–6.4M
17.
Common PIEZO1 allele in African populations causes RBC dehydration and attenuates Plasmodium infection
Shang Ma, Stuart Cahalan, Gregory LaMonte, Nathan D. Grubaugh, Weizheng Zeng, Swetha E. Murthy, Emma Paytas, Ramya Gamini, Viktor Lukacs, Tess Whitwam, Meaghan Loud, Rakhee Lohia, Laurence Berry, Shahid M. Khan, Chris J. Janse, Michael Bandell, Christian Schmedt, Kai Wengelnik, Andrew I. Su, Eric Honore, Elizabeth A. Winzeler, Kristian G. Andersen, Ardem Patapoutian
Cell. Author manuscript; available in PMC 2019 Apr 5.
Published in final edited form as: Cell. 2018 Apr 5; 173(2): 443–455.e12. Published online 2018 Mar 22. doi: 10.1016/j.cell.2018.02.047
PMCID:
PMC5889333
AbstractArticlePDF–1.9M
18.
KCa3.1 ion channel: A novel therapeutic target for corneal fibrosis
Govindaraj Anumanthan, Suneel Gupta, Michael K. Fink, Nathan P. Hesemann, Douglas K. Bowles, Lindsey M. McDaniel, Maaz Muhammad, Rajiv R. Mohan
PLoS One. 2018; 13(3): e0192145. Published online 2018 Mar 19. doi: 10.1371/journal.pone.0192145
PMCID:
PMC5858751
AbstractArticlePDF–6.1M
19.
K2P TASK‐2 and KCNQ1–KCNE3 K+ channels are major players contributing to intestinal anion and fluid secretion
Francisca Julio‐Kalajzić, Sandra Villanueva, Johanna Burgos, Margarita Ojeda, L. Pablo Cid, Thomas J. Jentsch, Francisco V. Sepúlveda
J Physiol. 2018 Feb 1; 596(3): 393–407. Published online 2017 Dec 18. doi: 10.1113/JP275178
PMCID:
PMC5792569
AbstractArticlePDF–973K
20.
The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke
Mengni Yi, Tianjiao Wei, Yanxia Wang, Qin Lu, Gaoxian Chen, Xiaoling Gao, Herbert M. Geller, Hongzhuan Chen, Zhihua Yu
J Neuroinflammation. 2017; 14: 203. Published online 2017 Oct 16. doi: 10.1186/s12974-017-0973-8
PMCID:
PMC5644250
AbstractArticlePDF–6.3M

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