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Select item 111896071.

An IL-4 signaling axis in bone marrow drives pro-tumorigenic myelopoiesis

Nelson M. LaMarche, Samarth Hegde, Matthew D. Park, Barbara B. Maier, Leanna Troncoso, Jessica Le Berichel, Pauline Hamon, Meriem Belabed, Raphaël Mattiuz, Clotilde Hennequin, Theodore Chin, Amanda M. Reid, Iván Reyes-Torres, Erika Nemeth, Ruiyuan Zhang, Oakley C. Olson, Deborah B. Doroshow, Nicholas C. Rohs, Jorge E. Gomez, Rajwanth Veluswamy, Nicole Hall, Nicholas Venturini, Florent Ginhoux, Zhaoyuan Liu, Mark Buckup, Igor Figueiredo, Vladimir Roudko, Kensuke Miyake, Hajime Karasuyama, Edgar Gonzalez-Kozlova, Sacha Gnjatic, Emmanuelle Passegué, Seunghee Kim-Schulze, Brian D. Brown, Fred R. Hirsch, Brian S. Kim, Thomas U. Marron, Miriam Merad

Nature. Author manuscript; available in PMC 2024 Jun 20.

Published in final edited form as: Nature. 2024 Jan; 625(7993): 166–174. Published online 2023 Dec 6. doi: 10.1038/s41586-023-06797-9

PMCID:: PMC11189607

Abstract Article PDF–3.7M

Select item 111592882.

Natural killer T cells from interleukin‐4‐deficient mice are defective in early interferon‐γ production in response to α‐galactosylceramide

Yuji Togashi, Kenji Chamoto, Daiko Wakita, Naonobu Tsutsumi, Yoichiro Iwakura, Naoki Matsubara, Hidemitsu Kitamura, Takashi Nishimura

Cancer Sci. 2007 May; 98(5): 721–725. Published online 2007 Mar 14. doi: 10.1111/j.1349-7006.2007.00451.x

PMCID:: PMC11159288

Abstract Article PDF–222K

Select item 110356503.

PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus

John TCHEN, Quentin SIMON, Léa CHAPART, Morgane K. THAMINY, Shamila VIBHUSHAN, Loredana SAVEANU, Yasmine LAMRI, Fanny SAIDOUNE, Emeline PACREAU, Christophe PELLEFIGUES, Julie BEX-COUDRAT, Hajime KARASUYAMA, Kensuke MIYAKE, Juan HIDALGO, Padraic G. FALLON, Thomas PAPO, Ulrich BLANK, Marc BENHAMOU, Guillaume HANOUNA, Karim SACRE, Eric DAUGAS, Nicolas CHARLES

Nat Commun. 2024; 15: 3389. Published online 2024 Apr 22. doi: 10.1038/s41467-024-47691-w

PMCID:: PMC11035650

Abstract Article PDF–6.1M

Select item 110290294.

IL-4 blockade alters the tumor microenvironment and augments the response to cancer immunotherapy in a mouse model

Shuku-ei Ito, Hidekazu Shirota, Yuki Kasahara, Ken Saijo, Chikashi Ishioka

Cancer Immunol Immunother. 2017 Nov; 66(11): 1485–1496. Published online 2017 Jul 21. doi: 10.1007/s00262-017-2043-6

PMCID:: PMC11029029

Abstract Article PDF–1.2M

Select item 110182095.

Effect of connexin 43 in LPS/IL-4-induced macrophage M1/M2 polarization: An observational study

Pengchen He, Mingxing Dai, Zongpin Li, Xiaoyi Wang, Hongyuan Liu, Yixiao He, Han Jiang

Medicine (Baltimore) 2024 Apr 12; 103(15): e37811. Published online 2024 Apr 12. doi: 10.1097/MD.0000000000037811

PMCID:: PMC11018209

Abstract Article PDF–868K

Select item 109972766.

IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4

Miriam Hils, Nils Hoffard, Caterina Iuliano, Luisa Kreft, Neera Chakrapani, Kyra Swiontek, Konrad Fischer, Bernadette Eberlein, Martin Köberle, Jörg Fischer, Christiane Hilger, Caspar Ohnmacht, Susanne Kaesler, Florian Wölbing, Tilo Biedermann

J Allergy Clin Immunol. 2024 Apr; 153(4): 1050–1062.e6. doi: 10.1016/j.jaci.2023.12.003

PMCID:: PMC10997276

Abstract Article

Select item 109325537.

Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response

Cécile Guth, Pia Philippa Schumacher, Archena Vijayakumar, Hannah Borgmann, Helene Balles, Marianne Koschel, Frederic Risch, Benjamin Lenz, Achim Hoerauf, Marc P. Hübner, Jesuthas Ajendra

J Innate Immun. 2024 Jan-Dec; 16(1): 159–172. Published online 2024 Feb 26. doi: 10.1159/000536357

PMCID:: PMC10932553

Abstract Article PDF–1.3M

Select item 108787898.

IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress

Chang Xu, Yilan Song, Wanting Liu, Ruobai Liu, Qiaoyun Bai, Liangchang Li, Chongyang Wang, Guanghai Yan

Redox Biol. 2024 May; 71: 103090. Published online 2024 Feb 15. doi: 10.1016/j.redox.2024.103090

PMCID:: PMC10878789

Abstract Article PDF–20M

Select item 108659979.

A type 2 immune circuit in the stomach controls mammalian adaptation to dietary chitin

Do-Hyun Kim, Yilin Wang, Haerin Jung, Rachael L. Field, Xinya Zhang, Ta-Chiang Liu, Changqing Ma, James S. Fraser, Jonathan R. Brestoff, Steven J. Van Dyken

Science. Author manuscript; available in PMC 2024 Feb 14.

Published in final edited form as: Science. 2023 Sep 8; 381(6662): 1092–1098. Published online 2023 Sep 7. doi: 10.1126/science.add5649

PMCID:: PMC10865997

Abstract Article PDF–957K

Select item 1071347010.

脂肪组织黏膜相关恒定T细胞通过分泌白介素4调节小鼠脂肪棕色化

叶潇, 宋迎香, 赵瑜, 朱大龙

Nan Fang Yi Ke Da Xue Xue Bao. 2023 Nov 20; 43(11): 1881–1885. Chinese. doi: 10.12122/j.issn.1673-4254.2023.11.07

PMCID:: PMC10713470

Abstract Article PDF–1.5M

Select item 1068711111.

Dermis resident macrophages orchestrate localized ILC2 eosinophil circuitries to promote non-healing cutaneous leishmaniasis

Sang Hun Lee, Byunghyun Kang, Olena Kamenyeva, Tiago Rodrigues Ferreira, Kyoungin Cho, Jaspal S. Khillan, Juraj Kabat, Brian L. Kelsall, David L. Sacks

Nat Commun. 2023; 14: 7852. Published online 2023 Nov 29. doi: 10.1038/s41467-023-43588-2

PMCID:: PMC10687111

Abstract Article PDF–6.1M

Select item 1033653412.

Immune tolerance of food is mediated by layers of CD4⁺ T cell dysfunction

Sung-Wook Hong, Peter D. Krueger, Kevin C. Osum, Thamotharampillai Dileepan, Adam Herman, Daniel L. Mueller, Marc K. Jenkins

Nature. Author manuscript; available in PMC 2023 Jul 12.

Published in final edited form as: Nature. 2022 Jul; 607(7920): 762–768. Published online 2022 Jul 6. doi: 10.1038/s41586-022-04916-6

PMCID:: PMC10336534

Abstract Article PDF–2.1M

Select item 1033029713.

Lung-resident CD69⁺ST2⁺ Th2 cells mediate long-term type 2 memory to inhaled antigen in mice

Takao Kobayashi, Koji Iijima, Koji Matsumoto, Jyoti K. Lama, Hirohito Kita

J Allergy Clin Immunol. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: J Allergy Clin Immunol. 2023 Jul; 152(1): 167–181.e6. Published online 2023 Jan 28. doi: 10.1016/j.jaci.2023.01.016

PMCID:: PMC10330297

Abstract Article PDF–3.6M

Select item 1020460514.

IL-4 Is Proangiogenic in the Lung under Hypoxic Conditions

Kazuyo Yamaji-Kegan, Qingning Su, Daniel J. Angelini, Roger A. Johns

J Immunol. Author manuscript; available in PMC 2023 May 23.

Published in final edited form as: J Immunol. 2009 May 1; 182(9): 5469–5476. doi: 10.4049/jimmunol.0713347

PMCID:: PMC10204605

Abstract Article PDF–1.7M

Select item 1017741015.

IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger

Mitsutoshi Kurosaka, Yung-Li Hung, Shuichi Machida, Kazuhisa Kohda

Cells. 2023 May; 12(9): 1284. Published online 2023 Apr 29. doi: 10.3390/cells12091284

PMCID:: PMC10177410

Abstract Article PDF–4.1M

Select item 1017418916.

Diet-mediated constitutive induction of novel IL-4⁺ ILC2 cells maintains intestinal homeostasis in mice

Wanlin Cui, Yuji Nagano, Satoru Morita, Takeshi Tanoue, Hidehiro Yamane, Keiko Ishikawa, Toshiro Sato, Masato Kubo, Shohei Hori, Tadatsugu Taniguchi, Masanori Hatakeyama, Koji Atarashi, Kenya Honda

J Exp Med. 2023 Aug 7; 220(8): e20221773. Published online 2023 May 10. doi: 10.1084/jem.20221773

PMCID:: PMC10174189

Abstract Article PDF–5.3M

Select item 990807617.

IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity

Judith Schick, Meltem Altunay, Matthew Lacorcia, Nathalie Marschner, Stefanie Westermann, Julia Schluckebier, Christoph Schubart, Barbara Bodendorfer, Dennis Christensen, Christian Alexander, Stefan Wirtz, David Voehringer, Clarissa Prazeres da Costa, Roland Lang

eLife. 2023; 12: e72923. Published online 2023 Feb 8. doi: 10.7554/eLife.72923

PMCID:: PMC9908076

Abstract Article PDF–1.5M

Select item 990633118.

Eosinophil‐derived IL‐4 is necessary to establish the inflammatory structure in innate inflammation

Anja Kolbinger, Tim J Schäufele, Hanna Steigerwald, Joschua Friedel, Sandra Pierre, Gerd Geisslinger, Klaus Scholich

EMBO Mol Med. 2023 Feb; 15(2): e16796. Published online 2022 Dec 21. doi: 10.15252/emmm.202216796

PMCID:: PMC9906331

Abstract Article PDF–4.6M

Select item 976811919.

IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation

Tian Zhou, Ziqi Yang, Biyan Ni, Hong Zhou, Huiyi Xu, Xiaojing Lin, Yingmin Li, Chunqiao Liu, Rong Ju, Jian Ge, Chang He, Xialin Liu

Cell Death Dis. 2022 Dec; 13(12): 1056. Published online 2022 Dec 20. doi: 10.1038/s41419-022-05433-0

PMCID:: PMC9768119

Abstract Article PDF–5.2M

Select item 970598820.

Role of Interleukin-4 (IL-4) in Respiratory Infection and Allergy Caused by Early-Life Chlamydia Infection

Shujun Li, Lijuan Wang, Yulong Zhang, Long Ma, Jing Zhang, Jianbing Zu, Xuecheng Wu

J Microbiol Biotechnol. 2021 Aug 28; 31(8): 1109–1114. Published online 2021 Jun 29. doi: 10.4014/jmb.2104.04028

PMCID:: PMC9705988

Abstract Article PDF–1.5M

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