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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516152.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 100729063.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 93533884.

SARS‐CoV‐2 spike protein enhances MAP4K3/GLK‐induced ACE2 stability in COVID‐19

Huai‐Chia Chuang, Chia‐Hsin Hsueh, Pu‐Ming Hsu, Rou‐Huei Huang, Ching‐Yi Tsai, Nai‐Hsiang Chung, Yen‐Hung Chow, Tse‐Hua Tan

EMBO Mol Med. 2022 Sep; 14(9): e15904. Published online 2022 Jul 27. doi: 10.15252/emmm.202215904

PMCID:: PMC9353388

Abstract Article PDF–3.8M

Select item 89515565.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 87620236.

Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus

Huai-Chia Chuang, Wei-Ting Hung, Yi-Ming Chen, Pu-Ming Hsu, Jeng-Hsien Yen, Joung-Liang Lan, Tse-Hua Tan

Ann Rheum Dis. 2022 Feb; 81(2): 243–254. Published online 2021 Oct 5. doi: 10.1136/annrheumdis-2021-221010

PMCID:: PMC8762023

Abstract Article PDF–5.7M

Select item 83641817.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74273279.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 738231310.

MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation

Gayoung Seo, Han Han, Rebecca Elizabeth Vargas, Bing Yang, Xu Li, Wenqi Wang

Cell Rep. Author manuscript; available in PMC 2020 Jul 25.

Published in final edited form as: Cell Rep. 2020 Jul 7; 32(1): 107860. doi: 10.1016/j.celrep.2020.107860

PMCID:: PMC7382313

Abstract Article PDF–2.6M

Select item 676665511.

AhR–ROR-γt complex is a therapeutic target for MAP4K3/GLK^highIL-17A^high subpopulation of systemic lupus erythematosus

Huai-Chia Chuang, Yi-Ming Chen, Ming-Han Chen, Wei-Ting Hung, Huang-Yu Yang, Yang-Hao Tseng, Tse-Hua Tan

FASEB J. 2019 Oct; 33(10): 11469–11480. Published online 2019 Aug 1. doi: 10.1096/fj.201900105RR

PMCID:: PMC6766655

Abstract Article

Select item 612890512.

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability

Hema Adhikari, Christopher M. Counter

Nat Commun. 2018; 9: 3646. Published online 2018 Sep 7. doi: 10.1038/s41467-018-05692-6

PMCID:: PMC6128905

Abstract Article PDF–2.2M

Select item 589141713.

Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner, Petra Beli

EMBO Rep. 2018 Apr; 19(4): e44754. Published online 2018 Feb 21. doi: 10.15252/embr.201744754

PMCID:: PMC5891417

Abstract Article PDF–1.0M

Select item 583822014.

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

Cynthia L. Hsu, Elian X. Lee, Kara L. Gordon, Edwin A. Paz, Wen-Chuan Shen, Kohta Ohnishi, Jill Meisenhelder, Tony Hunter, Albert R. La Spada

Nat Commun. 2018; 9: 942. Published online 2018 Mar 5. doi: 10.1038/s41467-018-03340-7

PMCID:: PMC5838220

Abstract Article PDF–3.5M

Select item 553358515.

The human cytoplasmic dynein interactome reveals novel activators of motility

William B Redwine, Morgan E DeSantis, Ian Hollyer, Zaw Min Htet, Phuoc Tien Tran, Selene K Swanson, Laurence Florens, Michael P Washburn, Samara L Reck-Peterson

eLife. 2017; 6: e28257. Published online 2017 Jul 18. doi: 10.7554/eLife.28257

PMCID:: PMC5533585

Abstract Article PDF–5.9M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 535512817.

MiR-199a-5p and let-7c cooperatively inhibit migration and invasion by targeting MAP4K3 in hepatocellular carcinoma

Lili Liu, Liqin Lu, Aihong Zheng, Jiansheng Xie, Qian Xue, Fuwei Wang, Xiao Wang, Hongying Zhou, Xiangmin Tong, Yaqing Li, Xiuming Zhu, Guoqing Wu

Oncotarget. 2017 Feb 21; 8(8): 13666–13677. Published online 2017 Jan 13. doi: 10.18632/oncotarget.14623

PMCID:: PMC5355128

Abstract Article PDF–13M

Select item 527574218.

Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension

Douglas Marcotte, Mia Rushe, Robert M. Arduini, Christine Lukacs, Kateri Atkins, Xin Sun, Kevin Little, Michael Cullivan, Murugan Paramasivam, Thomas A. Patterson, Thomas Hesson, Timothy D. McKee, Tricia L. May‐Dracka, Zhili Xin, Andrea Bertolotti‐Ciarlet, Govinda R. Bhisetti, Joseph P. Lyssikatos, Laura F. Silvian

Protein Sci. 2017 Feb; 26(2): 152–162. Published online 2016 Oct 21. doi: 10.1002/pro.3062

PMCID:: PMC5275742

Abstract Article PDF–1.1M

Select item 522654619.

Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase

Cheng-Hsun Ho, Huai-Chia Chuang, I-Chin Wu, Hung-Wen Tsai, Yih-Jyh Lin, Hung-Yu Sun, Kung-Chia Young, Yen-Cheng Chiu, Pin-Nan Cheng, Wen-Chun Liu, Tse-Hua Tan, Ting-Tsung Chang

Oncotarget. 2016 Aug 2; 7(31): 49765–49776. Published online 2016 Jun 20. doi: 10.18632/oncotarget.10176

PMCID:: PMC5226546

Abstract Article PDF–4.4M

Select item 517309320.

GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer

Chung-Ping Hsu, Huai-Chia Chuang, Ming-Ching Lee, Hsiao-Hui Tsou, Li-Wen Lee, Ju-Pi Li, Tse-Hua Tan

Oncotarget. 2016 Jul 5; 7(27): 41748–41757. Published online 2016 May 17. doi: 10.18632/oncotarget.9410

PMCID:: PMC5173093

Abstract Article PDF–2.4M

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