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Select item 91197361.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 87489582.

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing

Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6

PMCID:: PMC8748958

Abstract Article PDF–3.0M

Select item 82616213.

Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression

Siyuan Chen, Miaoming Huang, Xiarong Hu

Mol Med Rep. 2021 Sep; 24(3): 622. Published online 2021 Jun 30. doi: 10.3892/mmr.2021.12261

PMCID:: PMC8261621

Abstract Article PDF–11M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74156635.

Structure of a D₂ dopamine receptor-G protein complex in a lipid membrane

Jie Yin, Kuang-Yui M. Chen, Mary J. Clark, Mahdi Hijazi, Punita Kumari, Xiao-chen Bai, Roger K. Sunahara, Patrick Barth, Daniel M. Rosenbaum

Nature. Author manuscript; available in PMC 2020 Dec 11.

Published in final edited form as: Nature. 2020 Aug; 584(7819): 125–129. Published online 2020 Jun 11. doi: 10.1038/s41586-020-2379-5

PMCID:: PMC7415663

Abstract Article PDF–6.3M

Select item 60532476.

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB

Janina Bruening, Lisa Lasswitz, Pia Banse, Sina Kahl, Carine Marinach, Florian W. Vondran, Lars Kaderali, Olivier Silvie, Thomas Pietschmann, Felix Meissner, Gisa Gerold

PLoS Pathog. 2018 Jul; 14(7): e1007111. Published online 2018 Jul 19. doi: 10.1371/journal.ppat.1007111

PMCID:: PMC6053247

Abstract Article PDF–8.7M

Select item 58324417.

Phase-plate cryo-EM structure of a class B GPCR-G protein complex

Yi-Lynn Liang, Maryam Khoshouei, Mazdak Radjainia, Yan Zhang, Alisa Glukhova, Jeffrey Tarrasch, David M Thal, Sebastian G. B. Furness, George Christopoulos, Thomas Coudrat, Radostin Danev, Wolfgang Baumeister, Laurence J. Miller, Arthur Christopoulos, Brian K Kobilka, Denise Wootten, Georgios Skiniotis, Patrick M. Sexton

Nature. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Nature. 2017 Jun 1; 546(7656): 118–123. Published online 2017 Apr 24. doi: 10.1038/nature22327

PMCID:: PMC5832441

Abstract Article PDF–2.4M

Select item 55316118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 48494719.

Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination

Zhengyu Zha, Xiao-Ran Han, Matthew D Smith, Qun-Ying Lei, Kun-Liang Guan, Yue Xiong

Cell Discov. 2016; 2: 16005. Published online 2016 Apr 26. doi: 10.1038/celldisc.2016.5

PMCID:: PMC4849471

Abstract Article PDF–876K

Select item 465462810.

X-ray structure of the mammalian GIRK2 – ß? G protein complex

Matthew R. Whorton, Roderick MacKinnon

Nature. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Nature. 2013 Jun 13; 498(7453): 190–197. Published online 2013 Jun 5. doi: 10.1038/nature12241

PMCID:: PMC4654628

Abstract Article PDF–2.1M

Select item 461721111.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 445823812.

A non-canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation

Zhengyu Zha, Xiaoran Han, Matthew D. Smith, Yang Liu, Patrick M. Giguère, Dragana Kopanja, Pradip Raychaudhuri, David P. Siderovski, Kun-Liang Guan, Qun-Ying Lei, Yue Xiong

Mol Cell. Author manuscript; available in PMC 2016 Jun 4.

Published in final edited form as: Mol Cell. 2015 Jun 4; 58(5): 794–803. Published online 2015 May 14. doi: 10.1016/j.molcel.2015.04.017

PMCID:: PMC4458238

Abstract Article PDF–4.0M

Select item 444336013.

G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity

Jennifer B. Stott, Oleksandr V. Povstyan, Georgina Carr, Vincenzo Barrese, Iain A. Greenwood

Proc Natl Acad Sci U S A. 2015 May 19; 112(20): 6497–6502. Published online 2015 May 4. doi: 10.1073/pnas.1418605112

PMCID:: PMC4443360

Abstract Article PDF–1.2M

Select item 407681314.

A genome-wide gene–environment interaction analysis for tobacco smoke and lung cancer susceptibility

Ruyang Zhang, Minjie Chu, Yang Zhao, Chen Wu, Huan Guo, Yongyong Shi, Juncheng Dai, Yongyue Wei, Guangfu Jin, Hongxia Ma, Jing Dong, Honggang Yi, Jianling Bai, Jianhang Gong, Chongqi Sun, Meng Zhu, Tangchun Wu, Zhibin Hu, Dongxin Lin, Hongbing Shen, Feng Chen

Carcinogenesis. 2014 Jul; 35(7): 1528–1535. Published online 2014 Mar 22. doi: 10.1093/carcin/bgu076

PMCID:: PMC4076813

Abstract Article PDF–1.2M

Select item 377154215.

The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein

Zhizeng Sun, Caitlin Runne, Xiaoyun Tang, Fang Lin, Songhai Chen

Cell Signal. Author manuscript; available in PMC 2013 Dec 1.

Published in final edited form as: Cell Signal. 2012 Dec; 24(12): 2349–2359. Published online 2012 Aug 30. doi: 10.1016/j.cellsig.2012.08.011

PMCID:: PMC3771542

Abstract Article PDF–3.3M

Select item 369097116.

Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans

Mingfeng Zhang, Fengju Song, Liming Liang, Hongmei Nan, Jiangwen Zhang, Hongliang Liu, Li-E. Wang, Qingyi Wei, Jeffrey E. Lee, Christopher I. Amos, Peter Kraft, Abrar A. Qureshi, Jiali Han

Hum Mol Genet. 2013 Jul 15; 22(14): 2948–2959. Published online 2013 Apr 1. doi: 10.1093/hmg/ddt142