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Select item 103281081.

Expression analysis of loci associated with type 2 diabetes in human tissues

C. Cotsapas, L. Prokunina-Olsson, C. Welch, R. Saxena, C. Weaver, N. Usher, C. Guiducci, S. Bonakdar, N. Turner, B. LaCroix, J. L. Hall

Diabetologia. Author manuscript; available in PMC 2023 Jul 7.

Published in final edited form as: Diabetologia. 2010 Nov; 53(11): 2334–2339. Published online 2010 Aug 12. doi: 10.1007/s00125-010-1861-2

PMCID:: PMC10328108

Abstract Article PDF–1.0M

Select item 102662212.

Association of solute carrier family 30 A8 zinc transporter gene variations with gestational diabetes mellitus risk in a Chinese population

Qiaoli Zeng, Bing Tan, Fengqiong Han, Xiujuan Huang, Jinzhi Huang, Yue Wei, Runmin Guo

Front Endocrinol (Lausanne) 2023; 14: 1159714. Published online 2023 May 31. doi: 10.3389/fendo.2023.1159714

PMCID:: PMC10266221

Abstract Article PDF–1.3M

Select item 100470773.

ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition

Lina Sui, Qian Du, Anthony Romer, Qi Su, Pauline L. Chabosseau, Yurong Xin, Jinrang Kim, Sandra Kleiner, Guy A. Rutter, Dieter Egli

Cells. 2023 Mar; 12(6): 903. Published online 2023 Mar 15. doi: 10.3390/cells12060903

PMCID:: PMC10047077

Abstract Article PDF–3.6M

Select item 91658554.

Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes

Guanjie Chen, Daniel Shriner, Jianhua Zhang, Jie Zhou, Poorni Adikaram, Ayo P. Doumatey, Amy R. Bentley, Adebowale Adeyemo, Charles N. Rotimi

PLoS One. 2022; 17(6): e0269378. Published online 2022 Jun 3. doi: 10.1371/journal.pone.0269378

PMCID:: PMC9165855

Abstract Article PDF–1.7M

Select item 91524145.

Autoantibodies to Zinc Transporter 8 and SLC30A8 Genotype in Type 1 Diabetes Childhood: A Pioneering Study in North Africa

Raouia Fakhfakh, Sana Kmiha, Safa Tahri, Sawsan Feki, Ferjeni Zouidi, Olfa Abida, Mongia Hachicha, Thouraya Kammoun, Hatem Masmoudi

J Diabetes Res. 2022; 2022: 2539871. Published online 2022 May 23. doi: 10.1155/2022/2539871

PMCID:: PMC9152414

Abstract Article PDF–527K

Select item 82623506.

Pancreatic β cell–selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis

Jie Xu, Nadeeja Wijesekara, Romario Regeenes, Dana Al Rijjal, Anthony L. Piro, Youchen Song, Anne Wu, Alpana Bhattacharjee, Ying Liu, Lucy Marzban, Jonathan V. Rocheleau, Paul E. Fraser, Feihan F. Dai, Cheng Hu, Michael B. Wheeler

JCI Insight. 2021 May 24; 6(10): e143037. Published online 2021 May 24. doi: 10.1172/jci.insight.143037

PMCID:: PMC8262350

Abstract Article PDF–6.7M

Select item 80235867.

Insights into the Dynamics of the Human Zinc Transporter ZnT8 by MD Simulations

Davide Sala, Andrea Giachetti, Antonio Rosato

J Chem Inf Model. 2021 Feb 22; 61(2): 901–912. Published online 2021 Jan 29. doi: 10.1021/acs.jcim.0c01139

PMCID:: PMC8023586

Abstract Article PDF–7.8M

Select item 80158388.

Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma‐associated antigen‐2 and zinc transporter 8

Eiji Kawasaki, Yoichi Oikawa, Akira Okada, Norio Kanatsuna, Tomoyuki Kawamura, Tadashi Kikuchi, Jungo Terasaki, Junnosuke Miura, Yoshihisa Itoh, Toshiaki Hanafusa

J Diabetes Investig. 2021 Apr; 12(4): 510–515. Published online 2020 Aug 26. doi: 10.1111/jdi.13370

PMCID:: PMC8015838

Abstract Article PDF–284K

Select item 80009859.

Probing the Structure and Function of the Cytosolic Domain of the Human Zinc Transporter ZnT8 with Nickel(II) Ions

Maria Carmen Catapano, Douglas S. Parsons, Radosław Kotuniak, Přemysl Mladěnka, Wojciech Bal, Wolfgang Maret

Int J Mol Sci. 2021 Mar; 22(6): 2940. Published online 2021 Mar 14. doi: 10.3390/ijms22062940

PMCID:: PMC8000985

Abstract Article PDF–12M

Select item 742830710.

Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

Jing Xue, Tian Xie, Weizhong Zeng, Youxing Jiang, Xiao-chen Bai

eLife. 2020; 9: e58823. Published online 2020 Jul 29. doi: 10.7554/eLife.58823

PMCID:: PMC7428307

Abstract Article PDF–4.1M

Select item 736783511.

Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease

Xiuli Zhang, Tingwen Guan, Boxuan Yang, Harvest F. Gu, Zhihong Chi

Cell Death Dis. 2020 Jul; 11(7): 544. Published online 2020 Jul 17. doi: 10.1038/s41419-020-2731-6

PMCID:: PMC7367835

Abstract Article PDF–1.7M

Select item 716998312.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 711680813.

Mechanisms of Disease: genetic insights into the etiology of type 2 diabetes and obesity

Cecilia M Lindgren, Mark I McCarthy

Nat Clin Pract Endocrinol Metab. Author manuscript; available in PMC 2021 Feb 23.

Published in final edited form as: Nat Clin Pract Endocrinol Metab. 2008 Mar 1; 4(3): 156–63. Published online 2008 Jan 15. doi: 10.1038/ncpendmet0723

PMCID:: PMC7116808

Abstract Article PDF–309K

Select item 703703614.

C-Terminal Domain of the Human Zinc Transporter hZnT8 Is Structurally Indistinguishable from Its Disease Risk Variant (R325W)

Raheem Ullah, Aamir Shehzad, Majid Ali Shah, Matteo De March, Fouzia Ismat, Mazhar Iqbal, Silvia Onesti, Moazur Rahman, Michael J. McPherson

Int J Mol Sci. 2020 Feb; 21(3): 926. Published online 2020 Jan 31. doi: 10.3390/ijms21030926

PMCID:: PMC7037036

Abstract Article PDF–2.3M

Select item 685887415.

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Om Prakash Dwivedi, Mikko Lehtovirta, Benoit Hastoy, Vikash Chandra, Nicole A. J. Krentz, Sandra Kleiner, Deepak Jain, Ann-Marie Richard, Fernando Abaitua, Nicola L. Beer, Antje Grotz, Rashmi B. Prasad, Ola Hansson, Emma Ahlqvist, Ulrika Krus, Isabella Artner, Anu Suoranta, Daniel Gomez, Aris Baras, Benoite Champon, Anthony J Payne, Daniela Moralli, Soren K. Thomsen, Philipp Kramer, Ioannis Spiliotis, Reshma Ramracheya, Pauline Chabosseau, Andria Theodoulou, Rebecca Cheung, Martijn van de Bunt, Jason Flannick, Maddalena Trombetta, Enzo Bonora, Claes B. Wolheim, Leena Sarelin, Riccardo C. Bonadonna, Patrik Rorsman, Benjamin Davies, Julia Brosnan, Mark I. McCarthy, Timo Otonkoski, Jens O. Lagerstedt, Guy A Rutter, Jesper Gromada, Anna L. Gloyn, Tiinamaija Tuomi, Leif Groop

Nat Genet. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Nat Genet. 2019 Nov; 51(11): 1596–1606. Published online 2019 Nov 1. doi: 10.1038/s41588-019-0513-9

PMCID:: PMC6858874

Abstract Article PDF–5.1M

Select item 685131016.

Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress

Chengfeng Merriman, Dax Fu

J Biol Chem. 2019 Nov 8; 294(45): 16992–17006. Published online 2019 Oct 7. doi: 10.1074/jbc.RA119.010937

PMCID:: PMC6851310

Abstract Article PDF–3.2M

Select item 680582217.

What has zinc transporter 8 autoimmunity taught us about type 1 diabetes?

Claire L. Williams, Anna E. Long

Diabetologia. 2019; 62(11): 1969–1976. Published online 2019 Aug 23. doi: 10.1007/s00125-019-04975-x

PMCID:: PMC6805822

Abstract Article PDF–748K

Select item 639819818.

SLC30A8 Gene rs13266634 C/T Polymorphism in Children with Type 1 Diabetes in Tamil Nadu, India

Ramasamy Thirunavukkarasu, Arthur Joseph Asirvatham, Ayyappan Chitra, Mariakuttikan Jayalakshmi

J Clin Res Pediatr Endocrinol. 2019 Mar; 11(1): 55–60. Published online 2019 Feb 20. doi: 10.4274/jcrpe.galenos.2018.2018.0195

PMCID:: PMC6398198

Abstract Article PDF–443K

Select item 615500019.

Discovering human diabetes-risk gene function with genetics and physiological assays

Heshan Peiris, Sangbin Park, Shreya Louis, Xueying Gu, Jonathan Y. Lam, Olof Asplund, Gregory C. Ippolito, Rita Bottino, Leif Groop, Haley Tucker, Seung K. Kim

Nat Commun. 2018; 9: 3855. Published online 2018 Sep 21. doi: 10.1038/s41467-018-06249-3

PMCID:: PMC6155000

Abstract Article PDF–2.2M

Select item 582439920.

Increased free Zn²⁺ correlates induction of sarco(endo)plasmic reticulum stress via altered expression levels of Zn²⁺‐transporters in heart failure

Yusuf Olgar, Aysegul Durak, Erkan Tuncay, Ceylan Verda Bitirim, Evren Ozcinar, Mustafa Bahadir Inan, Zeynep Tokcaer‐Keskin, Kamil Can Akcali, Ahmet Ruchan Akar, Belma Turan

J Cell Mol Med. 2018 Mar; 22(3): 1944–1956. Published online 2018 Jan 15. doi: 10.1111/jcmm.13480

PMCID:: PMC5824399

Abstract Article PDF–940K

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