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Items: 1 to 20 of 54

1.
Decreased Tiam1‐mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia
Yi Wu, Wei Liu, Jia Li, Hang Shi, Shize Ma, Di Wang, Bo Pan, Ran Xiao, Haiyue Jiang, Xia Liu
J Cell Mol Med. 2024 Jun; 28(11): e18443. Published online 2024 Jun 4. doi: 10.1111/jcmm.18443
PMCID:
PMC11149491
AbstractArticlePDF–29M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Tiam1 Coordinates Synaptic Structural and Functional Plasticity Underpinning the Pathophysiology of Neuropathic Pain
Lingyong Li, Qin Ru, Yungang Lu, Xing Fang, Guanxing Chen, Ali Bin Saifullah, Changqun Yao, Kimberley F. Tolias
Neuron. Author manuscript; available in PMC 2024 Jul 5.
Published in final edited form as: Neuron. 2023 Jul 5; 111(13): 2038–2050.e6. Published online 2023 May 4. doi: 10.1016/j.neuron.2023.04.010
PMCID:
PMC10330505
AbstractArticlePDF–2.5M
4.
Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis
Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch
Front Immunol. 2023; 14: 1180886. Published online 2023 Jun 13. doi: 10.3389/fimmu.2023.1180886
PMCID:
PMC10293741
AbstractArticlePDF–22M
5.
TIAM1-mediated synaptic plasticity underlies comorbid depression–like and ketamine antidepressant–like actions in chronic pain
Qin Ru, Yungang Lu, Ali Bin Saifullah, Francisco A. Blanco, Changqun Yao, Juan P. Cata, De-Pei Li, Kimberley F. Tolias, Lingyong Li
J Clin Invest. 2022 Dec 15; 132(24): e158545. Published online 2022 Dec 15. doi: 10.1172/JCI158545
PMCID:
PMC9753999
AbstractArticlePDF–7.7M
6.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
7.
The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis
Flavian Thelen, Stefanie Wissmann, Nora Ruef, Jens V. Stein
Front Immunol. 2021; 12: 716405. Published online 2021 Sep 9. doi: 10.3389/fimmu.2021.716405
PMCID:
PMC8458560
AbstractArticlePDF–1001K
8.
The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions
Jinxuan Cheng, Federico Scala, Francisco A. Blanco, Sanyong Niu, Karen Firozi, Laura Keehan, Shalaka Mulherkar, Emmanouil Froudarakis, Lingyong Li, Joseph G. Duman, Xiaolong Jiang, Kimberley F. Tolias
J Neurosci. 2021 Feb 10; 41(6): 1191–1206. doi: 10.1523/JNEUROSCI.3271-17.2020
PMCID:
PMC7888217
AbstractArticlePDF–4.2M
9.
Myoblast Migration and Directional Persistence Affected by Syndecan-4-Mediated Tiam-1 Expression and Distribution
Daniel Becsky, Szuzina Gyulai-Nagy, Arpad Balind, Peter Horvath, Laszlo Dux, Aniko Keller-Pinter
Int J Mol Sci. 2020 Feb; 21(3): 823. Published online 2020 Jan 27. doi: 10.3390/ijms21030823
PMCID:
PMC7037462
AbstractArticlePDF–1.4M
10.
Opposite functions of STAT3 and Smad3 in regulating Tiam1 expression in Th17 cells
Thomas Buttrick, Samia J. Khoury, Wassim Elyaman
Small GTPases. 2020; 11(1): 62–68. Published online 2017 Sep 18. doi: 10.1080/21541248.2017.1341365
PMCID:
PMC6959293
AbstractArticlePDF–539K
11.
MiR-190a potentially ameliorates postoperative cognitive dysfunction by regulating Tiam1
Qiang Liu, Aisheng Hou, Yongyi Zhang, Ying Guo, Jingjing Li, Yinghao Yao, Kaimeng Niu, Hao Li, Yunlong Ma, Jiangbei Cao
BMC Genomics. 2019; 20: 670. Published online 2019 Aug 22. doi: 10.1186/s12864-019-6035-0
PMCID:
PMC6704709
AbstractArticlePDF–1.7M
12.
NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model
Rajakrishnan Veluthakal, Vaibhav Sidarala, Anjaneyulu Kowluru
Cell Physiol Biochem. Author manuscript; available in PMC 2019 Aug 8.
Published in final edited form as: Cell Physiol Biochem. 2016; 39(2): 760–767. Published online 2016 Jul 29. doi: 10.1159/000445666
PMCID:
PMC6686134
AbstractArticlePDF–670K
13.
Par3 is essential for the establishment of planar cell polarity of inner ear hair cells
Andre Landin Malt, Zachary Dailey, Julia Holbrook-Rasmussen, Yuqiong Zheng, Arielle Hogan, Quansheng Du, Xiaowei Lu
Proc Natl Acad Sci U S A. 2019 Mar 12; 116(11): 4999–5008. Published online 2019 Feb 27. doi: 10.1073/pnas.1816333116
PMCID:
PMC6421412
AbstractArticlePDF–3.8M
14.
TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells
Zoi Diamantopoulou, Gavin White, Muhammad Z.H. Fadlullah, Marcel Dreger, Karen Pickering, Joe Maltas, Garry Ashton, Ruth MacLeod, George S. Baillie, Valerie Kouskoff, Georges Lacaud, Graeme I. Murray, Owen J. Sansom, Adam F.L. Hurlstone, Angeliki Malliri
Cancer Cell. 2017 May 8; 31(5): 621–634.e6. doi: 10.1016/j.ccell.2017.03.007
PMCID:
PMC5425402
AbstractArticle
15.
Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
Ahmed T. Kurdi, Ribal Bassil, Marta Olah, Chuan Wu, Sheng Xiao, Mariko Taga, Michael Frangieh, Thomas Buttrick, William Orent, Elizabeth M. Bradshaw, Samia J. Khoury, Wassim Elyaman
Nat Commun. 2016; 7: 13048. Published online 2016 Oct 11. doi: 10.1038/ncomms13048
PMCID:
PMC5062600
AbstractArticlePDF–3.1M
16.
Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
Hadir Marei, Alejandro Carpy, Anna Woroniuk, Claire Vennin, Gavin White, Paul Timpson, Boris Macek, Angeliki Malliri
Nat Commun. 2016; 7: 10664. Published online 2016 Feb 18. doi: 10.1038/ncomms10664
PMCID:
PMC4759627
AbstractArticlePDF–7.6M
17.
Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation
Helen J. Whalley, Andrew P. Porter, Zoi Diamantopoulou, Gavin R. M. White, Eduardo Castañeda-Saucedo, Angeliki Malliri
Nat Commun. 2015; 6: 7437. Published online 2015 Jun 16. doi: 10.1038/ncomms8437
PMCID:
PMC4490568
AbstractArticlePDF–2.2M
18.
LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans
Ho-Chou Tu, Sarah Schwitalla, Zhirong Qian, Grace S. LaPier, Alena Yermalovich, Yuan-Chieh Ku, Shann-Ching Chen, Srinivas R. Viswanathan, Hao Zhu, Reiko Nishihara, Kentaro Inamura, Sun A. Kim, Teppei Morikawa, Kosuke Mima, Yasutaka Sukawa, Juhong Yang, Gavin Meredith, Charles S. Fuchs, Shuji Ogino, George Q. Daley
Genes Dev. 2015 May 15; 29(10): 1074–1086. doi: 10.1101/gad.256693.114
PMCID:
PMC4441054
AbstractArticlePDF–2.4M
19.
A high resolution spatiotemporal atlas of gene expression of the developing mouse brain
Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones
Neuron. Author manuscript; available in PMC 2015 Jul 16.
Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033
PMCID:
PMC4319559
AbstractArticlePDF–3.0M
20.
Dynamic Control of Excitatory Synapse Development by a Rac1 GEF/GAP Regulatory Complex
Kyongmi Um, Sanyong Niu, Joseph G. Duman, Jinxuan Cheng, Yen-Kuei Tu, Brandon Schwechter, Feng Liu, Laura Hiles, Anjana Narayanan, Ryan T. Ash, Shalaka Mulherkar, Kannan Alpadi, Stelios M. Smirnakis, Kimberley F. Tolias
Dev Cell. Author manuscript; available in PMC 2015 Jun 23.
Published in final edited form as: Dev Cell. 2014 Jun 23; 29(6): 701–715. doi: 10.1016/j.devcel.2014.05.011
PMCID:
PMC4111230
AbstractArticlePDF–1.3M

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