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Select item 109812151.

CCL21 and CLDN11 Are Key Driving Factors of Lymph Node Metastasis in Gastric Cancer

Shaofei Yang, Dandan Dong, Xunxia Bao, Rongting Lu, Pufei Cheng, Sibo Zhu, Guanghua Yang

Cancer Control. 2024 Jan-Dec; 31: 10732748241238616. Published online 2024 Mar 29. doi: 10.1177/10732748241238616

PMCID:: PMC10981215

Abstract Article PDF–2.0M

Select item 102670172.

CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma

Luiz Henrique Geraldo, Celina Garcia, Yunling Xu, Felipe Saceanu Leser, Izabella Grimaldi, Eduardo Sabino de Camargo Magalhães, Joost Dejaegher, Lien Solie, Cláudia Maria Pereira, Ana Helena Correia, Steven De Vleeschouwer, Bertrand Tavitian, Nathalie Henriques Silva Canedo, Thomas Mathivet, Jean-Leon Thomas, Anne Eichmann, Flavia Regina Souza Lima

Cell Mol Life Sci. 2023 Jul; 80(7): 179. Published online 2023 Jun 14. doi: 10.1007/s00018-023-04788-7

PMCID:: PMC10267017

Abstract Article PDF–10M

Select item 101941363.

Chemokine Analysis in Patients with Metastatic Uveal Melanoma Suggests a Role for CCL21 Signaling in Combined Epigenetic Therapy and Checkpoint Immunotherapy

Vasu R. Sah, Henrik Jespersen, Joakim Karlsson, Lisa M. Nilsson, Mattias Bergqvist, Iva Johansson, Ana Carneiro, Hildur Helgadottir, Max Levin, Gustav Ullenhag, Anders Ståhlberg, Roger Olofsson Bagge, Jonas A. Nilsson, Lars Ny

Cancer Res Commun. 2023 May; 3(5): 884–895. Published online 2023 May 18. doi: 10.1158/2767-9764.CRC-22-0490

PMCID:: PMC10194136

Abstract Article PDF–16M

Select item 100402474.

CCL21/CCR7 signaling in macrophages promotes joint inflammation and Th17-mediated osteoclast formation in rheumatoid arthritis

Katrien Van Raemdonck, Sadiq Umar, Karol Palasiewicz, Suncica Volkov, Michael V. Volin, Shiva Arami, Huan J. Chang, Brian Zanotti, Nadera Sweiss, Shiva Shahrara

Cell Mol Life Sci. 2020 Apr; 77(7): 1387–1399. Published online 2019 Jul 24. doi: 10.1007/s00018-019-03235-w

PMCID:: PMC10040247

Abstract Article PDF–8.4M

Select item 98669485.

Heparin Specifically Interacts with Basic BBXB Motifs of the Chemokine CCL21 to Define CCR7 Signaling

Marc Artinger, Oliver J. Gerken, Daniel F. Legler

Int J Mol Sci. 2023 Jan; 24(2): 1670. Published online 2023 Jan 14. doi: 10.3390/ijms24021670

PMCID:: PMC9866948

Abstract Article PDF–2.7M

Select item 95416176.

Target organ expression and biomarker characterization of chemokine CCL21 in systemic sclerosis associated pulmonary arterial hypertension

Henriette Didriksen, Øyvind Molberg, Adi Mehta, Suzana Jordan, Vyacheslav Palchevskiy, Håvard Fretheim, Einar Gude, Thor Ueland, Cathrine Brunborg, Torhild Garen, Øyvind Midtvedt, Arne K. Andreassen, Fridtjof Lund-Johansen, Oliver Distler, John Belperio, Anna-Maria Hoffmann-Vold

Front Immunol. 2022; 13: 991743. Published online 2022 Sep 23. doi: 10.3389/fimmu.2022.991743

PMCID:: PMC9541617

Abstract Article PDF–11M

Select item 92702467.

Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses

Evert J. Loef, Hilary M. Sheppard, Nigel P. Birch, P. Rod Dunbar

J Biol Chem. 2022 Jul; 298(7): 102112. Published online 2022 Jun 9. doi: 10.1016/j.jbc.2022.102112

PMCID:: PMC9270246

Abstract Article PDF–1.2M

Select item 85581798.

The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

Astrid Sissel Jørgensen, Emma Probst Brandum, Jeppe Malthe Mikkelsen, Klaudia A. Orfin, Ditte Rahbæk Boilesen, Kristoffer Lihme Egerod, Natasha A. Moussouras, Frederik Vilhardt, Pawel Kalinski, Per Basse, Yen-Hsi Chen, Zhang Yang, Michael B. Dwinell, Brian F. Volkman, Christopher T. Veldkamp, Peter Johannes Holst, Katharina Lahl, Christoffer Knak Goth, Mette Marie Rosenkilde, Gertrud Malene Hjortø

Cell Mol Life Sci. 2021 Nov; 78(21-22): 6963–6978. Published online 2021 Sep 29. doi: 10.1007/s00018-021-03930-7

PMCID:: PMC8558179

Abstract Article PDF–3.4M

Select item 84785339.

Crosstalk between Heart Failure and Cognitive Impairment via hsa-miR-933/RELB/CCL21 Pathway

Wenxiao Feng, Jie Yang, Wenchao Song, Yitao Xue

Biomed Res Int. 2021; 2021: 2291899. Published online 2021 Sep 18. doi: 10.1155/2021/2291899

PMCID:: PMC8478533

Abstract Article PDF–4.0M

Select item 837189210.

Urinary small extracellular vesicles derived CCL21 mRNA as biomarker linked with pathogenesis for diabetic nephropathy

Ye Feng, Xin Zhong, Hai-Feng Ni, Cui Wang, Tao-Tao Tang, Li-Ting Wang, Kai-Yun Song, Ri-Ning Tang, Hong Liu, Bi-Cheng Liu, Lin-Li Lv

J Transl Med. 2021; 19: 355. Published online 2021 Aug 17. doi: 10.1186/s12967-021-03030-x

PMCID:: PMC8371892

Abstract Article PDF–1.9M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 791547712.

CD9 Upregulation-Decreased CCL21 Secretion in Mesenchymal Stem Cells Reduces Cancer Cell Migration

Chia-Chu Hsieh, Szu-Chun Hsu, Ming Yao, Dong-Ming Huang

Int J Mol Sci. 2021 Feb; 22(4): 1738. Published online 2021 Feb 9. doi: 10.3390/ijms22041738

PMCID:: PMC7915477

Abstract Article PDF–4.1M

Select item 787796113.

Arrestin 3 Mediates Endocytosis of CCR7 Following Ligation of CCL19 but not CCL21

Melissa A. Byers, Psachal A. Calloway, Laurie Shannon, Heather D. Cunningham, Sarah Smith, Fang Li, Brian C. Fassold, Charlotte M. Vines

J Immunol. Author manuscript; available in PMC 2021 Feb 11.

Published in final edited form as: J Immunol. 2008 Oct 1; 181(7): 4723–4732. doi: 10.4049/jimmunol.181.7.4723

PMCID:: PMC7877961

Abstract Article PDF–1.3M

Select item 779813114.

Association of serum chemokine ligand 21 levels with asthma control in adults

Yueyan Lou, Yu Zheng, Yanhua Xu, Hui Lu, Yiwei Wang, Yinshi Guo

Clinics (Sao Paulo) 2021; 76: e1713. Published online 2021 Jan 11. doi: 10.6061/clinics/2021/e1713

PMCID:: PMC7798131

Abstract Article PDF–752K

Select item 774644215.

Serum CCL21 as a Potential Biomarker for Cognitive Impairment in Spinal Cord Injury

Yuanzhen Chen, Liangke Liang, Shengnan Cao, Guangjian Hou, Qian Zhang, Hong Ma, Bin Shi

Biomed Res Int. 2020; 2020: 6692802. Published online 2020 Dec 9. doi: 10.1155/2020/6692802

PMCID:: PMC7746442

Abstract Article PDF–348K

Select item 769427416.

Lymphatic Metastasis of NSCLC Involves Chemotaxis Effects of Lymphatic Endothelial Cells through the CCR7–CCL21 Axis Modulated by TNF-α

Shuai Zhang, Hongzheng Wang, Zhiyun Xu, Yongkang Bai, Lin Xu

Genes (Basel) 2020 Nov; 11(11): 1309. Published online 2020 Nov 4. doi: 10.3390/genes11111309

PMCID:: PMC7694274

Abstract Article PDF–3.6M

Select item 730764917.

Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21

Natasha A. Moussouras, Gertrud M. Hjortø, Francis C. Peterson, Martyna Szpakowska, Andy Chevigné, Mette M. Rosenkilde, Brian F. Volkman, Michael B. Dwinell

Biochemistry. Author manuscript; available in PMC 2021 Apr 7.

Published in final edited form as: Biochemistry. 2020 Apr 7; 59(13): 1338–1350. Published online 2020 Mar 26. doi: 10.1021/acs.biochem.0c00047

PMCID:: PMC7307649

Abstract Article PDF–1.7M

Select item 716998318.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 710916119.

Gene Expression Profiles in Chemokine (C-C Motif) Ligand 21-Overexpressing Pancreatic Cancer Cells

Kai Cui, Hongsheng Zou, Mingliang Shi, Yang Ou, Lu Han, Bo Zhang, Dawei Hu, Sheng Li

Pathol Oncol Res. 2020; 26(1): 201–208. Published online 2018 Apr 23. doi: 10.1007/s12253-018-0390-z

PMCID:: PMC7109161

Abstract Article PDF–4.5M

Select item 675317820.

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

Astrid S. Jørgensen, Olav Larsen, Edith Uetz-von Allmen, Michael Lückmann, Daniel F. Legler, Thomas M. Frimurer, Christopher T. Veldkamp, Gertrud M. Hjortø, Mette M. Rosenkilde

Front Immunol. 2019; 10: 2156. Published online 2019 Sep 13. doi: 10.3389/fimmu.2019.02156

PMCID:: PMC6753178

Abstract Article PDF–1.7M

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