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Select item 111094831.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 107193132.

Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis

Yu Muta, Juan F. Linares, Anxo Martinez-Ordoñez, Angeles Duran, Tania Cid-Diaz, Hiroto Kinoshita, Xiao Zhang, Qixiu Han, Yuki Nakanishi, Naoko Nakanishi, Thekla Cordes, Gurpreet K. Arora, Marc Ruiz-Martinez, Miguel Reina-Campos, Hiroaki Kasashima, Masakazu Yashiro, Kiyoshi Maeda, Ana Albaladejo-Gonzalez, Daniel Torres-Moreno, José García-Solano, Pablo Conesa-Zamora, Giorgio Inghirami, Christian M. Metallo, Timothy F. Osborne, Maria T. Diaz-Meco, Jorge Moscat

Nat Commun. 2023; 14: 8075. Published online 2023 Dec 13. doi: 10.1038/s41467-023-43690-5

PMCID:: PMC10719313

Abstract Article PDF–7.4M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100746574.

Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation

Juying Jiao, Linjie Ruan, Chien-shan Cheng, Fengjiao Wang, Peiwen Yang, Zhen Chen

Mol Med. 2023; 29: 47. Published online 2023 Apr 4. doi: 10.1186/s10020-023-00648-z

PMCID:: PMC10074657

Abstract Article PDF–10M

Select item 100729065.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 99563196.

Investigation of UTR Variants by Computational Approaches Reveal Their Functional Significance in PRKCI Gene Regulation

Hania Shah, Khushbukhat Khan, Yasmin Badshah, Naeem Mahmood Ashraf, Maria Shabbir, Janeen H. Trembley, Tayyaba Afsar, Ali Abusharha, Suhail Razak

Genes (Basel) 2023 Feb; 14(2): 247. Published online 2023 Jan 18. doi: 10.3390/genes14020247

PMCID:: PMC9956319

Abstract Article PDF–4.2M

Select item 98450197.

Protein kinase C_ι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities

Rajappa S. Kenchappa, Yi Liu, Michael G. Argenziano, Matei A. Banu, Ann C. Mladek, Rita West, Amanda Luu, Alfredo Quiñones-Hinojosa, Dolores Hambardzumyan, Verline Justilien, Michael Leitges, Jann N. Sarkaria, Peter A. Sims, Peter Canoll, Nicole R. Murray, Alan P. Fields, Steven S. Rosenfeld

Cell Rep. Author manuscript; available in PMC 2023 Jan 17.

Published in final edited form as: Cell Rep. 2021 Nov 23; 37(8): 110054. doi: 10.1016/j.celrep.2021.110054

PMCID:: PMC9845019

Abstract Article PDF–2.7M

Select item 97725588.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 97696989.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 948193310.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 927928511.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 917141112.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 911973613.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910523514.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 905883615.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 903641816.

Recurrent Copy Number Gains Drive Protein Kinase Cι Expression and Oncogenic Signaling in Human Cancers

Yi Liu, Verline Justilien, Alan P. Fields, Nicole R. Murray

Adv Biol Regul. Author manuscript; available in PMC 2022 Apr 25.

Published in final edited form as: Adv Biol Regul. 2020 Dec; 78: 100754. Published online 2020 Sep 12. doi: 10.1016/j.jbior.2020.100754

PMCID:: PMC9036418

Abstract Article PDF–1.6M

Select item 889702217.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 863715018.

Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl

Vlad Tocan, Junya Hayase, Sachiko Kamakura, Akira Kohda, Shouichi Ohga, Motoyuki Kohjima, Hideki Sumimoto

J Biol Chem. 2021 Dec; 297(6): 101354. Published online 2021 Oct 27. doi: 10.1016/j.jbc.2021.101354

PMCID:: PMC8637150

Abstract Article PDF–6.6M

Select item 862047919.

ELF3 Is a Target That Promotes Therapeutic Efficiency in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer Cells via Inhibiting PKCί

Jeon-Soo Lee, Young Eun Choi, Sunshin Kim, Ji-Youn Han, Sung-Ho Goh

Int J Mol Sci. 2021 Nov; 22(22): 12287. Published online 2021 Nov 13. doi: 10.3390/ijms222212287

PMCID:: PMC8620479

Abstract Article PDF–5.2M

Select item 857105420.

PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis

Juan F. Linares, Xiao Zhang, Anxo Martinez-Ordoñez, Angeles Duran, Hiroto Kinoshita, Hiroaki Kasashima, Naoko Nakanishi, Yuki Nakanishi, Ryan Carelli, Luca Cappelli, Esperanza Arias, Masakazu Yashiro, Masaichi Ohira, Sanjay Patel, Giorgio Inghirami, Massimo Loda, Ana Maria Cuervo, Maria T. Diaz-Meco, Jorge Moscat

Mol Cell. Author manuscript; available in PMC 2022 Nov 4.

Published in final edited form as: Mol Cell. 2021 Nov 4; 81(21): 4509–4526.e10. Published online 2021 Sep 23. doi: 10.1016/j.molcel.2021.08.039

PMCID:: PMC8571054

Abstract Article PDF–4.2M

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