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Select item 106183711.

Genetic Variants in WNT16 and PKD2L1 Locus Affect Heel Ultrasound Bone Stiffness: Analyses from the General Population and Patients Evaluated for Osteoporosis

Angelique Kragl, Anke Hannemann, Matthias Nauck, Uwe Völker, Heide Siggelkow, Alexander Teumer, Mladen V. Tzvetkov

Calcif Tissue Int. 2023; 113(5): 540–551. Published online 2023 Oct 13. doi: 10.1007/s00223-023-01141-9

PMCID:: PMC10618371

Abstract Article PDF–1.3M

Select item 98158002.

Wnt16 signaling in bone homeostasis and osteoarthristis

Xiaoping Ye, Xianwen Liu

Front Endocrinol (Lausanne) 2022; 13: 1095711. Published online 2022 Dec 22. doi: 10.3389/fendo.2022.1095711

PMCID:: PMC9815800

Abstract Article PDF–1.6M

Select item 87483763.

Bone mineral density in high-level endurance runners: Part B—genotype-dependent characteristics

A. J. Herbert, A. G. Williams, S. J. Lockey, R. M. Erskine, C. Sale, P. J. Hennis, S. H. Day, G. K. Stebbings

Eur J Appl Physiol. 2022; 122(1): 71–80. Published online 2021 Sep 22. doi: 10.1007/s00421-021-04789-z

PMCID:: PMC8748376

Abstract Article PDF–705K

Select item 86535934.

WNT16 elevation induced cell senescence of osteoblasts in ankylosing spondylitis

Sungsin Jo, Subin Weon, Bora Nam, Mi-Ae Jang, Hyundeok Kang, Tae-Jong Kim, Ye-Soo Park, Tae-Hwan Kim

Arthritis Res Ther. 2021; 23: 301. Published online 2021 Dec 8. doi: 10.1186/s13075-021-02670-0

PMCID:: PMC8653593

Abstract Article PDF–1.4M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74390036.

WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway

Romuald Binet, Damien Ythier, Ana I. Robles, Manuel Collado, Delphine Larrieu, Claire Fonti, Elisabeth Brambilla, Christian Brambilla, Manuel Serrano, Curtis C. Harris, Rémy Pedeux

Cancer Res. Author manuscript; available in PMC 2020 Aug 20.

Published in final edited form as: Cancer Res. 2009 Dec 15; 69(24): 9183–9191. doi: 10.1158/0008-5472.CAN-09-1016

PMCID:: PMC7439003

Abstract Article PDF–2.5M

Select item 69812067.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 60533848.

Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density

Núria Martínez-Gil, Neus Roca-Ayats, Anna Monistrol-Mula, Natàlia García-Giralt, Adolfo Díez-Pérez, Xavier Nogués, Leonardo Mellibovsky, Daniel Grinberg, Susana Balcells

Sci Rep. 2018; 8: 10951. Published online 2018 Jul 19. doi: 10.1038/s41598-018-29242-8

PMCID:: PMC6053384

Abstract Article PDF–1.6M

Select item 55316119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 536237910.

Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies

Tianhua Niu, Ning Liu, Xun Yu, Ming Zhao, Hyung Jin Choi, Paul J. Leo, Matthew A. Brown, Lei Zhang, Yu-Fang Pei, Hui Shen, Hao He, Xiaoying Fu, Shan Lu, Xiang-Ding Chen, Li-Jun Tan, Tie-Lin Yang, Yan Guo, Nam H. Cho, Jie Shen, Yan-Fang Guo, Geoffrey C. Nicholson, Richard L. Prince, John A. Eisman, Graeme Jones, Philip N. Sambrook, Qing Tian, Xue-Zhen Zhu, Christopher J. Papasian, Emma L. Duncan, André G. Uitterlinden, Chan Soo Shin, Shuanglin Xiang, Hong-Wen Deng

J Bone Miner Res. Author manuscript; available in PMC 2017 Mar 22.

Published in final edited form as: J Bone Miner Res. 2016 Feb; 31(2): 358–368. Published online 2015 Sep 11. doi: 10.1002/jbmr.2687

PMCID:: PMC5362379

Abstract Article PDF–1.6M

Select item 499401911.

SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment

Y Sun, D Zhu, F Chen, M Qian, H Wei, W Chen, J Xu

Oncogene. 2016 Aug 18; 35(33): 4321–4334. Published online 2016 Jan 11. doi: 10.1038/onc.2015.494

PMCID:: PMC4994019

Abstract Article PDF–4.1M

Select item 481068312.

WNT16-expressing Acute Lymphoblastic Leukemia Cells are Sensitive to Autophagy Inhibitors after ER Stress Induction

Meletios Verras, Ioanna Papandreou, Nicholas C. Denko

Anticancer Res. Author manuscript; available in PMC 2016 Mar 29.

Published in final edited form as: Anticancer Res. 2015 Sep; 35(9): 4625–4631.

PMCID:: PMC4810683

Abstract Article PDF–1.5M

Select item 473311513.

Osteoblast-Specific Overexpression of Human WNT16 Increases Both Cortical and Trabecular Bone Mass and Structure in Mice

Imranul Alam, Mohammed Alkhouli, Rita L. Gerard-O'Riley, Weston B. Wright, Dena Acton, Amie K. Gray, Bhavmik Patel, Austin M. Reilly, Kyung-Eun Lim, Alexander G. Robling, Michael J. Econs

Endocrinology. 2016 Feb; 157(2): 722–736. Published online 2015 Nov 19. doi: 10.1210/en.2015-1281

PMCID:: PMC4733115

Abstract Article

Select item 467278714.

The bone-sparing effects of estrogen and WNT16 are independent of each other

Sofia Movérare-Skrtic, Jianyao Wu, Petra Henning, Karin L. Gustafsson, Klara Sjögren, Sara H. Windahl, Antti Koskela, Juha Tuukkanen, Anna E. Börjesson, Marie K. Lagerquist, Ulf H. Lerner, Fu-Ping Zhang, Jan-Åke Gustafsson, Matti Poutanen, Claes Ohlsson

Proc Natl Acad Sci U S A. 2015 Dec 1; 112(48): 14972–14977. Published online 2015 Nov 16. doi: 10.1073/pnas.1520408112

PMCID:: PMC4672787

Abstract Article PDF–663K

Select item 439288815.

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

Sofia Movérare-Skrtic, Petra Henning, Xianwen Liu, Kenichi Nagano, Hiroaki Saito, Anna E Börjesson, Klara Sjögren, Sara H Windahl, Helen Farman, Bert Kindlund, Cecilia Engdahl, Antti Koskela, Fu-Ping Zhang, Emma E Eriksson, Farasat Zaman, Ann Hammarstedt, Hanna Isaksson, Marta Bally, Ali Kassem, Catharina Lindholm, Olof Sandberg, Per Aspenberg, Lars Sävendahl, Jian Q Feng, Jan Tuckermann, Juha Tuukkanen, Matti Poutanen, Roland Baron, Ulf H Lerner, Francesca Gori, Claes Ohlsson

Nat Med. Author manuscript; available in PMC 2015 Apr 10.

Published in final edited form as: Nat Med. 2014 Nov; 20(11): 1279–1288. Published online 2014 Oct 12. doi: 10.1038/nm.3654

PMCID:: PMC4392888

Abstract Article PDF–1.8M

Select item 434442516.

Wnt16 Attenuates TGFβ-induced Chondrogenic Transformation in Vascular Smooth Muscle

Kelly E. Beazley, Dmitry Nurminsky, Florence Lima, Chintan Gandhi, Maria V. Nurminskaya

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2016 Mar 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3): 573–579. Published online 2015 Jan 22. doi: 10.1161/ATVBAHA.114.304393

PMCID:: PMC4344425

Abstract Article PDF–961K

Select item 406369717.

Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment

John P. Kemp, Carolina Medina-Gomez, Karol Estrada, Beate St Pourcain, Denise H. M. Heppe, Nicole M. Warrington, Ling Oei, Susan M. Ring, Claudia J. Kruithof, Nicholas J. Timpson, Lisa E. Wolber, Sjur Reppe, Kaare Gautvik, Elin Grundberg, Bing Ge, Bram van der Eerden, Jeroen van de Peppel, Matthew A. Hibbs, Cheryl L. Ackert-Bicknell, Kwangbom Choi, Daniel L. Koller, Michael J. Econs, Frances M. K. Williams, Tatiana Foroud, M. Carola Zillikens, Claes Ohlsson, Albert Hofman, André G. Uitterlinden, George Davey Smith, Vincent W. V. Jaddoe, Jonathan H. Tobias, Fernando Rivadeneira, David M. Evans

PLoS Genet. 2014 Jun; 10(6): e1004423. Published online 2014 Jun 19. doi: 10.1371/journal.pgen.1004423

PMCID:: PMC4063697

Abstract Article PDF–805K

Select item 403879118.

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

Alireza Moayyeri, Yi-Hsiang Hsu, David Karasik, Karol Estrada, Su-Mei Xiao, Carrie Nielson, Priya Srikanth, Sylvie Giroux, Scott G. Wilson, Hou-Feng Zheng, Albert V. Smith, Stephen R. Pye, Paul J. Leo, Alexander Teumer, Joo-Yeon Hwang, Claes Ohlsson, Fiona McGuigan, Ryan L. Minster, Caroline Hayward, José M. Olmos, Leo-Pekka Lyytikäinen, Joshua R. Lewis, Karin M.A. Swart, Laura Masi, Chris Oldmeadow, Elizabeth G. Holliday, Sulin Cheng, Natasja M. van Schoor, Nicholas C. Harvey, Marcin Kruk, Fabiola del Greco M, Wilmar Igl, Olivia Trummer, Efi Grigoriou, Robert Luben, Ching-Ti Liu, Yanhua Zhou, Ling Oei, Carolina Medina-Gomez, Joseph Zmuda, Greg Tranah, Suzanne J. Brown, Frances M. Williams, Nicole Soranzo, Johanna Jakobsdottir, Kristin Siggeirsdottir, Kate L. Holliday, Anke Hannemann, Min Jin Go, Melissa Garcia, Ozren Polasek, Marika Laaksonen, Kun Zhu, Anke W. Enneman, Mark McEvoy, Roseanne Peel, Pak Chung Sham, Maciej Jaworski, Åsa Johansson, Andrew A. Hicks, Pawel Pludowski, Rodney Scott, Rosalie A.M. Dhonukshe-Rutten, Nathalie van der Velde, Mika Kähönen, Jorma S. Viikari, Harri Sievänen, Olli T. Raitakari, Jesús González-Macías, Jose L. Hernández, Dan Mellström, Östen Ljunggren, Yoon Shin Cho, Uwe Völker, Matthias Nauck, Georg Homuth, Henry Völzke, Robin Haring, Matthew A. Brown, Eugene McCloskey, Geoffrey C. Nicholson, Richard Eastell, John A. Eisman, Graeme Jones, Ian R. Reid, Elaine M. Dennison, John Wark, Steven Boonen, Dirk Vanderschueren, Frederick C.W. Wu, Thor Aspelund, J. Brent Richards, Doug Bauer, Albert Hofman, Kay-Tee Khaw, George Dedoussis, Barbara Obermayer-Pietsch, Ulf Gyllensten, Peter P. Pramstaller, Roman S. Lorenc, Cyrus Cooper, Annie Wai Chee Kung, Paul Lips, Markku Alen, John Attia, Maria Luisa Brandi, Lisette C.P.G.M. de Groot, Terho Lehtimäki, José A. Riancho, Harry Campbell, Yongmei Liu, Tamara B. Harris, Kristina Akesson, Magnus Karlsson, Jong-Young Lee, Henri Wallaschofski, Emma L. Duncan, Terence W. O'Neill, Vilmundur Gudnason, Timothy D. Spector, François Rousseau, Eric Orwoll, Steven R. Cummings, Nick J. Wareham, Fernando Rivadeneira, Andre G. Uitterlinden, Richard L. Prince, Douglas P. Kiel, Jonathan Reeve, Stephen K. Kaptoge

Hum Mol Genet. 2014 Jun 1; 23(11): 3054–3068. Published online 2014 Jan 14. doi: 10.1093/hmg/ddt675

PMCID:: PMC4038791

Abstract Article PDF–1.2M

Select item 394352119.

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density

Lei Zhang, Hyung Jin Choi, Karol Estrada, Paul J. Leo, Jian Li, Yu-Fang Pei, Yinping Zhang, Yong Lin, Hui Shen, Yao-Zhong Liu, Yongjun Liu, Yingchun Zhao, Ji-Gang Zhang, Qing Tian, Yu-ping Wang, Yingying Han, Shu Ran, Rong Hai, Xue-Zhen Zhu, Shuyan Wu, Han Yan, Xiaogang Liu, Tie-Lin Yang, Yan Guo, Feng Zhang, Yan-fang Guo, Yuan Chen, Xiangding Chen, Lijun Tan, Lishu Zhang, Fei-Yan Deng, Hongyi Deng, Fernando Rivadeneira, Emma L Duncan, Jong Young Lee, Bok Ghee Han, Nam H. Cho, Geoffrey C. Nicholson, Eugene McCloskey, Richard Eastell, Richard L. Prince, John A. Eisman, Graeme Jones, Ian R. Reid, Philip N. Sambrook, Elaine M. Dennison, Patrick Danoy, Laura M. Yerges-Armstrong, Elizabeth A. Streeten, Tian Hu, Shuanglin Xiang, Christopher J. Papasian, Matthew A. Brown, Chan Soo Shin, André G. Uitterlinden, Hong-Wen Deng

Hum Mol Genet. 2014 Apr 1; 23(7): 1923–1933. Published online 2013 Nov 17. doi: 10.1093/hmg/ddt575

PMCID:: PMC3943521

Abstract Article PDF–415K

Select item 380103720.

Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

Masanori Ono, Ping Yin, Antonia Navarro, Molly B. Moravek, John S. Coon, V, Stacy A. Druschitz, Vanida Ann Serna, Wenan Qiang, David C. Brooks, Saurabh S. Malpani, Jiajia Ma, Cihangir Mutlu Ercan, Navdha Mittal, Diana Monsivais, Matthew T. Dyson, Alex Yemelyanov, Tetsuo Maruyama, Debabrata Chakravarti, J. Julie Kim, Takeshi Kurita, Cara J. Gottardi, Serdar E. Bulun

Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42): 17053–17058. Published online 2013 Sep 30. doi: 10.1073/pnas.1313650110

PMCID:: PMC3801037

Abstract Article PDF–870K

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