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Select item 108643871.

HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression

Yi Zhang, Mingjie Wang, Ling Ye, Shengqi Shen, Yuxi Zhang, Xiaoyu Qian, Tong Zhang, Mengqiu Yuan, Zijian Ye, Jin Cai, Xiang Meng, Shiqiao Qiu, Shengzhi Liu, Rui Liu, Weidong Jia, Xianzhu Yang, Huafeng Zhang, Xiuying Zhong, Ping Gao

Nat Commun. 2024; 15: 1314. Published online 2024 Feb 13. doi: 10.1038/s41467-024-45712-2

PMCID:: PMC10864387

Abstract Article PDF–5.6M

Select item 95502662.

Spike S1 domain interactome in non-pulmonary systems: A role beyond the receptor recognition

Ilaria Iacobucci, Vittoria Monaco, Luisa Canè, Francesca Bibbò, Valentina Cioffi, Flora Cozzolino, Alfredo Guarino, Massimo Zollo, Maria Monti

Front Mol Biosci. 2022; 9: 975570. Published online 2022 Sep 26. doi: 10.3389/fmolb.2022.975570

PMCID:: PMC9550266

Abstract Article PDF–2.5M

Select item 92772623.

The HOXC‐AS2/miR‐876‐5p/HKDC1 axis regulates endometrial cancer progression in a high glucose‐related tumor microenvironment

Jing Guo, Feng Ye, Wenli Xie, Xinxin Zhang, Ru Zeng, Wang Sheng, Yanjun Mi, Xiugui Sheng

Cancer Sci. 2022 Jul; 113(7): 2297–2310. Published online 2022 May 29. doi: 10.1111/cas.15384

PMCID:: PMC9277262

Abstract Article PDF–9.9M

Select item 92581324.

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants

Laura Strohm, Zehan Hu, Yongwon Suk, Alina Rühmkorf, Erin Sternburg, Vanessa Gattringer, Henrick Riemenschneider, Riccardo Berutti, Elisabeth Graf, Jochen H Weishaupt, Monika S Brill, Angelika B Harbauer, Dorothee Dormann, Jörn Dengjel, Dieter Edbauer, Christian Behrends

Life Sci Alliance. 2022 Nov; 5(11): e202101327. Published online 2022 Jul 1. doi: 10.26508/lsa.202101327

PMCID:: PMC9258132

Abstract Article PDF–5.9M

Select item 90560265.

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis

Fenglong Jiao, Clinton Yu, Andrew Wheat, Xiaorong Wang, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2022 Apr 30.

Published in final edited form as: Anal Chem. 2022 Mar 15; 94(10): 4236–4242. Published online 2022 Mar 2. doi: 10.1021/acs.analchem.1c04485

PMCID:: PMC9056026

Abstract Article PDF–1.0M

Select item 88675216.

The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy

Joseph L. Zapater, Kristen R. Lednovich, Brian T. Layden

Curr Diab Rep. Author manuscript; available in PMC 2022 Feb 24.

Published in final edited form as: Curr Diab Rep. 2021 Jul 7; 21(8): 27. Published online 2021 Jul 7. doi: 10.1007/s11892-021-01394-4

PMCID:: PMC8867521

Abstract Article PDF–330K

Select item 86135377.

Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis

Veronica Massey, Austin Parrish, Josepmaria Argemi, Montserrat Moreno, Aline Mello, Mar García-Rocha, Jose Altamirano, Gemma Odena, Laurent Dubuquoy, Alexandre Louvet, Carlos Martinez, Anna Adrover, Silvia Affò, Oriol Morales-Ibanez, Pau Sancho-Bru, Cristina Millán, Edilmar Alvarado-Tapias, Dalia Morales-Arraez, Juan Caballería, Jelena Mann, Sheng Cao, Zhaoli Sun, Vijay Shah, Andrew Cameron, Phillipe Mathurin, Natasha Snider, Càndid Villanueva, Timothy R. Morgan, Joan Guinovart, Rajanikanth Vadigepalli, Ramon Bataller

Gastroenterology. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Gastroenterology. 2021 Apr; 160(5): 1725–1740.e2. Published online 2020 Dec 10. doi: 10.1053/j.gastro.2020.12.008

Correction in:: Gastroenterology. 2021 Jul 1

PMCID:: PMC8613537

Abstract Article PDF–2.1M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 72268129.

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle

Cells. 2020 Apr; 9(4): 834. Published online 2020 Mar 30. doi: 10.3390/cells9040834

PMCID:: PMC7226812

Abstract Article PDF–2.3M

Select item 677813710.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 638758511.

Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice

Md. Wasim Khan, Medha Priyadarshini, Jose Cordoba-Chacon, Thomas C. Becker, Brian T. Layden

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2019 Mar 1; 1865(3): 678–687. Published online 2018 Dec 10. doi: 10.1016/j.bbadis.2018.11.022

PMCID:: PMC6387585

Abstract Article PDF–1.0M

Select item 633426912.

Hepatic HKDC1 Expression Contributes to Liver Metabolism

Carolina M Pusec, Adam De Jesus, Md Wasim Khan, Alexander R Terry, Anton E Ludvik, Kai Xu, Nicholas Giancola, Haaris Pervaiz, Emily Daviau Smith, Xianzhong Ding, Stephen Harrison, Navdeep S Chandel, Thomas C Becker, Nissim Hay, Hossein Ardehali, Jose Cordoba-Chacon, Brian T Layden

Endocrinology. 2019 Feb; 160(2): 313–330. Published online 2018 Dec 3. doi: 10.1210/en.2018-00887

PMCID:: PMC6334269

Abstract Article

Select item 624073213.

Whole-exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa

Lin Zhang, Zixi Sun, Peiquan Zhao, Lulin Huang, Mingchu Xu, Yeming Yang, Xue Chen, Fang Lu, Xiang Zhang, Hui Wang, Shanshan Zhang, Wenjing Liu, Zhilin Jiang, Shi Ma, Rui Chen, Chen Zhao, Zhenglin Yang, Ruifang Sui, Xianjun Zhu

Hum Mol Genet. 2018 Dec 1; 27(23): 4157–4168. Published online 2018 Jul 31. doi: 10.1093/hmg/ddy281

PMCID:: PMC6240732

Abstract Article PDF–36M

Select item 616668214.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 595835715.

Studies on the Tissue Localization of HKDC1, a Putative Novel Fifth Hexokinase, in Humans

Md. Wasim Khan, Xianzhong Ding, Scott J. Cotler, Michael Clarke, Brian T. Layden

J Histochem Cytochem. 2018 May; 66(5): 385–392. Published online 2018 Feb 5. doi: 10.1369/0022155418756849

PMCID:: PMC5958357

Abstract Article PDF–1.2M

Select item 580517016.

Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response

Alexandra G. Evstafieva, Irina E. Kovaleva, Maria S. Shoshinova, Andrei V. Budanov, Peter M. Chumakov

PLoS One. 2018; 13(2): e0191107. Published online 2018 Feb 8. doi: 10.1371/journal.pone.0191107

PMCID:: PMC5805170

Abstract Article PDF–6.5M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 515976518.

Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1–q35.3 susceptibility locus identified by whole-exome sequencing

Justyna A Karolak, Tomasz Gambin, Jose A Pitarque, Andrea Molinari, Shalini Jhangiani, Pawel Stankiewicz, James R Lupski, Marzena Gajecka

Eur J Hum Genet. 2017 Jan; 25(1): 73–78. Published online 2016 Oct 5. doi: 10.1038/ejhg.2016.130

PMCID:: PMC5159765

Abstract Article PDF–550K

Select item 500789619.

HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use

Anton E. Ludvik, Carolina M. Pusec, Medha Priyadarshini, Anthony R. Angueira, Cong Guo, Amy Lo, Korri S. Hershenhouse, Guang-Yu Yang, Xianzhong Ding, Timothy E. Reddy, William L. Lowe, Jr, Brian T. Layden

Endocrinology. 2016 Sep; 157(9): 3452–3461. Published online 2016 Jul 20. doi: 10.1210/en.2016-1288

PMCID:: PMC5007896

Abstract Article

Select item 484160720.

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect

Philip J. Uren, Emad Bahrami-Samani, Patricia Rosa de Araujo, Christine Vogel, Mei Qiao, Suzanne C. Burns, Andrew D. Smith, Luiz O. F. Penalva

RNA Biol. 2016 Apr; 13(4): 400–411. Published online 2016 Jan 13. doi: 10.1080/15476286.2015.1138030

PMCID:: PMC4841607

Abstract Article PDF–1.6M

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