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Select item 109113801.

Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma

Jie Zheng, Yingqing Liu, Jiawei Wang, Jiewu Shi, Lin Li, Xuefeng Jiang, Lingsong Tao

Aging (Albany NY) 2024 Feb 15; 16(3): 2715–2735. Published online 2024 Feb 2. doi: 10.18632/aging.205506

PMCID:: PMC10911380

Abstract Article PDF–3.2M

Select item 108745812.

HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1

Hang You, Guojing Song, Zhizhen Xu, Saipeng Chen, Wenhao Shen, Heting Liu, Bingqian Deng, Jun Li, Gang Huang

J Transl Med. 2024; 22: 178. Published online 2024 Feb 18. doi: 10.1186/s12967-024-04970-w

PMCID:: PMC10874581

Abstract Article PDF–7.9M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 94871124.

Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer

Cora Palanca-Ballester, David Hervas, Maria Villalba, Teresa Valdes-Sanchez, Diana Garcia, Maria Isabel Alcoriza-Balaguer, Marta Benet, Raquel Martinez-Tomas, Andres Briones-Gomez, Jose Galbis-Caravajal, Alfonso Calvo, Oscar Juan, Agustin Lahoz, Enrique Cases, Juan Sandoval

Clin Epigenetics. 2022; 14: 116. Published online 2022 Sep 19. doi: 10.1186/s13148-022-01334-3

PMCID:: PMC9487112

Abstract Article PDF–878K

Select item 94836105.

BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation

Mengdan YU, Qianwei ZHAO, Jinxia LI, Fang XU, Zhibiao ZHANG, Yixian LIU, Liping DAI, Bingxia ZHANG, Jianying ZHANG, Jintao ZHANG

J Zhejiang Univ Sci B. 2022 Sep 15; 23(9): 760–769. doi: 10.1631/jzus.B2100985

PMCID:: PMC9483610

Article PDF–2.7M

Select item 94819336.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 92792857.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91052358.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 88947189.

BCAT1: A risk factor in multiple cancers based on a pan‐cancer analysis

Guo‐Sheng Li, He‐Qing Huang, Yao Liang, Qiu‐Yu Pang, Hao‐Jia Sun, Zhi‐Guang Huang, Yi‐Wu Dang, Lin‐Jie Yang, Gang Chen

Cancer Med. 2022 Mar; 11(5): 1396–1412. Published online 2022 Jan 4. doi: 10.1002/cam4.4525

PMCID:: PMC8894718

Abstract Article PDF–4.8M

Select item 849052310.

Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis

Lin Mao, Jin Chen, Xue Lu, Canlin Yang, Yi Ding, Mingming Wang, Yunpeng Zhang, Yuying Tian, Xing Li, Yunyun Fu, Yueying Yang, Yunyun Gu, Fei Gao, Junxing Huang, Lujian Liao

Theranostics. 2021; 11(19): 9705–9720. Published online 2021 Sep 27. doi: 10.7150/thno.61731

PMCID:: PMC8490523

Abstract Article PDF–3.4M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 806501212.

Differential expression of the BCAT isoforms between breast cancer subtypes

Mai Ahmed Shafei, Arwa Flemban, Carl Daly, Paul Kendrick, Paul White, Sarah Dean, David Qualtrough, Myra E. Conway

Breast Cancer. 2021; 28(3): 592–607. Published online 2020 Dec 24. doi: 10.1007/s12282-020-01197-7

PMCID:: PMC8065012

Abstract Article PDF–3.2M

Select item 796210113.

BCAT1 overexpression regulates proliferation and c-Myc/GLUT1 signaling in head and neck squamous cell carcinoma

Hongming Wang, Fei Wang, Wenyu Ouyang, Xuejun Jiang, Yan Wang

Oncol Rep. 2021 May; 45(5): 52. Published online 2021 Mar 4. doi: 10.3892/or.2021.8003

PMCID:: PMC7962101

Abstract Article PDF–1.5M

Select item 790617514.

Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas

Li Yi, Xiaoguang Fan, Jiabo Li, Feng Yuan, Jian Zhao, Monica Nistér, Xuejun Yang

Aging (Albany NY) 2021 Feb 15; 13(3): 3645–3660. Published online 2021 Jan 20. doi: 10.18632/aging.202328

PMCID:: PMC7906175

Abstract Article PDF–2.3M

Select item 743827515.

Tumor-Reprogrammed Stromal BCAT1 Fuels Branched Chain Ketoacid Dependency in Stromal-Rich PDAC Tumors

Ziwen Zhu, Abhinav Achreja, Noah Meurs, Olamide Animasahun, Sarah Owen, Anjali Mittal, Pooja Parikh, Ting-Wen Lo, Janusz Franco-Barraza, Jiaqi Shi, Valerie Gunchick, Mara H. Sherman, Edna Cukierman, Andrew M. Pickering, Anirban Maitra, Vaibhav Sahai, Meredith A. Morgan, Sunitha Nagrath, Theodore S. Lawrence, Deepak Nagrath

Nat Metab. Author manuscript; available in PMC 2021 Jan 6.

Published in final edited form as: Nat Metab. 2020 Aug; 2(8): 775–792. Published online 2020 Jul 6. doi: 10.1038/s42255-020-0226-5

PMCID:: PMC7438275

Abstract Article PDF–3.0M

Select item 731004216.

Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer

Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yan Lin, Liangrui Zhou, Qiang Sun

BMC Cancer. 2020; 20: 584. Published online 2020 Jun 22. doi: 10.1186/s12885-020-07070-2

PMCID:: PMC7310042

Abstract Article PDF–2.1M

Select item 716998317.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 711642718.

BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages

Jeong-Hun Ko, Antoni Olona, Adonia E. Papathanassiu, Norzawani Buang, Kwon-Sik Park, Ana S. H. Costa, Claudio Mauro, Christian Frezza, Jacques Behmoaras

J Cell Sci. 2020 Nov 15; 133(22): jcs247957. Published online 2020 Nov 27. doi: 10.1242/jcs.247957

PMCID:: PMC7116427

Abstract Article

Select item 683185119.

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis

Mohamed Taha Moutaoufik, Ramy Malty, Shahreen Amin, Qingzhou Zhang, Sadhna Phanse, Alla Gagarinova, Mara Zilocchi, Larissa Hoell, Zoran Minic, Maria Gagarinova, Hiroyuki Aoki, Jocelyn Stockwell, Matthew Jessulat, Florian Goebels, Kirsten Broderick, Nichollas E. Scott, James Vlasblom, Gabriel Musso, Bhanu Prasad, Eleonora Lamantea, Barbara Garavaglia, Alex Rajput, Kei Murayama, Yasushi Okazaki, Leonard J. Foster, Gary D. Bader, Francisco S. Cayabyab, Mohan Babu

iScience. 2019 Sep 27; 19: 1114–1132. Published online 2019 Sep 4. doi: 10.1016/j.isci.2019.08.057

PMCID:: PMC6831851

Abstract Article PDF–9.8M

Select item 654606320.

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks

Pierre Caron, Tibor Pankotai, Wouter W. Wiegant, Maxim A.X. Tollenaere, Audrey Furst, Celine Bonhomme, Angela Helfricht, Anton de Groot, Albert Pastink, Alfred C.O. Vertegaal, Martijn S. Luijsterburg, Evi Soutoglou, Haico van Attikum

Genes Dev. 2019 Jun 1; 33(11-12): 684–704. doi: 10.1101/gad.321943.118

PMCID:: PMC6546063

Abstract Article PDF–8.4M

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