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Select item 111615121.

Protein translation rate determines neocortical neuron fate

Ekaterina Borisova, Andrew G. Newman, Marta Couce Iglesias, Rike Dannenberg, Theres Schaub, Bo Qin, Alexandra Rusanova, Marisa Brockmann, Janina Koch, Marieatou Daniels, Paul Turko, Olaf Jahn, David R. Kaplan, Marta Rosário, Takao Iwawaki, Christian M. T. Spahn, Christian Rosenmund, David Meierhofer, Matthew L. Kraushar, Victor Tarabykin, Mateusz C. Ambrozkiewicz

Nat Commun. 2024; 15: 4879. Published online 2024 Jun 7. doi: 10.1038/s41467-024-49198-w

PMCID:: PMC11161512

Abstract Article PDF–17M

Select item 110277932.

Ring domains are essential for GATOR2-dependent mTORC1 activation

Cong Jiang, Xiaoming Dai, Shaohui He, Hongfei Zhou, Lan Fang, Jianping Guo, Songlei Liu, Tao Zhang, Weijuan Pan, Haihong Yu, Tianmin Fu, Dali Li, Hiroyuki Inuzuka, Ping Wang, Jianru Xiao, Wenyi Wei

Mol Cell. Author manuscript; available in PMC 2024 Apr 19.

Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 74–89.e9. Published online 2022 Dec 16. doi: 10.1016/j.molcel.2022.11.021

PMCID:: PMC11027793

Abstract Article PDF–3.0M

Select item 110146573.

A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis

Jingwen Yang, Lingxin Zhu, Haichun Pan, Hiroki Ueharu, Masako Toda, Qian Yang, Shawn A. Hallett, Lorin E. Olson, Yuji Mishina

J Clin Invest. 2024 Apr 15; 134(8): e165787. Published online 2024 Mar 11. doi: 10.1172/JCI165787

PMCID:: PMC11014657

Abstract Article PDF–16M

Select item 105896734.

Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction

Inna Radzishevsky, Maali Odeh, Oded Bodner, Salman Zubedat, Lihi Shaulov, Maxim Litvak, Kayoko Esaki, Takeo Yoshikawa, Bella Agranovich, Wen-Hong Li, Alex Radzishevsky, Eyal Gottlieb, Avi Avital, Herman Wolosker

Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2302780120. Published online 2023 Oct 9. doi: 10.1073/pnas.2302780120

PMCID:: PMC10589673

Abstract Article PDF–6.8M

Select item 105469765.

Uncovering a mammalian neural-specific poly(A) binding protein with unique properties

Sahil Sharma, Sam Kajjo, Zineb Harra, Benedeta Hasaj, Victoria Delisle, Debashish Ray, Rodrigo L. Gutierrez, Isabelle Carrier, Claudia Kleinman, Quaid Morris, Timothy R. Hughes, Roderick McInnes, Marc R. Fabian

Genes Dev. 2023 Aug 1; 37(15-16): 760–777. doi: 10.1101/gad.350597.123

PMCID:: PMC10546976

Abstract Article PDF–5.4M

Select item 101095196.

The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems

Charlotte Decourt, Julia Schaeffer, Beatrice Blot, Antoine Paccard, Blandine Excoffier, Mario Pende, Homaira Nawabi, Stephane Belin

PLoS Biol. 2023 Apr; 21(4): e3002044. Published online 2023 Apr 17. doi: 10.1371/journal.pbio.3002044

PMCID:: PMC10109519

Abstract Article PDF–5.3M

Select item 100979757.

Mechanosensitive mTORC1 signaling maintains lymphatic valves

Cansaran Saygili Demir, Amélie Sabine, Muyun Gong, Olivier Dormond, Tatiana V. Petrova

J Cell Biol. 2023 Jun 5; 222(6): e202207049. Published online 2023 Apr 10. doi: 10.1083/jcb.202207049

PMCID:: PMC10097975

Abstract Article PDF–9.6M

Select item 100489718.

Activation of the PI3K/AKT/mTOR Pathway in Cajal–Retzius Cells Leads to Their Survival and Increases Susceptibility to Kainate-Induced Seizures

Nasim Ramezanidoraki, Driss El Ouardi, Margaux Le, Stéphanie Moriceau, Mahboubeh Ahmadi, Dossi Elena, Danae Rolland, Philippe Bun, Gwenaëlle Le Pen, Guillaume Canaud, Nadia Bahi-Buisson, Nathalie Rouach, Rebecca Piskorowski, Alessandra Pierani, Pierre Billuart

Int J Mol Sci. 2023 Mar; 24(6): 5376. Published online 2023 Mar 11. doi: 10.3390/ijms24065376

PMCID:: PMC10048971

Abstract Article PDF–3.2M

Select item 98887259.

Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent

Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer

PLoS Genet. 2023 Jan; 19(1): e1010595. Published online 2023 Jan 19. doi: 10.1371/journal.pgen.1010595

PMCID:: PMC9888725

Abstract Article PDF–6.9M

Select item 985254310.

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis

Pranetha Baskaran, Simeon R. Mihaylov, Elin Vinsland, Kriti Shah, Lucy Granat, Sila K. Ultanir, Andrew R. Tee, Jernej Murn, Joseph M. Bateman

J Biol Chem. 2023 Jan; 299(1): 102788. Published online 2022 Dec 9. doi: 10.1016/j.jbc.2022.102788

PMCID:: PMC9852543

Abstract Article PDF–2.8M

Select item 984573911.

Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development

Xiangxing Kong, Xin Shu, Jiachuan Wang, Dandan Liu, Yingchun Ni, Weiqi Zhao, Lebo Wang, Zhihua Gao, Jiadong Chen, Bing Yang, Xing Guo, Zhiping Wang

Development. 2022 Dec 15; 149(24): dev201286. Published online 2022 Dec 20. doi: 10.1242/dev.201286

PMCID:: PMC9845739

Abstract Article

Select item 983203212.

Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons

Linh Tran Nguyen Truc, Satoshi Matsuda, Akiko Takenouchi, Quynh Tran Thuy Huong, Yui Kotani, Tatsuhiko Miyazaki, Hiroaki Kanda, Katsuhiko Yoshizawa, Hiroyasu Tsukaguchi

Sci Rep. 2023; 13: 508. Published online 2023 Jan 10. doi: 10.1038/s41598-023-27766-2

PMCID:: PMC9832032

Abstract Article PDF–17M

Select item 970078113.

mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity

Kuan Zhang, Erica Yao, Ethan Chuang, Biao Chen, Evelyn Y. Chuang, Pao-Tien Chuang

Nat Commun. 2022; 13: 7252. Published online 2022 Nov 25. doi: 10.1038/s41467-022-34763-y

PMCID:: PMC9700781

Abstract Article PDF–11M

Select item 963799914.

Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signaling

Elise Marechal, Anne Poliard, Kilian Henry, Mathias Moreno, Mathilde Legrix, Nicolas Macagno, Grégoire Mondielli, Teddy Fauquier, Anne Barlier, Heather C. Etchevers

Front Cell Dev Biol. 2022; 10: 1013001. Published online 2022 Oct 24. doi: 10.3389/fcell.2022.1013001

PMCID:: PMC9637999

Abstract Article PDF–7.1M

Select item 948193315.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 937601416.

Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex

Xiaoping Wu, Alexander A. Sosunov, Wudu Lado, Jia Jie Teoh, Ahrom Ham, Hongyu Li, Osama Al-Dalahmah, Brian J.A. Gill, Ottavio Arancio, Catherine A. Schevon, Wayne N. Frankel, Guy M. McKhann, II, David Sulzer, James E. Goldman, Guomei Tang

Cell Rep. Author manuscript; available in PMC 2022 Aug 14.

Published in final edited form as: Cell Rep. 2022 Jul 19; 40(3): 111085. doi: 10.1016/j.celrep.2022.111085