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Select item 109628051.

The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis

Fionä Caratis, Mikołaj Opiełka, Martin Hausmann, Maria Velasco-Estevez, Bartłomiej Rojek, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Bartosz Karaszewski, Aleksandra Rutkowska

PLoS One. 2024; 19(3): e0283060. Published online 2024 Mar 25. doi: 10.1371/journal.pone.0283060

PMCID:: PMC10962805

Abstract Article PDF–1.6M

Select item 106759182.

Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

Kun Zhang, Meng-Xia Zhang, Xiao-Xiang Meng, Jing Zhu, Jia-Jun Wang, Yi-Fan He, Ye-Hua Li, Si-Cong Zhao, Zhe-Min Shi, Li-Na Zheng, Tao Han, Wei Hong

Mil Med Res. 2023; 10: 56. Published online 2023 Nov 25. doi: 10.1186/s40779-023-00494-4

PMCID:: PMC10675918

Abstract Article PDF–21M

Select item 105247793.

Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis via regulating antimicrobial defense and restrains gut inflammation in inflammatory bowel disease

Gengfeng Li, Jian Lin, Xiang Gao, Huiling Su, Ritian Lin, Han Gao, Zhongsheng Feng, Huili Wu, Baisui Feng, Keqiang Zuo, Yingchuan Li, Wei Wu, Leilei Fang, Zhanju Liu

Gut Microbes. 2023; 15(2): 2257269. Published online 2023 Sep 25. doi: 10.1080/19490976.2023.2257269

PMCID:: PMC10524779

Abstract Article PDF–10M

Select item 105062274.

GPR65 inhibits human trophoblast cell adhesion through upregulation of MYLK and downregulation of fibronectin via cAMP-ERK signaling in a low pH environment

Jia Mao, Ying Feng, Yayun Zheng, Yaqiu Gao, Linyu Zhang, Xinrui Sun, Yilun Wu, Xiaofeng Zhu, Fang Ma

Cell Commun Signal. 2023; 21: 238. Published online 2023 Sep 18. doi: 10.1186/s12964-023-01249-3

Correction in:: Cell Commun Signal. 2024; 22: 414.

PMCID:: PMC10506227

Abstract Article PDF–13M

Select item 95360225.

IBD-associated G Protein-Coupled Receptor 65 variant compromises signalling and impairs key functions involved in inflammation

Virginie Mercier, Gabrielle Boucher, Dominic Devost, Kyla Bourque, Azadeh Alikashani, Claudine Beauchamp, Alain Bitton, Sylvain Foisy, Philippe Goyette, Guy Charron, Terence E. Hébert, John D. Rioux

Cell Signal. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Cell Signal. 2022 May; 93: 110294. Published online 2022 Feb 24. doi: 10.1016/j.cellsig.2022.110294

PMCID:: PMC9536022

Abstract Article PDF–2.1M

Select item 94945996.

MicroRNAs combined with the TLR4/TDAG8 mRNAs and proinflammatory cytokines are biomarkers for the rapid diagnosis of sepsis

Xiyuan Xu, Baoying Bu, Hongjun Tian, Rina Wu, Jingping Yang

Mol Med Rep. 2022 Nov; 26(5): 334. Published online 2022 Sep 12. doi: 10.3892/mmr.2022.12850

PMCID:: PMC9494599

Abstract Article PDF–1.3M

Select item 89583547.

GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2

Ritian Lin, Wei Wu, Huimin Chen, Han Gao, Xiaohan Wu, Gengfeng Li, Qiong He, Huiying Lu, Mingming Sun, Zhanju Liu

Clin Transl Med. 2022 Mar; 12(3): e771. Published online 2022 Mar 28. doi: 10.1002/ctm2.771

PMCID:: PMC8958354

Abstract Article PDF–6.6M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79484269.

The evolution and mechanism of GPCR proton sensing

Jacob B. Rowe, Nicholas J. Kapolka, Geoffrey J. Taghon, William M. Morgan, Daniel G. Isom

J Biol Chem. 2021 Jan-Jun; 296: 100167. Published online 2020 Dec 13. doi: 10.1074/jbc.RA120.016352

PMCID:: PMC7948426

Abstract Article PDF–4.1M

Select item 780144410.

Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes

Keimon Sayama, Katsuyuki Yuki, Keiichi Sugata, Satoko Fukagawa, Tetsuji Yamamoto, Shigaku Ikeda, Takatoshi Murase

Sci Rep. 2021; 11: 379. Published online 2021 Jan 11. doi: 10.1038/s41598-020-79519-0

PMCID:: PMC7801444

Abstract Article PDF–2.1M

Select item 756662811.

The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model

Koichi Sato, Ayaka Tobo, Chihiro Mogi, Masayuki Tobo, Nobuhiro Yamane, Masahiko Tosaka, Hideaki Tomura, Dong-Soon Im, Fumikazu Okajima

Sci Rep. 2020; 10: 17193. Published online 2020 Oct 14. doi: 10.1038/s41598-020-74372-7

PMCID:: PMC7566628

Abstract Article PDF–4.2M

Select item 750125312.

Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors

Wybke Klatt, Susanne Wallner, Christoph Brochhausen, Judith A. Stolwijk, Stephan Schreml

Sci Rep. 2020; 10: 15327. Published online 2020 Sep 18. doi: 10.1038/s41598-020-71700-9

PMCID:: PMC7501253

Abstract Article PDF–4.1M

Select item 632380513.

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation

Irina V. Tcymbarevich, Jyrki J. Eloranta, Jean-Benoît Rossel, Nicole Obialo, Marianne Spalinger, Jesus Cosin-Roger, Silvia Lang, Gerd A. Kullak-Ublick, Carsten A. Wagner, Michael Scharl, Klaus Seuwen, Pedro A. Ruiz, Gerhard Rogler, Cheryl de Vallière, Benjamin Misselwitz, on behalf of the Swiss IBD Cohort Study Group

BMC Gastroenterol. 2019; 19: 2. Published online 2019 Jan 7. doi: 10.1186/s12876-018-0922-8

PMCID:: PMC6323805

Abstract Article PDF–699K

Select item 612887814.

The role of acid-sensitive ion channels in panic disorder: a systematic review of animal studies and meta-analysis of human studies

Laiana A. Quagliato, Rafael C. Freire, Antonio E. Nardi

Transl Psychiatry. 2018; 8: 185. Published online 2018 Sep 7. doi: 10.1038/s41398-018-0238-z

PMCID:: PMC6128878

Abstract Article PDF–958K

Select item 569609115.

Acid-sensing T Cell Death Associated Gene-8 Receptor Expression in Panic Disorder

Jeffrey R. Strawn, Lauren L. Vollmer, Katherine M.J. McMurray, Jeffrey A. Mills, Sarah A. Mossman, Sara T. Varney, Heidi K. Schroeder, Renu Sah

Brain Behav Immun. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Brain Behav Immun. 2018 Jan; 67: 36–41. Published online 2017 Jul 20. doi: 10.1016/j.bbi.2017.07.014

PMCID:: PMC5696091

Abstract Article PDF–686K

Select item 563487616.

Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies

Calvin R. Justus, Edward J. Sanderlin, Lixue Dong, Tianai Sun, Jen-Tsan Chi, Kvin Lertpiriyapong, Li V. Yang

J Transl Med. 2017; 15: 204. Published online 2017 Oct 10. doi: 10.1186/s12967-017-1305-6

PMCID:: PMC5634876

Abstract Article PDF–2.0M

Select item 493641517.

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

Kara G. Lassen, Craig I. McKenzie, Muriel Mari, Tatsuro Murano, Jakob Begun, Leigh A. Baxt, Gautam Goel, Eduardo J. Villablanca, Szu-Yu Kuo, Hailiang Huang, Laurence Macia, Atul K. Bhan, Marcel Batten, Mark J. Daly, Fulvio Reggiori, Charles R. Mackay, Ramnik J. Xavier

Immunity. Author manuscript; available in PMC 2017 Jun 21.

Published in final edited form as: Immunity. 2016 Jun 21; 44(6): 1392–1405. Published online 2016 Jun 7. doi: 10.1016/j.immuni.2016.05.007

PMCID:: PMC4936415

Abstract Article PDF–1.1M

Select item 479694618.

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

Xi-Ping Huang, Joel Karpiak, Wesley K. Kroeze, Hu Zhu, Xin Chen, Sheryl S. Moy, Kara A. Saddoris, Viktoriya Nikolova, Martilias S. Farrell, Sheng Wang, Thomas J. Mangano, Deepak A. Deshpande, Alice Jiang, Raymond B. Penn, Jian Jin, Beverly H. Koller, Terry Kenakin, Brian K. Shoichet, Bryan L. Roth

Nature. Author manuscript; available in PMC 2016 Nov 26.

Published in final edited form as: Nature. 2015 Nov 26; 527(7579): 477–483. Published online 2015 Nov 9. doi: 10.1038/nature15699

PMCID:: PMC4796946

Abstract Article PDF–2.2M

Select item 417105319.

Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens

Rohina Rubicz, Robert Yolken, Armin Alaedini, Eugene Drigalenko, Jac C. Charlesworth, Melanie A. Carless, Emily G. Severance, Bogdana Krivogorsky, Thomas D. Dyer, Jack W. Kent, Jr., Joanne E. Curran, Matthew P. Johnson, Shelley A. Cole, Laura Almasy, Eric K. Moses, John Blangero, Harald H.H. Göring

Genet Epidemiol. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Genet Epidemiol. 2014 Jul; 38(5): 439–446. doi: 10.1002/gepi.21817

PMCID:: PMC4171053

Abstract Article PDF–398K

Select item 382161320.

Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8

Zhigang Li, Lixue Dong, Eric Dean, Li V. Yang

Int J Mol Sci. 2013 Oct; 14(10): 20236–20255. Published online 2013 Oct 11. doi: 10.3390/ijms141020236

PMCID:: PMC3821613

Abstract Article PDF–1.5M

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