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Select item 112280271.

Assessment of serum proprotein convertase subtilisin/kexin type 9 in pediatric sepsis syndrome

Suzan Omar Mousa, Mohamed Farouk Afifi, Noha Anwar Hassuna, Michael Fekry Yassa, Hend Mohamed Moness

Sci Rep. 2024; 14: 15634. Published online 2024 Jul 7. doi: 10.1038/s41598-024-65609-w

PMCID:: PMC11228027

Abstract Article PDF–941K

Select item 109645672.

Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis

Janne Pott, Azin Kheirkhah, Jesper R. Gadin, Marcus E. Kleber, Graciela E. Delgado, Holger Kirsten, Lukas Forer, Stefanie M. Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand van’t Hooft, Florian Kronenberg, Markus Scholz

Biol Sex Differ. 2024; 15: 26. Published online 2024 Mar 26. doi: 10.1186/s13293-024-00602-6

PMCID:: PMC10964567

Abstract Article PDF–1.6M

Select item 108946443.

PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells

Ran Xu, Tianhua Li, Jichang Luo, Xiao Zhang, Tao Wang, Yabing Wang, Yan Ma, Bin Yang, Jinzhu Jia, Adam A. Dmytriw, Wenjing Li, Liqun Jiao

CNS Neurosci Ther. 2024 Feb; 30(2): e14640. Published online 2024 Feb 25. doi: 10.1111/cns.14640

PMCID:: PMC10894644

Abstract Article PDF–16M

Select item 108829124.

Proteome-wide mendelian randomization investigates potential associations in heart failure and its etiology: emphasis on PCSK9

Lichao Lin, Huizhen Yu, Yan Xue, Liman Wang, Pengli Zhu

BMC Med Genomics. 2024; 17: 59. Published online 2024 Feb 21. doi: 10.1186/s12920-024-01826-6

PMCID:: PMC10882912

Abstract Article PDF–2.0M

Select item 108531935.

GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal

Ninna Karsbæk Senftleber, Mette K. Andersen, Emil Jørsboe, Frederik Filip Stæger, Anne Krogh Nøhr, Genis Garcia-Erill, Jonas Meisner, Cindy G. Santander, Renzo F. Balboa, Arthur Gilly, Peter Bjerregaard, Christina Viskum Lytken Larsen, Niels Grarup, Marit Eika Jørgensen, Eleftheria Zeggini, Ida Moltke, Torben Hansen, Anders Albrechtsen

Eur J Hum Genet. 2024 Feb; 32(2): 215–223. Published online 2023 Oct 30. doi: 10.1038/s41431-023-01485-8

PMCID:: PMC10853193

Abstract Article PDF–2.1M

Select item 106434906.

Data-driven transcriptomics analysis identifies PCSK9 as a novel key regulator in liver aging

Muhammad Arif, Csaba Matyas, Partha Mukhopadhyay, Burhan Yokus, Eszter Trojnar, Janos Paloczi, Bruno Paes-Leme, Suxian Zhao, Falk W. Lohoff, György Haskó, Pal Pacher

GeroScience. 2023 Oct; 45(5): 3059–3077. Published online 2023 Sep 20. doi: 10.1007/s11357-023-00928-w

PMCID:: PMC10643490

Abstract Article PDF–1.9M

Select item 106433647.

Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations

Jessica M. Cale, Kristin A. Ham, Dunhui Li, Craig S. McIntosh, Gerald F. Watts, Steve D. Wilton, May T. Aung-Htut

Sci Rep. 2023; 13: 19725. Published online 2023 Nov 13. doi: 10.1038/s41598-023-47005-y

PMCID:: PMC10643364

Abstract Article PDF–3.0M

Select item 106170468.

Elevated circulating PCSK9 level is associated with 28-day mortality in patients with sepsis: a prospective cohort study

Yuanlu Shu, Ziwei Deng, Ye Deng, Jianliang Zhou, Jin Wang, Zhenxing Duan, Tao Jiang, Xiang Zhao, Zhihua Shi, Chengfeng Qiu

BMC Emerg Med. 2023; 23: 127. Published online 2023 Oct 31. doi: 10.1186/s12873-023-00896-6

PMCID:: PMC10617046

Abstract Article PDF–1.9M

Select item 105858579.

Screening and verifying the mutations in the LDLR and APOB genes in a Chinese family with familial hypercholesterolemia

Xian Lv, Chunyue Wang, Lu Liu, Guoqing Yin, Wen Zhang, Fuad A. Abdu, Tingting Shi, Qingfeng Zhang, Wenliang Che

Lipids Health Dis. 2023; 22: 175. Published online 2023 Oct 18. doi: 10.1186/s12944-023-01935-8

PMCID:: PMC10585857

Abstract Article PDF–1.8M

Select item 1057255210.

Exploring PCSK9 Genetic Impact on Lipoprotein(a) via Dual Approaches: Association and Mendelian Randomization

Ya-Ching Chang, Lung-An Hsu, Yu-Lin Ko

Int J Mol Sci. 2023 Oct; 24(19): 14668. Published online 2023 Sep 28. doi: 10.3390/ijms241914668

PMCID:: PMC10572552

Abstract Article PDF–819K

Select item 1052745911.

Exploring the Link between Plasma Levels of PCSK9, Immune Dysregulation and Atherosclerosis in Patients with Primary Sjögren’s Syndrome

Vanessa Bianconi, Giacomo Cafaro, Massimo Raffaele Mannarino, Carlo Perricone, Elena Cosentini, Onelia Bistoni, Rita Paltriccia, Rita Lombardini, Roberto Gerli, Matteo Pirro, Elena Bartoloni

Biomolecules. 2023 Sep; 13(9): 1384. Published online 2023 Sep 12. doi: 10.3390/biom13091384

PMCID:: PMC10527459

Abstract Article PDF–1.1M

Select item 1049165412.

PCSK9 and the nervous system: a no-brainer?

Ali K. Jaafar, Romuald Techer, Kévin Chemello, Gilles Lambert, Steeve Bourane

J Lipid Res. 2023 Sep; 64(9): 100426. Published online 2023 Aug 14. doi: 10.1016/j.jlr.2023.100426

PMCID:: PMC10491654

Abstract Article PDF–1.3M

Select item 1038587713.

Plasma Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) as a Possible Biomarker for Severe COVID-19

Patricia Mester, Pablo Amend, Stephan Schmid, Martina Müller, Christa Buechler, Vlad Pavel

Viruses. 2023 Jul; 15(7): 1511. Published online 2023 Jul 6. doi: 10.3390/v15071511

PMCID:: PMC10385877

Abstract Article PDF–1.1M

Select item 1033147414.

PCSK9 inhibition interrupts the cross-talk between keratinocytes and macrophages and prevents UVB-induced skin damage

Chao Luan, Yingxue He, Wen Liu, Yicheng Rong, Jian Gao, Kang Xu, Hui Yu, Yu Hu, Jiaan Zhang, Kun Chen, Wenjie Guo

J Biol Chem. 2023 Jul; 299(7): 104895. Published online 2023 Jun 6. doi: 10.1016/j.jbc.2023.104895

PMCID:: PMC10331474

Abstract Article PDF–6.0M

Select item 1032273415.

Relationship between Serum Proprotein Convertase Subtilisin/Kexin Type 9 Concentration and Prevalence of Coronary Artery Calcium in a Community-Based Sample of Japanese Men

Ayako Kunimura, Katsuyuki Miura, Hiroyoshi Segawa, Sayuki Torii, Keiko Kondo, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Yuichiro Yano, Yoshihisa Nakagawa, Tomonori Okamura, Hirotsugu Ueshima

J Atheroscler Thromb. 2023 Jul 1; 30(7): 767–777. Published online 2022 Sep 17. doi: 10.5551/jat.63549

PMCID:: PMC10322734

Abstract Article PDF–388K

Select item 1029178316.

Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1

Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Patrick Lahni, Scarlett Ripberger, Adesuwa Ekunwe, Kyle R. Campbell, Keith R. Walley, Stephen W. Standage

Crit Care. 2023; 27: 250. Published online 2023 Jun 26. doi: 10.1186/s13054-023-04535-1

PMCID:: PMC10291783

Abstract Article PDF–10M

Select item 1021458317.

PCSK9 promotes T helper 1 and T helper 17 cell differentiation by activating the nuclear factor‐κB pathway in ankylosing spondylitis

Jianfei Cai, Yinghui Jiang, Fucai Chen, Shubin Wu, Hongjun Ren, Pingping Wang, Jiayong Wang, Wei Liu

Immun Inflamm Dis. 2023 May; 11(5): e870. Published online 2023 May 26. doi: 10.1002/iid3.870

PMCID:: PMC10214583

Abstract Article PDF–3.2M

Select item 1011994418.

Proprotein Convertase Subtilisin Kexin 9 (PCSK9) and nonHDL particles rise during normal pregnancy and differ by BMI

R.A. Wild, E. Weedin, K. Cox, Y.D. Zhao, D.S. Wrenn, D. Lopez, C.J. Wooten, Q.M. Melendez, D. Myers, K.R. Hansen

J Clin Lipidol. Author manuscript; available in PMC 2023 Apr 21.

Published in final edited form as: J Clin Lipidol. 2022 Jul-Aug; 16(4): 483–490. Published online 2022 Jun 6. doi: 10.1016/j.jacl.2022.05.070

PMCID:: PMC10119944

Abstract Article PDF–526K

Select item 1010218119.

PCSK9, a novel immune and ferroptosis related gene in abdominal aortic aneurysm neck

Junli Zhuang, Hua Zhu, Ziqi Cheng, Xinyao Hu, Xiaohui Yu, Jie Li, Huagang Liu, Peng Tang, Ying Zhang, Xiaoxing Xiong, Hongping Deng

Sci Rep. 2023; 13: 6054. Published online 2023 Apr 13. doi: 10.1038/s41598-023-33287-9

PMCID:: PMC10102181

Abstract Article PDF–6.2M

Select item 1003815220.

Heparin Does Not Regulate Circulating Human PCSK9 in a General Population

Vivian Q. Xia, Chui Mei Ong, Lucas S. Zier, John S. MacGregor, Alan H. B. Wu, John S. Chorba

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Feb; 43(2): 352–358. Published online 2022 Dec 8. doi: 10.1161/ATVBAHA.122.318556

PMCID:: PMC10038152

Abstract Article PDF–776K

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PMC Links for GEO Profiles (Select 112835494) (333)
PMC
txid245786[Organism:noexp] (21)
PopSet
phospholipase A and acyltransferase 5 isoform X3 [Homo sapiens]
phospholipase A and acyltransferase 5 isoform X3 [Homo sapiens]
gi|2217281059|ref|XP_047282295.1|

Protein
plant cysteine oxidase 3 isoform X1 [Oryza sativa Japonica Group]
plant cysteine oxidase 3 isoform X1 [Oryza sativa Japonica Group]
gi|1002288660|ref|XP_015648622.1|

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