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Select item 97137091.

Cryo‐EM structures of perforin‐2 in isolation and assembled on a membrane suggest a mechanism for pore formation

Xiulian Yu, Tao Ni, George Munson, Peijun Zhang, Robert J C Gilbert

EMBO J. 2022 Dec; 41(23): e111857. Published online 2022 Oct 17. doi: 10.15252/embj.2022111857

PMCID:: PMC9713709

Abstract Article PDF–3.9M

Select item 95451702.

Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation

Salimeh Ebrahimnezhaddarzi, Catherina H Bird, Cody C Allison, Daniel E Tuipulotu, Xenia Kostoulias, Christophe Macri, Michael D Stutz, Gilu Abraham, Dion Kaiserman, Siew Siew Pang, Si Ming Man, Justine D Mintern, Thomas Naderer, Anton Y Peleg, Marc Pellegrini, James C Whisstock, Phillip I Bird

Immunol Cell Biol. 2022 Aug; 100(7): 529–546. Published online 2022 May 12. doi: 10.1111/imcb.12554

PMCID:: PMC9545170

Abstract Article PDF–1.3M

Select item 86708433.

Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to perforin-2 suppression

Irena Pastar, Andrew P. Sawaya, Jelena Marjanovic, Jamie L. Burgess, Natasa Strbo, Katelyn E. Rivas, Tongyu C. Wikramanayake, Cheyanne R. Head, Rivka C. Stone, Ivan Jozic, Olivera Stojadinovic, Eran Y. Kornfeld, Robert S. Kirsner, Hadar Lev-Tov, Marjana Tomic-Canic

J Clin Invest. 2021 Dec 15; 131(24): e133727. Published online 2021 Dec 15. doi: 10.1172/JCI133727

PMCID:: PMC8670843

Abstract Article PDF–2.1M

Select item 83132394.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82570825.

Cellular context of IL-33 expression dictates impact on anti-helminth immunity

Li-Yin Hung, Yukinori Tanaka, Karl Herbine, Christopher Pastore, Brenal Singh, Annabel Ferguson, Nisha Vora, Bonnie Douglas, Kelly Zullo, Ed Behrens, Tiffany Li Hui Tan, Michael A. Kohanski, Paul Bryce, Cailu Lin, Taku Kambayashi, Danielle R. Reed, Breann L. Brown, Noam A. Cohen, De’Broski R. Herbert

Sci Immunol. Author manuscript; available in PMC 2021 Jul 5.

Published in final edited form as: Sci Immunol. 2020 Nov 13; 5(53): eabc6259. doi: 10.1126/sciimmunol.abc6259

PMCID:: PMC8257082

Abstract Article PDF–1.2M

Select item 76147796.

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

Pablo Rodríguez-Silvestre, Marco Laub, Patrycja A. Krawczyk, Alexandra K. Davies, Julia P. Schessner, Reejuana Parveen, Benjamin J. Tuck, William A. McEwan, Georg H.H. Borner, Patrycja Kozik

Science. Author manuscript; available in PMC 2023 Jul 19.

Published in final edited form as: Science. 2023 Jun 23; 380(6651): 1258–1265. Published online 2023 Jun 22. doi: 10.1126/science.adg8802

PMCID:: PMC7614779

Abstract Article PDF–1.8M

Select item 75765987.

Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS

Ching Serena Kao, Rebekah van Bruggen, Jihye Rachel Kim, Xiao Xiao Lily Chen, Cadia Chan, Jooyun Lee, Woo In Cho, Melody Zhao, Claudia Arndt, Katarina Maksimovic, Mashiat Khan, Qiumin Tan, Michael D. Wilson, Jeehye Park

Nat Commun. 2020; 11: 5304. Published online 2020 Oct 20. doi: 10.1038/s41467-020-18949-w

PMCID:: PMC7576598

Abstract Article PDF–4.2M

Select item 70578578.

Impaired B Cell Function in Mice Lacking Perforin-2

Daniela Frasca, Alain Diaz, Maria Romero, Thomas Vazquez, Natasa Strbo, Laura Romero, Ryan M. McCormack, Eckhard R. Podack, Bonnie B. Blomberg

Front Immunol. 2020; 11: 328. Published online 2020 Feb 27. doi: 10.3389/fimmu.2020.00328

PMCID:: PMC7057857

Abstract Article PDF–1.0M

Select item 69891459.

Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

Tao Ni, Fang Jiao, Xiulian Yu, Saša Aden, Lucy Ginger, Sophie I. Williams, Fangfang Bai, Vojtěch Pražák, Dimple Karia, Phillip Stansfeld, Peijun Zhang, George Munson, Gregor Anderluh, Simon Scheuring, Robert J. C. Gilbert

Sci Adv. 2020 Jan; 6(5): eaax8286. Published online 2020 Jan 29. doi: 10.1126/sciadv.aax8286

PMCID:: PMC6989145

Abstract Article PDF–5.1M

Select item 665555110.

WDFY4 is required for cross-presentation in response to viral and tumor antigens

Derek J. Theisen, Jesse T. Davidson, IV, Carlos G. Briseño, Marco Gargaro, Elvin J. Lauron, Qiuling Wang, Pritesh Desai, Vivek Durai, Prachi Bagadia, Joshua R. Brickner, Wandy L. Beatty, Herbert W. Virgin, William E. Gillanders, Nima Mosammaparast, Michael S. Diamond, L. David Sibley, Wayne Yokoyama, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy

Science. Author manuscript; available in PMC 2019 Jul 24.

Published in final edited form as: Science. 2018 Nov 9; 362(6415): 694–699. doi: 10.1126/science.aat5030

PMCID:: PMC6655551

Abstract Article PDF–1020K

Select item 632983111.

Single-cell transcriptomic analysis of mouse neocortical development

Lipin Loo, Jeremy M. Simon, Lei Xing, Eric S. McCoy, Jesse K. Niehaus, Jiami Guo, E. S. Anton, Mark J. Zylka

Nat Commun. 2019; 10: 134. Published online 2019 Jan 11. doi: 10.1038/s41467-018-08079-9

PMCID:: PMC6329831

Abstract Article PDF–3.6M

Select item 620058312.

Perforin-2 Breaches the Envelope of Phagocytosed Bacteria Allowing Antimicrobial Effectors Access to Intracellular Targets

Fangfang Bai, Ryan M. McCormack, Suzanne Hower, Gregory V. Plano, Mathias G. Lichtenheld, George P. Munson

J Immunol. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: J Immunol. 2018 Nov 1; 201(9): 2710–2720. Published online 2018 Sep 24. doi: 10.4049/jimmunol.1800365

PMCID:: PMC6200583

Abstract Article PDF–1.0M

Select item 538122613.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 529336714.

Molecular characterization of the genital organizer: Gene expression profile of the mouse urethral plate epithelium

Brooke A. Armfield, Ashley W. Seifert, Zhengui Zheng, Emily M. Merton, Jason R. Rock, Maria-Cecilia Lopez, Henry V. Baker, Martin J. Cohn

J Urol. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: J Urol. 2016 Oct; 196(4): 1295–1302. Published online 2016 May 9. doi: 10.1016/j.juro.2016.04.091

PMCID:: PMC5293367

Abstract Article PDF–1.4M

Select item 497241815.

Gene expression analysis of the embryonic subplate

Franziska M. Oeschger, Wei-Zhi Wang, Sheena Lee, Fernando García-Moreno, André M. Goffinet, Mariona Arbones, Sonia Rakic, Zoltán Molnár

Cereb Cortex. Author manuscript; available in PMC 2016 Aug 3.

Published in final edited form as: Cereb Cortex. 2012 Jun; 22(6): 1343–1359. Published online 2011 Aug 22. doi: 10.1093/cercor/bhr197

PMCID:: PMC4972418

Abstract Article PDF–7.1M

Select item 497021316.

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA

Xiaoyun Liu, Yan Jiao, Yanhong Cao, Nan Deng, Yonghui Ma, Karen A. Hasty, Andrew Kang, Hong Chen, John M. Stuart, Weikuan Gu

BMC Immunol. 2016; 17: 25. Published online 2016 Aug 2. doi: 10.1186/s12865-016-0163-y

PMCID:: PMC4970213

Abstract Article PDF–2.5M

Select item 480749417.

Perforin-2 Protects Host Cells and Mice by Restricting the Vacuole to Cytosol Transitioning of a Bacterial Pathogen

Ryan McCormack, Wael Bahnan, Niraj Shrestha, Justin Boucher, Marcella Barreto, Carlos M. Barrera, Edward A. Dauer, Nancy E. Freitag, Wasif N. Khan, Eckhard R. Podack, Kurt Schesser

Infect Immun. 2016 Apr; 84(4): 1083–1091. Prepublished online 2016 Feb 1. Published online 2016 Mar 24. doi: 10.1128/IAI.01434-15

PMCID:: PMC4807494

Abstract Article PDF–1.1M

Select item 462681118.

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

Ryan M McCormack, Lesley R de Armas, Motoaki Shiratsuchi, Desiree G Fiorentino, Melissa L Olsson, Mathias G Lichtenheld, Alejo Morales, Kirill Lyapichev, Louis E Gonzalez, Natasa Strbo, Neelima Sukumar, Olivera Stojadinovic, Gregory V Plano, George P Munson, Marjana Tomic-Canic, Robert S Kirsner, David G Russell, Eckhard R Podack

eLife. 2015; 4: e06508. Published online 2015 Sep 24. doi: 10.7554/eLife.06508