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Select item 107820291.

Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis

Jianbo Liu, Kaixuan Liu, Ying Wang, Ziru Shi, Runze Xu, Yundi Zhang, Jingxin Li, Chuanyong Liu, Bing Xue

Cell Death Dis. 2024 Jan; 15(1): 27. Published online 2024 Jan 10. doi: 10.1038/s41419-023-06409-4

PMCID:: PMC10782029

Abstract Article PDF–7.1M

Select item 103523452.

A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury

Chen Yang, Huidie Xu, Dong Yang, Yunhao Xie, Mingrui Xiong, Yu Fan, XiKai Liu, Yu Zhang, Yushuo Xiao, Yuchen Chen, Yihao Zhou, Liangliang Song, Chen Wang, Anlin Peng, Robert B. Petersen, Hong Chen, Kun Huang, Ling Zheng

Nat Commun. 2023; 14: 4261. Published online 2023 Jul 17. doi: 10.1038/s41467-023-40036-z

PMCID:: PMC10352345

Abstract Article PDF–5.2M

Select item 95699683.

TRAIL-R Deficient Mice Are Protected from Neurotoxic Effects of Amyloid-β

Giulia Di Benedetto, Chiara Burgaletto, Maria Francesca Serapide, Rosario Caltabiano, Antonio Munafò, Carlo Maria Bellanca, Rosaria Di Mauro, Renato Bernardini, Giuseppina Cantarella

Int J Mol Sci. 2022 Oct; 23(19): 11625. Published online 2022 Oct 1. doi: 10.3390/ijms231911625

PMCID:: PMC9569968

Abstract Article PDF–3.5M

Select item 82572554.

Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

Dongjin Jeong, Hye Sung Kim, Hye Young Kim, Min Jueng Kang, Hyeryeon Jung, Yumi Oh, Donghyun Kim, Jaemoon Koh, Sung-Yup Cho, Yoon Kyung Jeon, Eun Bong Lee, Seung Hyo Lee, Eui-Cheol Shin, Ho Min Kim, Eugene C Yi, Doo Hyun Chung

eLife. 2021; 10: e48840. Published online 2021 Jul 5. doi: 10.7554/eLife.48840

PMCID:: PMC8257255

Abstract Article PDF–3.9M

Select item 80265635.

Robust p53 stabilization is dispensable for its activation and tumor suppressor function

Ning Kon, Michael Churchill, Huan Li, Siddhartha Mukherjee, James J. Manfredi, Wei Gu

Cancer Res. Author manuscript; available in PMC 2021 Aug 15.

Published in final edited form as: Cancer Res. 2021 Feb 15; 81(4): 935–944. Published online 2020 Dec 15. doi: 10.1158/0008-5472.CAN-20-1804

PMCID:: PMC8026563

Abstract Article PDF–1.5M

Select item 76572386.

Functional roles of tumor necrosis factor‐related apoptosis‐inducing ligand–DR5 interaction in B16F10 cells by activating the nuclear factor‐κB pathway to induce metastatic potential

Kei Takahashi, Kazuyoshi Takeda, Ikuo Saiki, Tatsuro Irimura, Yoshihiro Hayakawa

Cancer Sci. 2013 May; 104(5): 558–562. Published online 2013 Feb 28. doi: 10.1111/cas.12112

PMCID:: PMC7657238

Abstract Article PDF–285K

Select item 68611367.

RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury

Santosh Krishna-Subramanian, Stephan Singer, Marietta Armaka, Jesus M. Banales, Kerstin Holzer, Peter Schirmacher, Henning Walczak, George Kollias, Manolis Pasparakis, Vangelis Kondylis

Cell Death Differ. 2019 Dec; 26(12): 2710–2726. Published online 2019 Apr 15. doi: 10.1038/s41418-019-0330-9

PMCID:: PMC6861136

Abstract Article PDF–7.1M

Select item 65911408.

Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion and metastasis

Silvia von Karstedt, Annalisa Conti, Max Nobis, Antonella Montinaro, Torsten Hartwig, Johannes Lemke, Karen Legler, Franka Annewanter, Andrew D. Campbell, Lucia Taraborrelli, Anne Grosse-Wilde, Johannes F. Coy, Mona A. El-Bahrawy, Frank Bergmann, Ronald Koschny, Jens Werner, Tom M. Ganten, Thomas Schweiger, Konrad Hoetzenecker, Istvan Kenessey, Balazs Hegedüs, Michael Bergmann, Charlotte Hauser, Jan-Hendrik Egberts, Thomas Becker, Christoph Röcken, Holger Kalthoff, Anna Trauzold, Kurt I. Anderson, Owen J. Sansom, Henning Walczak

Cancer Cell. Author manuscript; available in PMC 2019 Jun 24.

Published in final edited form as: Cancer Cell. 2015 Apr 13; 27(4): 561–573. Published online 2015 Apr 2. doi: 10.1016/j.ccell.2015.02.014

PMCID:: PMC6591140

Abstract Article PDF–2.4M

Select item 64119799.

Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo

Ning Kon, Donglai Wang, Wei Gu

Cell Death Dis. 2019 Mar; 10(3): 237. Published online 2019 Mar 11. doi: 10.1038/s41419-019-1484-6

PMCID:: PMC6411979

Abstract Article PDF–2.3M

Select item 640846810.

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

Jong-Sung Park, Yumin Oh, Yong Joo Park, Ogyi Park, Hoseong Yang, Stephanie Slania, Laura K. Hummers, Ami A. Shah, Hyoung-Tae An, Jiyeon Jang, Maureen R. Horton, Joseph Shin, Harry C. Dietz, Eric Song, Dong Hee Na, Eun Ji Park, Kwangmeyung Kim, Kang Choon Lee, Viktor V. Roschke, Justin Hanes, Martin G. Pomper, Seulki Lee

Nat Commun. 2019; 10: 1128. Published online 2019 Mar 8. doi: 10.1038/s41467-019-09101-4

PMCID:: PMC6408468

Abstract Article PDF–3.1M

Select item 615622911.

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak

Nat Commun. 2018; 9: 3910. Published online 2018 Sep 25. doi: 10.1038/s41467-018-06155-8

PMCID:: PMC6156229

Abstract Article PDF–3.3M

Select item 584002212.

Many helper T cell subsets have Fas ligand-dependent cytotoxic potential

Dmitri I. Kotov, Jessica A. Kotov, Michael F. Goldberg, Marc K. Jenkins

J Immunol. Author manuscript; available in PMC 2019 Mar 15.

Published in final edited form as: J Immunol. 2018 Mar 15; 200(6): 2004–2012. Published online 2018 Feb 7. doi: 10.4049/jimmunol.1700420

PMCID:: PMC5840022

Abstract Article PDF–773K

Select item 578652813.

TRAIL-Mediated Suppression of T Cell Receptor Signaling Inhibits T Cell Activation and Inflammation in Experimental Autoimmune Encephalomyelitis

I-Tsu Chyuan, Hwei-Fang Tsai, Chien-Sheng Wu, Chi-Chang Sung, Ping-Ning Hsu

Front Immunol. 2018; 9: 15. Published online 2018 Jan 22. doi: 10.3389/fimmu.2018.00015

PMCID:: PMC5786528

Abstract Article PDF–6.3M

Select item 538636914.

Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice

Maria Eugenia Guicciardi, Anuradha Krishnan, Steven F Bronk, Petra Hirsova, Thomas S Griffith, Gregory J Gores

Cell Death Dis. 2017 Jan; 8(1): e2535. Published online 2017 Jan 5. doi: 10.1038/cddis.2016.459

PMCID:: PMC5386369

Abstract Article PDF–7.8M

Select item 507244015.

Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain

P Grigaravicius, E Kaminska, C A Hübner, P J McKinnon, A von Deimling, P-O Frappart

Cell Death Differ. 2016 Mar; 23(3): 454–468. Published online 2015 Sep 18. doi: 10.1038/cdd.2015.113

PMCID:: PMC5072440

Abstract Article PDF–7.0M

Select item 500185316.

Agonists of the TRAIL death receptor DR5 sensitize intestinal stem cells to chemotherapy-induced cell death and trigger gastrointestinal toxicity

Niklas K. Finnberg, Prashanth Gokare, Arunasalam Navaraj, Krystle A. Lang Kuhs, George Cerniglia, Hideo Yagita, Kazuyoshi Takeda, Noboru Motoyama, Wafik S. El-Deiry

Cancer Res. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Cancer Res. 2016 Feb 1; 76(3): 700–712. Published online 2015 Nov 25. doi: 10.1158/0008-5472.CAN-15-2759

PMCID:: PMC5001853

Abstract Article PDF–1.9M

Select item 480391017.

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

Katerina Vlantis, Andy Wullaert, Apostolos Polykratis, Vangelis Kondylis, Marius Dannappel, Robin Schwarzer, Patrick Welz, Teresa Corona, Henning Walczak, Falk Weih, Ulf Klein, Michelle Kelliher, Manolis Pasparakis

Immunity. 2016 Mar 15; 44(3): 553–567. doi: 10.1016/j.immuni.2016.02.020

PMCID:: PMC4803910

Abstract Article

Select item 478333818.

Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear

Shyan‐Yuan Kao, Vitor Y.R. Soares, Arthur G. Kristiansen, Konstantina M. Stankovic

Aging Cell. 2016 Apr; 15(2): 301–308. Published online 2016 Jan 21. doi: 10.1111/acel.12437

PMCID:: PMC4783338

Abstract Article PDF–1.2M

Select item 428414819.

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

Min Lu, David A. Lawrence, Scot Marsters, Diego Acosta-Alvear, Philipp Kimmig, Aaron S. Mendez, Adrienne W. Paton, James C. Paton, Peter Walter, Avi Ashkenazi

Science. Author manuscript; available in PMC 2015 Jan 5.

Published in final edited form as: Science. 2014 Jul 4; 345(6192): 98–101. doi: 10.1126/science.1254312

PMCID:: PMC4284148

Abstract Article PDF–1.2M

Select item 421137020.

Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout

H Ehlken, S Krishna-Subramanian, L Ochoa-Callejero, V Kondylis, N E Nadi, B K Straub, P Schirmacher, H Walczak, G Kollias, M Pasparakis

Cell Death Differ. 2014 Nov; 21(11): 1721–1732. Published online 2014 Jun 27. doi: 10.1038/cdd.2014.83

PMCID:: PMC4211370

Abstract Article PDF–6.5M

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