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Items: 1 to 20 of 50

1.
Identification of RAD17 as a candidate cancer predisposition gene in families with histories of pancreatic and breast cancers
Sofie Joris, Philippe Giron, Catharina Olsen, Sara Seneca, Alexander Gheldof, Shula Staessens, Rajendra Bahadur Shahi, Sylvia De Brakeleer, Erik Teugels, Jacques De Grève, Frederik J. Hes
BMC Cancer. 2024; 24: 723. Published online 2024 Jun 13. doi: 10.1186/s12885-024-12442-z
PMCID:
PMC11170902
AbstractArticlePDF–1.4M
2.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
3.
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang
J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009
PMCID:
PMC9058836
AbstractArticlePDF–2.9M
4.
mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells
David A. Merle, Francesca Provenzano, Mohamed Ali Jarboui, Ellen Kilger, Simon J. Clark, Michela Deleidi, Angela Armento, Marius Ueffing
Antioxidants (Basel) 2021 Dec; 10(12): 1944. Published online 2021 Dec 3. doi: 10.3390/antiox10121944
PMCID:
PMC8750186
AbstractArticlePDF–2.7M
5.
Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry
Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang
Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118
PMCID:
PMC8364181
AbstractArticlePDF–3.0M
6.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y
PMCID:
PMC8352964
AbstractArticlePDF–4.5M
7.
Nuclear translocation promotes proteasomal degradation of human Rad17 protein through the N-terminal destruction boxes
Yasunori Fukumoto, Masayoshi Ikeuchi, Liang Qu, Tyuji Hoshino, Naoto Yamaguchi, Yuji Nakayama, Yasumitsu Ogra
J Biol Chem. 2021 Aug; 297(2): 100831. Published online 2021 Jun 24. doi: 10.1016/j.jbc.2021.100831
PMCID:
PMC8318897
AbstractArticlePDF–4.2M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
The noncoding function of NELFA mRNA promotes the development of oesophageal squamous cell carcinoma by regulating the Rad17‐RFC2‐5 complex
Jiancheng Xu, Guangchao Wang, Wei Gong, Shichao Guo, Dan Li, Qimin Zhan
Mol Oncol. 2020 Mar; 14(3): 611–624. Published online 2020 Jan 28. doi: 10.1002/1878-0261.12619
PMCID:
PMC7053240
AbstractArticlePDF–2.4M
10.
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets
Kristen Mengwasser, Richard Adeyemi, Yumei Leng, Mei Yuk Choi, Connor Clairmont, Alan D’Andrea, Stephen J. Elledge
Mol Cell. Author manuscript; available in PMC 2019 Dec 4.
Published in final edited form as: Mol Cell. 2019 Mar 7; 73(5): 885–899.e6. Published online 2019 Jan 24. doi: 10.1016/j.molcel.2018.12.008
PMCID:
PMC6892393
AbstractArticlePDF–1.7M
11.
The RAD17 promoter sequence contains a potential tail-dependent G-quadruplex that downregulates gene expression upon oxidative modification
Judy Zhu, Aaron M. Fleming, Cynthia J. Burrows
ACS Chem Biol. Author manuscript; available in PMC 2019 Sep 21.
Published in final edited form as: ACS Chem Biol. 2018 Sep 21; 13(9): 2577–2584. Published online 2018 Aug 15. doi: 10.1021/acschembio.8b00522
PMCID:
PMC6238950
AbstractArticlePDF–995K
12.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck
Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924
PMCID:
PMC6166682
AbstractArticlePDF–3.8M
13.
Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites
Takuya Abe, Masato Ooka, Ryotaro Kawasumi, Keiji Miyata, Minoru Takata, Kouji Hirota, Dana Branzei
Proc Natl Acad Sci U S A. 2018 Aug 14; 115(33): 8412–8417. Published online 2018 Jul 30. doi: 10.1073/pnas.1803110115
PMCID:
PMC6099846
AbstractArticlePDF–1.4M
14.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
15.
A network of conserved synthetic lethal interactions for exploration of precision cancer therapy
Rohith Srivas, John Paul Shen, Chih Cheng Yang, Su Ming Sun, Jianfeng Li, Andrew M. Gross, James Jensen, Katherine Licon, Ana Bojorquez-Gomez, Kristin Klepper, Justin Huang, Daniel Pekin, Jia L. Xu, Huwate Yeerna, Vignesh Sivaganesh, Leonie Kollenstart, Haico van Attikum, Pedro Aza-Blanc, Robert W. Sobol, Trey Ideker
Mol Cell. Author manuscript; available in PMC 2017 Aug 4.
Published in final edited form as: Mol Cell. 2016 Aug 4; 63(3): 514–525. Published online 2016 Jul 21. doi: 10.1016/j.molcel.2016.06.022
PMCID:
PMC5209245
AbstractArticlePDF–1.6M
16.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
AbstractArticlePDF–2.2M
17.
Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression
Fabio Valenti, Federica Ganci, Giulia Fontemaggi, Andrea Sacconi, Sabrina Strano, Giovanni Blandino, Silvia Di Agostino
Oncotarget. 2015 Mar 20; 6(8): 5547–5566. Published online 2015 Feb 5. doi: 10.18632/oncotarget.2587
PMCID:
PMC4467386
AbstractArticlePDF–8.9M
18.
Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks
Qinhong Wang, Michael Goldstein, Peter Alexander, Timothy P Wakeman, Tao Sun, Junjie Feng, Zhenkun Lou, Michael B Kastan, Xiao-Fan Wang
EMBO J. 2014 Apr 16; 33(8): 862–877. Published online 2014 Feb 17. doi: 10.1002/embj.201386064
PMCID:
PMC4194111
AbstractArticlePDF–4.5M
19.
Ubiquitin-specific Peptidase 20 Regulates Rad17 Stability, Checkpoint Kinase 1 Phosphorylation and DNA Repair by Homologous Recombination
Ilanchezhian Shanmugam, Mohammad Abbas, Farhan Ayoub, Susan Mirabal, Manal Bsaili, Erin K. Caulder, David M. Weinstock, Alan E. Tomkinson, Robert Hromas, Monte Shaheen
J Biol Chem. 2014 Aug 15; 289(33): 22739–22748. Published online 2014 Jun 12. doi: 10.1074/jbc.M114.550459
PMCID:
PMC4132780
AbstractArticlePDF–2.5M
20.
Regulation of Rad17 Protein Turnover Unveils an Impact of Rad17-APC Cascade in Breast Carcinogenesis and Treatment
Zhuan Zhou, Chao Jing, Liyong Zhang, Fujita Takeo, Hyun Kim, Yi Huang, Zhihua Liu, Yong Wan
J Biol Chem. 2013 Jun 21; 288(25): 18134–18145. Published online 2013 May 1. doi: 10.1074/jbc.M113.456962
PMCID:
PMC3689957
AbstractArticlePDF–3.7M

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