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Select item 110146561.

Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency

Sarah Aminov, Orsi Giricz, David T. Melnekoff, R. Alejandro Sica, Veronika Polishchuk, Cristian Papazoglu, Bonnie Yates, Hao-Wei Wang, Srabani Sahu, Yanhua Wang, Shanisha Gordon-Mitchell, Violetta V. Leshchenko, Carolina Schinke, Kith Pradhan, Srinivas Aluri, Moah Sohn, Stefan K. Barta, Beamon Agarwal, Mendel Goldfinger, Ioannis Mantzaris, Aditi Shastri, William Matsui, Ulrich Steidl, Joshua D. Brody, Nirali N. Shah, Samir Parekh, Amit Verma

J Clin Invest. 2024 Apr 15; 134(8): e175199. Published online 2024 Feb 20. doi: 10.1172/JCI175199

PMCID:: PMC11014656

Abstract Article PDF–1.5M

Select item 106087972.

Host B cells escape CAR-T immunotherapy by reversible downregulation of CD19

Sara Fioretti, Courtney A. Matson, Kenneth M. Rosenberg, Nevil J. Singh

Cancer Immunol Immunother. 2023 Jan; 72(1): 257–264. Published online 2022 Jun 26. doi: 10.1007/s00262-022-03231-3

PMCID:: PMC10608797

Abstract Article PDF–3.0M

Select item 103539313.

Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia

Nathaniel D. Anderson, Jack Birch, Theo Accogli, Ignacio Criado, Eleonora Khabirova, Conor Parks, Yvette Wood, Matthew D. Young, Tarryn Porter, Rachel Richardson, Sarah J. Albon, Bilyana Popova, Andre Lopes, Robert Wynn, Rachael Hough, Satyen H. Gohil, Martin Pule, Persis J. Amrolia, Sam Behjati, Sara Ghorashian

Nat Med. 2023; 29(7): 1700–1709. Published online 2023 Jul 6. doi: 10.1038/s41591-023-02415-3

PMCID:: PMC10353931

Abstract Article PDF–7.3M

Select item 102757074.

Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function

Isabel Leung, Megan L. Templeton, Yun Lo, Anusha Rajan, Sylvia M. Stull, Sarah M. Garrison, Alexander I. Salter, Kimberly S. Smythe, Colin E. Correnti, Shivani Srivastava, Cecilia C. S. Yeung, Stanley R. Riddell

Blood Adv. 2023 Jun 27; 7(12): 2718–2730. Published online 2022 Dec 7. doi: 10.1182/bloodadvances.2022008559

PMCID:: PMC10275707

Abstract Article PDF–1.6M

Select item 100134145.

ROR1/CD19 receptor complex promotes growth of mantle cell lymphoma cells independently of the B Cell Receptor-BTK signaling pathway

Qian Zhang, Hong Y Wang, Xiaobin Liu, Selene Nunez-Cruz, Mowafaq Jillab, Olga Melnikov, Kavindra Nath, Jerry Glickson, Mariusz A Wasik

J Immunol. Author manuscript; available in PMC 2023 Mar 14.

Published in final edited form as: J Immunol. 2019 Oct 15; 203(8): 2043–2048. Published online 2019 Sep 18. doi: 10.4049/jimmunol.1801327

PMCID:: PMC10013414

Abstract Article PDF–808K

Select item 98003246.

CD19+ B cell values predict the increase of anti-SARS CoV2 antibodies in fingolimod-treated and COVID-19-vaccinated patients with multiple sclerosis

Irene Schiavetti, Lucrezia Barcellini, Caterina Lapucci, Francesco Tazza, Maria Cellerino, Elisabetta Capello, Diego Franciotta, Matilde Inglese, Maria Pia Sormani, Antonio Uccelli, Alice Laroni

Mult Scler Relat Disord. 2023 Feb; 70: 104494. Published online 2022 Dec 30. doi: 10.1016/j.msard.2022.104494

PMCID:: PMC9800324

Abstract Article PDF–958K

Select item 96115067.

NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia

Matthew T. Witkowski, Soobeom Lee, Eric Wang, Anna K. Lee, Alexis Talbot, Chao Ma, Nikolaos Tsopoulidis, Justin Brumbaugh, Yaqi Zhao, Kathryn G. Roberts, Simon J. Hogg, Sofia Nomikou, Yohana Ghebrechristos, Palaniraja Thandapani, Charles G. Mullighan, Konrad Hochedlinger, Weiqiang Chen, Omar Abdel-Wahab, Justin Eyquem, Iannis Aifantis

Nat Immunol. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Nat Immunol. 2022 Oct; 23(10): 1424–1432. Published online 2022 Sep 22. doi: 10.1038/s41590-022-01314-y

PMCID:: PMC9611506

Abstract Article PDF–5.2M

Select item 88572768.

Identification of genomic signatures in bone marrow associated with clinical response of CD19 CAR T-cell therapy

Lipei Shao, Avinash Iyer, Yingdong Zhao, Rob Somerville, Sandhya Panch, Alejandra Pelayo, David F. Stroncek, Ping Jin

Sci Rep. 2022; 12: 2830. Published online 2022 Feb 18. doi: 10.1038/s41598-022-06830-3

PMCID:: PMC8857276

Abstract Article PDF–3.4M

Select item 85712349.

CD19 CAR-T cell treatment conferred sustained remission in B-ALL patients with minimal residual disease

Wenyi Lu, Yunxiong Wei, Yaqing Cao, Xia Xiao, Qing Li, Hairong Lyu, Yili Jiang, Huan Zhang, Xin Li, Yanyu Jiang, Juanxia Meng, Ting Yuan, Haibo Zhu, Xiaoyuan He, Xin Jin, Rui Sun, Tao Sui, Kaiqi Liu, Mingfeng Zhao

Cancer Immunol Immunother. 2021 Dec; 70(12): 3501–3511. Published online 2021 Apr 25. doi: 10.1007/s00262-021-02941-4

PMCID:: PMC8571234

Abstract Article PDF–1.2M

Select item 851664810.

CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial

Shaun Cordoba, Shimobi Onuoha, Simon Thomas, Daniela Soriano Pignataro, Rachael Hough, Sara Ghorashian, Ajay Vora, Denise Bonney, Paul Veys, Kanchan Rao, Giovanna Lucchini, Robert Chiesa, Jan Chu, Liz Clark, Mei Mei Fung, Koval Smith, Carlotta Peticone, Muhammad Al-Hajj, Vania Baldan, Mathieu Ferrari, Saket Srivastava, Ram Jha, Frederick Arce Vargas, Kevin Duffy, William Day, Paul Virgo, Lucy Wheeler, Jeremy Hancock, Farzin Farzaneh, Sabine Domning, Yiyun Zhang, Nushmia Z. Khokhar, Vijay G. R. Peddareddigari, Robert Wynn, Martin Pule, Persis J. Amrolia

Nat Med. 2021; 27(10): 1797–1805. Published online 2021 Oct 12. doi: 10.1038/s41591-021-01497-1

PMCID:: PMC8516648

Abstract Article PDF–7.9M

Select item 846236111.

CD19 target evasion as a mechanism of relapse in large B-cell lymphoma treated with axicabtagene ciloleucel

Vicki Plaks, John M. Rossi, Justin Chou, Linghua Wang, Soumya Poddar, Guangchun Han, Zixing Wang, Shao-Qing Kuang, Fuliang Chu, Richard E. Davis, Francisco Vega, Zahid Bashir, Caron A. Jacobson, Frederick L. Locke, Patrick M. Reagan, Scott J. Rodig, Lazaros J. Lekakis, Ian W. Flinn, David B. Miklos, Adrian Bot, Sattva S. Neelapu

Blood. 2021 Sep 23; 138(12): 1081–1085. Prepublished online 2021 May 27. doi: 10.1182/blood.2021010930

PMCID:: PMC8462361

Article

Select item 845640512.

SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism

Yukai Jing, Li Luo, Ying Chen, Lisa S. Westerberg, Peng Zhou, Zhiping Xu, Andrés A. Herrada, Chan-Sik Park, Masato Kubo, Heng Mei, Yu Hu, Pamela Pui-Wah Lee, Bing Zheng, Zhiwei Sui, Wei Xiao, Quan Gong, Zhongxin Lu, Chaohong Liu

Signal Transduct Target Ther. 2021; 6: 345. Published online 2021 Sep 22. doi: 10.1038/s41392-021-00749-3

PMCID:: PMC8456405

Abstract Article PDF–6.1M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 811155814.

Cryo-EM Structure of the B Cell Co-receptor CD19 Bound to the Tetraspanin CD81

Katherine J. Susa, Shaun Rawson, Andrew C. Kruse, Stephen C. Blacklow

Science. Author manuscript; available in PMC 2021 May 15.

Published in final edited form as: Science. 2021 Jan 15; 371(6526): 300–305. doi: 10.1126/science.abd9836

PMCID:: PMC8111558

Abstract Article PDF–946K

Select item 806403415.

Early Recovery of Circulating Immature B Cells in B-Lymphoblastic Leukemia Patients after CD19 Targeted CAR T Cell Therapy: A Pitfall for Minimal Residual Disease Detection

Wenbin Xiao, Dalia Salem, Catharine S. McCoy, Daniel Lee, Nirali N. Shah, Maryalice Stetler-Stevenson, Constance M. Yuan

Cytometry B Clin Cytom. Author manuscript; available in PMC 2021 Apr 23.

Published in final edited form as: Cytometry B Clin Cytom. 2018 May; 94(3): 434–443. Published online 2017 Oct 31. doi: 10.1002/cyto.b.21591

PMCID:: PMC8064034

Abstract Article PDF–1.2M

Select item 775153416.

Frequency of IL-10+CD19+ B cells in patients with prostate cancer compared to patients with benign prostatic hyperplasia

Nazmabadi Roya, Taheri Fatemeh, Mohammad-Alibeigi Faramarz, Sabzevary-Ghahfarokhi Milad, Sanaei Mohammad-Javad, Salehi-Vanani Najmeh, Mirzaei Yousef, Bagheri Nader

Afr Health Sci. 2020 Sep; 20(3): 1264–1272. doi: 10.4314/ahs.v20i3.31

PMCID:: PMC7751534

Abstract Article PDF–448K

Select item 770264617.

CD9 Is a Very Helpful Marker for Discriminating AML-M3 from HLA-DR-Negative Non-M3 AML

Esmaeil Shahabi Satlsar, Mohammad Mosleh, Mahdieh Mehrpouri

Turk J Haematol. 2020 Dec; 37(4): 287–289. Published online 2020 Nov 19. doi: 10.4274/tjh.galenos.2020.2020.0110

PMCID:: PMC7702646

Article PDF–377K

Select item 745391618.

TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy

Nuoyan Zheng, Kaifeng Xie, Hongjian Ye, Yu Dong, Bing Wang, Ning Luo, Jinjin Fan, Jiaqing Tan, Wei Chen, Xueqing Yu

JCI Insight. 2020 Jul 23; 5(14): e136965. Published online 2020 Jul 23. doi: 10.1172/jci.insight.136965

PMCID:: PMC7453916

Abstract Article PDF–9.8M

Select item 722876919.

A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking

Katherine J Susa, Tom CM Seegar, Stephen C Blacklow, Andrew C Kruse

eLife. 2020; 9: e52337. Published online 2020 Apr 27. doi: 10.7554/eLife.52337

PMCID:: PMC7228769

Abstract Article PDF–3.4M

Select item 685698820.

Alexandra Laberko, Elvira Sultanova, Elena Gutovskaya, Irina Shipitsina, Larisa Shelikhova, Elena Kurnikova, Yakov Muzalevskii, Alexei Kazachenok, Dmitriy Pershin, Kirill Voronin, Anna Shcherbina, Michael Maschan, Alexey Maschan, Dmitry Balashov

Blood. 2019 Nov 14; 134(20): 1755–1763. Prepublished online 2019 Sep 26. doi: 10.1182/blood.2019001757

PMCID:: PMC6856988

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