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Items: 1 to 20 of 88

1.
The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell quiescence by inhibiting their activation
Darren M. Blackburn, Korin Sahinyan, Aldo Hernández-Corchado, Felicia Lazure, Vincent Richard, Laura Raco, Gabrielle Perron, René P. Zahedi, Christoph H. Borchers, Christoph Lepper, Hiroshi Kawabe, Arezu Jahani-Asl, Hamed S. Najafabadi, Vahab D. Soleimani
iScience. 2024 Jul 19; 27(7): 110241. Published online 2024 Jun 11. doi: 10.1016/j.isci.2024.110241
PMCID:
PMC11250905
AbstractArticlePDF–5.6M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke
Wenjie Su, Xiang Yu, Shan Wang, Xu Wang, Zheng Dai, Yi Li
Cell Biol Toxicol. 2024; 40(1): 8. Published online 2024 Feb 2. doi: 10.1007/s10565-024-09844-x
PMCID:
PMC10834616
AbstractArticlePDF–7.0M
4.
Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity
Bekir Altas, Hong-Jun Rhee, Anes Ju, Hugo Cruces Solís, Samir Karaca, Jan Winchenbach, Oykum Kaplan-Arabaci, Manuela Schwark, Mateusz C. Ambrozkiewicz, ChungKu Lee, Lena Spieth, Georg L. Wieser, Viduth K. Chaugule, Irina Majoul, Mohamed A. Hassan, Rashi Goel, Sonja M. Wojcik, Noriko Koganezawa, Kenji Hanamura, Daniela Rotin, Andrea Pichler, Miso Mitkovski, Livia de Hoz, Alexandros Poulopoulos, Henning Urlaub, Olaf Jahn, Gesine Saher, Nils Brose, JeongSeop Rhee, Hiroshi Kawabe
J Cell Biol. 2024 Jan 1; 223(1): e201902050. Published online 2023 Nov 30. doi: 10.1083/jcb.201902050
PMCID:
PMC10689203
AbstractArticlePDF–6.2M
5.
Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension
Mazher Mohammed, Blessing Ogunlade, Mona Elgazzaz, Clara Berdasco, Navya Lakkappa, Ioana Ghita, Jessie J Guidry, Srinivas Sriramula, Jiaxi Xu, Luke Restivo, Michelle A Mendiola Plá, Dawn E Bowles, Andreas M Beyer, Xinping Yue, Eric Lazartigues, Catalin M Filipeanu
Cardiovasc Res. 2023 Aug; 119(11): 2130–2141. Published online 2023 May 10. doi: 10.1093/cvr/cvad070
PMCID:
PMC10478751
AbstractArticlePDF–1.4M
6.
Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1
Xin Gu, Haoyu Meng, Chengyi Peng, Shiyu Lin, Baihong Li, Lin Zhao, Xue Yang, Guangyan Wang, Wenyuan Cai, Jiawen Zhou, Shuiyuan Liu, Peng Wu, Yingqiang Du, Jianliang Jin, Xiaoyan Wang
Clin Transl Med. 2023 Jun; 13(6): e1308. Published online 2023 Jun 21. doi: 10.1002/ctm2.1308
PMCID:
PMC10285269
AbstractArticlePDF–20M
7.
A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis
Qian Guo, Mingyang Xin, Qingchun Lu, Dechun Feng, Vicky Yang, Lee F. Peng, Kelly A. Whelan, Wenhui Hu, Sheng Wu, Xiaofeng Yang, Hong Wang, Brad S. Rothberg, Ana M. Gamero, Glenn S. Gerhard, Bin Gao, Ling Yang
Theranostics. 2023; 13(7): 2210–2225. Published online 2023 Apr 9. doi: 10.7150/thno.81192
PMCID:
PMC10157740
AbstractArticlePDF–10M
8.
Molecular Mechanism of Long Noncoding RNA SNHG14 in Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells through the NEDD4L/FOXA2/PCP4 Axis
Han Wang, Mingxing Fan, Yan An, Da He
Stem Cells Int. 2023; 2023: 7545635. Published online 2023 Jan 5. doi: 10.1155/2023/7545635
PMCID:
PMC9836812
AbstractArticlePDF–3.3M
9.
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2
Hui Li, Ning Wang, Yu Jiang, Haofei Wang, Zengfeng Xin, Huazhang An, Hao Pan, Wangqian Ma, Ting Zhang, Xiaojian Wang, Wenlong Lin
EMBO Rep. 2022 Nov; 23(11): e54603. Published online 2022 Sep 26. doi: 10.15252/embr.202254603
PMCID:
PMC9638856
AbstractArticlePDF–4.2M
10.
Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures
Xiaoliang Liu, Lu Zhang, Hebo Zhang, Xiaoyan Liang, Bijun Zhang, Jianqiao Tu, Yanyan Zhao
Front Mol Neurosci. 2022; 15: 919718. Published online 2022 Jun 27. doi: 10.3389/fnmol.2022.919718
PMCID:
PMC9271913
AbstractArticlePDF–5.6M
11.
E3 Ubiquitin Ligase Nedd4-2 Exerts Neuroprotective Effects During Endoplasmic Reticulum Stress
Daphne E Lodes, Jiuhe Zhu, Nien-Pei Tsai
J Neurochem. Author manuscript; available in PMC 2023 Mar 1.
Published in final edited form as: J Neurochem. 2022 Mar; 160(6): 613–624. Published online 2021 Dec 29. doi: 10.1111/jnc.15567
PMCID:
PMC8930443
AbstractArticlePDF–1.9M
12.
The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel NaV1.7 via the Ubiquitin-Ligase NEDD4-2
Alexandru-Florian Deftu, Paul Chu Sin Chung, Cédric J. Laedermann, Ludovic Gillet, Marie Pertin, Guylène Kirschmann, Isabelle Decosterd
eNeuro. 2022 Mar-Apr; 9(2): ENEURO.0409-21.2022. Prepublished online 2022 Feb 7. Published online 2022 Mar 3. doi: 10.1523/ENEURO.0409-21.2022
PMCID:
PMC8906783
AbstractArticlePDF–2.1M
13.
ROMK channels are inhibited in the aldosterone-sensitive distal nephron of renal tubule Nedd4-2-deficient mice
Dan-Dan Zhang, Jun-Ya Zheng, Xin-Peng Duan, Dao-Hong Lin, Wen-Hui Wang
Am J Physiol Renal Physiol. 2022 Jan 1; 322(1): F55–F67. Published online 2021 Nov 29. doi: 10.1152/ajprenal.00306.2021
PMCID:
PMC8714254
AbstractArticle
14.
Infantile spasms‐linked Nedd4‐2 mediates hippocampal plasticity and learning via cofilin signaling
Kwan Young Lee, Jiuhe Zhu, Cathryn A Cutia, Catherine A Christian‐Hinman, Justin S Rhodes, Nien‐Pei Tsai
EMBO Rep. 2021 Oct 5; 22(10): e52645. Published online 2021 Aug 3. doi: 10.15252/embr.202152645
PMCID:
PMC8490988
AbstractArticlePDF–2.3M
15.
Deletion of renal Nedd4-2 abolishes the effect of high K+ intake on Kir4.1/Kir5.1 and NCC activity in the distal convoluted tubule
Yu Xiao, Xin-Peng Duan, Dan-Dan Zhang, Wen-Hui Wang, Dao-Hong Lin
Am J Physiol Renal Physiol. 2021 Jul 1; 321(1): F1–F11. Published online 2021 May 24. doi: 10.1152/ajprenal.00072.2021
PMCID:
PMC8321800
AbstractArticle
16.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
17.
Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of Nedd4-2
Theresa A. Engelmann, Lars Knudsen, Dominik H. W. Leitz, Julia Duerr, Michael F. Beers, Marcus A. Mall, Matthias Ochs
Int J Mol Sci. 2021 Jul; 22(14): 7607. Published online 2021 Jul 16. doi: 10.3390/ijms22147607
PMCID:
PMC8306112
AbstractArticlePDF–4.3M
18.
14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains
Pavel Pohl, Rohit Joshi, Olivia Petrvalska, Tomas Obsil, Veronika Obsilova
Commun Biol. 2021; 4: 899. Published online 2021 Jul 22. doi: 10.1038/s42003-021-02419-0
PMCID:
PMC8298602
AbstractArticlePDF–3.3M
19.
Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice
Dominik H. W. Leitz, Julia Duerr, Surafel Mulugeta, Ayça Seyhan Agircan, Stefan Zimmermann, Hiroshi Kawabe, Alexander H. Dalpke, Michael F. Beers, Marcus A. Mall
Int J Mol Sci. 2021 Jun; 22(11): 6146. Published online 2021 Jun 7. doi: 10.3390/ijms22116146
PMCID:
PMC8201155
AbstractArticlePDF–2.3M
20.
E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte hyperplasia by promoting GP130 degradation
Huan Liu, Wenlong Lin, Zhiyong Liu, Yinjing Song, Hao Cheng, Huazhang An, Xiaojian Wang
EMBO Rep. 2021 May 5; 22(5): e52063. Published online 2021 Mar 26. doi: 10.15252/embr.202052063
PMCID:
PMC8097351
AbstractArticlePDF–3.1M

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