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Items: 1 to 20 of 28

1.
Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain FXII mediated kallikrein kinin system activation
Allen C. Clermont, Nivetha Murugesan, Hannah J. Edwards, Daniel K. Lee, Natasha P. Bayliss, Edward J. Duckworth, Stephen J. Pethen, Sally L. Hampton, David Gailani, Edward P. Feener
Front Pharmacol. 2023; 14: 1287487. Published online 2023 Dec 19. doi: 10.3389/fphar.2023.1287487
PMCID:
PMC10766353
AbstractArticlePDF–1.6M
2.
Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease
Erica M. Sparkenbaugh, Michael W. Henderson, Megan Miller-Awe, Christina Abrams, Anton Ilich, Fatima Trebak, Nirupama Ramadas, Shantel Vital, Dillon Bohinc, Kara L. Bane, Chunsheng Chen, Margi Patel, Michael Wallisch, Thomas Renné, Andras Gruber, Brian Cooley, David Gailani, Malgorzata Kasztan, Gregory M. Vercellotti, John D. Belcher, Felicity E. Gavins, Evi X. Stavrou, Nigel S. Key, Rafal Pawlinski
Blood. 2023 Apr 13; 141(15): 1871–1883. Published online 2023 Feb 2. doi: 10.1182/blood.2022017074
PMCID:
PMC10122107
AbstractArticle
3.
Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice
Christian Stetter, Simon Lopez-Caperuchipi, Sarah Hopp-Krämer, Michael Bieber, Christoph Kleinschnitz, Anna-Leena Sirén, Christiane Albert-Weißenberger
Int J Mol Sci. 2021 May; 22(9): 4855. Published online 2021 May 3. doi: 10.3390/ijms22094855
PMCID:
PMC8124758
AbstractArticlePDF–3.3M
4.
FXII regulates the formation of deep vein thrombosis via the PI3K/AKT signaling pathway in mice
Yan Meng, Qian Yin, Qiang Ma, Hao Qin, Junbo Zhang, Bo Zhang, Honggang Pang, Hongyan Tian
Int J Mol Med. 2021 May; 47(5): 87. Published online 2021 Mar 23. doi: 10.3892/ijmm.2021.4920
PMCID:
PMC8018183
AbstractArticlePDF–1.2M
5.
Coagulation factor XII contributes to hemostasis when activated by soil in wounds
Lih Jiin Juang, Nima Mazinani, Stefanie K. Novakowski, Emily N. P. Prowse, Martin Haulena, David Gailani, Leslie M. Lavkulich, Christian J. Kastrup
Blood Adv. 2020 Apr 28; 4(8): 1737–1745. Published online 2020 Apr 27. doi: 10.1182/bloodadvances.2019000425
PMCID:
PMC7189277
AbstractArticlePDF–1.0M
6.
Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits
Dorit Farfara, Emily Feierman, Allison Richards, Alexey S. Revenko, Robert A. MacLeod, Erin H. Norris, Sidney Strickland
Glia. Author manuscript; available in PMC 2020 Jul 1.
Published in final edited form as: Glia. 2019 Jul; 67(7): 1359–1373. Published online 2019 Mar 18. doi: 10.1002/glia.23611
PMCID:
PMC6551624
AbstractArticlePDF–2.5M
7.
Factor XII activation promotes platelet consumption in the presence of bacterial-type long-chain polyphosphate in vitro and in vivo
Jevgenia Zilberman-Rudenko, Stephanie E. Reitsma, Cristina Puy, Rachel A. Rigg, Stephanie A. Smith, Erik I. Tucker, Robert Silasi, Alona Merkulova, Keith R. McCrae, Coen Maas, Rolf T. Urbanus, David Gailani, James H. Morrissey, András Gruber, Florea Lupu, Alvin H. Schmaier, Owen J. T. McCarty
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Aug 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Aug; 38(8): 1748–1760. doi: 10.1161/ATVBAHA.118.311193
PMCID:
PMC6205188
AbstractArticlePDF–1.7M
8.
Factor XII and uPAR upregulate neutrophil functions to influence wound healing
Evi X. Stavrou, Chao Fang, Kara L. Bane, Andy T. Long, Clément Naudin, Erdem Kucukal, Agharnan Gandhi, Adina Brett-Morris, Michele M. Mumaw, Sudeh Izadmehr, Alona Merkulova, Cindy C. Reynolds, Omar Alhalabi, Lalitha Nayak, Wen-Mei Yu, Cheng-Kui Qu, Howard J. Meyerson, George R. Dubyak, Umut A. Gurkan, Marvin T. Nieman, Anirban Sen Gupta, Thomas Renné, Alvin H. Schmaier
J Clin Invest. 2018 Mar 1; 128(3): 944–959. Published online 2018 Jan 29. doi: 10.1172/JCI92880
PMCID:
PMC5824869
AbstractArticlePDF–9.6M
9.
Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice
Zu-Lin Chen, Alexey S. Revenko, Pradeep Singh, A. Robert MacLeod, Erin H. Norris, Sidney Strickland
Blood. 2017 May 4; 129(18): 2547–2556. Prepublished online 2017 Feb 27. doi: 10.1182/blood-2016-11-753202
PMCID:
PMC5418637
AbstractArticle
10.
Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke
Fabrício Simão, Tuna Ustunkaya, Allen C. Clermont, Edward P. Feener
Blood. 2017 Apr 20; 129(16): 2280–2290. Prepublished online 2017 Jan 27. doi: 10.1182/blood-2016-09-740670
PMCID:
PMC5399481
AbstractArticle
11.
Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa
Sarah Hopp, Marc W. Nolte, Christian Stetter, Christoph Kleinschnitz, Anna-Leena Sirén, Christiane Albert-Weissenberger
J Neuroinflammation. 2017; 14: 39. Published online 2017 Feb 20. doi: 10.1186/s12974-017-0815-8
PMCID:
PMC5319055
AbstractArticlePDF–932K
12.
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
Kerstin Göbel, Susann Pankratz, Chloi-Magdalini Asaridou, Alexander M. Herrmann, Stefan Bittner, Monika Merker, Tobias Ruck, Sarah Glumm, Friederike Langhauser, Peter Kraft, Thorsten F. Krug, Johanna Breuer, Martin Herold, Catharina C. Gross, Denise Beckmann, Adelheid Korb-Pap, Michael K. Schuhmann, Stefanie Kuerten, Ioannis Mitroulis, Clemens Ruppert, Marc W. Nolte, Con Panousis, Luisa Klotz, Beate Kehrel, Thomas Korn, Harald F. Langer, Thomas Pap, Bernhard Nieswandt, Heinz Wiendl, Triantafyllos Chavakis, Christoph Kleinschnitz, Sven G. Meuth
Nat Commun. 2016; 7: 11626. Published online 2016 May 18. doi: 10.1038/ncomms11626
PMCID:
PMC4873982
AbstractArticlePDF–1.5M
13.
A Comparison of the Effects of Factor XII Deficiency and Prekallikrein Deficiency on Thrombus Formation
Yasin Kokoye, Ivan Ivanov, Qiufang Cheng, Anton Matafonov, S. Kent Dickeson, Shauna Mason, Daniel J. Sexton, Thomas Renné, Keith McCrae, Edward P. Feener, David Gailani
Thromb Res. Author manuscript; available in PMC 2017 Apr 1.
Published in final edited form as: Thromb Res. 2016 Apr; 140: 118–124. Published online 2016 Feb 18. doi: 10.1016/j.thromres.2016.02.020
PMCID:
PMC4821716
AbstractArticlePDF–2.9M
14.
The polyphosphate–factor XII pathway drives coagulation in prostate cancer-associated thrombosis
Katrin F. Nickel, Göran Ronquist, Florian Langer, Linda Labberton, Tobias A. Fuchs, Carsten Bokemeyer, Guido Sauter, Markus Graefen, Nigel Mackman, Evi X. Stavrou, Gunnar Ronquist, Thomas Renné
Blood. 2015 Sep 10; 126(11): 1379–1389. Prepublished online 2015 Jul 7. doi: 10.1182/blood-2015-01-622811
PMCID:
PMC4566812
AbstractArticle
15.
Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III
Jenny Björkqvist, Steven de Maat, Urs Lewandrowski, Antonio Di Gennaro, Chris Oschatz, Kai Schönig, Markus M. Nöthen, Christian Drouet, Hal Braley, Marc W. Nolte, Albert Sickmann, Con Panousis, Coen Maas, Thomas Renné
J Clin Invest. 2015 Aug 3; 125(8): 3132–3146. Published online 2015 Jul 20. doi: 10.1172/JCI77139
PMCID:
PMC4563738
AbstractArticlePDF–7.7M
16.
Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding
Alexey S. Revenko, Dacao Gao, Jeff R. Crosby, Gourab Bhattacharjee, Chenguang Zhao, Chris May, David Gailani, Brett P. Monia, A. Robert MacLeod
Blood. 2011 Nov 10; 118(19): 5302–5311. Prepublished online 2011 Aug 5. doi: 10.1182/blood-2011-05-355248
PMCID:
PMC4425441
AbstractArticle
17.
Activation of the factor XII-driven contact system in Alzheimer’s disease patient and mouse model plasma
Daria Zamolodchikov, Zu-Lin Chen, Brooke A. Conti, Thomas Renné, Sidney Strickland
Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13): 4068–4073. Published online 2015 Mar 16. doi: 10.1073/pnas.1423764112
PMCID:
PMC4386355
AbstractArticlePDF–896K
18.
Reduced thrombosis in Klkb1−/− mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor
Evi X. Stavrou, Chao Fang, Alona Merkulova, Omar Alhalabi, Nadja Grobe, Silvio Antoniak, Nigel Mackman, Alvin H. Schmaier
Blood. 2015 Jan 22; 125(4): 710–719. Prepublished online 2014 Oct 22. doi: 10.1182/blood-2014-01-550285
PMCID:
PMC4304115
AbstractArticle
19.
Factor XII inhibition reduces thrombus formation in a primate thrombosis model
Anton Matafonov, Philberta Y. Leung, Adam E. Gailani, Stephanie L. Grach, Cristina Puy, Qiufang Cheng, Mao-fu Sun, Owen J. T. McCarty, Erik I. Tucker, Hiroaki Kataoka, Thomas Renné, James H. Morrissey, Andras Gruber, David Gailani
Blood. 2014 Mar 13; 123(11): 1739–1746. Prepublished online 2014 Jan 9. doi: 10.1182/blood-2013-04-499111
PMCID:
PMC3954054
AbstractArticle
20.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M

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