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Items: 1 to 20 of 84

1.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
2.
Assessment of community efforts to advance network-based prediction of protein–protein interactions
Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P. Wytock, István A. Kovács, Olivér M. Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A. Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K. Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu
Nat Commun. 2023; 14: 1582. Published online 2023 Mar 22. doi: 10.1038/s41467-023-37079-7
PMCID:
PMC10033937
AbstractArticlePDF–1.5M
3.
Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway
Ting Lan, Ying Li, Yue Wang, Zhong-Cheng Wang, Chun-Yan Mu, Ai-Bin Tao, Jian-Li Gong, Yuan Zhou, Hao Xu, Shi-Bao Li, Bing Gu, Ping Ma, Lan Luo
Cell Death Dis. 2023 Jan; 14(1): 39. Published online 2023 Jan 19. doi: 10.1038/s41419-023-05580-y
PMCID:
PMC9849337
AbstractArticlePDF–4.9M
4.
Downexpression of miR-200c-3p Contributes to Achalasia Disease by Targeting the PRKG1 Gene
Lucia Micale, Carmela Fusco, Grazia Nardella, Orazio Palmieri, Tiziana Latiano, Domenica Gioffreda, Francesca Tavano, Anna Panza, Antonio Merla, Giuseppe Biscaglia, Marco Gentile, Antonello Cuttitta, Marco Castori, Francesco Perri, Anna Latiano
Int J Mol Sci. 2023 Jan; 24(1): 668. Published online 2022 Dec 30. doi: 10.3390/ijms24010668
PMCID:
PMC9820813
AbstractArticlePDF–2.1M
5.
Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening
Antonella Falconieri, Giovanni Minervini, Federica Quaglia, Geppo Sartori, Silvio C. E. Tosatto
Cancers (Basel) 2022 Feb; 14(4): 1009. Published online 2022 Feb 17. doi: 10.3390/cancers14041009
PMCID:
PMC8869832
AbstractArticlePDF–1.1M
6.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
7.
Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes
Neda M. Bogari, Amr A. Amin, Husni H. Rayes, Ahmed Abdelmotelb, Mohiuddin M. Taher, Faisal A. Al-Allaf, Abdellatif Bouazzaoui, Luke O'Gorman, John W. Holloway
Dis Markers. 2021; 2021: 8884229. Published online 2021 Feb 8. doi: 10.1155/2021/8884229
PMCID:
PMC7888305
AbstractArticlePDF–413K
8.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
9.
A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP
Matthew H. Chan, Sahar Aminzai, Tingfei Hu, Amatya Taran, Sheng Li, Choel Kim, Renate B. Pilz, Darren E. Casteel
J Biol Chem. 2020 Jul 24; 295(30): 10394–10405. Published online 2020 Jun 5. doi: 10.1074/jbc.RA119.010984
PMCID:
PMC7383375
AbstractArticlePDF–2.8M
10.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
11.
O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth
Hao Nie, Haixing Ju, Jiayi Fan, Xiaoliu Shi, Yaxian Cheng, Xiaohui Cang, Zhiguo Zheng, Xiaotao Duan, Wen Yi
Nat Commun. 2020; 11: 36. Published online 2020 Jan 7. doi: 10.1038/s41467-019-13601-8
PMCID:
PMC6946671
AbstractArticlePDF–3.3M
12.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu
Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3
PMCID:
PMC6742646
AbstractArticlePDF–1.2M
13.
Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension
Olena Rudyk, Alice Rowan, Oleksandra Prysyazhna, Susanne Krasemann, Kristin Hartmann, Min Zhang, Ajay M. Shah, Clemens Ruppert, Astrid Weiss, Ralph T. Schermuly, Tomoaki Ida, Takaaki Akaike, Lan Zhao, Philip Eaton
Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26): 13016–13025. Published online 2019 Jun 11. doi: 10.1073/pnas.1904064116
PMCID:
PMC6601250
AbstractArticlePDF–2.1M
14.
PKG-Modified TSC2 Regulates mTORC1 Activity to Counter Adverse Cardiac Stress
Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen, Brittany L. Dunkerly-Eyring, Miguel Pinilla Vera, Christian U. Oeing, Chirag H. Patel, Taishi Nakamura, Guangshuo Zhu, Djahida Bedja, Masayuki Sasaki, Ronald J. Holewinski, Jennifer E. Van Eyk, Jonathan D. Powell, Dong Ik Lee, David A. Kass
Nature. Author manuscript; available in PMC 2019 Jul 30.
Published in final edited form as: Nature. 2019 Feb; 566(7743): 264–269. Published online 2019 Jan 30. doi: 10.1038/s41586-019-0895-y
PMCID:
PMC6426636
AbstractArticlePDF–3.7M
15.
Self-regulation and the foraging gene (PRKG1) in humans
Andriy A. Struk, Jhotisha Mugon, Andrea Huston, Abigail A. Scholer, Gertraud Stadler, E. Tory Higgins, Marla B. Sokolowski, James Danckert
Proc Natl Acad Sci U S A. 2019 Mar 5; 116(10): 4434–4439. Published online 2019 Feb 19. doi: 10.1073/pnas.1809924116
PMCID:
PMC6410783
AbstractArticlePDF–891K
16.
Replication of the Interaction of PRKG1 and Trauma Exposure on Alcohol Misuse in an Independent African American Sample
Sage E. Hawn, Christina M. Sheerin, Bradley T. Webb, Roseann E. Peterson, Elizabeth K. Do, Danielle Dick, Kenneth S. Kendler, Silviu-Alin Bacanu, Ananda B. Amstadter
J Trauma Stress. Author manuscript; available in PMC 2019 Dec 1.
Published in final edited form as: J Trauma Stress. 2018 Dec; 31(6): 927–932. Published online 2018 Oct 30. doi: 10.1002/jts.22339
PMCID:
PMC6295354
AbstractArticlePDF–345K
17.
Structural Basis of Analog Specificity in PKG I and II
James C. Campbell, Philipp Henning, Eugen Franz, Banumathi Sankaran, Friedrich W. Herberg, Choel Kim
ACS Chem Biol. Author manuscript; available in PMC 2018 Sep 15.
Published in final edited form as: ACS Chem Biol. 2017 Sep 15; 12(9): 2388–2398. Published online 2017 Aug 22. doi: 10.1021/acschembio.7b00369
PMCID:
PMC5896746
AbstractArticlePDF–943K
18.
A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus
Renato Polimanti, Joan Kaufman, Hongyu Zhao, Henry R. Kranzler, Robert J. Ursano, Ronald C. Kessler, Joel Gelernter, Murray B. Stein
Mol Psychiatry. Author manuscript; available in PMC 2018 Jan 4.
Published in final edited form as: Mol Psychiatry. 2018 Jan; 23(1): 154–160. Published online 2017 Mar 7. doi: 10.1038/mp.2017.24
PMCID:
PMC5589475
AbstractArticlePDF–555K
19.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
20.
Reversibility of glioma stem cells’ phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells as a discovery tool
Thomas J. Wilson, Daniel B. Zamler, Robert Doherty, Maria G. Castro, Pedro R. Lowenstein
Oncotarget. 2016 Sep 27; 7(39): 63020–63041. Published online 2016 Aug 24. doi: 10.18632/oncotarget.11589
PMCID:
PMC5325344
AbstractArticlePDF–10M

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