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Select item 100145351.

“From molecular to clinic”: The pivotal role of CDC42 in pathophysiology of human papilloma virus related cancers and a correlated sensitivity of afatinib

Erdong Wei, Jiahua Li, Philipp Anand, Lars E. French, Adam Wattad, Benjamin Clanner-Engelshofen, Markus Reinholz

Front Immunol. 2023; 14: 1118458. Published online 2023 Mar 1. doi: 10.3389/fimmu.2023.1118458

PMCID:: PMC10014535

Abstract Article PDF–26M

Select item 97018392.

Cell division cycle 42 positively correlates with T helper 2 cytokine, effusion viscosity, and hearing loss degree in otitis media with effusion patients

Dan Wu, Yang Yang, Chuanxin Duan

J Clin Lab Anal. 2022 Nov; 36(11): e24681. Published online 2022 Sep 26. doi: 10.1002/jcla.24681

PMCID:: PMC9701839

Abstract Article PDF–4.2M

Select item 95509623.

Cell division cycle 42 reflects disease risk, symptoms, Th1/Th2 disproportion, and its short‐term variation indicates symptom amelioration after treatment in allergic rhinitis patients

Xiaote Zhang, Lujie Xie, Xiaoyun Fang

J Clin Lab Anal. 2022 Oct; 36(10): e24684. Published online 2022 Aug 31. doi: 10.1002/jcla.24684

PMCID:: PMC9550962

Abstract Article PDF–4.3M

Select item 88108034.

Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues

Masumi Tsuda, Runa Horio, Lei Wang, Tomoko Takenami, Jun Moriya, Jun Suzuka, Hirokazu Sugino, Zenichi Tanei, Mishie Tanino, Shinya Tanaka

Sci Rep. 2022; 12: 1733. Published online 2022 Feb 2. doi: 10.1038/s41598-022-05892-7

PMCID:: PMC8810803

Abstract Article PDF–1.8M

Select item 87636565.

Novel CTRP8‐RXFP1‐JAK3‐STAT3 axis promotes Cdc42‐dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells

Aleksandra Glogowska, Thatchawan Thanasupawat, Jason Beiko, Marshall Pitz, Sabine Hombach‐Klonisch, Thomas Klonisch

Mol Oncol. 2022 Jan; 16(2): 368–387. Published online 2021 Jun 18. doi: 10.1002/1878-0261.12981

PMCID:: PMC8763656

Abstract Article PDF–949K

Select item 84295526.

Macrothrombocytopenia of Takenouchi-Kosaki syndrome is ameliorated by CDC42 specific- and lipidation inhibitors in MEG-01 cells

Etsuko Daimon, Yukinao Shibukawa, Suganya Thanasegaran, Natsuko Yamazaki, Nobuhiko Okamoto

Sci Rep. 2021; 11: 17990. Published online 2021 Sep 9. doi: 10.1038/s41598-021-97478-y

PMCID:: PMC8429552

Abstract Article PDF–5.6M

Select item 84257707.

Severe autoinflammation in 4 patients with C-terminal variants in cell division control protein 42 homolog (CDC42) successfully treated with IL-1β inhibition

Yael Gernez, Adriana A. de Jesus, Hanouf Alsaleem, Claudia Macaubas, Amitava Roy, Daniel Lovell, Karthik A. Jagadeesh, Sara Alehashemi, Laura Erdman, Michael Grimley, Susanna Talarico, Rosa Bacchetta, David B. Lewis, Scott W. Canna, Ron M. Laxer, Elizabeth D. Mellins, Raphaela Goldbach-Mansky, Katja G. Weinacht

J Allergy Clin Immunol. Author manuscript; available in PMC 2021 Sep 8.

Published in final edited form as: J Allergy Clin Immunol. 2019 Oct; 144(4): 1122–1125.e6. Published online 2019 Jul 2. doi: 10.1016/j.jaci.2019.06.017

PMCID:: PMC8425770

Article PDF–434K

Select item 84121108.

Molecular subversion of Cdc42 signalling in cancer

Natasha P. Murphy, Ana Masara binti Ahmad Mokhtar, Helen R. Mott, Darerca Owen

Biochem Soc Trans. 2021 Jun 30; 49(3): 1425–1442. Published online 2021 Jul 1. doi: 10.1042/BST20200557

PMCID:: PMC8412110

Abstract Article PDF–4.7M

Select item 82868269.

Progress in the therapeutic inhibition of Cdc42 signalling

Natasha P. Murphy, Helen R. Mott, Darerca Owen

Biochem Soc Trans. 2021 Jun 30; 49(3): 1443–1456. Published online 2021 Jun 8. doi: 10.1042/BST20210112

PMCID:: PMC8286826

Abstract Article PDF–13M

Select item 792379610.

Pancytopenia, Recurrent Infection, Poor Wound Healing, Heterotopia of the Brain Probably Associated with A Candidate Novel de Novo CDC42 Gene Defect: Expanding the Molecular and Phenotypic Spectrum

Abdulaziz Asiri, Deemah Alwadaani, Muhammad Umair, Kheloud M. Alhamoudi, Mohammed H. Almuhanna, Abdul Nasir, Bahauddeen M. Alrfaei, Abeer Al Tuwaijri, Tlili Barhoumi, Yusra Alyafee, Bader Almuzzaini, Mohammed Aldrees, Mariam Ballow, Latifah Alayyar, Abdulkareem Al Abdulrahman, Yazeid Alhaidan, Nahlah Al Ghasham, Sulaiman Al-Ajaji, Mohammad Alsalamah, Wafa Al Suwairi, Majid Alfadhel

Genes (Basel) 2021 Feb; 12(2): 294. Published online 2021 Feb 20. doi: 10.3390/genes12020294

PMCID:: PMC7923796

Abstract Article PDF–1.5M

Select item 754970411.

Increasing spatial resolution of photoregulated GTPases through immobilized peripheral membrane proteins

Orry Van Geel, Roland Hartsuiker, Theodorus W. J. Gadella

Small GTPases. 2020; 11(6): 441–450. Published online 2018 Sep 5. doi: 10.1080/21541248.2018.1507411

PMCID:: PMC7549704

Abstract Article PDF–2.1M

Select item 751187512.

Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice

Maria Carolina Florian, Hanna Leins, Michael Gobs, Yang Han, Gina Marka, Karin Soller, Angelika Vollmer, Vadim Sakk, Kalpana J. Nattamai, Ahmad Rayes, Xueheng Zhao, Kenneth Setchell, Medhanie Mulaw, Wolfgang Wagner, Yi Zheng, Hartmut Geiger

Aging Cell. 2020 Sep; 19(9): e13208. Published online 2020 Aug 4. doi: 10.1111/acel.13208

PMCID:: PMC7511875

Abstract Article PDF–605K

Select item 733526313.

The growing spectrum of human diseases caused by inherited CDC42 mutations

Helen C. Su, Jordan S. Orange

J Clin Immunol. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: J Clin Immunol. 2020 May; 40(4): 551–553. doi: 10.1007/s10875-020-00785-8

PMCID:: PMC7335263

Abstract Article PDF–283K

Select item 727229514.

Cdc42 mediates cancer cell chemotaxis in perineural invasion

Natalya Chernichenko, Tatiana Omelchenko, Sylvie Deborde, Richard Bakst, Shizhi He, Chun-Hao Chen, Laxmi Gusain, Efsevia Vakiani, Nora Katabi, Alan Hall, Richard J Wong

Mol Cancer Res. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Mol Cancer Res. 2020 Jun; 18(6): 913–925. Published online 2020 Feb 21. doi: 10.1158/1541-7786.MCR-19-0726

PMCID:: PMC7272295

Abstract Article PDF–1.3M

Select item 705862015.

Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer

Li-li Ma, Li-li Guo, Yang Luo, Guang-long Liu, Yan Lei, Fang-yan Jing, Yun-li Zhang, Gui-hui Tong, Zhi-Liang Jing, Lan Shen, Min-shan Tang, Yan-qing Ding, Yong-jian Deng

Cell Death Dis. 2020 Mar; 11(3): 171. Published online 2020 Mar 5. doi: 10.1038/s41419-020-2370-y

PMCID:: PMC7058620

Abstract Article PDF–7.7M

Select item 691253616.

Cdc42 Couples T Cell Receptor Endocytosis to GRAF1-Mediated Tubular Invaginations of the Plasma Membrane

Pascal Rossatti, Luca Ziegler, Richard Schregle, Verena M. Betzler, Manuela Ecker, Jérémie Rossy

Cells. 2019 Nov; 8(11): 1388. Published online 2019 Nov 4. doi: 10.3390/cells8111388

PMCID:: PMC6912536

Abstract Article PDF–3.0M

Select item 610445217.

Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase

Mahadevappa Hemshekhar, Ka-Yee Grace Choi, Neeloffer Mookherjee

Front Immunol. 2018; 9: 1871. Published online 2018 Aug 13. doi: 10.3389/fimmu.2018.01871

PMCID:: PMC6104452

Abstract Article PDF–2.8M

Select item 601794718.

Regulating Cdc42 and Its Signaling Pathways in Cancer: Small Molecules and MicroRNA as New Treatment Candidates

Xing-Hua Xiao, Lin-Chen Lv, Jing Duan, Ye-Meng Wu, Shu-Jin He, Zhen-Zhen Hu, Li-Xia Xiong

Molecules. 2018 Apr; 23(4): 787. Published online 2018 Mar 29. doi: 10.3390/molecules23040787

PMCID:: PMC6017947

Abstract Article PDF–3.8M

Select item 598541719.

Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes

Simone Martinelli, Oliver H.F. Krumbach, Francesca Pantaleoni, Simona Coppola, Ehsan Amin, Luca Pannone, Kazem Nouri, Luciapia Farina, Radovan Dvorsky, Francesca Lepri, Marcel Buchholzer, Raphael Konopatzki, Laurence Walsh, Katelyn Payne, Mary Ella Pierpont, Samantha Schrier Vergano, Katherine G. Langley, Douglas Larsen, Kelly D. Farwell, Sha Tang, Cameron Mroske, Ivan Gallotta, Elia Di Schiavi, Matteo della Monica, Licia Lugli, Cesare Rossi, Marco Seri, Guido Cocchi, Lindsay Henderson, Berivan Baskin, Mariëlle Alders, Roberto Mendoza-Londono, Lucie Dupuis, Deborah A. Nickerson, Jessica X. Chong, The University of Washington Center for Mendelian Genomics, Naomi Meeks, Kathleen Brown, Tahnee Causey, Megan T. Cho, Stephanie Demuth, Maria Cristina Digilio, Bruce D. Gelb, Michael J. Bamshad, Martin Zenker, Mohammad Reza Ahmadian, Raoul C. Hennekam, Marco Tartaglia, Ghayda M. Mirzaa

Am J Hum Genet. 2018 Feb 1; 102(2): 309–320. Published online 2018 Jan 25. doi: 10.1016/j.ajhg.2017.12.015

PMCID:: PMC5985417

Abstract Article PDF–2.4M

Select item 550942520.

Spatial analysis of Cdc42 activity reveals a role for plasma membrane–associated Cdc42 in centrosome regulation

Kari A. Herrington, Andrew L. Trinh, Carolyn Dang, Ellen O’Shaughnessy, Klaus M. Hahn, Enrico Gratton, Michelle A. Digman, Christine Sütterlin

Mol Biol Cell. 2017 Jul 15; 28(15): 2135–2145. doi: 10.1091/mbc.E16-09-0665

PMCID:: PMC5509425

Abstract Article PDF–1.4M

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