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Select item 77570311.

Potential roles of mediator Complex Subunit 13 in Cardiac Diseases

Wenqian Zhou, He Cai, Jia Li, He Xu, Xiang Wang, Hongbo Men, Yang Zheng, Lu Cai

Int J Biol Sci. 2021; 17(1): 328–338. Published online 2021 Jan 1. doi: 10.7150/ijbs.52290

PMCID:: PMC7757031

Article PDF–1.1M

Select item 59739762.

De novo mutations in MED13, a component of the Mediator complex, are associated with a novel neurodevelopmental disorder

Lot Snijders Blok, Susan M. Hiatt, Kevin M. Bowling, Jeremy W. Prokop, Krysta L. Engel, J. Nicholas Cochran, E. Martina Bebin, Emilia K. Bijlsma, Claudia A. L. Ruivenkamp, Paulien Terhal, Marleen E. H. Simon, Rosemarie Smith, Jane A. Hurst, The DDD study, Heather McLaughlin, Richard Person, Amy Crunk, Michael F. Wangler, Haley Streff, Joseph D. Symonds, Sameer M. Zuberi, Katherine S. Elliott, Victoria R. Sanders, Abigail Masunga, Robert J. Hopkin, Holly A. Dubbs, Xilma R. Ortiz-Gonzalez, Rolph Pfundt, Han G. Brunner, Simon E. Fisher, Tjitske Kleefstra, Gregory M. Cooper

Hum Genet. 2018; 137(5): 375–388. Published online 2018 May 8. doi: 10.1007/s00439-018-1887-y

PMCID:: PMC5973976

Article PDF–2.6M

Select item 42879783.

MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver

Kedryn K Baskin, Chad E Grueter, Christine M Kusminski, William L Holland, Angie L Bookout, Santosh Satapati, Y Megan Kong, Shawn C Burgess, Craig R Malloy, Philipp E Scherer, Christopher B Newgard, Rhonda Bassel-Duby, Eric N Olson

EMBO Mol Med. 2014 Dec; 6(12): 1610–1621. Published online 2014 Nov 24. doi: 10.15252/emmm.201404218

PMCID:: PMC4287978

Article PDF–1.4M

Select item 49283754.

Mediator kinase module and human tumorigenesis

Alison D. Clark, Marieke Oldenbroek, Thomas G. Boyer

Crit Rev Biochem Mol Biol. Author manuscript; available in PMC 2016 Jun 30.

Published in final edited form as: Crit Rev Biochem Mol Biol. 2015; 50(5): 393–426. Published online 2015 Jul 16. doi: 10.3109/10409238.2015.1064854

PMCID:: PMC4928375

Article PDF–1.5M

Select item 1863165.

Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation

Anders M. Näär, Dylan J. Taatjes, Weiguo Zhai, Eva Nogales, Robert Tjian

Genes Dev. 2002 Jun 1; 16(11): 1339–1344. doi: 10.1101/gad.987602

PMCID:: PMC186316

Article PDF–185K

Select item 26306856.

The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator

Matthew T. Knuesel, Krista D. Meyer, Aaron J. Donner, Joaquin M. Espinosa, Dylan J. Taatjes

Mol Cell Biol. 2009 Feb; 29(3): 650–661. Published online 2008 Dec 1. doi: 10.1128/MCB.00993-08

PMCID:: PMC2630685

Article PDF–1.5M

Select item 63771487.

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7

Kerstin Köhler, Luis Sanchez-Pulido, Verena Höfer, Anika Marko, Chris P. Ponting, Ambrosius P. Snijders, Regina Feederle, Aloys Schepers, Dominik Boos

PLoS Biol. 2019 Jan; 17(1): e2006767. Published online 2019 Jan 29. doi: 10.1371/journal.pbio.2006767

PMCID:: PMC6377148

Article PDF–4.1M

Select item 36814298.

HIF1A employs CDK8-Mediator to stimulate RNAPII elongation

Matthew D. Galbraith, Mary A. Allen, Claire L. Bensard, Xiaoxing Wang, Marie K. Schwinn, Bo Qin, Henry W. Long, Danette L. Daniels, William C. Hahn, Robin D. Dowell, Joaquín M. Espinosa

Cell. Author manuscript; available in PMC 2014 Jun 6.

Published in final edited form as: Cell. 2013 Jun 6; 153(6): 1327–1339. doi: 10.1016/j.cell.2013.04.048

PMCID:: PMC3681429

Article PDF–2.7M

Select item 386709.

Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.

J D Fondell, H Ge, R G Roeder

Proc Natl Acad Sci U S A. 1996 Aug 6; 93(16): 8329–8333. doi: 10.1073/pnas.93.16.8329

PMCID:: PMC38670

Summary Page Browse PDF–1.5M

Select item 292028610.

CDK8 is a positive regulator of transcriptional elongation within the serum response network

Aaron J. Donner, Christopher C. Ebmeier, Dylan J. Taatjes, Joaquín M. Espinosa

Nat Struct Mol Biol. Author manuscript; available in PMC 2010 Aug 11.

Published in final edited form as: Nat Struct Mol Biol. 2010 Feb; 17(2): 194–201. Published online 2010 Jan 24. doi: 10.1038/nsmb.1752

PMCID:: PMC2920286

Article PDF–2.1M

Select item 29181411.

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells

Gerhard Mittler, Thomas Stühler, Lisa Santolin, Thomas Uhlmann, Elisabeth Kremmer, F. Lottspeich, Lucia Berti, Michael Meisterernst

EMBO J. 2003 Dec 15; 22(24): 6494–6504. doi: 10.1093/emboj/cdg619

PMCID:: PMC291814

Article PDF–382K

Select item 720600812.

FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation

Kai T. Richter, Yvonne T. Kschonsak, Barbara Vodicska, Ingrid Hoffmann

Cell Death Differ. 2020 Feb; 27(2): 758–772. Published online 2019 Jul 8. doi: 10.1038/s41418-019-0385-7

PMCID:: PMC7206008

Article PDF–2.8M

Select item 239639513.

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3

Krista D Meyer, Aaron J Donner, Matthew T Knuesel, Autumn G York, Joaquín M Espinosa, Dylan J Taatjes

EMBO J. 2008 May 21; 27(10): 1447–1457. Published online 2008 Apr 17. doi: 10.1038/emboj.2008.78

PMCID:: PMC2396395

Article PDF–303K

Select item 414102414.

Genetic Determinants of P Wave Duration and PR Segment

Niek Verweij, Irene Mateo Leach, Malou van den Boogaard, Dirk J. van Veldhuisen, Vincent M. Christoffels, LifeLines Cohort Study, Hans L. Hillege, Wiek H. van Gilst, Phil Barnett, Rudolf A. de Boer, Pim van der Harst

Circ Cardiovasc Genet. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Circ Cardiovasc Genet. 2014 Aug; 7(4): 475–481. Published online 2014 May 21. doi: 10.1161/CIRCGENETICS.113.000373

PMCID:: PMC4141024

Article PDF–410K

Select item 364861215.

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

Kuang-Lei Tsai, Shigeo Sato, Chieri Tomomori-Sato, Ronald C. Conaway, Joan W. Conaway, Francisco J. Asturias

Nat Struct Mol Biol. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: Nat Struct Mol Biol. 2013 May; 20(5): 611–619. Published online 2013 Apr 7. doi: 10.1038/nsmb.2549

PMCID:: PMC3648612

Article PDF–1.4M

Select item 222328316.

STAGA Recruits Mediator to the MYC Oncoprotein To Stimulate Transcription and Cell Proliferation

Xiaohui Liu, Marina Vorontchikhina, Yuan-Liang Wang, Francesco Faiola, Ernest Martinez

Mol Cell Biol. 2008 Jan; 28(1): 108–121. Published online 2007 Oct 27. doi: 10.1128/MCB.01402-07

PMCID:: PMC2223283

Article PDF–664K

Select item 264865317.

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

Matthew T. Knuesel, Krista D. Meyer, Carrie Bernecky, Dylan J. Taatjes

Genes Dev. 2009 Feb 15; 23(4): 439–451. doi: 10.1101/gad.1767009

PMCID:: PMC2648653

Article PDF–767K

Select item 356630718.

The SCF–Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator

Michael A. Davis, Elizabeth A. Larimore, Brian M. Fissel, Jherek Swanger, Dylan J. Taatjes, Bruce E. Clurman

Genes Dev. 2013 Jan 15; 27(2): 151–156. doi: 10.1101/gad.207720.112

PMCID:: PMC3566307

Article PDF–1.2M

Select item 12240119.

The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function invitro

Yun Kyoung Kang, Mohamed Guermah, Chao-Xing Yuan, Robert G. Roeder

Proc Natl Acad Sci U S A. 2002 Mar 5; 99(5): 2642–2647. Published online 2002 Feb 26. doi: 10.1073/pnas.261715899

PMCID:: PMC122401

Article PDF–285K

Select item 447459920.

DNA Damage Regulates Translation through β-TRCP Targeting of CReP

Theresa B. Loveless, Benjamin R. Topacio, Ajay A. Vashisht, Shastyn Galaang, Katie M. Ulrich, Brian D. Young, James A. Wohlschlegel, David P. Toczyski

PLoS Genet. 2015 Jun; 11(6): e1005292. Published online 2015 Jun 19. doi: 10.1371/journal.pgen.1005292

PMCID:: PMC4474599

Article PDF–12M

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