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Items: 1 to 20 of 57

1.
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism
Marisa Nacke, Emma Sandilands, Konstantina Nikolatou, Álvaro Román-Fernández, Susan Mason, Rachana Patel, Sergio Lilla, Tamas Yelland, Laura C. A. Galbraith, Eva C. Freckmann, Lynn McGarry, Jennifer P. Morton, Emma Shanks, Hing Y. Leung, Elke Markert, Shehab Ismail, Sara Zanivan, Karen Blyth, David M. Bryant
Nat Commun. 2021; 12: 1623. Published online 2021 Mar 12. doi: 10.1038/s41467-021-21847-4
PMCID:
PMC7955138
AbstractArticlePDF–21M
2.
The Pleckstrin Homology (PH) Domain of the Arf Exchange Factor Brag2 Is an Allosteric Binding Site
Xiaoying Jian, James M. Gruschus, Elizabeth Sztul, Paul A. Randazzo
J Biol Chem. 2012 Jul 13; 287(29): 24273–24283. Published online 2012 May 21. doi: 10.1074/jbc.M112.368084
PMCID:
PMC3397853
AbstractArticlePDF–1.7M
3.
Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex
Ryan S D'Souza, Jun Y Lim, Alper Turgut, Kelly Servage, Junmei Zhang, Kim Orth, Nisha G Sosale, Matthew J Lazzara, Jeremy Allegood, James E Casanova
eLife. 2020; 9: e54113. Published online 2020 Apr 1. doi: 10.7554/eLife.54113
PMCID:
PMC7159923
AbstractArticlePDF–7.4M
4.
Co-Overexpression of GEP100 and AMAP1 Proteins Correlates with Rapid Local Recurrence after Breast Conservative Therapy
Rumiko Kinoshita, Jin-Min Nam, Yoichi M. Ito, Kanako C. Hatanaka, Ari Hashimoto, Haruka Handa, Yutaro Otsuka, Shigeru Hashimoto, Yasuhito Onodera, Mitsuchika Hosoda, Shunsuke Onodera, Shinichi Shimizu, Shinya Tanaka, Hiroki Shirato, Mishie Tanino, Hisataka Sabe
PLoS One. 2013; 8(10): e76791. Published online 2013 Oct 7. doi: 10.1371/journal.pone.0076791
PMCID:
PMC3792161
AbstractArticlePDF–1.1M
5.
The Arf6 GEF GEP100/BRAG2 Regulates Cell Adhesion by Controlling Endocytosis of β1 Integrins
Jillian L. Dunphy, Radim Moravec, Kim Ly, Troy K. Lasell, Paul Melancon, James E. Casanova
Curr Biol. Author manuscript; available in PMC 2013 Mar 18.
Published in final edited form as: Curr Biol. 2006 Feb 7; 16(3): 315–320. doi: 10.1016/j.cub.2005.12.032
PMCID:
PMC3600433
AbstractArticlePDF–2.2M
6.
BRAG2/GEP100/IQSec1 Interacts with Clathrin and Regulates α5β1 Integrin Endocytosis through Activation of ADP Ribosylation Factor 5 (Arf5)
Radim Moravec, Kathryn K. Conger, Ryan D'Souza, Anne B. Allison, James E. Casanova
J Biol Chem. 2012 Sep 7; 287(37): 31138–31147. Published online 2012 Jul 19. doi: 10.1074/jbc.M112.383117
PMCID:
PMC3438945
AbstractArticlePDF–3.6M
7.
Down-Regulation of GEP100 Causes Increase in E-Cadherin Levels and Inhibits Pancreatic Cancer Cell Invasion
Chuan-gao Xie, Shu-mei Wei, Jia-min Chen, Xuan-fu Xu, Jian-ting Cai, Qin-yu Chen, Li-tao Jia
PLoS One. 2012; 7(5): e37854. Published online 2012 May 25. doi: 10.1371/journal.pone.0037854
PMCID:
PMC3360599
AbstractArticlePDF–3.4M
8.
The Guanine Nucleotide Exchange Protein for ADP-ribosylation Factor 6, ARF-GEP100/BRAG2, Regulates Phagocytosis of Monocytic Phagocytes in an ARF6-dependent Process
Akimasa Someya, Joel Moss, Isao Nagaoka
J Biol Chem. 2010 Oct 1; 285(40): 30698–30707. Published online 2010 Jul 2. doi: 10.1074/jbc.M110.107458
PMCID:
PMC2945564
AbstractArticlePDF–5.2M
9.
GEP100/BRAG2: Activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and α-catenin
Toyoko Hiroi, Akimasa Someya, Walter Thompson, Joel Moss, Martha Vaughan
Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28): 10672–10677. Published online 2006 Jun 28. doi: 10.1073/pnas.0604091103
PMCID:
PMC1502290
AbstractArticlePDF–2.2M
10.
circ-Iqsec1 induces bone marrow-derived mesenchymal stem cell (BMSC) osteogenic differentiation through the miR-187-3p/Satb2 signaling pathway
Lixia Fan, Kaiyun Yang, Ruixuan Yu, Houde Hui, Wenliang Wu
Arthritis Res Ther. 2022; 24: 273. Published online 2022 Dec 14. doi: 10.1186/s13075-022-02964-x
PMCID:
PMC9749292
AbstractArticlePDF–6.3M
11.
ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma
Jae Hyuk Yoo, Dallas S. Shi, Allie H. Grossmann, Lise K. Sorensen, ZongZhong Tong, Tara M. Mleynek, Aaron Rogers, Weiquan Zhu, Jackson R. Richards, Jacob M. Winter, Jie Zhu, Christine Dunn, Ashok Bajji, Mark Shenderovich, Alan L. Mueller, Scott E. Woodman, J. William Harbour, Kirk R. Thomas, Shannon J. Odelberg, Kirill Ostanin, Dean Y. Li
Cancer Cell. Author manuscript; available in PMC 2017 Jun 13.
Published in final edited form as: Cancer Cell. 2016 Jun 13; 29(6): 889–904. Published online 2016 Jun 2. doi: 10.1016/j.ccell.2016.04.015
PMCID:
PMC5027844
AbstractArticlePDF–2.8M
12.
GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 Cells
ZhenZhen Hu, Jun Du, Ling Yang, YiChao Zhu, Yu Yang, DaTong Zheng, Akimasa Someya, Luo Gu, Xiang Lu
PLoS One. 2012; 7(6): e38777. Published online 2012 Jun 11. doi: 10.1371/journal.pone.0038777
PMCID:
PMC3372492
AbstractArticlePDF–2.9M
13.
Engagement of Overexpressed Her2 with GEP100 Induces Autonomous Invasive Activities and Provides a Biomarker for Metastases of Lung Adenocarcinoma
Toshi Menju, Shigeru Hashimoto, Ari Hashimoto, Yutaro Otsuka, Haruka Handa, Eiji Ogawa, Yoshinobu Toda, Hiromi Wada, Hiroshi Date, Hisataka Sabe
PLoS One. 2011; 6(9): e25301. Published online 2011 Sep 22. doi: 10.1371/journal.pone.0025301
PMCID:
PMC3178645
AbstractArticlePDF–1.4M
14.
ARF-GEP100, a guanine nucleotide-exchange protein for ADP-ribosylation factor 6
Akimasa Someya, Makoto Sata, Kazuyo Takeda, Gustavo Pacheco-Rodriguez, Victor J. Ferrans, Joel Moss, Martha Vaughan
Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5): 2413–2418. doi: 10.1073/pnas.051634798
PMCID:
PMC30152
AbstractArticlePDF–3.8M
15.
Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature
Muhammad Ansar, Hyung-lok Chung, Ali Al-Otaibi, Mohammad Nael Elagabani, Thomas A. Ravenscroft, Sohail A. Paracha, Ralf Scholz, Tayseer Abdel Magid, Muhammad T. Sarwar, Sayyed Fahim Shah, Azhar Ali Qaisar, Periklis Makrythanasis, Paul C. Marcogliese, Erik-Jan Kamsteeg, Emilie Falconnet, Emmanuelle Ranza, Federico A. Santoni, Hesham Aldhalaan, Ali Al-Asmari, Eissa Ali Faqeih, Jawad Ahmed, Hans-Christian Kornau, Hugo J. Bellen, Stylianos E. Antonarakis
Am J Hum Genet. 2019 Nov 7; 105(5): 907–920. Published online 2019 Oct 10. doi: 10.1016/j.ajhg.2019.09.013
PMCID:
PMC6848997
AbstractArticlePDF–2.2M
16.
Phosphatidylinositol-4-phosphate 5-Kinase and GEP100/Brag2 Protein Mediate Antiangiogenic Signaling by Semaphorin 3E-Plexin-D1 through Arf6 Protein
Atsuko Sakurai, Xiaoying Jian, Charity J. Lee, Yosif Manavski, Emmanouil Chavakis, Julie Donaldson, Paul A. Randazzo, J. Silvio Gutkind
J Biol Chem. 2011 Sep 30; 286(39): 34335–34345. Published online 2011 Jul 27. doi: 10.1074/jbc.M111.259499
PMCID:
PMC3190799
AbstractArticlePDF–2.1M
17.
GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis
Ari Hashimoto, Shigeru Hashimoto, Ryo Ando, Kosuke Noda, Eiji Ogawa, Hirokazu Kotani, Mayumi Hirose, Toshi Menju, Masaki Morishige, Toshiaki Manabe, Yoshinobu Toda, Susumu Ishida, Hisataka Sabe
PLoS One. 2011; 6(8): e23359. Published online 2011 Aug 15. doi: 10.1371/journal.pone.0023359
PMCID:
PMC3156124
AbstractArticlePDF–2.7M
18.
Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation
Mohammad Nael Elagabani, Dušica Briševac, Michael Kintscher, Jörg Pohle, Georg Köhr, Dietmar Schmitz, Hans-Christian Kornau
J Biol Chem. 2016 Apr 22; 291(17): 9105–9118. Published online 2016 Feb 16. doi: 10.1074/jbc.M115.691717
PMCID:
PMC4861478
AbstractArticlePDF–3.7M
19.
Impact of WIN site inhibitor on the WDR5 interactome
Alissa D. Guarnaccia, Kristie L. Rose, Jing Wang, Bin Zhao, Tessa M. Popay, Christina E. Wang, Kiana Guerrazzi, Salisha Hill, Chase M. Woodley, Tyler J. Hansen, Shelly L. Lorey, J. Grace Shaw, William G. Payne, April M. Weissmiller, Edward T. Olejniczak, Stephen W. Fesik, Qi Liu, William P. Tansey
Cell Rep. Author manuscript; available in PMC 2021 Feb 9.
Published in final edited form as: Cell Rep. 2021 Jan 19; 34(3): 108636. doi: 10.1016/j.celrep.2020.108636
PMCID:
PMC7871196
AbstractArticlePDF–3.3M
20.
HEY1 functions are regulated by its phosphorylation at Ser-68
Irene López-Mateo, Amaia Arruabarrena-Aristorena, Cristina Artaza-Irigaray, Juan A. López, Enrique Calvo, Borja Belandia
Biosci Rep. 2016 Jun; 36(3): e00343. Prepublished online 2016 Apr 27. Published online 2016 Jun 3. doi: 10.1042/BSR20160123
PMCID:
PMC5293587
AbstractArticlePDF–1.8M

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