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Select item 111302431.

Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2

Samira Schiefer, Benjamin G. Hale

Nat Commun. 2024; 15: 4484. Published online 2024 May 27. doi: 10.1038/s41467-024-48800-5

PMCID:: PMC11130243

Abstract Article PDF–2.3M

Select item 108795002.

Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer

Laura Rinaldi, Francesco Chiuso, Emanuela Senatore, Domenica Borzacchiello, Luca Lignitto, Rosa Iannucci, Rossella Delle Donne, Mariano Fuggi, Carla Reale, Filomena Russo, Nicola Antonino Russo, Giorgio Giurato, Francesca Rizzo, Assunta Sellitto, Michele Santangelo, Davide De Biase, Orlando Paciello, Chiara D’Ambrosio, Stefano Amente, Corrado Garbi, Emiliano Dalla, Andrea Scaloni, Alessandro Weisz, Concetta Ambrosino, Luigi Insabato, Antonio Feliciello

Commun Biol. 2024; 7: 208. Published online 2024 Feb 20. doi: 10.1038/s42003-024-05823-4

PMCID:: PMC10879500

Abstract Article PDF–11M

Select item 79061493.

Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways

Zhiwei Zhao, Lin Zhu, Yanwei Xing, Zhenan Zhang

Aging (Albany NY) 2021 Feb 15; 13(3): 3886–3897. Published online 2021 Jan 10. doi: 10.18632/aging.202356

PMCID:: PMC7906149

Abstract Article PDF–1.5M

Select item 76542404.

Detection of novel paraja ring finger 2‐fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non‐small cell lung cancer

Masanori Kawakami, Rie Ishikawa, Yosuke Amano, Mitsuhiro Sunohara, Kousuke Watanabe, Nobuya Ohishi, Yutaka Yatomi, Jun Nakajima, Masashi Fukayama, Takahide Nagase, Daiya Takai

Cancer Sci. 2013 Nov; 104(11): 1447–1454. Published online 2013 Sep 5. doi: 10.1111/cas.12250

PMCID:: PMC7654240

Abstract Article PDF–957K

Select item 65778745.

A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse

M Nakayama, T Miyake, Y Gahara, O Ohara, T Kitamura

J Neurosci. 1995 Jul 1; 15(7): 5238–5248. doi: 10.1523/JNEUROSCI.15-07-05238.1995

PMCID:: PMC6577874

Abstract PDF–2.3M

Select item 62852916.

Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1

Yonghee Song, Somyung Lee, Jeong-Rae Kim, Eek-hoon Jho

Int J Stem Cells. 2018; 11(2): 242–247. Published online 2018 Aug 31. doi: 10.15283/ijsc18032

PMCID:: PMC6285291

Abstract Article PDF–947K

Select item 55206847.

Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways

Jing Zhong, Huihui Wang, Wankun Chen, Zhirong Sun, Jiawei Chen, Yajun Xu, Meilin Weng, Qiqing Shi, Duan Ma, Changhong Miao

Cell Death Dis. 2017 May; 8(5): e2763. Published online 2017 May 4. doi: 10.1038/cddis.2017.102

Correction in:: Cell Death Dis. 2018 Aug; 9(8): 782.

PMCID:: PMC5520684

Abstract Article PDF–2.4M

Select item 49176488.

praja2 regulates KSR1 stability and mitogenic signaling

L Rinaldi, R Delle Donne, M Sepe, M Porpora, C Garbi, F Chiuso, A Gallo, S Parisi, L Russo, V Bachmann, R G Huber, E Stefan, T Russo, A Feliciello

Cell Death Dis. 2016 May; 7(5): e2230. Published online 2016 May 19. doi: 10.1038/cddis.2016.109

PMCID:: PMC4917648

Abstract Article PDF–1.5M

Select item 36742429.

Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

Luca Lignitto, Antonietta Arcella, Maria Sepe, Laura Rinaldi, Rossella Delle Donne, Adriana Gallo, Eduard Stefan, Verena A. Bachmann, Maria A. Oliva, Clelia Tiziana Storlazzi, Alberto L'Abbate, Arturo Brunetti, Sara Gargiulo, Matteo Gramanzini, Luigi Insabato, Corrado Garbi, Max E. Gottesman, Antonio Feliciello

Nat Commun. 2013 May 7; 4: 1822. Published online 2013 May 7. doi: 10.1038/ncomms2791

PMCID:: PMC3674242

Abstract Article PDF–2.8M

Select item 902328610.

Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway

Jiaqi Jin, Lei Zhang, Xueying Li, Weizhi Xu, Siyuan Yang, Jiagui Song, Wenhao Zhang, Jun Zhan, Jianyuan Luo, Hongquan Zhang

Nucleic Acids Res. 2022 Apr 22; 50(7): 3817–3834. Published online 2022 Mar 29. doi: 10.1093/nar/gkac189

PMCID:: PMC9023286

Abstract Article PDF–4.3M

Select item 812693911.

The TBC1D31/praja2 complex controls primary ciliogenesis through PKA‐directed OFD1 ubiquitylation

Emanuela Senatore, Francesco Chiuso, Laura Rinaldi, Daniela Intartaglia, Rossella Delle Donne, Emilia Pedone, Bruno Catalanotti, Luciano Pirone, Bianca Fiorillo, Federica Moraca, Giuliana Giamundo, Giovanni Scala, Andrea Raffeiner, Omar Torres‐Quesada, Eduard Stefan, Marcel Kwiatkowski, Alienke van Pijkeren, Manuela Morleo, Brunella Franco, Corrado Garbi, Ivan Conte, Antonio Feliciello

EMBO J. 2021 May 17; 40(10): e106503. Published online 2021 May 2. doi: 10.15252/embj.2020106503

PMCID:: PMC8126939

Abstract Article PDF–5.4M

Select item 536694812.

PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription

Tyler B. Faust, Yang Li, Gwendolyn M. Jang, Jeffrey R. Johnson, Shumin Yang, Amit Weiss, Nevan J. Krogan, Alan D. Frankel

Sci Rep. 2017; 7: 45394. Published online 2017 Mar 27. doi: 10.1038/srep45394

PMCID:: PMC5366948

Abstract Article PDF–2.1M

Select item 1007411813.

Ubiquitylation of BBSome is required for ciliary assembly and signaling

Francesco Chiuso, Rossella delle Donne, Giuliana Giamundo, Laura Rinaldi, Domenica Borzacchiello, Federica Moraca, Daniela Intartaglia, Rosa Iannucci, Emanuela Senatore, Luca Lignitto, Corrado Garbi, Paolo Conflitti, Bruno Catalanotti, Ivan Conte, Antonio Feliciello

EMBO Rep. 2023 Apr; 24(4): e55571. Published online 2023 Feb 6. doi: 10.15252/embr.202255571

PMCID:: PMC10074118

Abstract Article PDF–6.3M

Select item 347830614.

CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly

Maria Ana Gomez-Ferreria, Mikhail Bashkurov, Michael Mullin, Anne-Claude Gingras, Laurence Pelletier

Cell Cycle. 2012 Oct 1; 11(19): 3555–3558. doi: 10.4161/cc.21574

PMCID:: PMC3478306

Abstract Article PDF–2.4M

Select item 488478615.

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

Madalina Raducu, Ella Fung, Sébastien Serres, Paola Infante, Alessandro Barberis, Roman Fischer, Claire Bristow, Marie‐Laëtitia Thézénas, Csaba Finta, John C Christianson, Francesca M Buffa, Benedikt M Kessler, Nicola R Sibson, Lucia Di Marcotullio, Rune Toftgård, Vincenzo D'Angiolella

EMBO J. 2016 Jul 1; 35(13): 1400–1416. Published online 2016 May 27. doi: 10.15252/embj.201593374

PMCID:: PMC4884786

Abstract Article PDF–1.5M

Select item 934596916.

Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth

Rossella Delle Donne, Rosa Iannucci, Laura Rinaldi, Luca Roberto, Maria A. Oliva, Emanuela Senatore, Domenica Borzacchiello, Luca Lignitto, Giorgio Giurato, Francesca Rizzo, Assunta Sellitto, Francesco Chiuso, Salvatore Castaldo, Giovanni Scala, Virginia Campani, Valeria Nele, Giuseppe De Rosa, Chiara D’Ambrosio, Corrado Garbi, Andrea Scaloni, Alessandro Weisz, Concetta Ambrosino, Antonella Arcella, Antonio Feliciello

Commun Biol. 2022; 5: 780. Published online 2022 Aug 2. doi: 10.1038/s42003-022-03639-8

PMCID:: PMC9345969

Abstract Article PDF–2.3M

Select item 596730617.

FAM188B enhances cell survival via interaction with USP7

Eun-Seok Choi, Hanna Lee, Jee Young Sung, Chang-Hun Lee, Hyonchol Jang, Kyung Tae Kim, Yong-Nyun Kim, Hyoung-Pyo Kim, Sung-Ho Goh

Cell Death Dis. 2018 Jun; 9(6): 633. Published online 2018 May 24. doi: 10.1038/s41419-018-0650-6

PMCID:: PMC5967306

Abstract Article PDF–2.8M

Select item 261466318.

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

Gabriela Alexandru, Johannes Graumann, Geoffrey T. Smith, Natalie J. Kolawa, Ruihua Fang, Raymond J. Deshaies

Cell. Author manuscript; available in PMC 2009 Mar 5.

Published in final edited form as: Cell. 2008 Sep 5; 134(5): 804–816. doi: 10.1016/j.cell.2008.06.048

PMCID:: PMC2614663

Abstract Article PDF–3.7M

Select item 948511919.

CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway

Peng Yang, Dongsheng Zhang, Tuo Wang, Jiangzhou Ji, Chi Jin, Chaofan Peng, Yuqian Tan, Jiahui Zhou, Lu Wang, Yifei Feng, Yueming Sun

Cell Death Dis. 2022 Sep; 13(9): 796. Published online 2022 Sep 19. doi: 10.1038/s41419-022-05240-7

PMCID:: PMC9485119

Abstract Article PDF–8.2M

Select item 1002268620.

Myosin-X recruits lamellipodin to filopodia tips

Ana Popović, Mitro Miihkinen, Sujan Ghimire, Rafael Saup, Max L. B. Grönloh, Neil J. Ball, Benjamin T. Goult, Johanna Ivaska, Guillaume Jacquemet

J Cell Sci. 2023 Mar 1; 136(5): jcs260574. Published online 2023 Mar 2. doi: 10.1242/jcs.260574

PMCID:: PMC10022686

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