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Select item 109826451.

Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs

Audrey Lumeau, Nicolas Bery, Audrey Francès, Marion Gayral, Guillaume Labrousse, Cyril Ribeyre, Charlene Lopez, Adele Nevot, Abdessamad El Kaoutari, Naima Hanoun, Emeline Sarot, Marion Perrier, Frederic Pont, Juan-Pablo Cerapio, Jean-Jacques Fournié, Frederic Lopez, Miguel Madrid-Mencia, Vera Pancaldi, Marie-Jeanne Pillaire, Valerie Bergoglio, Jerome Torrisani, Nelson Dusetti, Jean-Sebastien Hoffmann, Louis Buscail, Malik Lutzmann, Pierre Cordelier

Cancer Res. 2024 Apr 1; 84(7): 1013–1028. Published online 2024 Jan 31. doi: 10.1158/0008-5472.CAN-22-3219

PMCID:: PMC10982645

Article PDF–14M

Select item 88437782.

Neural stem cell-based anti-cancer gene therapy: a first-in-human study in recurrent high grade glioma patients

Jana Portnow, Timothy W. Synold, Behnam Badie, Revathiswari Tirughana, Simon F. Lacey, Massimo D’Apuzzo, Marianne Z. Metz, Joseph Najbauer, Victoria Bedell, Tien Vo, Margarita Gutova, Paul Frankel, Mike Chen, Karen S. Aboody

Clin Cancer Res. Author manuscript; available in PMC 2022 Feb 14.

Published in final edited form as: Clin Cancer Res. 2017 Jun 15; 23(12): 2951–2960. Published online 2016 Dec 15. doi: 10.1158/1078-0432.CCR-16-1518

PMCID:: PMC8843778

Article PDF–563K

Select item 66366843.

An Initial Genetic Analysis of Gemcitabine-Induced High-Grade Neutropenia in Pancreatic Cancer Patients in CALGB 80303 (Alliance)

Federico Innocenti, Chen Jiang, Alexander B. Sibley, Stefanie Denning, Amy S. Etheridge, Dorothy Watson, Donna Niedzwiecki, Ace J. Hatch, Herbert I. Hurwitz, Andrew B. Nixon, Yoichi Furukawa, Michiaki Kubo, Daniel J. Crona, Hedy L. Kindler, Howard L. McLeod, Mark J. Ratain, Kouros Owzar

Pharmacogenet Genomics. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Pharmacogenet Genomics. 2019 Aug; 29(6): 123–131. doi: 10.1097/FPC.0000000000000375

PMCID:: PMC6636684

Article PDF–1023K

Select item 48664714.

CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer

Melania Zauri, Georgina Berridge, Marie-Laëtitia Thézénas, Kathryn M. Pugh, Robert Goldin, Benedikt M. Kessler, Skirmantas Kriaucionis

Nature. Author manuscript; available in PMC 2016 May 13.

Published in final edited form as: Nature. 2015 Aug 6; 524(7563): 114–118. Published online 2015 Jul 22. doi: 10.1038/nature14948

PMCID:: PMC4866471

Article PDF–5.1M

Select item 39045065.

Human cytidine deaminase: A biochemical characterization of its naturally occurring variants

Daniela Micozzi, Francesco Martino Carpi, Stefania Pucciarelli, Valeria Polzonetti, Paolo Polidori, Santiago Vilar, Brian Williams, Stefano Costanzi, Silvia Vincenzetti

Int J Biol Macromol. Author manuscript; available in PMC 2015 Feb 1.

Published in final edited form as: Int J Biol Macromol. 2014 Feb; 63: 64–74. Published online 2013 Oct 29. doi: 10.1016/j.ijbiomac.2013.10.029

Correction in:: volume 63 on page 262

PMCID:: PMC3904506

Article PDF–2.4M

Select item 30205946.

Role of tyrosine 33 residue for the stabilization of the tetrameric structure of human cytidine deaminase

Daniela Micozzi, Stefania Pucciarelli, Francesco M Carpi, Stefano Costanzi, Giampiero De Sanctis, Valeria Polzonetti, Paolo Natalini, Ivano F Santarelli, Alberto Vita, Silvia Vincenzetti

Int J Biol Macromol. Author manuscript; available in PMC 2011 Nov 1.

Published in final edited form as: Int J Biol Macromol. 2010 Nov 1; 47(4): 471–482. Published online 2010 Jul 14. doi: 10.1016/j.ijbiomac.2010.07.001

Correction in:: volume 49 on page 439

PMCID:: PMC3020594

Article PDF–1.1M

Select item 28689967.

Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism

Jan Gerard Maring, Floris M. Wachters, Monique Slijfer, J. Marina Maurer, H. Marike Boezen, Donald R. A. Uges, Elisabeth G. E. de Vries, Harry J. M. Groen

Eur J Clin Pharmacol. 2010; 66(6): 611–617. Published online 2010 Mar 6. doi: 10.1007/s00228-010-0799-0

PMCID:: PMC2868996

Article PDF–152K

Select item 26617888.

Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients

H Ueno, N Kaniwa, T Okusaka, M Ikeda, C Morizane, S Kondo, E Sugiyama, S R Kim, R Hasegawa, Y Saito, T Yoshida, N Saijo, J Sawada

Br J Cancer. 2009 Mar 24; 100(6): 870–873. Published online 2009 Mar 17. doi: 10.1038/sj.bjc.6604971

PMCID:: PMC2661788

Article PDF–97K

Select item 102828989.

Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A

Harikrishnan M. Kurup, Maksim V. Kvach, Stefan Harjes, Geoffrey B. Jameson, Elena Harjes, Vyacheslav V. Filichev

Org Biomol Chem. 2023 Jun 21; 21(24): 5117–5128. Published online 2023 Jun 7. doi: 10.1039/d3ob00392b

PMCID:: PMC10282898

Article

Select item 716506710.

MUC1 Oncoprotein Mitigates ER Stress via CDA-mediated Reprogramming of Pyrimidine Metabolism

Appolinaire A Olou, Ryan J King, Fang Yu, Pankaj K Singh

Oncogene. Author manuscript; available in PMC 2020 Aug 26.

Published in final edited form as: Oncogene. 2020 Apr; 39(16): 3381–3395. Published online 2020 Feb 26. doi: 10.1038/s41388-020-1225-4

PMCID:: PMC7165067

Article PDF–2.7M

Select item 549982811.

Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1 activity

Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Christian Jaulin, Mounira Amor-Guéret

Cell Cycle. 2017; 16(11): 1128–1135. Published online 2017 May 2. doi: 10.1080/15384101.2017.1317413

PMCID:: PMC5499828

Article PDF–947K

Select item 450451912.

Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA

Simon Gemble, Akshay Ahuja, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Julien Dairou, Denis S. F. Biard, Sarah Lambert, Massimo Lopes, Mounira Amor-Guéret

PLoS Genet. 2015 Jul; 11(7): e1005384. Published online 2015 Jul 16. doi: 10.1371/journal.pgen.1005384

PMCID:: PMC4504519

Article PDF–3.1M

Select item 446744613.

Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer

Xandra García-González, Lucía Cortejoso, María I. García, Pilar García-Alfonso, Luis Robles, Cristina Grávalos, Eva González-Haba, Pellicer Marta, María Sanjurjo, Luis A. López-Fernández

Oncotarget. 2015 Mar 20; 6(8): 6422–6430. Published online 2015 Jan 21. doi: 10.18632/oncotarget.3289

PMCID:: PMC4467446

Article PDF–835K

Select item 445023914.

Role of Genetic Polymorphisms of Deoxycytidine Kinase and Cytidine Deaminase to Predict Risk of Death in Children with Acute Myeloid Leukemia

Aurora Medina-Sanson, Arturo Ramírez-Pacheco, Silvia Selene Moreno-Guerrero, Elisa María Dorantes-Acosta, Metzeri Sánchez-Preza, Alfonso Reyes-López

Biomed Res Int. 2015; 2015: 309491. Published online 2015 May 18. doi: 10.1155/2015/309491

PMCID:: PMC4450239

Article PDF–798K

Select item 315737915.

Mechanisms of Resistance to Decitabine in the Myelodysplastic Syndrome

Taichun Qin, Ryan Castoro, Samih El Ahdab, Jaroslav Jelinek, Xiaodan Wang, Jiali Si, Jingmin Shu, Rong He, Nianxiang Zhang, Woonbok Chung, Hagop M. Kantarjian, Jean-Pierre J. Issa

PLoS One. 2011; 6(8): e23372. Published online 2011 Aug 17. doi: 10.1371/journal.pone.0023372

PMCID:: PMC3157379

Article PDF–699K

Select item 743158316.

A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD⁺

Sandra Cunha Silveira, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Simon Gemble, Elias Bou Samra, Hamza Mameri, Patricia Duchambon, Christelle Machon, Jérôme Guitton, Mounira Amor-Guéret

Sci Rep. 2020; 10: 13907. Published online 2020 Aug 17. doi: 10.1038/s41598-020-70874-6

PMCID:: PMC7431583

Article PDF–1.2M

Select item 711590717.

RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia

Ajay Abraham, Savitha Varatharajan, Sreeja Karathedath, Chepsy Philip, Kavitha M Lakshmi, Ashok Kumar Jayavelu, Ezhilpavai Mohanan, Nancy Beryl Janet, Vivi M Srivastava, Ramachandran V Shaji, Wei Zhang, Aby Abraham, Auro Viswabandya, Biju George, Mammen Chandy, Alok Srivastava, Vikram Mathews, Poonkuzhali Balasubramanian

Pharmacogenomics. Author manuscript; available in PMC 2020 Aug 4.

Published in final edited form as: Pharmacogenomics. 2015 Jul 1; 16(8): 877–90. Published online 2015 Jun 17. doi: 10.2217/pgs.15.44

PMCID:: PMC7115907

Article PDF–1.9M

Select item 369424318.

Pharmacogenetic variants in the DPYD, TYMS, CDA and MTHFR genes are clinically significant predictors of fluoropyrimidine toxicity

A Loganayagam, M Arenas Hernandez, A Corrigan, L Fairbanks, C M Lewis, P Harper, N Maisey, P Ross, J D Sanderson, A M Marinaki

Br J Cancer. 2013 Jun 25; 108(12): 2505–2515. Published online 2013 Jun 4. doi: 10.1038/bjc.2013.262

PMCID:: PMC3694243

Article PDF–467K

Select item 296685919.

Gemcitabine Metabolic and Transporter Gene Polymorphisms Are Associated with Drug Toxicity and Efficacy in Patients with Locally Advanced Pancreatic Cancer

Motofumi Tanaka, Milind Javle, Xiaoqun Dong, Cathy Eng, James L. Abbruzzese, Donghui Li

Cancer. Author manuscript; available in PMC 2011 Nov 15.

Published in final edited form as: Cancer. 2010 Nov 15; 116(22): 5325–5335. doi: 10.1002/cncr.25282

PMCID:: PMC2966859

Article PDF–390K

Select item 280265520.

Single Nucleotide Polymorphisms of Gemcitabine Metabolic Genes and Pancreatic Cancer Survival and Drug Toxicity

Taro Okazaki, Milind Javle, Motofumi Tanaka, James L. Abbruzzese, Donghui Li

Clin Cancer Res. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: Clin Cancer Res. 2010 Jan 1; 16(1): 320–329. Published online 2009 Dec 22. doi: 10.1158/1078-0432.CCR-09-1555

PMCID:: PMC2802655

Article PDF–700K

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