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Items: 1 to 20 of 80

1.
ORMDL3 regulates NLRP3 inflammasome activation by maintaining ER-mitochondria contacts in human macrophages and dictates ulcerative colitis patient outcome
Jyotsna Sharma, Shaziya Khan, Nishakumari C. Singh, Shikha Sahu, Desh Raj, Shakti Prakash, Pamela Bandyopadhyay, Kabita Sarkar, Vivek Bhosale, Tulika Chandra, Jagavelu Kumaravelu, Manoj Kumar Barthwal, Shashi Kumar Gupta, Mrigank Srivastava, Rajdeep Guha, Veena Ammanathan, Uday C. Ghoshal, Kalyan Mitra, Amit Lahiri
J Biol Chem. 2024 Apr; 300(4): 107120. Published online 2024 Feb 27. doi: 10.1016/j.jbc.2024.107120
PMCID:
PMC11065740
AbstractArticlePDF–3.9M
2.
Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy
Yixiao Sun, Xueran Guan, Ting Zhang, Yue Li, Huiling Shi, Ashleigh Tinotenda Chitakunye, Hanyu Hong, Shihui Zhang, Qin Zhu, Lin Cai
Med Oncol. 2022; 39(11): 159. Published online 2022 Aug 16. doi: 10.1007/s12032-022-01767-z
PMCID:
PMC9381447
AbstractArticlePDF–8.4M
3.
Asthma Susceptibility Gene ORMDL3 Promotes Autophagy in Human Bronchial Epithelium
Feng Guo, Yuan Hao, Li Zhang, Damien C. Croteau-Chonka, Derek Thibault, Parul Kothari, Lijia Li, Bruce D. Levy, Xiaobo Zhou, Benjamin A. Raby
Am J Respir Cell Mol Biol. 2022 Jun; 66(6): 661–670. Published online 2022 Mar 30. doi: 10.1165/rcmb.2021-0305OC
PMCID:
PMC9163638
AbstractArticlePDF–1.7M
4.
Single cell sequencing analysis identifies genetics-modulated ORMDL3+ cholangiocytes having higher metabolic effects on primary biliary cholangitis
Bingyu Xiang, Chunyu Deng, Fei Qiu, Jingjing Li, Shanshan Li, Huifang Zhang, Xiuli Lin, Yukuan Huang, Yijun Zhou, Jianzhong Su, Mingqin Lu, Yunlong Ma
J Nanobiotechnology. 2021; 19: 406. Published online 2021 Dec 6. doi: 10.1186/s12951-021-01154-2
PMCID:
PMC8647381
AbstractArticlePDF–6.7M
5.
ORMDL3 overexpression facilitates FcεRI‐mediated transcription of proinflammatory cytokines and thapsigargin‐mediated PERK phosphorylation in RBL‐2H3 cells
Kazuhiro Ogi, Tetsuji Takabayashi, Kaori Tomita, Masafumi Sakashita, Taiyo Morikawa, Takahiro Ninomiya, Masayuki Okamoto, Norihiko Narita, Shigeharu Fujieda
Immun Inflamm Dis. 2021 Dec; 9(4): 1394–1405. Published online 2021 Jul 19. doi: 10.1002/iid3.489
PMCID:
PMC8589398
AbstractArticlePDF–1.7M
6.
ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility
Alexa K. Pham, Marina Miller, Peter Rosenthal, Sudipta Das, Ning Weng, Sunghoon Jang, Richard C. Kurten, Jana Badrani, Taylor A. Doherty, Brian Oliver, David H. Broide
JCI Insight. 2021 Apr 8; 6(7): e136911. Published online 2021 Apr 8. doi: 10.1172/jci.insight.136911
PMCID:
PMC8119187
AbstractArticlePDF–6.7M
7.
CREB在反复喘息患儿中的表达及对ORMDL3基因表达的影响
金 蕊, 张 振兴, 朱 亮华, 庄 丽丽, 陈 筱青
Zhongguo Dang Dai Er Ke Za Zhi. 2020 Sep 15; 22(9): 980–983. Chinese. doi: 10.7499/j.issn.1008-8830.2003278
PMCID:
PMC7499448
AbstractArticlePDF–1.2M
8.
湖南省98例哮喘儿童ORMDL3基因多态性分析及与OPN、TGF-β1水平相关性探讨
阳 爱梅, 黄 榕, 金 世杰
Zhongguo Dang Dai Er Ke Za Zhi. 2016 Apr 15; 18(4): 324–328. Chinese. doi: 10.7499/j.issn.1008-8830.2016.04.009
PMCID:
PMC7390067
AbstractArticlePDF–1.3M
9.
Orosomucoid-like 3 Supports Rhinovirus Replication in Human Epithelial Cells
Yiping Liu, Yury A. Bochkov, Jens C. Eickhoff, Tianchen Hu, Nicholas A. Zumwalde, Jin Wen Tan, Christopher Lopez, Paul S. Fichtinger, Thiruchelvi R. Reddy, Katherine A. Overmyer, Jennifer E. Gumperz, Joshua Coon, Sameer K. Mathur, James E. Gern, Judith A. Smith
Am J Respir Cell Mol Biol. 2020 Jun; 62(6): 783–792. doi: 10.1165/rcmb.2019-0237OC
PMCID:
PMC7258826
AbstractArticlePDF–1.1M
10.
Association between peripheral blood mononuclear cell ORMDL3 expression and the asthma predictive index in preschool children
Yaqin Li, Lanfang Cao, Qing Yu, Haiyan Xue, Yanming Lu
J Int Med Res. 2019 Aug; 47(8): 3727–3736. Published online 2019 Jul 25. doi: 10.1177/0300060519862674
PMCID:
PMC6726768
AbstractArticlePDF–334K
11.
An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma
Rachel S. Kelly, Bo L. Chawes, Kevin Blighe, Yamini V. Virkud, Damien C. Croteau-Chonka, Michael J. McGeachie, Clary B. Clish, Kevin Bullock, Juan C. Celedón, Scott T. Weiss, Jessica A. Lasky-Su
Chest. 2018 Aug; 154(2): 335–348. Published online 2018 Jun 13. doi: 10.1016/j.chest.2018.05.038
PMCID:
PMC6689076
AbstractArticlePDF–361K
12.
The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation
Youming Zhang, Saffron A. G. Willis-Owen, Sarah Spiegel, Clare M. Lloyd, Miriam F. Moffatt, William O. C. M. Cookson
Am J Respir Crit Care Med. 2019 Feb 15; 199(4): 478–488. Published online 2019 Feb 15. doi: 10.1164/rccm.201803-0438OC
PMCID:
PMC6376621
AbstractArticlePDF–1.0M
13.
ORMDL3 UPREGULATES AIRWAY SMOOTH MUSCLE PROLIFERATION, CONTRACTION, AND Ca2+ OSCILLATIONS IN ASTHMA
Jun Chen, Marina Miller, Hirotoshi Unno, Peter Rosenthal, Michael Sanderson, David H. Broide
J Allergy Clin Immunol. Author manuscript; available in PMC 2019 Jul 1.
Published in final edited form as: J Allergy Clin Immunol. 2018 Jul; 142(1): 207–218.e6. Published online 2017 Sep 7. doi: 10.1016/j.jaci.2017.08.015
PMCID:
PMC5842097
AbstractArticlePDF–892K
14.
RHINOVIRUS INFECTION OF ORMDL3 TRANSGENIC MICE IS ASSOCIATED WITH REDUCED RHINOVIRUS VIRAL LOAD AND AIRWAY INFLAMMATION
Dae Jin Song, Marina Miller, Andrew Beppu, Peter Rosenthal, Sudipta Das, Maya Karta, Christine Vuong, Amit Kumar Mehta, Michael Croft, David H. Broide
J Immunol. Author manuscript; available in PMC 2018 Oct 1.
Published in final edited form as: J Immunol. 2017 Oct 1; 199(7): 2215–2224. Published online 2017 Aug 21. doi: 10.4049/jimmunol.1601412
PMCID:
PMC5605463
AbstractArticlePDF–1.6M
15.
Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide
Marina Miller, Peter Rosenthal, Andrew Beppu, Ruth Gordillo, David H. Broide
J Allergy Clin Immunol. Author manuscript; available in PMC 2018 Apr 1.
Published in final edited form as: J Allergy Clin Immunol. 2017 Apr; 139(4): 1373–1376.e4. Published online 2016 Nov 5. doi: 10.1016/j.jaci.2016.08.053
PMCID:
PMC5385289
ArticlePDF–890K
16.
Association of ORMDL3 with rhinovirus-induced endoplasmic reticulum stress and type I Interferon responses in human leukocytes
Yi-Ping Liu, Victoria Rajamanikham, Marissa Baron, Sagar Patel, Sameer K. Mathur, Elizabeth A. Schwantes, Carole Ober, Daniel J. Jackson, James E. Gern, Robert F. Lemanske, Jr., Judith A Smith
Clin Exp Allergy. Author manuscript; available in PMC 2018 Mar 1.
Published in final edited form as: Clin Exp Allergy. 2017 Mar; 47(3): 371–382. doi: 10.1111/cea.12903
PMCID:
PMC5376287
AbstractArticlePDF–981K
17.
ORMDL3 contributes to the risk of atherosclerosis in Chinese Han population and mediates oxidized low-density lipoprotein-induced autophagy in endothelial cells
Xiaochun Ma, Rongfang Qiu, Jie Dang, Jiangxia Li, Qin Hu, Shan Shan, Qian Xin, Wenying Pan, Xianli Bian, Qianqian Yuan, Feng Long, Na Liu, Yan Li, Fei Gao, Chengwei Zou, Yaoqin Gong, Qiji Liu
Sci Rep. 2015; 5: 17194. Published online 2015 Nov 25. doi: 10.1038/srep17194
PMCID:
PMC4658630
AbstractArticlePDF–1.5M
18.
All-Trans Retinoic Acid Modulates ORMDL3 Expression via Transcriptional Regulation
Li-Li Zhuang, Bo-Xian Huang, Jie Feng, Liang-Hua Zhu, Rui Jin, Ling-Zhi Qiu, Guo-Ping Zhou
PLoS One. 2013; 8(10): e77304. Published online 2013 Oct 29. doi: 10.1371/journal.pone.0077304
PMCID:
PMC3812219
AbstractArticlePDF–867K
19.
A sequence variant on 17q21 is associated with age at onset and severity of asthma
Eva Halapi, Daniel F Gudbjartsson, Gudrun M Jonsdottir, Unnur S Bjornsdottir, Gudmar Thorleifsson, Hafdis Helgadottir, Carolyn Williams, Gerard H Koppelman, Andrea Heinzmann, H Marike Boezen, Aslaug Jonasdottir, Thorarinn Blondal, Sigurjon A Gudjonsson, Adalbjorg Jonasdottir, Theodora Thorlacius, Amanda P Henry, Janine Altmueller, Marcus Krueger, Hyoung Doo Shin, Soo-Taek Uh, Hyun Sub Cheong, Brynja Jonsdottir, Bjorn R Ludviksson, Dora Ludviksdottir, David Gislason, Choon-Sik Park, Klaus Deichmann, Philip J Thompson, Matthias Wjst, Ian P Hall, Dirkje S Postma, Thorarinn Gislason, Augustine Kong, Ingileif Jonsdottir, Unnur Thorsteinsdottir, Kari Stefansson
Eur J Hum Genet. 2010 Aug; 18(8): 902–908. Published online 2010 Apr 7. doi: 10.1038/ejhg.2010.38
PMCID:
PMC2987388
AbstractArticlePDF–337K
20.
ORMDL3 Gene Is Associated with Asthma in Three Ethnically Diverse Populations
Joshua Galanter, Shweta Choudhry, Celeste Eng, Sylvette Nazario, José R. Rodríguez-Santana, Jesús Casal, Alfonso Torres-Palacios, Jorge Salas, Rocio Chapela, H. Geoffrey Watson, Kelley Meade, Michael LeNoir, William Rodríguez-Cintrón, Pedro C. Avila, Esteban González Burchard
Am J Respir Crit Care Med. 2008 Jun 1; 177(11): 1194–1200. Published online 2008 Feb 28. doi: 10.1164/rccm.200711-1644OC
PMCID:
PMC2408437
AbstractArticlePDF–282K

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