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Select item 108304231.

Motion of VAPB molecules reveals ER–mitochondria contact site subdomains

Christopher J. Obara, Jonathon Nixon-Abell, Andrew S. Moore, Federica Riccio, David P. Hoffman, Gleb Shtengel, C. Shan Xu, Kathy Schaefer, H. Amalia Pasolli, Jean-Baptiste Masson, Harald F. Hess, Christopher P. Calderon, Craig Blackstone, Jennifer Lippincott-Schwartz

Nature. 2024; 626(7997): 169–176. Published online 2024 Jan 24. doi: 10.1038/s41586-023-06956-y

PMCID:: PMC10830423

Abstract Article PDF–12M

Select item 106360172.

Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma

Amanda Faria Assoni, Thiago Giove Mitsugi, René Wardenaar, Raiane Oliveira Ferreira, Elisa Helena Farias Jandrey, Gabriela Machado Novaes, Isabela Fonseca de Oliveira Granha, Petra Bakker, Carolini Kaid, Mayana Zatz, Floris Foijer, Oswaldo Keith Okamoto

Sci Rep. 2023; 13: 19481. Published online 2023 Nov 9. doi: 10.1038/s41598-023-45319-5

PMCID:: PMC10636017

Abstract Article PDF–2.8M

Select item 103771163.

Yeast Models of Amyotrophic Lateral Sclerosis Type 8 Mimic Phenotypes Seen in Mammalian Cells Expressing Mutant VAPB^P56S

AnnaMari L. Stump, Daniel J. Rioux, Richard Albright, Guiliano L. Melki, Derek C. Prosser

Biomolecules. 2023 Jul; 13(7): 1147. Published online 2023 Jul 19. doi: 10.3390/biom13071147

PMCID:: PMC10377116

Abstract Article PDF–4.9M

Select item 81108094.

Pathomechanisms of ALS8: altered autophagy and defective RNA binding protein (RBP) homeostasis due to the VAPB P56S mutation

Priyanka Tripathi, Haihong Guo, Alice Dreser, Alfred Yamoah, Antonio Sechi, Christopher Marvin Jesse, Istvan Katona, Panagiotis Doukas, Stefan Nikolin, Sabrina Ernst, Eleonora Aronica, Hannes Glaß, Andreas Hermann, Harry Steinbusch, Alfred C. Feller, Markus Bergmann, Dick Jaarsma, Joachim Weis, Anand Goswami

Cell Death Dis. 2021 May; 12(5): 466. Published online 2021 May 10. doi: 10.1038/s41419-021-03710-y

PMCID:: PMC8110809

Abstract Article PDF–3.5M

Select item 70170805.

VAPB ER-Aggregates, A Possible New Biomarker in ALS Pathology

Maria Piera L Cadoni, Maria Luigia Biggio, Giannina Arru, Giannina Secchi, Nicola Orrù, Maria Grazia Clemente, GianPietro Sechi, Alfred Yamoah, Priyanka Tripathi, Sandro Orrù, Roberto Manetti, Grazia Galleri

Cells. 2020 Jan; 9(1): 164. Published online 2020 Jan 9. doi: 10.3390/cells9010164

PMCID:: PMC7017080

Abstract Article PDF–4.6M

Select item 66729756.

Motor Neuron Disease-Associated Mutant Vesicle-Associated Membrane Protein-Associated Protein (VAP) B Recruits Wild-Type VAPs into Endoplasmic Reticulum-Derived Tubular Aggregates

Eva Teuling, Suaad Ahmed, Elize Haasdijk, Jeroen Demmers, Michel O. Steinmetz, Anna Akhmanova, Dick Jaarsma, Casper C. Hoogenraad

J Neurosci. 2007 Sep 5; 27(36): 9801–9815. doi: 10.1523/JNEUROSCI.2661-07.2007

PMCID:: PMC6672975

Abstract Article PDF–1.0M

Select item 64062917.

Host Vesicle Fusion Protein VAPB Contributes to the Nuclear Egress Stage of Herpes Simplex Virus Type-1 (HSV-1) Replication

Natalia Saiz-Ros, Rafal Czapiewski, Ilaria Epifano, Andrew Stevenson, Selene K. Swanson, Charles R. Dixon, Dario B. Zamora, Marion McElwee, Swetha Vijayakrishnan, Christine A. Richardson, Li Dong, David A. Kelly, Lior Pytowski, Martin W. Goldberg, Laurence Florens, Sheila V. Graham, Eric C. Schirmer

Cells. 2019 Feb; 8(2): 120. Published online 2019 Feb 3. doi: 10.3390/cells8020120

PMCID:: PMC6406291

Abstract Article PDF–13M

Select item 60785638.

Neuronal overexpression of human VAPB slows motor impairment and neuromuscular denervation in a mouse model of ALS

Ji-Yoen Kim, Ava Jang, Rohit Reddy, Wan Hee Yoon, Joanna L. Jankowsky

Hum Mol Genet. 2016 Nov 1; 25(21): 4661–4673. Published online 2016 Aug 29. doi: 10.1093/hmg/ddw294

PMCID:: PMC6078563

Abstract Article PDF–1.9M

Select item 47778549.

VAMP-associated Proteins (VAP) as Receptors That Couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis

Wayne L. Ernst, Kuntala Shome, Christine C. Wu, Xiaoyan Gong, Raymond A. Frizzell, Meir Aridor

J Biol Chem. 2016 Mar 4; 291(10): 5206–5220. Published online 2016 Jan 6. doi: 10.1074/jbc.M115.692749

PMCID:: PMC4777854

Abstract Article PDF–2.2M

Select item 471851310.

C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex

Garvita Gupta, Jianxing Song

PLoS One. 2016; 11(1): e0147278. Published online 2016 Jan 19. doi: 10.1371/journal.pone.0147278

PMCID:: PMC4718513

Abstract Article PDF–4.3M

Select item 379268911.

Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons

Leonardo Aliaga, Chen Lai, Jia Yu, Nikolai Chub, Hoon Shim, Lixin Sun, Chengsong Xie, Wan-Jou Yang, Xian Lin, Michael J. O'Donovan, Huaibin Cai

Hum Mol Genet. 2013 Nov 1; 22(21): 4293–4305. Published online 2013 Jun 13. doi: 10.1093/hmg/ddt279

Correction in:: Hum Mol Genet. 2014 Jun 1; 23(11): 3069.

PMCID:: PMC3792689

Abstract Article PDF–2.1M

Select item 353856812.

Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

Linghua Qiu, Tao Qiao, Melissa Beers, Weijia Tan, Hongyan Wang, Bin Yang, Zuoshang Xu

Mol Neurodegener. 2013; 8: 1. Published online 2013 Jan 3. doi: 10.1186/1750-1326-8-1

PMCID:: PMC3538568

Abstract Article PDF–2.8M

Select item 346220913.

VAMP-Associated Protein B (VAPB) Promotes Breast Tumor Growth by Modulation of Akt Activity

Meghana Rao, Wenqiang Song, Aixiang Jiang, Yu Shyr, Sima Lev, David Greenstein, Dana Brantley-Sieders, Jin Chen

PLoS One. 2012; 7(10): e46281. Published online 2012 Oct 1. doi: 10.1371/journal.pone.0046281

PMCID:: PMC3462209

Abstract Article PDF–2.0M

Select item 339889514.

VAPC, an Human Endogenous Inhibitor for Hepatitis C Virus (HCV) Infection, Is Intrinsically Unstructured but Forms a “Fuzzy Complex” with HCV NS5B

Shaveta Goyal, Garvita Gupta, Haina Qin, Megha Haridas Upadya, Yee Joo Tan, Vincent T. K. Chow, Jianxing Song

PLoS One. 2012; 7(7): e40341. Published online 2012 Jul 17. doi: 10.1371/journal.pone.0040341

PMCID:: PMC3398895

Abstract Article PDF–983K

Select item 331520515.

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

Gábor M. Mórotz, Kurt J. De Vos, Alessio Vagnoni, Steven Ackerley, Christopher E. Shaw, Christopher C.J. Miller

Hum Mol Genet. 2012 May 1; 21(9): 1979–1988. Published online 2012 Jan 17. doi: 10.1093/hmg/dds011

PMCID:: PMC3315205

Abstract Article PDF–352K

Select item 320607616.

Structural, Stability, Dynamic and Binding Properties of the ALS-Causing T46I Mutant of the hVAPB MSP Domain as Revealed by NMR and MD Simulations

Shixiong Lua, Haina Qin, Liangzhong Lim, Jiahai Shi, Garvita Gupta, Jianxing Song

PLoS One. 2011; 6(11): e27072. Published online 2011 Nov 1. doi: 10.1371/journal.pone.0027072

PMCID:: PMC3206076

Abstract Article PDF–1022K

Select item 318783917.

Accumulation of Wildtype and ALS-Linked Mutated VAPB Impairs Activity of the Proteasome

Anice Moumen, Isabelle Virard, Cédric Raoul

PLoS One. 2011; 6(10): e26066. Published online 2011 Oct 5. doi: 10.1371/journal.pone.0026066

PMCID:: PMC3187839

Abstract Article PDF–2.2M

Select item 315955118.

Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients

Miguel Mitne-Neto, Marcela Machado-Costa, Maria C.N. Marchetto, Mario H. Bengtson, Claudio A. Joazeiro, Hiroshi Tsuda, Hugo J. Bellen, Helga C.A. Silva, Acary S.B. Oliveira, Monize Lazar, Alysson R. Muotri, Mayana Zatz

Hum Mol Genet. 2011 Sep 15; 20(18): 3642–3652. Published online 2011 Jun 17. doi: 10.1093/hmg/ddr284

PMCID:: PMC3159551

Abstract Article PDF–513K

Select item 285954719.

Structural Requirements for VAP-B Oligomerization and Their Implication in Amyotrophic Lateral Sclerosis-associated VAP-B(P56S) Neurotoxicity

SoHui Kim, Sónia S. Leal, Daniel Ben Halevy, Cláudio M. Gomes, Sima Lev

J Biol Chem. 2010 Apr 30; 285(18): 13839–13849. Published online 2010 Mar 5. doi: 10.1074/jbc.M109.097345

PMCID:: PMC2859547

Abstract Article PDF–2.3M

Select item 284719820.

The p.P56S mutation in the VAPB gene is not due to a single founder: the first European case

AD Funke, M Esser, A Krüttgen, J Weis, M Mitne-Neto, M Lazar, AL Nishimura, AD Sperfeld, P Trillenberg, J Senderek, M Krasnianski, M Zatz, S Zierz, M Deschauer

Clin Genet. 2010 Mar; 77(3): 302–303. doi: 10.1111/j.1399-0004.2009.01319.x