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Select item 90153171.

Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID‐19 patients

Prakash Jha, Prithvi Singh, Shweta Arora, Armiya Sultan, Arnab Nayek, Kalaiarasan Ponnusamy, Mansoor Ali Syed, Ravins Dohare, Madhu Chopra

J Cell Biochem. 2022 Mar; 123(3): 673–690. Published online 2022 Jan 17. doi: 10.1002/jcb.30213

PMCID:: PMC9015317

Abstract Article PDF–2.8M

Select item 40768292.

Modification of p115RhoGEF Ser³³⁰ regulates its RhoGEF activity

Christina R. Chow, Nobuchika Suzuki, Takeshi Kawamura, Takao Hamakubo, Tohru Kozasa

Cell Signal. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Cell Signal. 2013 Nov; 25(11): 2085–2092. Published online 2013 Jun 29. doi: 10.1016/j.cellsig.2013.06.012

PMCID:: PMC4076829

Abstract Article PDF–697K

Select item 39004213.

A Novel Role for p115RhoGEF in Regulation of Epithelial Plasticity

Swapnil S. Kher, Amanda P. Struckhoff, Arthur S. Alberts, Rebecca A Worthylake

PLoS One. 2014; 9(1): e85409. Published online 2014 Jan 23. doi: 10.1371/journal.pone.0085409

PMCID:: PMC3900421

Abstract Article PDF–1.7M

Select item 30470674.

Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

Zhe Chen, Liang Guo, Stephen R Sprang, Paul C Sternweis

Protein Sci. 2011 Jan; 20(1): 107–117. Published online 2010 Dec 1. doi: 10.1002/pro.542

PMCID:: PMC3047067

Abstract Article PDF–1.1M

Select item 27421795.

P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium

Gloria Slattum, Karen M. McGee, Jody Rosenblatt

J Cell Biol. 2009 Sep 7; 186(5): 693–702. doi: 10.1083/jcb.200903079

PMCID:: PMC2742179

Abstract Article PDF–2.8M

Select item 12233246.

Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF.

Raja Bhattacharyya, Philip B Wedegaertner

Biochem J. 2003 May 1; 371(Pt 3): 709–720. doi: 10.1042/BJ20021897

PMCID:: PMC1223324

Summary PDF–391K

Select item 57465257.

Transforming growth factor‐β enhances Rho‐kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1

Yasin Shaifta, Charles E. MacKay, Nneka Irechukwu, Katie A. O'Brien, David B. Wright, Jeremy P. T. Ward, Greg A. Knock

J Physiol. 2018 Jan 1; 596(1): 47–66. Published online 2017 Nov 23. doi: 10.1113/JP275033

PMCID:: PMC5746525

Abstract Article PDF–2.5M

Select item 53674618.

Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF

Nicholas Spellmon, Joshua Holcomb, Andrea Niu, Vishakha Choudhary, Xiaonan Sun, Yingxue Zhang, Junmei Wan, Maysaa Doughan, Stephanie Hayden, Fatme Hachem, Joseph Brunzelle, Chunying Li, Zhe Yang

Biochem Biophys Res Commun. Author manuscript; available in PMC 2018 Apr 1.

Published in final edited form as: Biochem Biophys Res Commun. 2017 Apr 1; 485(2): 529–534. Published online 2017 Feb 6. doi: 10.1016/j.bbrc.2017.02.010

PMCID:: PMC5367461

Abstract Article PDF–731K

Select item 40940839.

Regulated Localization Is Sufficient for Hormonal Control of Regulator of G Protein Signaling Homology Rho Guanine Nucleotide Exchange Factors (RH-RhoGEFs)

Angela M. Carter, Stephen Gutowski, Paul C. Sternweis

J Biol Chem. 2014 Jul 11; 289(28): 19737–19746. Published online 2014 May 22. doi: 10.1074/jbc.M114.564930

PMCID:: PMC4094083

Abstract Article PDF–1.8M

Select item 340816510.

Activation of p115-RhoGEF Requires Direct Association of Gα₁₃ and the Dbl Homology Domain

Zhe Chen, Liang Guo, Jana Hadas, Stephen Gutowski, Stephen R. Sprang, Paul C. Sternweis

J Biol Chem. 2012 Jul 20; 287(30): 25490–25500. Published online 2012 Jun 1. doi: 10.1074/jbc.M111.333716

PMCID:: PMC3408165

Abstract Article PDF–3.3M

Select item 557293311.

p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine–induced vascular smooth muscle cell migration and proliferation

Nikhlesh K. Singh, Jagadeesh Janjanam, Gadiparthi N. Rao

J Biol Chem. 2017 Aug 25; 292(34): 14080–14091. Published online 2017 Jun 27. doi: 10.1074/jbc.M117.777896

PMCID:: PMC5572933

Abstract Article PDF–2.6M

Select item 309389212.

Mechanistic Insights into Specificity, Activity, and Regulatory Elements of the Regulator of G-protein Signaling (RGS)-containing Rho-specific Guanine Nucleotide Exchange Factors (GEFs) p115, PDZ-RhoGEF (PRG), and Leukemia-associated RhoGEF (LARG)

Mamta Jaiswal, Lothar Gremer, Radovan Dvorsky, Lars Christian Haeusler, Ion C. Cirstea, Katharina Uhlenbrock, Mohammad Reza Ahmadian

J Biol Chem. 2011 May 20; 286(20): 18202–18212. Published online 2011 Mar 28. doi: 10.1074/jbc.M111.226431

PMCID:: PMC3093892

Abstract Article PDF–2.2M

Select item 375268513.

Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7

Yeyun Zhou, Jared L. Johnson, Richard A. Cerione, Jon W. Erickson

Biochemistry. Author manuscript; available in PMC 2014 Jun 25.

Published in final edited form as: Biochemistry. 2013 Jun 25; 52(25): 4354–4363. Published online 2013 Jun 14. doi: 10.1021/bi301688g

PMCID:: PMC3752685

Abstract Article PDF–3.2M

Select item 135122014.

Functional consequences of Gα₁₃ mutations that disrupt interaction with p115RhoGEF

Elda Grabocka, Philip B. Wedegaertner

Oncogene. Author manuscript; available in PMC 2006 Jan 25.

Published in final edited form as: Oncogene. 2005 Mar 24; 24(13): 2155–2165. doi: 10.1038/sj.onc.1208414

PMCID:: PMC1351220

Abstract Article PDF–982K

Select item 324794815.

Thromboxane Receptor Signaling Is Required for Fibronectin-induced Matrix Metalloproteinase 9 Production by Human and Murine Macrophages and Is Attenuated by the Arhgef1 Molecule

John M. Hartney, Claire E. Gustafson, Russell P. Bowler, Roberta Pelanda, Raul M. Torres

J Biol Chem. 2011 Dec 30; 286(52): 44521–44531. Published online 2011 Nov 15. doi: 10.1074/jbc.M111.282772

PMCID:: PMC3247948

Abstract Article PDF–962K

Select item 336592716.

Acute Activation of β₂-Adrenergic Receptor Regulates Focal Adhesions through βArrestin2- and p115RhoGEF Protein-mediated Activation of RhoA

Xiaojie Ma, Yu Zhao, Yehia Daaka, Zhongzhen Nie

J Biol Chem. 2012 Jun 1; 287(23): 18925–18936. Published online 2012 Apr 12. doi: 10.1074/jbc.M112.352260

PMCID:: PMC3365927

Abstract Article PDF–4.2M

Select item 286857317.

A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis

Na Dong, Liping Liu, Feng Shao

EMBO J. 2010 Apr 21; 29(8): 1363–1376. Published online 2010 Mar 18. doi: 10.1038/emboj.2010.33

PMCID:: PMC2868573

Abstract Article PDF–2.5M

Select item 451366118.

Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF

H. Zhang, L. Wang, S. Kao, I.P. Whitehead, M.J. Hart, B. Liu, K. Duus, K. Burridge, C.J. Der, L. Su

Curr Biol. Author manuscript; available in PMC 2015 Jul 24.

Published in final edited form as: Curr Biol. 1999 Nov 4; 9(21): 1271–1274. doi: 10.1016/s0960-9822(99)80511-9

PMCID:: PMC4513661

Abstract Article PDF–551K

Select item 45257319.

CIN85 Associates with Multiple Effectors Controlling Intracellular Trafficking of Epidermal Growth Factor Receptors

Katarzyna Kowanetz, Koraljka Husnjak, Daniela Höller, Marcin Kowanetz, Philippe Soubeyran, Dianne Hirsch, Mirko H.H Schmidt, Kresimir Pavelic, Pietro De Camilli, Paul A. Randazzo, Ivan Dikic

Mol Biol Cell. 2004 Jul; 15(7): 3155–3166. doi: 10.1091/mbc.E03-09-0683

PMCID:: PMC452573

Abstract Article PDF–657K

Select item 368665320.

The frantic play of the concealed HIV envelope cytoplasmic tail

Eveline Santos da Silva, Martin Mulinge, Danielle Perez Bercoff

Retrovirology. 2013; 10: 54. Published online 2013 May 24. doi: 10.1186/1742-4690-10-54

PMCID:: PMC3686653

Abstract Article PDF–3.2M

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PMC Links for Gene (Select 9138) (59)
PMC
Carrot red leaf virus strain UK-RG-3 putative RNA-dependent RNA polymerase gene,...
Carrot red leaf virus strain UK-RG-3 putative RNA-dependent RNA polymerase gene, partial cds
gi|33242463|gb|AY325505.1|

Nucleotide
Pantoea piersonii strain IIIF1SW-P2 scaffold26.1, whole genome shotgun sequence
Pantoea piersonii strain IIIF1SW-P2 scaffold26.1, whole genome shotgun sequence
gi|1487854300|ref|NZ_RARB01000026.1 |WGS:NZ_RARB01|scaffold26.1

Nucleotide
PREDICTED: Homo sapiens Rho guanine nucleotide exchange factor 1 (ARHGEF1), tran...
PREDICTED: Homo sapiens Rho guanine nucleotide exchange factor 1 (ARHGEF1), transcript variant X4, mRNA
gi|2217323798|ref|XM_047439665.1|

Nucleotide
PREDICTED: Homo sapiens Rho guanine nucleotide exchange factor 1 (ARHGEF1), tran...
PREDICTED: Homo sapiens Rho guanine nucleotide exchange factor 1 (ARHGEF1), transcript variant X1, mRNA
gi|2217323792|ref|XM_047439662.1|

Nucleotide

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