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Select item 79443651.

E3 ubiquitin ligase Casitas B lineage lymphoma‐b and its potential therapeutic implications for immunotherapy

D. Jafari, M. J. Mousavi, S. Keshavarz Shahbaz, L. Jafarzadeh, S. Tahmasebi, J. Spoor, A. Esmaeilzadeh

Clin Exp Immunol. 2021 Apr; 204(1): 14–31. Published online 2021 Jan 10. doi: 10.1111/cei.13560

PMCID:: PMC7944365

Abstract Article PDF–573K

Select item 69417322.

Juvenile myelomonocytic leukemia due to a germline CBL Y371C mutation: 35-year follow-up of a large family

Anand Pathak, Alexander Pemov, Mary L. McMaster, Ramita Dewan, Sarangan Ravichandran, Evgenia Pak, Amalia Dutra, Hyo Jung Lee, Aurelie Vogt, Xijun Zhang, Meredith Yeager, Stacie Anderson, Martha Kirby, NCI DCEG Cancer Genomics Research Laboratory, NCI DCEG Cancer Sequencing Working Group, Neil Caporaso, Mark H. Greene, Lynn R. Goldin, Douglas R. Stewart

Hum Genet. Author manuscript; available in PMC 2020 Jan 3.

Published in final edited form as: Hum Genet. 2015 Jul; 134(7): 775–787. Published online 2015 May 5. doi: 10.1007/s00439-015-1550-9

PMCID:: PMC6941732

Abstract Article PDF–934K

Select item 69396563.

c-Cbl Acts as an E3 Ligase Against DDA3 for Spindle Dynamics and Centriole Duplication during Mitosis

Dasom Gwon, Jihee Hong, Chang-Young Jang

Mol Cells. 2019 Dec; 42(12): 840–849. Published online 2019 Nov 14. doi: 10.14348/molcells.2019.0142

PMCID:: PMC6939656

Abstract Article PDF–2.4M

Select item 58806224.

Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms

Seishi Ogawa, Masashi Sanada, Lee-Young Shih, Takahiro Suzuki, Makoto Otsu, Hiromitsu Nakauchi, H. Philip Koeffler

Cell Cycle. Author manuscript; available in PMC 2018 Apr 2.

Published in final edited form as: Cell Cycle. 2010 Mar 15; 9(6): 1051–1056. Published online 2010 Mar 15. doi: 10.4161/cc.9.6.11034

PMCID:: PMC5880622

Abstract Article PDF–408K

Select item 55691085.

Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL

Yi-Hung Carol Tan, Tamara Mirzapoiazova, Brian M. Won, Li Zhu, Minu K. Srivastava, Everett E. Vokes, Aliya N. Husain, Surinder K. Batra, Sherven Sharma, Ravi Salgia

Sci Rep. 2017; 7: 9192. Published online 2017 Aug 23. doi: 10.1038/s41598-017-09078-4

PMCID:: PMC5569108

Abstract Article PDF–4.4M

Select item 54113436.

C-CBL E3 ubiquitin ligase expression increases across the spectrum of benign and malignant T-cell skin diseases

Katrin A. Salva, Margo J. Reeder, Rita Lloyd, Gary S. Wood

Am J Dermatopathol. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Am J Dermatopathol. 2017 Oct; 39(10): 731–737. doi: 10.1097/DAD.0000000000000780

PMCID:: PMC5411343

Abstract Article PDF–1.3M

Select item 52882277.

c-CBL regulates melanoma proliferation, migration, invasion and the FAK-SRC-GRB2 nexus

Minakshi Nihal, Gary S. Wood

Oncotarget. 2016 Aug 16; 7(33): 53869–53880. Published online 2016 Jul 27. doi: 10.18632/oncotarget.10861

PMCID:: PMC5288227

Abstract Article PDF–4.8M

Select item 43241198.

c-CBL E3 Ubiquitin Ligase is Over-Expressed in Cutaneous T-Cell Lymphoma: Its Inhibition Promotes Activation Induced Cell Death

Jianqiang Wu, Katrin A. Salva, Gary S. Wood

J Invest Dermatol. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: J Invest Dermatol. 2015 Mar; 135(3): 861–868. Published online 2014 Aug 14. doi: 10.1038/jid.2014.364

PMCID:: PMC4324119

Abstract Article PDF–907K

Select item 42972859.

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

Charlotte M. Niemeyer, Michelle W. Kang, Danielle H. Shin, Ingrid Furlan, Miriam Erlacher, Nancy J Bunin, Severa Bunda, Jerry Z. Finklestein, Thomas A. Gorr, Parinda Mehta, Irene Schmid, Gabriele Kropshofer, Selim Corbacioglu, Peter J Lang, Christoph Klein, Paul-Gerhard Schlegel, Andrea Heinzmann, Michaela Schneider, Jan Starý, Marry M. van den Heuvel-Eibrink, Henrik Hasle, Franco Locatelli, Debbie Sakai, Sophie Archambeault, Leslie Chen, Ryan C. Russell, Stephanie S. Sybingco, Michael Ohh, Benjamin S. Braun, Christian Flotho, Mignon L. Loh

Nat Genet. Author manuscript; available in PMC 2015 Jan 17.

Published in final edited form as: Nat Genet. 2010 Sep; 42(9): 794–800. Published online 2010 Aug 8. doi: 10.1038/ng.641

PMCID:: PMC4297285

Abstract Article PDF–1.5M

Select item 411247710.

Glucocorticoid regulates TrkB protein levels via c-Cbl dependent ubiquitination: a decrease in c-Cbl mRNA in the prefrontal cortex of suicide subjects

Chirayu Pandya, Ammar Kutiyanawalla, Gustavo Turecki, Anilkumar Pillai

Psychoneuroendocrinology. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Psychoneuroendocrinology. 2014 Jul; 45: 108–118. Published online 2014 Apr 6. doi: 10.1016/j.psyneuen.2014.03.020

PMCID:: PMC4112477

Abstract Article PDF–422K

Select item 369394211.

Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia

Yuka Saito, Yoko Aoki, Hideki Muramatsu, Hideki Makishima, Jaroslaw P. Maciejewski, Masue Imaizumi, Takeshi Rikiishi, Yoji Sasahara, Shigeo Kure, Tetsuya Niihori, Shigeru Tsuchiya, Seiji Kojima, Yoichi Matsubara

Leuk Res. Author manuscript; available in PMC 2013 Jun 26.

Published in final edited form as: Leuk Res. 2012 Aug; 36(8): 1009–1015. Published online 2012 May 14. doi: 10.1016/j.leukres.2012.04.018

PMCID:: PMC3693942

Abstract Article PDF–2.0M

Select item 368528512.

Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases

Susanne Schnittger, Ulrike Bacher, Tamara Alpermann, Andreas Reiter, Madlen Ulke, Frank Dicker, Christiane Eder, Alexander Kohlmann, Vera Grossmann, Andreas Kowarsch, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach

Haematologica. 2012 Dec; 97(12): 1890–1894. doi: 10.3324/haematol.2012.065375

PMCID:: PMC3685285

Abstract Article PDF–1.4M

Select item 313430013.

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders

Mayumi Naramura, Scott Nadeau, Bhopal Mohapatra, Gulzar Ahmad, Chandrani Mukhopadhyay, Martin Sattler, Srikumar M Raja, Amarnath Natarajan, Vimla Band, Hamid Band

Oncotarget. 2011 Mar; 2(3): 245–250. Published online 2011 Mar 20. doi: 10.18632/oncotarget.233

PMCID:: PMC3134300

Abstract Article PDF–623K

Select item 304000914.

Mutations of E3 Ubiquitin Ligase Cbl Family Members Constitute a Novel Common Pathogenic Lesion in Myeloid Malignancies

Hideki Makishima, Heather Cazzolli, Hadrian Szpurka, Andrew Dunbar, Ramon Tiu, Jungwon Huh, Hideki Muramatsu, Christine O'Keefe, Eric Hsi, Ronald L. Paquette, Seiji Kojima, Alan F. List, Mikkael A. Sekeres, Michael A. McDevitt, Jaroslaw P. Maciejewski

J Clin Oncol. 2009 Dec 20; 27(36): 6109–6116. Published online 2009 Nov 9. doi: 10.1200/JCO.2009.23.7503

PMCID:: PMC3040009

Abstract Article PDF–470K

Select item 295226215.

Novel Oncogenic Mutations of CBL in Human Acute Myeloid Leukemia That Activate Growth and Survival Pathways Depend on Increased Metabolism

Margret S. Fernandes, Mamatha M. Reddy, Nicole J. Croteau, Christoph Walz, Henry Weisbach, Klaus Podar, Hamid Band, Martin Carroll, Andreas Reiter, Richard A. Larson, Ravi Salgia, James D. Griffin, Martin Sattler

J Biol Chem. 2010 Oct 15; 285(42): 32596–32605. Published online 2010 Jul 9. doi: 10.1074/jbc.M110.106161

PMCID:: PMC2952262

Abstract Article PDF–1.8M

Select item 291770516.

Heterozygous Germline Mutations in the CBL Tumor-Suppressor Gene Cause a Noonan Syndrome-like Phenotype

Simone Martinelli, Alessandro De Luca, Emilia Stellacci, Cesare Rossi, Saula Checquolo, Francesca Lepri, Viviana Caputo, Marianna Silvano, Francesco Buscherini, Federica Consoli, Grazia Ferrara, Maria C. Digilio, Maria L. Cavaliere, Johanna M. van Hagen, Giuseppe Zampino, Ineke van der Burgt, Giovanni B. Ferrero, Laura Mazzanti, Isabella Screpanti, Helger G. Yntema, Willy M. Nillesen, Ravi Savarirayan, Martin Zenker, Bruno Dallapiccola, Bruce D. Gelb, Marco Tartaglia

Am J Hum Genet. 2010 Aug 13; 87(2): 250–257. doi: 10.1016/j.ajhg.2010.06.015

PMCID:: PMC2917705

Abstract Article PDF–501K

Select item 266853817.

250K SNP array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies

Andrew J. Dunbar, Lukasz P. Gondek, Christine L. O’Keefe, Hideki Makishima, Manjot S. Rataul, Hadrian Szpurka, Mikkael A. Sekeres, Xiao Fei Wang, Michael A. McDevitt, Jaroslaw P. Maciejewski

Cancer Res. Author manuscript; available in PMC 2009 Dec 15.

Published in final edited form as: Cancer Res. 2008 Dec 15; 68(24): 10349–10357. doi: 10.1158/0008-5472.CAN-08-2754

PMCID:: PMC2668538

Abstract Article PDF–2.8M

Select item 248155818.

c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells

Nicolò C. Brembilla, Johann Weber, Donata Rimoldi, Sylvain Pradervand, Frédéric Schütz, Giuseppe Pantaleo, Curzio Rüegg, Manfredo Quadroni, Keith Harshman, Marie-Agnès Doucey

Blood. 2008 Aug 1; 112(3): 652–660. Prepublished online 2008 May 27. doi: 10.1182/blood-2008-01-134486

PMCID:: PMC2481558

Abstract Article

Select item 1111554919.

Bimodal expression of Sprouty2 during the cell cycle is mediated by phase-specific Ras/MAPK and c-Cbl activities

Christoph-Erik Mayer, Barbara Haigl, Florian Jantscher, Gerald Siegwart, Michael Grusch, Walter Berger, Hedwig Sutterlüty

Cell Mol Life Sci. 2010 Oct; 67(19): 3299–3311. Published online 2010 May 12. doi: 10.1007/s00018-010-0379-6

PMCID:: PMC11115549

Abstract Article PDF–796K

Select item 1109226020.

PSMD9 promotes the malignant progression of hepatocellular carcinoma by interacting with c-Cbl to activate EGFR signaling and recycling

Yuting Su, Lili Meng, Chao Ge, Yuqi Liu, Chi Zhang, Yue Yang, Wei Tian, Hua Tian

J Exp Clin Cancer Res. 2024; 43: 142. Published online 2024 May 14. doi: 10.1186/s13046-024-03062-3

PMCID:: PMC11092260

Abstract Article PDF–7.1M

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