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Items: 1 to 20 of 58

1.
The ORMDL/Orm–serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes
Deanna L. Davis, Kenneth Gable, John Suemitsu, Teresa M. Dunn, Binks W. Wattenberg
J Biol Chem. 2019 Mar 29; 294(13): 5146–5156. Published online 2019 Jan 30. doi: 10.1074/jbc.RA118.007291
PMCID:
PMC6442065
AbstractArticlePDF–1.2M
2.
Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway
Jihui Ren, Essa M. Saied, Aaron Zhong, Justin Snider, Christian Ruiz, Christoph Arenz, Lina M. Obeid, Geoffrey D. Girnun, Yusuf A. Hannun
J Lipid Res. 2018 Nov; 59(11): 2126–2139. Published online 2018 Aug 28. doi: 10.1194/jlr.M088195
PMCID:
PMC6210917
AbstractArticlePDF–1.6M
3.
Membrane engineering of S. cerevisiae targeting sphingolipid metabolism
Lina Lindahl, Aline X. S. Santos, Helén Olsson, Lisbeth Olsson, Maurizio Bettiga
Sci Rep. 2017; 7: 41868. Published online 2017 Feb 1. doi: 10.1038/srep41868
PMCID:
PMC5286413
AbstractArticlePDF–812K
4.
Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae
Françoise M. Roelants, David K. Breslow, Alexander Muir, Jonathan S. Weissman, Jeremy Thorner
Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48): 19222–19227. Published online 2011 Nov 11. doi: 10.1073/pnas.1116948108
PMCID:
PMC3228448
AbstractArticlePDF–668K
5.
Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether
Fernando Martínez-Montañés, Museer A. Lone, Fong-Fu Hsu, Roger Schneiter
J Lipid Res. 2016 Nov; 57(11): 2040–2050. Published online 2016 Oct 27. doi: 10.1194/jlr.M070748
PMCID:
PMC5087871
AbstractArticlePDF–1.3M
6.
Loss of Ypk1, the Yeast Homolog to the Human Serum- and Glucocorticoid-induced Protein Kinase, Accelerates Phospholipase B1-mediated Phosphatidylcholine Deacylation
Beth A. Surlow, Benjamin M. Cooley, Patrick G. Needham, Jeffrey L. Brodsky, Jana Patton-Vogt
J Biol Chem. 2014 Nov 7; 289(45): 31591–31604. Published online 2014 Sep 25. doi: 10.1074/jbc.M114.581157
PMCID:
PMC4223355
AbstractArticlePDF–1.4M
7.
Structure of the ceramide-bound SPOTS complex
Jan-Hannes Schäfer, Carolin Körner, Bianca M. Esch, Sergej Limar, Kristian Parey, Stefan Walter, Dovile Januliene, Arne Moeller, Florian Fröhlich
Nat Commun. 2023; 14: 6196. Published online 2023 Oct 4. doi: 10.1038/s41467-023-41747-z
PMCID:
PMC10550967
AbstractArticlePDF–11M
8.
Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways
Delphine Rispal, Sandra Eltschinger, Michael Stahl, Stefania Vaga, Bernd Bodenmiller, Yann Abraham, Ireos Filipuzzi, N. Rao Movva, Ruedi Aebersold, Stephen B. Helliwell, Robbie Loewith
J Biol Chem. 2015 Jun 12; 290(24): 14963–14978. Published online 2015 Apr 16. doi: 10.1074/jbc.M114.627794
PMCID:
PMC4463442
AbstractArticlePDF–1.6M
9.
Iron, Glucose and Intrinsic Factors Alter Sphingolipid Composition as Yeast Cells Enter Stationary Phase
Robert L. Lester, Bradley R. Withers, Megan A. Schultz, Robert C. Dickson
Biochim Biophys Acta. Author manuscript; available in PMC 2014 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Apr; 1831(4): 726–736. Published online 2012 Dec 31. doi: 10.1016/j.bbalip.2012.12.012
PMCID:
PMC3594326
AbstractArticlePDF–2.5M
10.
Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1
Neha Chauhan, Gongshe Han, Niranjanakumari Somashekarappa, Kenneth Gable, Teresa Dunn, Sepp D. Kohlwein
J Biol Chem. 2016 Jan 29; 291(5): 2524–2534. Published online 2015 Dec 3. doi: 10.1074/jbc.M115.693200
Correction in:
J Biol Chem. 2017 Jun 2; 292(22): 9431.
PMCID:
PMC4732232
AbstractArticlePDF–1.0M
11.
The Synthetic Amphipathic Peptidomimetic LTX109 Is a Potent Fungicide That Disturbs Plasma Membrane Integrity in a Sphingolipid Dependent Manner
Rasmus Bojsen, Rasmus Torbensen, Camilla Eggert Larsen, Anders Folkesson, Birgitte Regenberg
PLoS One. 2013; 8(7): e69483. Published online 2013 Jul 12. doi: 10.1371/journal.pone.0069483
PMCID:
PMC3709891
AbstractArticlePDF–548K
12.
Sphingolipid Signaling Mediates Iron Toxicity
Yueh-Jung Lee, Xinhe Huang, Janette Kropat, Anthony Henras, Sabeeha S Merchant, Robert C Dickson, Guillaume F. Chanfreau
Cell Metab. Author manuscript; available in PMC 2013 Jul 3.
Published in final edited form as: Cell Metab. 2012 Jul 3; 16(1): 90–96. doi: 10.1016/j.cmet.2012.06.004
PMCID:
PMC3653578
AbstractArticlePDF–1.9M
13.
TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis
Mitsugu Shimobayashi, Wolfgang Oppliger, Suzette Moes, Paul Jenö, Michael N. Hall
Mol Biol Cell. 2013 Mar 15; 24(6): 870–881. doi: 10.1091/mbc.E12-10-0753
PMCID:
PMC3596256
AbstractArticlePDF–4.8M
14.
Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
Ming Liu, Chunjuan Huang, Surendranath R. Polu, Roger Schneiter, Amy Chang
J Cell Sci. 2012 May 15; 125(10): 2428–2435. doi: 10.1242/jcs.100578
PMCID:
PMC3383258
AbstractArticle
15.
Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae
Bianca M. Esch, Sergej Limar, André Bogdanowski, Christos Gournas, Tushar More, Celine Sundag, Stefan Walter, Jürgen J. Heinisch, Christer S. Ejsing, Bruno André, Florian Fröhlich
PLoS Genet. 2020 Aug; 16(8): e1008745. Published online 2020 Aug 26. doi: 10.1371/journal.pgen.1008745
PMCID:
PMC7478846
AbstractArticlePDF–3.5M
16.
The protein kinase Cmk2 negatively regulates the calcium/calcineurin signalling pathway and expression of calcium pump genes PMR1 and PMC1 in budding yeast
Huihui Xu, Tianshu Fang, Hongbo Yan, Linghuo Jiang
Cell Commun Signal. 2019; 17: 7. Published online 2019 Jan 21. doi: 10.1186/s12964-019-0320-z
PMCID:
PMC6341702
AbstractArticlePDF–1.3M
17.
Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control
Sumin Han, Museer A. Lone, Roger Schneiter, Amy Chang
Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13): 5851–5856. Published online 2010 Mar 8. doi: 10.1073/pnas.0911617107
PMCID:
PMC2851911
AbstractArticlePDF–944K
18.
Expression of the Bacterial Type III Effector DspA/E in Saccharomyces cerevisiae Down-regulates the Sphingolipid Biosynthetic Pathway Leading to Growth Arrest
Sabrina Siamer, Isabelle Guillas, Mitsugu Shimobayashi, Caroline Kunz, Michael N. Hall, Marie-Anne Barny
J Biol Chem. 2014 Jun 27; 289(26): 18466–18477. Published online 2014 May 14. doi: 10.1074/jbc.M114.562769
PMCID:
PMC4140250
AbstractArticlePDF–1.6M
19.
Novel interconnections of HOG signaling revealed by combined use of two proteomic software packages
Marion Janschitz, Natalie Romanov, Gina Varnavides, David Maria Hollenstein, Gabriela Gérecová, Gustav Ammerer, Markus Hartl, Wolfgang Reiter
Cell Commun Signal. 2019; 17: 66. Published online 2019 Jun 17. doi: 10.1186/s12964-019-0381-z
PMCID:
PMC6572760
AbstractArticlePDF–2.7M
20.
The ORMs Interact with Transmembrane Domain 1 of Lcb1 and Regulate Serine Palmitoyltransferase Oligomerization, Activity and Localization
Gongshe Han, Sita D. Gupta, Kenneth Gable, Dagmar Bacikova, Nivedita Sengupta, Niranjanakumari Somashekarappa, Richard L. Proia, Jeffrey M. Harmon, Teresa M. Dunn
Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2020 Mar 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar; 1864(3): 245–259. Published online 2018 Dec 6. doi: 10.1016/j.bbalip.2018.11.007
PMCID:
PMC6373489
AbstractArticlePDF–1.7M

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