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Select item 98677491.

SPRTN patient variants cause global-genome DNA-protein crosslink repair defects

Pedro Weickert, Hao-Yi Li, Maximilian J. Götz, Sophie Dürauer, Denitsa Yaneva, Shubo Zhao, Jacqueline Cordes, Aleida C. Acampora, Ignasi Forne, Axel Imhof, Julian Stingele

Nat Commun. 2023; 14: 352. Published online 2023 Jan 21. doi: 10.1038/s41467-023-35988-1

PMCID:: PMC9867749

Abstract Article PDF–5.4M

Select item 86745352.

The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

Annamaria Ruggiano, Bruno Vaz, Susan Kilgas, Marta Popović, Gonzalo Rodriguez-Berriguete, Abhay N. Singh, Geoff S. Higgins, Anne E. Kiltie, Kristijan Ramadan

Cell Rep. 2021 Dec 7; 37(10): 110080. Published online 2021 Dec 7. doi: 10.1016/j.celrep.2021.110080

PMCID:: PMC8674535

Abstract Article

Select item 78262513.

A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN

Shubo Zhao, Anja Kieser, Hao-Yi Li, Hannah K Reinking, Pedro Weickert, Simon Euteneuer, Denitsa Yaneva, Aleida C Acampora, Maximilian J Götz, Regina Feederle, Julian Stingele

Nucleic Acids Res. 2021 Jan 25; 49(2): 902–915. Published online 2020 Dec 22. doi: 10.1093/nar/gkaa1224

PMCID:: PMC7826251

Abstract Article PDF–2.3M

Select item 75347984.

DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease

Hannah K. Reinking, Hyun-Seo Kang, Maximilian J. Götz, Hao-Yi Li, Anja Kieser, Shubo Zhao, Aleida C. Acampora, Pedro Weickert, Evelyn Fessler, Lucas T. Jae, Michael Sattler, Julian Stingele

Mol Cell. 2020 Oct 1; 80(1): 102–113.e6. doi: 10.1016/j.molcel.2020.08.003

PMCID:: PMC7534798

Abstract Article

Select item 53896355.

DNA-dependent protease activity of human Spartan facilitates replication of DNA–protein crosslink-containing DNA

Mónika Mórocz, Eszter Zsigmond, Róbert Tóth, Márton Zs Enyedi, Lajos Pintér, Lajos Haracska

Nucleic Acids Res. 2017 Apr 7; 45(6): 3172–3188. Published online 2017 Jan 2. doi: 10.1093/nar/gkw1315

PMCID:: PMC5389635

Abstract Article PDF–2.6M

Select item 91273656.

Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN

Alexander Kröning, Johannes van den Boom, Matthias Kracht, Anja F. Kueck, Hemmo Meyer

J Biol Chem. 2022 Jun; 298(6): 101976. Published online 2022 Apr 22. doi: 10.1016/j.jbc.2022.101976

PMCID:: PMC9127365

Abstract Article PDF–1.1M

Select item 85019617.

Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexes

Liton Kumar Saha, Yasuhisa Murai, Sourav Saha, Ukhyun Jo, Masataka Tsuda, Shunichi Takeda, Yves Pommier

Nucleic Acids Res. 2021 Oct 11; 49(18): 10493–10506. Published online 2021 Sep 22. doi: 10.1093/nar/gkab777

PMCID:: PMC8501961

Abstract Article PDF–4.1M

Select item 51287268.

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

Julian Stingele, Roberto Bellelli, Ferdinand Alte, Graeme Hewitt, Grzegorz Sarek, Sarah L. Maslen, Susan E. Tsutakawa, Annabel Borg, Svend Kjær, John A. Tainer, J. Mark Skehel, Michael Groll, Simon J. Boulton

Mol Cell. 2016 Nov 17; 64(4): 688–703. doi: 10.1016/j.molcel.2016.09.031

PMCID:: PMC5128726

Abstract Article PDF–3.5M

Select item 43432119.

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

Davor Lessel, Bruno Vaz, Swagata Halder, Paul J Lockhart, Ivana Marinovic-Terzic, Jaime Lopez-Mosqueda, Melanie Philipp, Joe C H Sim, Katherine R Smith, Judith Oehler, Elisa Cabrera, Raimundo Freire, Kate Pope, Amsha Nahid, Fiona Norris, Richard J Leventer, Martin B Delatycki, Gotthold Barbi, Simon von Ameln, Josef Högel, Marina Degoricija, Regina Fertig, Martin D Burkhalter, Kay Hofmann, Holger Thiele, Janine Altmüller, Gudrun Nürnberg, Peter Nürnberg, Melanie Bahlo, George M Martin, Cora M Aalfs, Junko Oshima, Janos Terzic, David J Amor, Ivan Dikic, Kristijan Ramadan, Christian Kubisch

Nat Genet. Author manuscript; available in PMC 2015 Feb 27.

Published in final edited form as: Nat Genet. 2014 Nov; 46(11): 1239–1244. Published online 2014 Sep 28. doi: 10.1038/ng.3103

PMCID:: PMC4343211

Abstract Article PDF–1.4M

Select item 452239610.

The identification of translesion DNA synthesis regulators: inhibitors in the spotlight

AP Bertolin, SF Mansilla, V Gottifredi

DNA Repair (Amst) Author manuscript; available in PMC 2016 Aug 1.

Published in final edited form as: DNA Repair (Amst). 2015 Aug; 32: 158–164. Published online 2015 May 12. doi: 10.1016/j.dnarep.2015.04.027

PMCID:: PMC4522396

Abstract Article PDF–679K

Select item 426917011.

Spartan deficiency causes genomic instability and progeroid phenotypes

Reeja S. Maskey, Myoung Shin Kim, Darren J. Baker, Bennett Childs, Liviu A. Malureanu, Karthik B. Jeganathan, Yuka Machida, Jan M. van Deursen, Yuichi J. Machida

Nat Commun. 2014 Dec 11; 5: 5744. Published online 2014 Dec 11. doi: 10.1038/ncomms6744

PMCID:: PMC4269170

Abstract Article PDF–1.5M

Select item 351051412.

Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance

Szilvia Juhasz, David Balogh, Ildiko Hajdu, Peter Burkovics, Mark A. Villamil, Zhihao Zhuang, Lajos Haracska

Nucleic Acids Res. 2012 Nov; 40(21): 10795–10808. Published online 2012 Sep 16. doi: 10.1093/nar/gks850

PMCID:: PMC3510514

Abstract Article PDF–9.3M

Select item 706275113.

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

John Fielden, Katherine Wiseman, Ignacio Torrecilla, Shudong Li, Samuel Hume, Shih-Chieh Chiang, Annamaria Ruggiano, Abhay Narayan Singh, Raimundo Freire, Sylvana Hassanieh, Enric Domingo, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Timothy S. Maughan, Sherif F. El-Khamisy, Kristijan Ramadan

Nat Commun. 2020; 11: 1274. Published online 2020 Mar 9. doi: 10.1038/s41467-020-15000-w

PMCID:: PMC7062751

Abstract Article PDF–3.7M

Select item 512764414.

SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks

Jaime Lopez-Mosqueda, Karthik Maddi, Stefan Prgomet, Sissy Kalayil, Ivana Marinovic-Terzic, Janos Terzic, Ivan Dikic

eLife. 2016; 5: e21491. Published online 2016 Nov 17. doi: 10.7554/eLife.21491

PMCID:: PMC5127644

Abstract Article PDF–2.6M

Select item 988172915.

The FANCJ Helicase Unfolds DNA-Protein Cross-Links to Promote Their Repair

Denitsa Yaneva, Justin L. Sparks, Maximilian Donsbach, Shubo Zhao, Pedro Weickert, Rachel Bezalel-Buch, Julian Stingele, Johannes C. Walter

Mol Cell. Author manuscript; available in PMC 2024 Jan 5.

Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 43–56.e10. doi: 10.1016/j.molcel.2022.12.005

PMCID:: PMC9881729

Abstract Article PDF–1.2M

Select item 787081816.

SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

Juri Na, Joseph A. Newman, Chee Kin Then, Junetha Syed, Iolanda Vendrell, Ignacio Torrecilla, Sophie Ellermann, Kristijan Ramadan, Roman Fischer, Anne E. Kiltie

Cell Death Dis. 2021 Feb; 12(2): 165. Published online 2021 Feb 8. doi: 10.1038/s41419-021-03437-w

PMCID:: PMC7870818

Abstract Article PDF–3.1M

Select item 748410417.

Tandem deubiquitination and acetylation of SPRTN promotes DNA-protein crosslinks repair and protects against aging

Jinzhou Huang, Qin Zhou, Ming Gao, Somaira Nowsheen, Fei Zhao, Wootae Kim, Qian Zhu, Yusuke Kojima, Ping Yin, Yong Zhang, Guijie Guo, Xinyi Tu, Min Deng, Kuntian Luo, Bo Qin, Yuichi Machida, Zhenkun Lou

Mol Cell. Author manuscript; available in PMC 2021 Sep 3.

Published in final edited form as: Mol Cell. 2020 Sep 3; 79(5): 824–835.e5. Published online 2020 Jul 9. doi: 10.1016/j.molcel.2020.06.027

PMCID:: PMC7484104

Abstract Article PDF–2.1M

Select item 512872718.

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

Bruno Vaz, Marta Popovic, Joseph A. Newman, John Fielden, Hazel Aitkenhead, Swagata Halder, Abhay Narayan Singh, Iolanda Vendrell, Roman Fischer, Ignacio Torrecilla, Neele Drobnitzky, Raimundo Freire, David J. Amor, Paul J. Lockhart, Benedikt M. Kessler, Gillies W. McKenna, Opher Gileadi, Kristijan Ramadan

Mol Cell. 2016 Nov 17; 64(4): 704–719. doi: 10.1016/j.molcel.2016.09.032

PMCID:: PMC5128727

Abstract Article

Select item 346655019.

Spartan/C1orf124 is important to prevent UV-induced mutagenesis

Yuka Machida, Myoung Shin Kim, Yuichi J. Machida

Cell Cycle. 2012 Sep 15; 11(18): 3395–3402. doi: 10.4161/cc.21694

PMCID:: PMC3466550

Abstract Article PDF–2.8M

Select item 357509020.

Spartan/C1orf124, a Reader of PCNA Ubiquitylation and a Regulator of UV-Induced DNA Damage Response

Richard C. Centore, Stephanie A. Yazinski, Alice Tse, Lee Zou

Mol Cell. Author manuscript; available in PMC 2013 Jun 8.

Published in final edited form as: Mol Cell. 2012 Jun 8; 46(5): 625–635. doi: 10.1016/j.molcel.2012.05.020

PMCID:: PMC3575090

Abstract Article PDF–4.3M

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