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Select item 92719131.

Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures

Xiaoliang Liu, Lu Zhang, Hebo Zhang, Xiaoyan Liang, Bijun Zhang, Jianqiao Tu, Yanyan Zhao

Front Mol Neurosci. 2022; 15: 919718. Published online 2022 Jun 27. doi: 10.3389/fnmol.2022.919718

PMCID:: PMC9271913

Abstract Article PDF–5.6M

Select item 89304432.

E3 Ubiquitin Ligase Nedd4-2 Exerts Neuroprotective Effects During Endoplasmic Reticulum Stress

Daphne E Lodes, Jiuhe Zhu, Nien-Pei Tsai

J Neurochem. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: J Neurochem. 2022 Mar; 160(6): 613–624. Published online 2021 Dec 29. doi: 10.1111/jnc.15567

PMCID:: PMC8930443

Abstract Article PDF–1.9M

Select item 89067833.

The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel Na_V1.7 via the Ubiquitin-Ligase NEDD4-2

Alexandru-Florian Deftu, Paul Chu Sin Chung, Cédric J. Laedermann, Ludovic Gillet, Marie Pertin, Guylène Kirschmann, Isabelle Decosterd

eNeuro. 2022 Mar-Apr; 9(2): ENEURO.0409-21.2022. Prepublished online 2022 Feb 7. Published online 2022 Mar 3. doi: 10.1523/ENEURO.0409-21.2022

PMCID:: PMC8906783

Abstract Article PDF–2.1M

Select item 87142544.

ROMK channels are inhibited in the aldosterone-sensitive distal nephron of renal tubule Nedd4-2-deficient mice

Dan-Dan Zhang, Jun-Ya Zheng, Xin-Peng Duan, Dao-Hong Lin, Wen-Hui Wang

Am J Physiol Renal Physiol. 2022 Jan 1; 322(1): F55–F67. Published online 2021 Nov 29. doi: 10.1152/ajprenal.00306.2021

PMCID:: PMC8714254

Abstract Article

Select item 83218005.

Deletion of renal Nedd4-2 abolishes the effect of high K⁺ intake on Kir4.1/Kir5.1 and NCC activity in the distal convoluted tubule

Yu Xiao, Xin-Peng Duan, Dan-Dan Zhang, Wen-Hui Wang, Dao-Hong Lin

Am J Physiol Renal Physiol. 2021 Jul 1; 321(1): F1–F11. Published online 2021 May 24. doi: 10.1152/ajprenal.00072.2021

PMCID:: PMC8321800

Abstract Article

Select item 83061126.

Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of Nedd4-2

Theresa A. Engelmann, Lars Knudsen, Dominik H. W. Leitz, Julia Duerr, Michael F. Beers, Marcus A. Mall, Matthias Ochs

Int J Mol Sci. 2021 Jul; 22(14): 7607. Published online 2021 Jul 16. doi: 10.3390/ijms22147607

PMCID:: PMC8306112

Abstract Article PDF–4.3M

Select item 82011557.

Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice

Dominik H. W. Leitz, Julia Duerr, Surafel Mulugeta, Ayça Seyhan Agircan, Stefan Zimmermann, Hiroshi Kawabe, Alexander H. Dalpke, Michael F. Beers, Marcus A. Mall

Int J Mol Sci. 2021 Jun; 22(11): 6146. Published online 2021 Jun 7. doi: 10.3390/ijms22116146

PMCID:: PMC8201155

Abstract Article PDF–2.3M

Select item 80547228.

Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage

TaeHee Kim, Anil K Chokkalla, Raghu Vemuganti

J Cereb Blood Flow Metab. 2021 May; 41(5): 1058–1066. Published online 2020 Jul 23. doi: 10.1177/0271678X20943804

PMCID:: PMC8054722

Abstract Article PDF–1.3M

Select item 56863539.

Deletion of Nedd4-2 results in progressive kidney disease in mice

Tanya L Henshall, Jantina A Manning, Omri S Alfassy, Pranay Goel, Natasha A Boase, Hiroshi Kawabe, Sharad Kumar

Cell Death Differ. 2017 Dec; 24(12): 2150–2160. Published online 2017 Sep 1. doi: 10.1038/cdd.2017.137

PMCID:: PMC5686353

Abstract Article PDF–3.0M

Select item 553322910.

Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion

Lama Al-Qusairi, Denis Basquin, Ankita Roy, Renuga Devi Rajaram, Marc P. Maillard, Arohan R. Subramanya, Olivier Staub

J Am Soc Nephrol. 2017 Aug; 28(8): 2431–2442. Published online 2017 Mar 13. doi: 10.1681/ASN.2016070732

PMCID:: PMC5533229

Abstract Article

Select item 548609011.

An Isoform of Nedd4-2 Plays a Pivotal Role in Electrophysiological Cardiac Abnormalities

Shintaro Minegishi, Tomoaki Ishigami, Hisho Kawamura, Tabito Kino, Lin Chen, Rie Nakashima-Sasaki, Hiroshi Doi, Kengo Azushima, Hiromichi Wakui, Yumi Chiba, Kouichi Tamura

Int J Mol Sci. 2017 Jun; 18(6): 1268. Published online 2017 Jun 14. doi: 10.3390/ijms18061268

PMCID:: PMC5486090

Abstract Article PDF–2.7M

Select item 538645512.

Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson's disease model

Yunlong Zhang, Xiaoliang He, Xingjun Meng, Xiaojuan Wu, Huichun Tong, Xiuping Zhang, Shaogang Qu

Cell Death Dis. 2017 Feb; 8(2): e2574. Published online 2017 Feb 2. doi: 10.1038/cddis.2016.454

PMCID:: PMC5386455

Abstract Article PDF–3.6M

Select item 489173013.

An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice

Shintaro Minegishi, Tomoaki Ishigami, Tabito Kino, Lin Chen, Rie Nakashima-Sasaki, Naomi Araki, Keisuke Yatsu, Megumi Fujita, Satoshi Umemura

Sci Rep. 2016; 6: 27137. Published online 2016 Jun 3. doi: 10.1038/srep27137

PMCID:: PMC4891730

Abstract Article PDF–1.5M

Select item 379837914.

The Short Isoform of the Ubiquitin Ligase NEDD4L Is a CREB Target Gene in Hepatocytes

Jingqi Fu, Dmitry Akhmedov, Rebecca Berdeaux

PLoS One. 2013; 8(10): e78522. Published online 2013 Oct 17. doi: 10.1371/journal.pone.0078522

PMCID:: PMC3798379

Abstract Article PDF–517K

Select item 369656115.

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

Cédric J. Laedermann, Matthieu Cachemaille, Guylène Kirschmann, Marie Pertin, Romain-Daniel Gosselin, Isabelle Chang, Maxime Albesa, Chris Towne, Bernard L. Schneider, Stephan Kellenberger, Hugues Abriel, Isabelle Decosterd

J Clin Invest. 2013 Jul 1; 123(7): 3002–3013. Published online 2013 Jun 17. doi: 10.1172/JCI68996

PMCID:: PMC3696561

Abstract Article PDF–2.7M

Select item 351487616.

Salt-Induced Hypertension in a Mouse Model of Liddle's Syndrome is Mediated by Epithelial Sodium Channels in the Brain

James W. Van Huysse, Md. Shahrier Amin, Baoli Yang, Frans H. H. Leenen

Hypertension. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: Hypertension. 2012 Sep; 60(3): 691–696. Published online 2012 Jul 16. doi: 10.1161/HYPERTENSIONAHA.112.193045

PMCID:: PMC3514876

Abstract Article PDF–1.3M

Select item 197814317.

Crystallization and preliminary X-ray diffraction studies of the WW4 domain of the Nedd4-2 ubiquitin–protein ligase

N. Umadevi, S. Kumar, N. Narayana

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Dec 1; 61(Pt 12): 1084–1086. Published online 2005 Nov 24. doi: 10.1107/S174430910503767X

PMCID:: PMC1978143

Abstract Article PDF–258K

Select item 1125090518.

The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell quiescence by inhibiting their activation

Darren M. Blackburn, Korin Sahinyan, Aldo Hernández-Corchado, Felicia Lazure, Vincent Richard, Laura Raco, Gabrielle Perron, René P. Zahedi, Christoph H. Borchers, Christoph Lepper, Hiroshi Kawabe, Arezu Jahani-Asl, Hamed S. Najafabadi, Vahab D. Soleimani

iScience. 2024 Jul 19; 27(7): 110241. Published online 2024 Jun 11. doi: 10.1016/j.isci.2024.110241

PMCID:: PMC11250905

Abstract Article PDF–5.6M

Select item 1047875119.

Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension

Mazher Mohammed, Blessing Ogunlade, Mona Elgazzaz, Clara Berdasco, Navya Lakkappa, Ioana Ghita, Jessie J Guidry, Srinivas Sriramula, Jiaxi Xu, Luke Restivo, Michelle A Mendiola Plá, Dawn E Bowles, Andreas M Beyer, Xinping Yue, Eric Lazartigues, Catalin M Filipeanu

Cardiovasc Res. 2023 Aug; 119(11): 2130–2141. Published online 2023 May 10. doi: 10.1093/cvr/cvad070

PMCID:: PMC10478751

Abstract Article PDF–1.4M

Select item 1028526920.

Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

Xin Gu, Haoyu Meng, Chengyi Peng, Shiyu Lin, Baihong Li, Lin Zhao, Xue Yang, Guangyan Wang, Wenyuan Cai, Jiawen Zhou, Shuiyuan Liu, Peng Wu, Yingqiang Du, Jianliang Jin, Xiaoyan Wang

Clin Transl Med. 2023 Jun; 13(6): e1308. Published online 2023 Jun 21. doi: 10.1002/ctm2.1308

PMCID:: PMC10285269

Abstract Article PDF–20M

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PMC Links for Gene (Select 83814) (88)
PMC
PREDICTED: Mus musculus neural precursor cell expressed, developmentally down-re...
PREDICTED: Mus musculus neural precursor cell expressed, developmentally down-regulated gene 4-like (Nedd4l), transcript variant X30, mRNA
gi|1907130937|ref|XM_036161335.1|

Nucleotide
E3 ubiquitin-protein ligase NEDD4-like isoform X19 [Mus musculus]
E3 ubiquitin-protein ligase NEDD4-like isoform X19 [Mus musculus]
gi|1907130934|ref|XP_036017226.1|

Protein
E3 ubiquitin-protein ligase NEDD4-like isoform X17 [Mus musculus]
E3 ubiquitin-protein ligase NEDD4-like isoform X17 [Mus musculus]
gi|1907130922|ref|XP_036017221.1|

Protein
E3 ubiquitin-protein ligase NEDD4-like isoform 4 [Mus musculus]
E3 ubiquitin-protein ligase NEDD4-like isoform 4 [Mus musculus]
gi|2219517899|ref|NP_001390938.1|

Protein

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