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Select item 106298221.

Mutant SF3B1 promotes malignancy in PDAC

Patrik Simmler, Eleonora I Ioannidi, Tamara Mengis, Kim Fabiano Marquart, Simran Asawa, Kjong Van-Lehmann, Andre Kahles, Tinu Thomas, Cornelia Schwerdel, Nicola Aceto, Gunnar Rätsch, Markus Stoffel, Gerald Schwank

eLife. 2023; 12: e80683. Published online 2023 Oct 12. doi: 10.7554/eLife.80683

PMCID:: PMC10629822

Abstract Article PDF–8.5M

Select item 77629982.

U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing

Namjeong Choi, Yongchao Liu, Jagyeong Oh, Jiyeon Ha, Xuexiu Zheng, Haihong Shen

Cells. 2020 Dec; 9(12): 2647. Published online 2020 Dec 9. doi: 10.3390/cells9122647

PMCID:: PMC7762998

Abstract Article PDF–4.5M

Select item 42662103.

Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts

Valeria Visconte, Ali Tabarroki, Li Zhang, Yvonne Parker, Edy Hasrouni, Reda Mahfouz, Kyoichi Isono, Haruhiko Koseki, Mikkael A Sekeres, Yogen Saunthararajah, John Barnard, Daniel Lindner, Heesun J Rogers, Ramon V Tiu

J Hematol Oncol. 2014; 7: 89. Published online 2014 Dec 7. doi: 10.1186/s13045-014-0089-x

PMCID:: PMC4266210

Abstract Article PDF–1.8M

Select item 94120074.

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

Atsushi Tanaka, Taizo A. Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P. Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C. Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue

Blood. 2022 Aug 25; 140(8): 875–888. doi: 10.1182/blood.2021015325

PMCID:: PMC9412007

Abstract Article

Select item 81885175.

Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization

Zhaoqi Liu, Akihide Yoshimi, Jiguang Wang, Hana Cho, Stanley Chun-Wei Lee, Michelle Ki, Lillian Bitner, Timothy Chu, Harshal Shah, Bo Liu, Anthony R. Mato, Peter Ruvolo, Giulia Fabbri, Laura Pasqualucci, Omar Abdel-Wahab, Raul Rabadan

Cancer Discov. Author manuscript; available in PMC 2021 Jun 9.

Published in final edited form as: Cancer Discov. 2020 Jun; 10(6): 806–821. Published online 2020 Mar 18. doi: 10.1158/2159-8290.CD-19-1330

PMCID:: PMC8188517

Abstract Article PDF–4.1M

Select item 34765366.

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes

Valeria Visconte, Heesun J. Rogers, Jarnail Singh, John Barnard, Manoj Bupathi, Fabiola Traina, James McMahon, Hideki Makishima, Hadrian Szpurka, Anna Jankowska, Andres Jerez, Mikkael A. Sekeres, Yogen Saunthararajah, Anjali S. Advani, Edward Copelan, Haruhiko Koseki, Kyoichi Isono, Richard A. Padgett, Sami Osman, Kazunori Koide, Christine O'Keefe, Jaroslaw P. Maciejewski, Ramon V. Tiu

Blood. 2012 Oct 18; 120(16): 3173–3186. Prepublished online 2012 Jul 23. doi: 10.1182/blood-2012-05-430876

PMCID:: PMC3476536

Abstract Article

Select item 63734727.

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

Stanley Chun-Wei Lee, Khrystyna North, Eunhee Kim, Eunjung Jang, Esther Obeng, Sydney X. Lu, Bo Liu, Daichi Inoue, Akihide Yoshimi, Michelle Ki, Mirae Yeo, Xiao Jing Zhang, Min Kyung Kim, Hana Cho, Young Rock Chung, Justin Taylor, Benjamin H. Durham, Young Joon Kim, Alessandro Pastore, Sebastien Monette, James Palacino, Michael Seiler, Silvia Buonamici, Peter G. Smith, Benjamin L. Ebert, Robert K. Bradley, Omar Abdel-Wahab

Cancer Cell. Author manuscript; available in PMC 2019 Aug 13.

Published in final edited form as: Cancer Cell. 2018 Aug 13; 34(2): 225–241.e8. doi: 10.1016/j.ccell.2018.07.003

PMCID:: PMC6373472

Abstract Article PDF–1.6M

Select item 63723568.

A murine model of chronic lymphocytic leukemia based on B cell-restricted expression of Sf3b1 mutation and Atm deletion

Shanye Yin, Rutendo G. Gambe, Jing Sun, Aina Zurita Martinez, Zachary J. Cartun, Fara Faye D. Regis, Youzhong Wan, Jean Fan, Angela N. Brooks, Sarah E.M. Herman, Elisa ten Hacken, Amaro Taylor-Weiner, Laura Z. Rassenti, Emanuela M. Ghia, Thomas J. Kipps, Esther A. Obeng, Carrie L. Cibulskis, Donna Neuberg, Dean R. Campagna, Mark D. Fleming, Benjamin L. Ebert, Adrian Wiestner, Ignaty Leshchiner, James A. DeCaprio, Gad Getz, Robin Reed, Ruben D. Carrasco, Catherine J. Wu, Lili Wang

Cancer Cell. Author manuscript; available in PMC 2019 Feb 12.

Published in final edited form as: Cancer Cell. 2019 Feb 11; 35(2): 283–296.e5. Published online 2019 Jan 31. doi: 10.1016/j.ccell.2018.12.013

PMCID:: PMC6372356

Abstract Article PDF–4.0M

Select item 53361929.

Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts

A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, A A Agrawal, F Iorio, R Bautista, S Pacharne, K Tzelepis, N Manes, P Wright, E Papaemmanuil, D G Kent, P C Campbell, S Buonamici, N Bolli, G S Vassiliou

Leukemia. 2017 Mar; 31(3): 720–727. Prepublished online 2016 Sep 8. Published online 2016 Oct 21. doi: 10.1038/leu.2016.251

PMCID:: PMC5336192

Abstract Article PDF–2.5M

Select item 502306910.

Physiologic expression of SF3B1^K700E causes impaired erythropoiesis, aberrant splicing, and sensitivity to pharmacologic spliceosome modulation

Esther A. Obeng, Ryan J. Chappell, Michael Seiler, Michelle C. Chen, Dean R. Campagna, Paul J. Schmidt, Rebekka K. Schneider, Allegra M. Lord, Lili Wang, Rutendo G. Gambe, Marie E. McConkey, Abdullah M. Ali, Azra Raza, Lihua Yu, Silvia Buonamici, Peter G. Smith, Ann Mullally, Catherine J. Wu, Mark D. Fleming, Benjamin L. Ebert

Cancer Cell. Author manuscript; available in PMC 2017 Sep 12.

Published in final edited form as: Cancer Cell. 2016 Sep 12; 30(3): 404–417. doi: 10.1016/j.ccell.2016.08.006

PMCID:: PMC5023069

Abstract Article PDF–2.1M

Select item 855957711.

Modulation of SF3B1 in the pre-mRNA spliceosome induces a RIG-I-dependent type I IFN response

Aaron Y. Chang, Yu Jerry Zhou, Sharanya Iyengar, Piotr W. Pobiarzyn, Pavel Tishchenko, Kesha M. Shah, Heather Wheeler, Yue-Ming Wang, Paula M. Loria, Frank Loganzo, Seng-Ryong Woo

J Biol Chem. 2021 Nov; 297(5): 101277. Published online 2021 Oct 5. doi: 10.1016/j.jbc.2021.101277

PMCID:: PMC8559577

Abstract Article PDF–2.4M

Select item 556938712.

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities

Daichi Inoue, Omar Abdel-Wahab

Cancer Cell. Author manuscript; available in PMC 2017 Aug 24.

Published in final edited form as: Cancer Cell. 2016 Sep 12; 30(3): 371–373. doi: 10.1016/j.ccell.2016.08.013

PMCID:: PMC5569387

Abstract Article PDF–482K

Select item 817706513.

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

Daichi Inoue, Jacob T. Polaski, Justin Taylor, Pau Castel, Sisi Chen, Susumu Kobayashi, Simon J. Hogg, Yasutaka Hayashi, Jose Mario Bello Pineda, Ettaib El Marabti, Caroline Erickson, Katherine Knorr, Miki Fukumoto, Hiromi Yamazaki, Atsushi Tanaka, Chie Fukui, Sydney X. Lu, Benjamin H. Durham, Bo Liu, Eric Wang, Sanjoy Mehta, Daniel Zakheim, Ralph Garippa, Alex Penson, Guo-Liang Chew, Frank McCormick, Robert K. Bradley, Omar Abdel-Wahab

Nat Genet. Author manuscript; available in PMC 2021 Oct 12.

Published in final edited form as: Nat Genet. 2021 May; 53(5): 707–718. Published online 2021 Apr 12. doi: 10.1038/s41588-021-00828-9

PMCID:: PMC8177065

Abstract Article PDF–2.6M

Select item 777337014.

Mutant SF3B1 promotes AKT- and NF-κB–driven mammary tumorigenesis

Bo Liu, Zhaoqi Liu, Sisi Chen, Michelle Ki, Caroline Erickson, Jorge S. Reis-Filho, Benjamin H. Durham, Qing Chang, Elisa de Stanchina, Yiwei Sun, Raul Rabadan, Omar Abdel-Wahab, Sarat Chandarlapaty

J Clin Invest. 2021 Jan 4; 131(1): e138315. Published online 2021 Jan 4. doi: 10.1172/JCI138315

PMCID:: PMC7773370

Abstract Article PDF–23M

Select item 478386915.

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease

Peter Mirtschink, Jaya Krishnan, Fiona Grimm, Alexandre Sarre, Manuel Hörl, Melis Kayikci, Niklaus Fankhauser, Yann Christinat, Cédric Cortijo, Owen Feehan, Ana Vukolic, Samuel Sossalla, Sebastian N. Stehr, Jernej Ule, Nicola Zamboni, Thierry Pedrazzini, Wilhelm Krek

Nature. Author manuscript; available in PMC 2016 Mar 9.

Published in final edited form as: Nature. 2015 Jun 25; 522(7557): 444–449. Published online 2015 Jun 17. doi: 10.1038/nature14508

PMCID:: PMC4783869

Abstract Article PDF–5.0M

Select item 879485016.

Disruption of MeCP2–TCF20 complex underlies distinct neurodevelopmental disorders

Jian Zhou, Hamdan Hamdan, Hari Krishna Yalamanchili, Kaifang Pang, Amy E. Pohodich, Joanna Lopez, Yingyao Shao, Juan A. Oses-Prieto, Lifang Li, Wonho Kim, Mark A. Durham, Sameer S. Bajikar, Donna J. Palmer, Philip Ng, Michelle L. Thompson, E. Martina Bebin, Amelie J. Müller, Alma Kuechler, Antje Kampmeier, Tobias B. Haack, Alma L. Burlingame, Zhandong Liu, Matthew N. Rasband, Huda Y. Zoghbi

Proc Natl Acad Sci U S A. 2022 Jan 25; 119(4): e2119078119. Published online 2022 Jan 24. doi: 10.1073/pnas.2119078119