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Select item 75647151.

Multivalent and Bidirectional Binding of Transcriptional Transactivation Domains to the MED25 Coactivator

Heather M. Jeffery, Robert O. J. Weinzierl

Biomolecules. 2020 Sep; 10(9): 1205. Published online 2020 Aug 19. doi: 10.3390/biom10091205

PMCID:: PMC7564715

Abstract Article PDF–5.6M

Select item 45388352.

Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25

Isabelle Landrieu, Alexis Verger, Jean-Luc Baert, Prakash Rucktooa, François-Xavier Cantrelle, Frédérique Dewitte, Elisabeth Ferreira, Zoé Lens, Vincent Villeret, Didier Monté

Nucleic Acids Res. 2015 Aug 18; 43(14): 7110–7121. Published online 2015 Jun 29. doi: 10.1093/nar/gkv650

PMCID:: PMC4538835

Abstract Article PDF–4.4M

Select item 36094123.

Solution NMR structure of MED25(391–543) comprising the activator-interacting domain (ACID) of human mediator subunit 25

A. Eletsky, T. Szyperski, A. Eletsky, T. Szyperski, W.T Ruyechan, W.T Ruyechan, R. Xiao, T.B Acton, G.T Montelione, R. Xiao, T.B Acton, G.T Montelione, R. Xiao, T.B Acton, G.T Montelione

J Struct Funct Genomics. Author manuscript; available in PMC 2013 Mar 27.

Published in final edited form as: J Struct Funct Genomics. 2011 Sep; 12(3): 159–166. Published online 2011 Jul 23. doi: 10.1007/s10969-011-9115-1

PMCID:: PMC3609412

Abstract Article PDF–783K

Select item 30766744.

Structure of the VP16 Transactivator Target in ARC/Mediator

Alexander G. Milbradt, Madhura Kulkarni, Tingfang Yi, Koh Takeuchi, Zhen-Yu J. Sun, Rafael E. Luna, Philipp Selenko, Anders M. Näär, Gerhard Wagner

Nat Struct Mol Biol. Author manuscript; available in PMC 2011 Oct 1.

Published in final edited form as: Nat Struct Mol Biol. 2011 Apr; 18(4): 410–415. Published online 2011 Mar 6. doi: 10.1038/nsmb.1999

PMCID:: PMC3076674

Abstract Article PDF–1006K

Select item 30286165.

Med25 Is Required for RNA Polymerase II Recruitment to Specific Promoters, Thus Regulating Xenobiotic and Lipid Metabolism in Human Liver

Ritu Rana, Sailesh Surapureddi, WayneKid Kam, Stephen Ferguson, Joyce A. Goldstein

Mol Cell Biol. 2011 Feb; 31(3): 466–481. Published online 2010 Dec 6. doi: 10.1128/MCB.00847-10

PMCID:: PMC3028616

Abstract Article PDF–3.0M

Select item 12349266.

A Second Locus for an Axonal Form of Autosomal Recessive Charcot-Marie-Tooth Disease Maps to Chromosome 19q13.3

Alejandro Leal, Bernal Morera, Gerardo Del Valle, Dieter Heuss, Corinna Kayser, Martin Berghoff, Ramón Villegas, Erick Hernández, María Méndez, Hans Christian Hennies, Bernhard Neundörfer, Ramiro Barrantes, André Reis, Bernd Rautenstrauss

Am J Hum Genet. 2001 Jan; 68(1): 269–274. Published online 2000 Dec 7. doi: 10.1086/316934

PMCID:: PMC1234926

Abstract Article PDF–201K

Select item 95552027.

An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25

Tessa Van Royen, Koen Sedeyn, George D. Moschonas, Wendy Toussaint, Marnik Vuylsteke, Delphi Van Haver, Francis Impens, Sven Eyckerman, Irma Lemmens, Jan Tavernier, Bert Schepens, Xavier Saelens

J Virol. 2022 Oct; 96(19): e01297-22. Published online 2022 Sep 14. doi: 10.1128/jvi.01297-22

PMCID:: PMC9555202

Abstract Article PDF–2.8M

Select item 37648228.

Role for Human Mediator Subunit MED25 in Recruitment of Mediator to Promoters by Endoplasmic Reticulum Stress-responsive Transcription Factor ATF6α

Dotan Sela, Juliana J. Conkright, Lu Chen, Joshua Gilmore, Michael P. Washburn, Laurence Florens, Ronald C. Conaway, Joan Weliky Conaway

J Biol Chem. 2013 Sep 6; 288(36): 26179–26187. Published online 2013 Jul 17. doi: 10.1074/jbc.M113.496968

PMCID:: PMC3764822

Abstract Article PDF–1.1M

Select item 56321389.

ETV4 and AP1 transcription factors form multivalent interactions with three sites on the MED25 activator-interacting domain

Simon L. Currie, Jedediah J. Doane, Kathryn S. Evans, Niraja Bhachech, Bethany J. Madison, Desmond K. W. Lau, Lawrence P. McIntosh, Jack J. Skalicky, Kathleen A. Clark, Barbara J. Graves

J Mol Biol. Author manuscript; available in PMC 2018 Oct 13.

Published in final edited form as: J Mol Biol. 2017 Oct 13; 429(20): 2975–2995. Published online 2017 Jul 17. doi: 10.1016/j.jmb.2017.06.024

PMCID:: PMC5632138

Abstract Article PDF–3.3M

Select item 403859010.

Interaction Studies of the Human and Arabidopsis thaliana Med25-ACID Proteins with the Herpes Simplex Virus VP16- and Plant-Specific Dreb2a Transcription Factors

Ximena Aguilar, Jeanette Blomberg, Kristoffer Brännström, Anders Olofsson, Jürgen Schleucher, Stefan Björklund

PLoS One. 2014; 9(5): e98575. Published online 2014 May 29. doi: 10.1371/journal.pone.0098575

PMCID:: PMC4038590

Abstract Article PDF–2.6M

Select item 340145011.

Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes

Jeanette Blomberg, Ximena Aguilar, Kristoffer Brännström, Linn Rautio, Anders Olofsson, Pernilla Wittung-Stafshede, Stefan Björklund

Nucleic Acids Res. 2012 Jul; 40(13): 5938–5950. Published online 2012 Mar 24. doi: 10.1093/nar/gks265

PMCID:: PMC3401450

Abstract Article PDF–2.8M

Select item 429288812.

Med25 is Required for Estrogen Receptor alpha (ERα)-mediated Regulation of Human CYP2C9 Expression

Zhe Shi, Wenjun Yang, Joyce A. Goldstein, Shu-Yun Zhang

Biochem Pharmacol. Author manuscript; available in PMC 2015 Jan 13.

Published in final edited form as: Biochem Pharmacol. 2014 Aug 15; 90(4): 425–431. Published online 2014 Jun 21. doi: 10.1016/j.bcp.2014.06.016

PMCID:: PMC4292888

Abstract Article PDF–3.0M

Select item 343137313.

MED25 Is a Mediator Component of HNF4α-Driven Transcription Leading to Insulin Secretion in Pancreatic Beta-Cells

Eun Hee Han, Geun Bae Rha, Young-In Chi

PLoS One. 2012; 7(8): e44007. Published online 2012 Aug 30. doi: 10.1371/journal.pone.0044007

PMCID:: PMC3431373

Abstract Article PDF–545K

Select item 284715114.

Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models

Alejandro Leal, Kathrin Huehne, Finn Bauer, Heinrich Sticht, Philipp Berger, Ueli Suter, Bernal Morera, Gerardo Del Valle, James R. Lupski, Arif Ekici, Francesca Pasutto, Sabine Endele, Ramiro Barrantes, Corinna Berghoff, Martin Berghoff, Bernhard Neundörfer, Dieter Heuss, Thomas Dorn, Peter Young, Lisa Santolin, Thomas Uhlmann, Michael Meisterernst, Michael Sereda, Gerd Meyer zu Horste, Klaus-Armin Nave, André Reis, Bernd Rautenstrauss

Neurogenetics. 2009 Oct; 10(4): 275–287. Published online 2009 Mar 17. doi: 10.1007/s10048-009-0183-3

Correction in:: Neurogenetics. 2009 Oct; 10(4): 375–376.

PMCID:: PMC2847151

Abstract Article PDF–558K

Select item 35695215.

The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator

Fajun Yang, Rosalie DeBeaumont, Sharleen Zhou, Anders M. Näär

Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8): 2339–2344. Published online 2004 Feb 12. doi: 10.1073/pnas.0308676100

PMCID:: PMC356952

Abstract Article PDF–597K

Select item 430367716.

Epigenetic Modification of Histone 3 Lysine 27: MEDIATOR SUBUNIT MED25 IS REQUIRED FOR THE DISSOCIATION OF POLYCOMB REPRESSIVE COMPLEX 2 FROM THE PROMOTER OF CYTOCHROME P450 2C9

Neal A. Englert, George Luo, Joyce A. Goldstein, Sailesh Surapureddi

J Biol Chem. 2015 Jan 23; 290(4): 2264–2278. Published online 2014 Nov 12. doi: 10.1074/jbc.M114.579474

PMCID:: PMC4303677

Abstract Article PDF–2.3M

Select item 404094517.

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

Yukio Nakamura, Koji Yamamoto, Xinjun He, Bungo Otsuki, Youngwoo Kim, Hiroki Murao, Tsunemitsu Soeda, Noriyuki Tsumaki, Jian Min Deng, Zhaoping Zhang, Richard R. Behringer, Benoit de Crombrugghe, John H. Postlethwait, Matthew L. Warman, Takashi Nakamura, Haruhiko Akiyama

Nat Commun. Author manuscript; available in PMC 2014 Jun 2.

Published in final edited form as: Nat Commun. 2011; 2: 251. doi: 10.1038/ncomms1242