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Select item 111600211.

Production and characterization of highly tumor‐specific rat monoclonal antibodies recognizing the extracellular domain of human l‐type amino‐acid transporter 1

Yoshiya Ohno, Kentaro Suda, Kazue Masuko, Hideki Yagi, Yoshiyuki Hashimoto, Takashi Masuko

Cancer Sci. 2008 May; 99(5): 1000–1007. Published online 2008 Feb 24. doi: 10.1111/j.1349-7006.2008.00770.x

PMCID:: PMC11160021

Abstract Article PDF–954K

Select item 99169022.

Association of High LAT1 Expression with Poor Prognosis and Recurrence in Colorectal Cancer Patients Treated with Oxaliplatin-Based Adjuvant Chemotherapy

Yuta Shibasaki, Takehiko Yokobori, Makoto Sohda, Ikuma Shioi, Naoya Ozawa, Chika Komine, Kunihiko Suga, Nobuhiro Nakazawa, Katsuya Osone, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Hiroomi Ogawa, Kyoichi Kaira, Ken Shirabe, Hiroshi Saeki

Int J Mol Sci. 2023 Feb; 24(3): 2604. Published online 2023 Jan 30. doi: 10.3390/ijms24032604

PMCID:: PMC9916902

Abstract Article PDF–1.9M

Select item 98553233.

Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy

Tsubasa Watanabe, Yu Sanada, Yoshihide Hattori, Minoru Suzuki

J Radiat Res. 2023 Jan; 64(1): 91–98. Published online 2022 Nov 14. doi: 10.1093/jrr/rrac077

PMCID:: PMC9855323

Abstract Article PDF–1.1M

Select item 98491484.

CD98 defines a metabolically flexible, proinflammatory subset of low‐density neutrophils in systemic lupus erythematosus

Katherine R. Martin, Jessica A. Day, Jacinta A. Hansen, Damian B. D'Silva, Huon L. Wong, Alexandra Garnham, Jarrod J. Sandow, Brunda Nijagal, Nicholas Wilson, Ian P. Wicks

Clin Transl Med. 2023 Jan; 13(1): e1150. Published online 2023 Jan 18. doi: 10.1002/ctm2.1150

PMCID:: PMC9849148

Abstract Article PDF–3.1M

Select item 89310685.

Vitamin D stimulates placental L-type amino acid transporter 1 (LAT1) in preeclampsia

Xiaotong Jia, Yang Cao, Lingyu Ye, Xueqing Liu, Yujia Huang, Xiaolei Yuan, Chunmei Lu, Jie Xu, Hui Zhu

Sci Rep. 2022; 12: 4651. Published online 2022 Mar 17. doi: 10.1038/s41598-022-08641-y

PMCID:: PMC8931068

Abstract Article PDF–5.4M

Select item 88546436.

Association of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer

Sasagu Kurozumi, Kyoichi Kaira, Hiroshi Matsumoto, Masafumi Kurosumi, Takehiko Yokobori, Yoshikatsu Kanai, Chikako Sekine, Chikako Honda, Ayaka Katayama, Mio Furuya, Sho Shiino, Takaya Makiguchi, Nigel P. Mongan, Emad A. Rakha, Tetsunari Oyama, Takaaki Fujii, Ken Shirabe, Jun Horiguchi

Sci Rep. 2022; 12: 2742. Published online 2022 Feb 17. doi: 10.1038/s41598-022-06615-8

PMCID:: PMC8854643

Abstract Article PDF–1.6M

Select item 88534867.

Management precautions for risk of obesity are necessary among infants with PKU carrying the rs113883650 variant of the LAT1 gene: A cross-sectional study

Miroslaw Bik-Multanowski, Bozena Didycz, Kinga Bik-Multanowska

PLoS One. 2022; 17(2): e0264084. Published online 2022 Feb 17. doi: 10.1371/journal.pone.0264084

PMCID:: PMC8853486

Abstract Article PDF–1.0M

Select item 86114048.

SLC7A5 is linked to increased expression of genes related to proliferation and hypoxia in estrogen-receptor-positive breast cancer

Rasmus Törnroos, Elisabet Tina, Anna Göthlin Eremo

Oncol Rep. 2022 Jan; 47(1): 17. Published online 2021 Nov 16. doi: 10.3892/or.2021.8228

PMCID:: PMC8611404

Abstract Article PDF–807K

Select item 85690199.

Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma

Narangerel Jigjidkhorloo, Kohsuke Kanekura, Jun Matsubayashi, Daigo Akahane, Koji Fujita, Keiki Oikawa, Atsushi Kurata, Masakatsu Takanashi, Hitoshi Endou, Toshitaka Nagao, Akihiko Gotoh, Oyundelger Norov, Masahiko Kuroda

Sci Rep. 2021; 11: 21638. Published online 2021 Nov 4. doi: 10.1038/s41598-021-00811-8

PMCID:: PMC8569019

Abstract Article PDF–4.7M

Select item 853756310.

L-Type Amino Acid Transporter 1 Regulates Cancer Stemness and the Expression of Programmed Cell Death 1 Ligand 1 in Lung Cancer Cells

Yi-Heng Liu, Yu-Ling Li, Huan-Ting Shen, Peng-Ju Chien, Gwo-Tarng Sheu, Bing-Yen Wang, Wen-Wei Chang

Int J Mol Sci. 2021 Oct; 22(20): 10955. Published online 2021 Oct 11. doi: 10.3390/ijms222010955

PMCID:: PMC8537563

Abstract Article PDF–3.3M

Select item 770270311.

Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation

Lili Quan, Ryuichi Ohgaki, Saori Hara, Suguru Okuda, Ling Wei, Hiroki Okanishi, Shushi Nagamori, Hitoshi Endou, Yoshikatsu Kanai

J Exp Clin Cancer Res. 2020; 39: 266. Published online 2020 Nov 30. doi: 10.1186/s13046-020-01762-0

PMCID:: PMC7702703

Abstract Article PDF–7.0M

Select item 754186312.

LAT1 (SLC7A5) Overexpression in Negative Her2 Group of Breast Cancer: A Potential Therapy Target

Khaldon Bodoor, Rowida Almomani, Mohammad Alqudah, Yazan Haddad, Walaa Samouri

Asian Pac J Cancer Prev. 2020 May; 21(5): 1453–1458. doi: 10.31557/APJCP.2020.21.5.1453

PMCID:: PMC7541863

Abstract Article PDF–1.3M

Select item 745737013.

Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes

Jing Xu, Congshan Jiang, Yongsong Cai, Yuanxu Guo, Xipeng Wang, Jiaxiang Zhang, Jiawen Xu, Ke Xu, Wenhua Zhu, Si Wang, Fujun Zhang, Manman Geng, Yan Han, Qilan Ning, Peng Xu, Liesu Meng, Shemin Lu

Arthritis Res Ther. 2020; 22: 200. Published online 2020 Aug 31. doi: 10.1186/s13075-020-02296-8

PMCID:: PMC7457370

Abstract Article PDF–1.9M

Select item 725977114.

Prognostic value of LAT-1 status in solid cancer: A systematic review and meta-analysis

Jing-jing Lu, Ping Li, Yong Yang, Le Wang, Yan Zhang, Jia-yao Zhu, Xiao-ren Zhu, Min-bin Chen

PLoS One. 2020; 15(5): e0233629. Published online 2020 May 29. doi: 10.1371/journal.pone.0233629

PMCID:: PMC7259771

Abstract Article PDF–1016K

Select item 724447115.

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

Magdalena Markowicz-Piasecka, Johanna Huttunen, Ahmed Montaser, Kristiina M. Huttunen

Apoptosis. 2020; 25(5): 426–440. Published online 2020 May 13. doi: 10.1007/s10495-020-01603-7

PMCID:: PMC7244471

Abstract Article PDF–2.1M

Select item 698713916.

Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma

Maihulan Maimaiti, Shinichi Sakamoto, Yasutaka Yamada, Masahiro Sugiura, Junryo Rii, Nobuyoshi Takeuchi, Yusuke Imamura, Tomomi Furihata, Keisuke Ando, Kosuke Higuchi, Minhui Xu, Tomokazu Sazuka, Kazuyoshi Nakamura, Atsushi Kaneda, Yoshikatsu Kanai, Natasha Kyprianou, Yuzuru Ikehara, Naohiko Anzai, Tomohiko Ichikawa

Sci Rep. 2020; 10: 1292. Published online 2020 Jan 28. doi: 10.1038/s41598-020-58136-x

PMCID:: PMC6987139

Abstract Article PDF–2.3M

Select item 686814317.

Characterization of the expression of LAT1 as a prognostic indicator and a therapeutic target in renal cell carcinoma

Kosuke Higuchi, Shinichi Sakamoto, Keisuke Ando, Maihulan Maimaiti, Nobushige Takeshita, Kentaro Okunushi, Yoshie Reien, Yusuke Imamura, Tomokazu Sazuka, Kazuyoshi Nakamura, Jun Matsushima, Tomomi Furihata, Yuzuru Ikehara, Tomohiko Ichikawa, Naohiko Anzai

Sci Rep. 2019; 9: 16776. Published online 2019 Nov 20. doi: 10.1038/s41598-019-53397-7

PMCID:: PMC6868143

Abstract Article PDF–3.7M

Select item 680369818.

Rigorous sampling of docking poses unveils binding hypothesis for the halogenated ligands of L-type Amino acid Transporter 1 (LAT1)

Natesh Singh, Bruno O. Villoutreix, Gerhard F. Ecker

Sci Rep. 2019; 9: 15061. Published online 2019 Oct 21. doi: 10.1038/s41598-019-51455-8

PMCID:: PMC6803698

Abstract Article PDF–3.9M

Select item 643366019.

Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma

Yann Cormerais, Marina Pagnuzzi‐Boncompagni, Sandra Schrötter, Sandy Giuliano, Eric Tambutté, Hitoshi Endou, Michael F. Wempe, Gilles Pagès, Jacques Pouysségur, Vincent Picco

J Cell Mol Med. 2019 Apr; 23(4): 2711–2718. Published online 2019 Feb 19. doi: 10.1111/jcmm.14176