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Select item 107049861.

pH-sensing G protein-coupled orphan receptor GPR68 is expressed in human cartilage and correlates with degradation of extracellular matrix during OA progression

Nazir M. Khan, Martha E. Diaz-Hernandez, William N. Martin, Bhakti Patel, Samir Chihab, Hicham Drissi

PeerJ. 2023; 11: e16553. Published online 2023 Dec 5. doi: 10.7717/peerj.16553

PMCID:: PMC10704986

Abstract Article PDF–14M

Select item 88359662.

pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis

Cheryl de Vallière, Jesus Cosin-Roger, Katharina Baebler, Anja Schoepflin, Céline Mamie, Michelle Mollet, Cordelia Schuler, Susan Bengs, Silvia Lang, Michael Scharl, Klaus Seuwen, Pedro A. Ruiz, Martin Hausmann, Gerhard Rogler

Int J Mol Sci. 2022 Feb; 23(3): 1419. Published online 2022 Jan 26. doi: 10.3390/ijms23031419

PMCID:: PMC8835966

Abstract Article PDF–81M

Select item 58927293.

GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells

Shu Z. Wiley, Krishna Sriram, Wenjing Liang, Sarah E. Chang, Randall French, Thalia McCann, Jason Sicklick, Hiroshi Nishihara, Andrew M. Lowy, Paul A. Insel

FASEB J. 2018 Mar; 32(3): 1170–1183. Published online 2018 Jan 5. doi: 10.1096/fj.201700834R

PMCID:: PMC5892729

Abstract Article

Select item 58884004.

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines

Tonio Pera, Deepak A. Deshpande, Michael Ippolito, Bin Wang, Adelina Gavrila, James V. Michael, Ajay P. Nayak, Eric Tompkins, Eleni Farrell, Wesley K. Kroeze, Bryan L. Roth, Reynold A. Panettieri, Jr., Jeffrey L. Benovic, Steven S. An, Nickolai O. Dulin, Raymond B. Penn

FASEB J. 2018 Feb; 32(2): 862–874. Published online 2017 Oct 17. doi: 10.1096/fj.201700555R

PMCID:: PMC5888400

Abstract Article

Select item 34174235.

The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH

H Saxena, DA Deshpande, BC Tiegs, H Yan, RJ Battafarano, WM Burrows, G Damera, RA Panettieri, TD DuBose Jr, SS An, RB Penn

Br J Pharmacol. 2012 Jun; 166(3): 981–990. doi: 10.1111/j.1476-5381.2011.01807.x

PMCID:: PMC3417423

Abstract Article PDF–1.3M

Select item 107174416.

The roles of acid-sensing ion channel 1a and ovarian cancer G protein-coupled receptor 1 on passive Mg²⁺ transport across intestinal epithelium-like Caco-2 monolayers

Narongrit Thongon, Pattamaporn Ketkeaw, Chanin Nuekchob

J Physiol Sci. 2014 Mar; 64(2): 129–139. Published online 2013 Dec 28. doi: 10.1007/s12576-013-0301-8

PMCID:: PMC10717441

Abstract Article PDF–1.2M

Select item 76786727.

GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia

Tao Wang, Guokun Zhou, Mindi He, Yuanyuan Xu, W.G. Rusyniak, Yan Xu, Yonghua Ji, Roger P. Simon, Zhi-Gang Xiong, Xiang-ming Zha

Stroke. 2020 Dec; 51(12): 3690–3700. Published online 2020 Oct 16. doi: 10.1161/STROKEAHA.120.031479

PMCID:: PMC7678672

Abstract Article PDF–8.9M

Select item 59516158.

GPR68 senses flow and is essential for vascular physiology

Jie Xu, Jayanti Mathur, Emilie Vessières, Scott Hammack, Keiko Nonomura, Julie Favre, Linda Grimaud, Matt Petrus, Allain Francisco, Jingyuan Li, Van Lee, Fu-li Xiang, James K. Mainquist, Stuart M. Cahalan, Anthony P. Orth, John R. Walker, Shang Ma, Viktor Lukacs, Laura Bordone, Michael Bandell, Bryan Laffitte, Yan Xu, Shu Chien, Daniel Henrion, Ardem Patapoutian

Cell. Author manuscript; available in PMC 2019 Apr 19.

Published in final edited form as: Cell. 2018 Apr 19; 173(3): 762–775.e16. doi: 10.1016/j.cell.2018.03.076

PMCID:: PMC5951615

Abstract Article PDF–1.4M

Select item 55561679.

Functional expression of calcium‐permeable canonical transient receptor potential 4‐containing channels promotes migration of medulloblastoma cells

Wei‐Chun Wei, Wan‐Chen Huang, Yu‐Ping Lin, Esther B. E. Becker, Olaf Ansorge, Veit Flockerzi, Daniele Conti, Giovanna Cenacchi, Maike D. Glitsch

J Physiol. 2017 Aug 15; 595(16): 5525–5544. Published online 2017 Jul 20. doi: 10.1113/JP274659

PMCID:: PMC5556167

Abstract Article PDF–896K

Select item 506568410.

Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta

David A. Parry, Claire E.L. Smith, Walid El-Sayed, James A. Poulter, Roger C. Shore, Clare V. Logan, Chihiro Mogi, Koichi Sato, Fumikazu Okajima, Akihiro Harada, Hong Zhang, Mine Koruyucu, Figen Seymen, Jan C.-C. Hu, James P. Simmer, Mushtaq Ahmed, Hussain Jafri, Colin A. Johnson, Chris F. Inglehearn, Alan J. Mighell

Am J Hum Genet. 2016 Oct 6; 99(4): 984–990. Published online 2016 Sep 29. doi: 10.1016/j.ajhg.2016.08.020

PMCID:: PMC5065684

Abstract Article PDF–1.1M

Select item 486315111.

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells

Vikash Chandra, Angeliki Karamitri, Paul Richards, Françoise Cormier, Cyrille Ramond, Ralf Jockers, Mathieu Armanet, Olivier Albagli-Curiel, Raphael Scharfmann

Sci Rep. 2016; 6: 25765. Published online 2016 May 11. doi: 10.1038/srep25765

PMCID:: PMC4863151

Abstract Article PDF–1.4M

Select item 480715912.

Proton-sensing GPCR-YAP Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells

Hongyi Zhu, Shangchun Guo, Yuelei Zhang, Junhui Yin, Wenjing Yin, Shicong Tao, Yang Wang, Changqing Zhang

Int J Biol Sci. 2016; 12(4): 389–396. Published online 2016 Feb 5. doi: 10.7150/ijbs.13688

PMCID:: PMC4807159

Abstract Article PDF–2.6M

Select item 794842613.

The evolution and mechanism of GPCR proton sensing

Jacob B. Rowe, Nicholas J. Kapolka, Geoffrey J. Taghon, William M. Morgan, Daniel G. Isom

J Biol Chem. 2021 Jan-Jun; 296: 100167. Published online 2020 Dec 13. doi: 10.1074/jbc.RA120.016352

PMCID:: PMC7948426

Abstract Article PDF–4.1M

Select item 479694614.

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

Xi-Ping Huang, Joel Karpiak, Wesley K. Kroeze, Hu Zhu, Xin Chen, Sheryl S. Moy, Kara A. Saddoris, Viktoriya Nikolova, Martilias S. Farrell, Sheng Wang, Thomas J. Mangano, Deepak A. Deshpande, Alice Jiang, Raymond B. Penn, Jian Jin, Beverly H. Koller, Terry Kenakin, Brian K. Shoichet, Bryan L. Roth

Nature. Author manuscript; available in PMC 2016 Nov 26.

Published in final edited form as: Nature. 2015 Nov 26; 527(7579): 477–483. Published online 2015 Nov 9. doi: 10.1038/nature15699

PMCID:: PMC4796946

Abstract Article PDF–2.2M

Select item 455378315.

Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca²⁺ and H⁺

Wei-Chun Wei, Benjamin Jacobs, Esther B. E. Becker, Maike D. Glitsch

Proc Natl Acad Sci U S A. 2015 Aug 25; 112(34): 10738–10743. Published online 2015 Aug 10. doi: 10.1073/pnas.1506085112

PMCID:: PMC4553783

Abstract Article PDF–1.2M

Select item 750125316.

Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors

Wybke Klatt, Susanne Wallner, Christoph Brochhausen, Judith A. Stolwijk, Stephan Schreml

Sci Rep. 2020; 10: 15327. Published online 2020 Sep 18. doi: 10.1038/s41598-020-71700-9

PMCID:: PMC7501253

Abstract Article PDF–4.1M

Select item 729408917.

CRISPR-addressable yeast strains with applications in human G protein–coupled receptor profiling and synthetic biology

Jacob B. Rowe, Geoffrey J. Taghon, Nicholas J. Kapolka, William M. Morgan, Daniel G. Isom

J Biol Chem. 2020 Jun 12; 295(24): 8262–8271. Published online 2020 May 1. doi: 10.1074/jbc.RA120.013066

PMCID:: PMC7294089

Abstract Article PDF–2.8M

Select item 54508918.

Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells

Caius G. Radu, Amar Nijagal, Jami McLaughlin, Li Wang, Owen N. Witte

Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5): 1632–1637. Published online 2005 Jan 21. doi: 10.1073/pnas.0409415102

PMCID:: PMC545089

Abstract Article PDF–631K

Select item 464794119.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012