PMC Links for Gene (Select 8036) - PMC

Rita Sulahian, Jason J. Kwon, Katherine H. Walsh, Emma Pailler, Timothy L. Bosse, Maneesha Thaker, Diego Almanza, Joshua M. Dempster, Joshua Pan, Federica Piccioni, Nancy Dumont, Alfredo Gonzalez, Jonathan Rennhack, Behnam Nabet, John A. Bachman, Amy Goodale, Yenarae Lee, Mukta Bagul, Rosy Liao, Adrija Navarro, Tina L. Yuan, Raymond W.S. Ng, Srivatsan Raghavan, Nathanael S. Gray, Aviad Tsherniak, Francisca Vazquez, David E. Root, Ari J. Firestone, Jeff Settleman, William C. Hahn, Andrew J. Aguirre

Cell Rep. Author manuscript; available in PMC 2019 Dec 18.

Published in final edited form as: Cell Rep. 2019 Oct 1; 29(1): 118–134.e8. doi: 10.1016/j.celrep.2019.08.090

PMCID:: PMC6918830

Abstract Article PDF–2.4M

Select item 66131454.

SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics

Isabel Boned del Río, Lucy C. Young, Sibel Sari, Greg G. Jones, Benjamin Ringham-Terry, Nicole Hartig, Ewa Rejnowicz, Winnie Lei, Amandeep Bhamra, Silvia Surinova, Pablo Rodriguez-Viciana

Proc Natl Acad Sci U S A. 2019 Jul 2; 116(27): 13330–13339. Published online 2019 Jun 18. doi: 10.1073/pnas.1902658116

PMCID:: PMC6613145

Abstract Article PDF–1.9M

Select item 62467695.

Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol

Huang Xiao-pei, Chen Ji-kuai, Wei Xue, Yi-Fan Dong, Lang Yan, Zhang Xiao-fang, Pan Ya-min, Chang Wen-jun, Zhu Jiang-bo

Biosci Rep. 2018 Dec 21; 38(6): BSR20181233. Prepublished online 2018 Oct 17. Published online 2018 Nov 21. doi: 10.1042/BSR20181233

Correction in:: Biosci Rep. 2021 Apr 30; 41(4): BSR-20181233_COR.

PMCID:: PMC6246769

Abstract Article PDF–922K

Select item 49733166.

Sur8 mediates tumorigenesis and metastasis in colorectal cancer

Young-Mi Lee, Saluja Kaduwal, Kug Hwa Lee, Jong-Chan Park, Woo-Jeong Jeong, Kang-Yell Choi

Exp Mol Med. 2016 Jul; 48(7): e249. Published online 2016 Jul 29. doi: 10.1038/emm.2016.58

PMCID:: PMC4973316

Abstract Article PDF–2.7M

Select item 42314157.

Clinical Heterogeneity in two patients with Noonan-like Syndrome associated with the same SHOC2 mutation

Donatella Capalbo, Maria Giuseppa Scala, Daniela Melis, Giorgia Minopoli, Nicola Improda, Loredana Palamaro, Claudio Pignata, Mariacarolina Salerno

Ital J Pediatr. 2012; 38: 48. Published online 2012 Sep 20. doi: 10.1186/1824-7288-38-48

PMCID:: PMC4231415

Abstract Article PDF–946K

Select item 40319278.

Rare copy number variations containing genes involved in RASopathies: deletion of SHOC2 and duplication of PTPN11

Jin-Lan Chen, Xin Zhu, Tian-Li Zhao, Jian Wang, Yi-Feng Yang, Zhi-Ping Tan

Mol Cytogenet. 2014; 7: 28. Published online 2014 Apr 16. doi: 10.1186/1755-8166-7-28

PMCID:: PMC4031927

Abstract Article PDF–1.2M

Select item 33514329.

Shoc2 Is Targeted to Late Endosomes and Required for Erk1/2 Activation in EGF-Stimulated Cells

Emilia Galperin, Lina Abdelmoti, Alexander Sorkin

PLoS One. 2012; 7(5): e36469. Published online 2012 May 14. doi: 10.1371/journal.pone.0036469

PMCID:: PMC3351432

Abstract Article PDF–2.9M

Select item 284422510.

The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf

Rie Matsunaga-Udagawa, Yoshihisa Fujita, Sayaka Yoshiki, Kenta Terai, Yuji Kamioka, Etsuko Kiyokawa, Katsuyuki Yugi, Kazuhiro Aoki, Michiyuki Matsuda

J Biol Chem. 2010 Mar 5; 285(10): 7818–7826. Published online 2010 Jan 5. doi: 10.1074/jbc.M109.053975

PMCID:: PMC2844225

Abstract Article PDF–2.8M

Select item 945230111.

Structural basis for SHOC2 modulation of RAS signalling

Nicholas P. D. Liau, Matthew C. Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M. Bruning, Timothy J. Wendorff, Wilson Phung, Sarah G. Hymowitz, Jawahar Sudhamsu

Nature. 2022; 609(7926): 400–407. Published online 2022 Jun 29. doi: 10.1038/s41586-022-04838-3

PMCID:: PMC9452301

Abstract Article PDF–21M

Select item 940224012.

Expanding the molecular spectrum of pathogenic SHOC2 variants underlying Mazzanti syndrome

Marialetizia Motta, Maja Solman, Adeline A Bonnard, Alma Kuechler, Francesca Pantaleoni, Manuela Priolo, Balasubramanian Chandramouli, Simona Coppola, Simone Pizzi, Erika Zara, Marco Ferilli, Hülya Kayserili, Roberta Onesimo, Chiara Leoni, Julia Brinkmann, Yoann Vial, Susanne B Kamphausen, Cécile Thomas-Teinturier, Anne Guimier, Viviana Cordeddu, Laura Mazzanti, Giuseppe Zampino, Giovanni Chillemi, Martin Zenker, Hélène Cavé, Jeroen den Hertog, Marco Tartaglia

Hum Mol Genet. 2022 Aug 15; 31(16): 2766–2778. Published online 2022 Mar 26. doi: 10.1093/hmg/ddac071

PMCID:: PMC9402240

Abstract Article PDF–1.2M

Select item 795899313.

The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease

HyeIn Jang, Payton Stevens, Tianyan Gao, Emilia Galperin

FEBS J. Author manuscript; available in PMC 2021 Mar 15.

Published in final edited form as: FEBS J. 2021 Feb; 288(3): 721–739. Published online 2020 Jul 6. doi: 10.1111/febs.15450

PMCID:: PMC7958993

Abstract Article PDF–1.1M

Select item 672775914.

VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology

HyeIn Jang, Eun Ryoung Jang, Patricia G. Wilson, Daniel Anderson, Emilia Galperin

Mol Biol Cell. 2019 Jul 1; 30(14): 1655–1663. doi: 10.1091/mbc.E19-03-0144

PMCID:: PMC6727759

Abstract Article PDF–1.3M

Select item 426773115.

Shoc2/Sur8 Protein Regulates Neurite Outgrowth

Gonzalo Leon, Lucia Sanchez-Ruiloba, Andrea Perez-Rodriguez, Teresa Gragera, Natalia Martinez, Silvia Hernandez, Berta Anta, Olga Calero, Carlota A. Garcia-Dominguez, Lara M. Dura, Daniel Peña-Jimenez, Judit Castro, Natasha Zarich, Pilar Sanchez-Gomez, Miguel Calero, Teresa Iglesias, Jose L. Oliva, Jose M. Rojas

PLoS One. 2014; 9(12): e114837. Published online 2014 Dec 16. doi: 10.1371/journal.pone.0114837

PMCID:: PMC4267731

Abstract Article PDF–1.1M

Select item 283696016.

Ras and Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein

Sayaka Yoshiki, Rie Matsunaga-Udagawa, Kazuhiro Aoki, Yuji Kamioka, Etsuko Kiyokawa, Michiyuki Matsuda

Mol Biol Cell. 2010 Mar 15; 21(6): 1088–1096. doi: 10.1091/mbc.E09-06-0455

PMCID:: PMC2836960

Abstract Article PDF–2.0M

Select item 1082615717.

circCPA4 induces malignant behaviors of prostate cancer via miR-491-5p/SHOC2 feedback loop

Wenqing Xu, Zhihong Zhong, Long Gu, Yiming Xiao, BinShen Chen, Weilie Hu

Clinics (Sao Paulo) 2024 Jan-Dec; 79: 100314. Published online 2024 Jan 13. doi: 10.1016/j.clinsp.2023.100314

PMCID:: PMC10826157

Abstract Article PDF–3.8M

Select item 1044928818.

LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis

Haiming Du, Senlin Hou, Lichao Zhang, Chao Liu, Tingting Yu, Wei Zhang

Aging (Albany NY) 2023 May 15; 15(9): 3759–3770. Published online 2023 May 9. doi: 10.18632/aging.204709

PMCID:: PMC10449288

Abstract Article PDF–1.0M

Select item 1036501319.

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

Daniel A. Bonsor, Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing, Lorenzo I. Finci, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Pablo Rodriguez-Viciana, Andrew G. Stephen, Dhirendra K. Simanshu

Nat Struct Mol Biol. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: Nat Struct Mol Biol. 2022 Oct; 29(10): 966–977. Published online 2022 Sep 29. doi: 10.1038/s41594-022-00841-4

PMCID:: PMC10365013

Abstract Article PDF–6.2M

Select item 969433820.

Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex

Jason J. Kwon, Behnoush Hajian, Yuemin Bian, Lucy C. Young, Alvaro J. Amor, James R. Fuller, Cara V. Fraley, Abbey M. Sykes, Jonathan So, Joshua Pan, Laura Baker, Sun Joo Lee, Douglas B. Wheeler, David L. Mayhew, Nicole S. Persky, Xiaoping Yang, David E. Root, Anthony M. Barsotti, Andrew W. Stamford, Charles K. Perry, Alex Burgin, Frank McCormick, Christopher T. Lemke, William C. Hahn, Andrew J. Aguirre

Nature. Author manuscript; available in PMC 2022 Nov 25.

Published in final edited form as: Nature. 2022 Sep; 609(7926): 408–415. Published online 2022 Jul 13. doi: 10.1038/s41586-022-04928-2

PMCID:: PMC9694338

Abstract Article PDF–5.8M

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