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Select item 48083981.

The CASTOR proteins are arginine sensors for the mTORC1 pathway

Lynne Chantranupong, Sonia M. Scaria, Robert A. Saxton, Melanie P. Gygi, Kuang Shen, Gregory A. Wyant, Tim Wang, J. Wade Harper, Steven P. Gygi, David M. Sabatini

Cell. Author manuscript; available in PMC 2016 Apr 24.

Published in final edited form as: Cell. 2016 Mar 24; 165(1): 153–164. Published online 2016 Mar 10. doi: 10.1016/j.cell.2016.02.035

PMCID:: PMC4808398

Article PDF–764K

Select item 94645922.

Structure of the nutrient-sensing hub GATOR2

Max L. Valenstein, Kacper B. Rogala, Pranav V. Lalgudi, Edward J. Brignole, Xin Gu, Robert A. Saxton, Lynne Chantranupong, Jonas Kolibius, Jan-Philipp Quast, David M. Sabatini

Nature. Author manuscript; available in PMC 2023 Jan 13.

Published in final edited form as: Nature. 2022 Jul; 607(7919): 610–616. Published online 2022 Jul 13. doi: 10.1038/s41586-022-04939-z

PMCID:: PMC9464592

Article PDF–6.9M

Select item 42238663.

The Sestrins interact with GATOR2 to negatively regulate the amino acid sensing pathway upstream of mTORC1

Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco, Robert A. Saxton, Sonia M. Scaria, Liron Bar-Peled, Eric Spooner, Marta Isasa, Steven P. Gygi, David M. Sabatini

Cell Rep. Author manuscript; available in PMC 2014 Nov 7.

Published in final edited form as: Cell Rep. 2014 Oct 9; 9(1): 1–8. Published online 2014 Sep 25. doi: 10.1016/j.celrep.2014.09.014

PMCID:: PMC4223866

Article PDF–616K

Select item 110277934.

Ring domains are essential for GATOR2-dependent mTORC1 activation

Cong Jiang, Xiaoming Dai, Shaohui He, Hongfei Zhou, Lan Fang, Jianping Guo, Songlei Liu, Tao Zhang, Weijuan Pan, Haihong Yu, Tianmin Fu, Dali Li, Hiroyuki Inuzuka, Ping Wang, Jianru Xiao, Wenyi Wei

Mol Cell. Author manuscript; available in PMC 2024 Apr 19.

Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 74–89.e9. Published online 2022 Dec 16. doi: 10.1016/j.molcel.2022.11.021

PMCID:: PMC11027793

Article PDF–3.0M

Select item 55705945.

SZT2 Dictates GATOR Control of mTORC1 Signaling

Min Peng, Na Yin, Ming O. Li

Nature. Author manuscript; available in PMC 2017 Aug 24.

Published in final edited form as: Nature. 2017 Mar 16; 543(7645): 433–437. Published online 2017 Feb 15. doi: 10.1038/nature21378

Correction in:: Nature. 2018 May 16

PMCID:: PMC5570594

Article PDF–2.1M

Select item 37286546.

A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

Liron Bar-Peled, Lynne Chantranupong, Andrew D. Cherniack, Walter W. Chen, Kathleen A. Ottina, Brian C. Grabiner, Eric D. Spear, Scott L. Carter, Matthew Meyerson, David M. Sabatini

Science. Author manuscript; available in PMC 2013 Jul 31.

Published in final edited form as: Science. 2013 May 31; 340(6136): 1100–1106. doi: 10.1126/science.1232044

PMCID:: PMC3728654

Article PDF–2.5M

Select item 53609897.

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Rachel L. Wolfson, Lynne Chantranupong, Gregory A. Wyant, Xin Gu, Jose M. Orozco, Kuang Shen, Kendall J. Condon, Sabrina Petri, Jibril Kedir, Sonia M. Scaria, Monther Abu-Remaileh, Wayne N. Frankel, David M. Sabatini

Nature. Author manuscript; available in PMC 2017 Aug 15.

Published in final edited form as: Nature. 2017 Mar 16; 543(7645): 438–442. Published online 2017 Feb 15. doi: 10.1038/nature21423

PMCID:: PMC5360989

Article PDF–1.9M

Select item 28247758.

Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects

Zari Dastani, Päivi Pajukanta, Michel Marcil, Nicholas Rudzicz, Isabelle Ruel, Swneke D Bailey, Jenny C Lee, Mathieu Lemire, Janet Faith, Jill Platko, John Rioux, Thomas J Hudson, Daniel Gaudet, James C Engert, Jacques Genest

Eur J Hum Genet. 2010 Mar; 18(3): 342–347. Published online 2009 Oct 21. doi: 10.1038/ejhg.2009.157

PMCID:: PMC2824775

Article PDF–366K

Select item 41916669.

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Brian M. Wolpin, Cosmeri Rizzato, Peter Kraft, Charles Kooperberg, Gloria M. Petersen, Zhaoming Wang, Alan A. Arslan, Laura Beane-Freeman, Paige M. Bracci, Julie Buring, Federico Canzian, Eric J. Duell, Steven Gallinger, Graham G. Giles, Gary E. Goodman, Phyllis J. Goodman, Eric J. Jacobs, Aruna Kamineni, Alison P. Klein, Laurence N. Kolonel, Matthew H. Kulke, Donghui Li, Núria Malats, Sara H. Olson, Harvey A. Risch, Howard D. Sesso, Kala Visvanathan, Emily White, Wei Zheng, Christian C. Abnet, Demetrius Albanes, Gabriella Andreotti, Melissa A. Austin, Richard Barfield, Daniela Basso, Sonja I. Berndt, Marie-Christine Boutron-Ruault, Michelle Brotzman, Markus W. Büchler, H. Bas Bueno-de-Mesquita, Peter Bugert, Laurie Burdette, Daniele Campa, Neil E. Caporaso, Gabriele Capurso, Charles Chung, Michelle Cotterchio, Eithne Costello, Joanne Elena, Niccola Funel, J. Michael Gaziano, Nathalia A. Giese, Edward L. Giovannucci, Michael Goggins, Megan J. Gorman, Myron Gross, Christopher A. Haiman, Manal Hassan, Kathy J. Helzlsouer, Brian E. Henderson, Elizabeth A. Holly, Nan Hu, David J. Hunter, Federico Innocenti, Mazda Jenab, Rudolf Kaaks, Timothy J. Key, Kay-Tee Khaw, Eric A. Klein, Manolis Kogevinas, Vittorio Krogh, Juozas Kupcinskas, Robert C. Kurtz, Andrea LaCroix, Maria T. Landi, Stefano Landi, Loic Le Marchand, Andrea Mambrini, Satu Mannisto, Roger L. Milne, Yusuke Nakamura, Ann L. Oberg, Kouros Owzar, Alpa V. Patel, Petra H. M. Peeters, Ulrike Peters, Raffaele Pezzilli, Ada Piepoli, Miquel Porta, Francisco X. Real, Elio Riboli, Nathaniel Rothman, Aldo Scarpa, Xiao-Ou Shu, Debra T. Silverman, Pavel Soucek, Malin Sund, Renata Talar-Wojnarowska, Philip R. Taylor, George E. Theodoropoulos, Mark Thornquist, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Pavel Vodicka, Jean Wactawski-Wende, Nicolas Wentzensen, Chen Wu, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Robert Hoover, Patricia Hartge, Charles Fuchs, Stephen J. Chanock, Rachael S. Stolzenberg-Solomon, Laufey T. Amundadottir

Nat Genet. Author manuscript; available in PMC 2015 Mar 1.

Published in final edited form as: Nat Genet. 2014 Sep; 46(9): 994–1000. Published online 2014 Aug 3. doi: 10.1038/ng.3052

PMCID:: PMC4191666

Article PDF–2.0M

Select item 52484210.

Large-scale cDNA transfection screening for genes related to cancer development and progression

Dafang Wan, Yi Gong, Wenxin Qin, Pingping Zhang, Jinjun Li, Lin Wei, Xiaomei Zhou, Hongnian Li, Xiaokun Qiu, Fei Zhong, Liping He, Jian Yu, Genfu Yao, Huiqiu Jiang, Lianfang Qian, Ye Yu, Huiqun Shu, Xianlian Chen, Huili Xu, Minglei Guo, Zhimei Pan, Yan Chen, Chao Ge, Shengli Yang, Jianren Gu

Proc Natl Acad Sci U S A. 2004 Nov 2; 101(44): 15724–15729. Published online 2004 Oct 21. doi: 10.1073/pnas.0404089101

Correction in:: Proc Natl Acad Sci U S A. 2004 Dec 14; 101(50): 17565.

PMCID:: PMC524842

Article PDF–245K

Select item 432443911.

Proteomic Analysis and Identification of Cellular Interactors of the Giant Ubiquitin Ligase HERC2

Jeffrey T. Galligan, Gustavo Martinez-Noël, Verena Arndt, Sebastian Hayes, Thomas W. Chittenden, J. Wade Harper, Peter M. Howley

J Proteome Res. 2015 Feb 6; 14(2): 953–966. Published online 2014 Dec 4. doi: 10.1021/pr501005v

PMCID:: PMC4324439

Article PDF–7.5M

Select item 461025712.

Systematic VCP-UBXD Adaptor Network Proteomics Identifies a Role for UBXN10 in Regulating Ciliogenesis

Malavika Raman, Mikhail Sergeev, Maija Garnaas, John R. Lydeard, Edward L. Huttlin, Wolfram Goessling, Jagesh V. Shah, J. Wade Harper

Nat Cell Biol. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Nat Cell Biol. 2015 Oct; 17(10): 1356–1369. Published online 2015 Sep 21. doi: 10.1038/ncb3238

Correction in:: Nat Cell Biol. 2016 Mar; 18(3): 347.

PMCID:: PMC4610257

Article PDF–4.5M

Select item 541404713.

FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis

Feng Xie, Ke Jin, Li Shao, Yao Fan, Yifei Tu, Yihao Li, Bin Yang, Hans van Dam, Peter ten Dijke, Honglei Weng, Steven Dooley, Shuai Wang, Junling Jia, Jin Jin, Fangfang Zhou, Long Zhang

Nat Commun. 2017; 8: 15021. Published online 2017 Apr 26. doi: 10.1038/ncomms15021

PMCID:: PMC5414047

Article PDF–4.4M

Select item 737208114.

Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding

Duc T. Tran, Anita Pottekat, Saiful A. Mir, Salvatore Loguercio, Insook Jang, Alexandre Rosa Campos, Kathleen M. Scully, Reyhaneh Lahmy, Ming Liu, Peter Arvan, William E. Balch, Randal J. Kaufman, Pamela Itkin-Ansari

Diabetes. 2020 Aug; 69(8): 1723–1734. Published online 2020 May 26. doi: 10.2337/db20-0245

PMCID:: PMC7372081

Article PDF–2.0M

Select item 903755415.

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy

Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell

Autophagy. 2022; 18(4): 829–840. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1960116

PMCID:: PMC9037554

Article PDF–4.1M

Select item 316943216.

Protein interactome reveals converging molecular pathways among autism disorders

Yasunari Sakai, Chad A. Shaw, Brian C. Dawson, Diana V. Dugas, Zaina Al-Mohtaseb, David E. Hill, Huda Y. Zoghbi

Sci Transl Med. Author manuscript; available in PMC 2011 Dec 8.

Published in final edited form as: Sci Transl Med. 2011 Jun 8; 3(86): 86ra49. doi: 10.1126/scitranslmed.3002166

PMCID:: PMC3169432

Article PDF–6.0M

Select item 995018317.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Article PDF–2.4M

Select item 826661718.

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P Maurer

Nucleic Acids Res. 2021 Jul 9; 49(12): 6702–6721. Published online 2021 Jun 16. doi: 10.1093/nar/gkab490

PMCID:: PMC8266617

Article PDF–4.0M

Select item 852757819.

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity

Yuehui Zhang, Limin Shang, Jing Zhang, Yuchen Liu, Chaozhi Jin, Yanan Zhao, Xiaobo Lei, Wenjing Wang, Xia Xiao, Xiuyuan Zhang, Yujiao Liu, Linlin Liu, Meng-Wei Zhuang, Qingkun Mi, Chunyan Tian, Jianwei Wang, Fuchu He, Pei-Hui Wang, Jian Wang

Cell Chem Biol. 2022 Jan 20; 29(1): 5–18.e6. Published online 2021 Oct 20. doi: 10.1016/j.chembiol.2021.10.008

PMCID:: PMC8527578

Article PDF–4.5M

Select item 780840820.

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V. Rezelj, Svenja Ulferts, Hannes Braberg, Alexander S. Jureka, Kirsten Obernier, Jeffrey Z. Guo, Jyoti Batra, Robyn M. Kaake, Andrew R. Weckstein, Tristan W. Owens, Meghna Gupta, Sergei Pourmal, Erron W. Titus, Merve Cakir, Margaret Soucheray, Michael McGregor, Zeynep Cakir, Gwendolyn Jang, Matthew J. O’Meara, Tia A. Tummino, Ziyang Zhang, Helene Foussard, Ajda Rojc, Yuan Zhou, Dmitry Kuchenov, Ruth Hüttenhain, Jiewei Xu, Manon Eckhardt, Danielle L. Swaney, Jacqueline M. Fabius, Manisha Ummadi, Beril Tutuncuoglu, Ujjwal Rathore, Maya Modak, Paige Haas, Kelsey M. Haas, Zun Zar Chi Naing, Ernst H. Pulido, Ying Shi, Inigo Barrio-Hernandez, Danish Memon, Eirini Petsalaki, Alistair Dunham, Miguel Correa Marrero, David Burke, Cassandra Koh, Thomas Vallet, Jesus A. Silvas, Caleigh M. Azumaya, Christian Billesbølle, Axel F. Brilot, Melody G. Campbell, Amy Diallo, Miles Sasha Dickinson, Devan Diwanji, Nadia Herrera, Nick Hoppe, Huong T. Kratochvil, Yanxin Liu, Gregory E. Merz, Michelle Moritz, Henry C. Nguyen, Carlos Nowotny, Cristina Puchades, Alexandrea N. Rizo, Ursula Schulze-Gahmen, Amber M. Smith, Ming Sun, Iris D. Young, Jianhua Zhao, Daniel Asarnow, Justin Biel, Alisa Bowen, Julian R. Braxton, Jen Chen, Cynthia M. Chio, Un Seng Chio, Ishan Deshpande, Loan Doan, Bryan Faust, Sebastian Flores, Mingliang Jin, Kate Kim, Victor L. Lam, Fei Li, Junrui Li, Yen-Li Li, Yang Li, Xi Liu, Megan Lo, Kyle E. Lopez, Arthur A. Melo, Frank R. Moss, III, Phuong Nguyen, Joana Paulino, Komal Ishwar Pawar, Jessica K. Peters, Thomas H. Pospiech, Jr., Maliheh Safari, Smriti Sangwan, Kaitlin Schaefer, Paul V. Thomas, Aye C. Thwin, Raphael Trenker, Eric Tse, Tsz Kin Martin Tsui, Feng Wang, Natalie Whitis, Zanlin Yu, Kaihua Zhang, Yang Zhang, Fengbo Zhou, Daniel Saltzberg, QCRG Structural Biology Consortium, Anthony J. Hodder, Amber S. Shun-Shion, Daniel M. Williams, Kris M. White, Romel Rosales, Thomas Kehrer, Lisa Miorin, Elena Moreno, Arvind H. Patel, Suzannah Rihn, Mir M. Khalid, Albert Vallejo-Gracia, Parinaz Fozouni, Camille R. Simoneau, Theodore L. Roth, David Wu, Mohd Anisul Karim, Maya Ghoussaini, Ian Dunham, Francesco Berardi, Sebastian Weigang, Maxime Chazal, Jisoo Park, James Logue, Marisa McGrath, Stuart Weston, Robert Haupt, C. James Hastie, Matthew Elliott, Fiona Brown, Kerry A. Burness, Elaine Reid, Mark Dorward, Clare Johnson, Stuart G. Wilkinson, Anna Geyer, Daniel M. Giesel, Carla Baillie, Samantha Raggett, Hannah Leech, Rachel Toth, Nicola Goodman, Kathleen C. Keough, Abigail L. Lind, Zoonomia Consortium, Reyna J. Klesh, Kafi R. Hemphill, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Travis Maures, Katherine S. Pollard, Andrej Sali, David A. Agard, Yifan Cheng, James S. Fraser, Adam Frost, Natalia Jura, Tanja Kortemme, Aashish Manglik, Daniel R. Southworth, Robert M. Stroud, Dario R. Alessi, Paul Davies, Matthew B. Frieman, Trey Ideker, Carmen Abate, Nolwenn Jouvenet, Georg Kochs, Brian Shoichet, Melanie Ott, Massimo Palmarini, Kevan M. Shokat, Adolfo García-Sastre, Jeremy A. Rassen, Robert Grosse, Oren S. Rosenberg, Kliment A. Verba, Christopher F. Basler, Marco Vignuzzi, Andrew A. Peden, Pedro Beltrao, Nevan J. Krogan

Science. 2020 Dec 4; 370(6521): eabe9403. Published online 2020 Oct 15. doi: 10.1126/science.abe9403

PMCID:: PMC7808408

Article PDF–4.2M

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