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Select item 111117961.

Deletion of IRE1α in podocytes exacerbates diabetic nephropathy in mice

Andrey V. Cybulsky, Joan Papillon, Julie Guillemette, José R. Navarro-Betancourt, Chen-Fang Chung, Takao Iwawaki, I. George Fantus

Sci Rep. 2024; 14: 11718. Published online 2024 May 22. doi: 10.1038/s41598-024-62599-7

PMCID:: PMC11111796

Abstract Article PDF–12M

Select item 108262822.

Tumorous IRE1α facilitates CD8⁺T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma

Yuqi Yang, Sijia Wang, Xiang-xu Wang, Sen Guo, Huina Wang, Qiong Shi, Yangzi Tian, Hao Wang, Tao Zhao, Hengxiang Zhang, Baolu Zhang, Tianwen Gao, Chunying Li, Xiuli Yi, Weinan Guo

Cell Commun Signal. 2024; 22: 83. Published online 2024 Jan 30. doi: 10.1186/s12964-024-01470-8

PMCID:: PMC10826282

Abstract Article PDF–10M

Select item 101486643.

Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration

Dawiyat Massoudi, Seán Gorman, Yien-Ming Kuo, Takao Iwawaki, Scott A. Oakes, Feroz R. Papa, Douglas B. Gould

Invest Ophthalmol Vis Sci. 2023 Apr; 64(4): 30. Published online 2023 Apr 25. doi: 10.1167/iovs.64.4.30

PMCID:: PMC10148664

Abstract Article PDF–3.6M

Select item 91202564.

The ER Stress Sensor IRE1α Regulates the UV DNA Repair Response Through Control of Intracellular Calcium Homeostasis

Jeongin Son, Saie Mogre, Fiona E. Chalmers, Jack Ibinson, Stephen Worrell, Adam B. Glick

J Invest Dermatol. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: J Invest Dermatol. 2022 Jun; 142(6): 1682–1691.e7. Published online 2021 Nov 20. doi: 10.1016/j.jid.2021.11.010

PMCID:: PMC9120256

Abstract Article PDF–741K

Select item 90360945.

Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation

Ofer Guttman, Adrien Le Thomas, Scot Marsters, David A. Lawrence, Lauren Gutgesell, Iratxe Zuazo-Gaztelu, Jonathan M. Harnoss, Simone M. Haag, Aditya Murthy, Geraldine Strasser, Zora Modrusan, Thomas Wu, Ira Mellman, Avi Ashkenazi

J Cell Biol. 2022 Jun 6; 221(6): e202111068. Published online 2022 Apr 21. doi: 10.1083/jcb.202111068

PMCID:: PMC9036094

Abstract Article PDF–6.9M

Select item 89860666.

Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis

Stefanie Marek-Iannucci, Asli D. Yildirim, Syed M. Hamid, Asli B. Ozdemir, Angela C. Gomez, Begüm Kocatürk, Rebecca A. Porritt, Michael C. Fishbein, Takao Iwawaki, Magali Noval Rivas, Ebru Erbay, Moshe Arditi

JCI Insight. 2022 Mar 22; 7(6): e157203. Published online 2022 Mar 22. doi: 10.1172/jci.insight.157203

PMCID:: PMC8986066

Abstract Article PDF–18M

Select item 87887557.

IRE1α-Driven Inflammation Promotes Clearance of Citrobacter rodentium Infection

Lydia A. Sweet, Sharon K. Kuss-Duerkop, A. Marijke Keestra-Gounder

Infect Immun. 2022 Jan; 90(1): e00481-21. Prepublished online 2021 Nov 8. Published online 2022 Jan 25. doi: 10.1128/IAI.00481-21

PMCID:: PMC8788755

Abstract Article PDF–1.4M

Select item 87667148.

Pharmacological Inhibition of IRE-1 Alpha Activity in Herpes Simplex Virus Type 1 and Type 2-Infected Dendritic Cells Enhances T Cell Activation

Eduardo I. Tognarelli, Angello Retamal-Díaz, Mónica A. Farías, Luisa F. Duarte, Tomás F. Palomino, Francisco J. Ibañez, Claudia A. Riedel, Alexis M. Kalergis, Susan M. Bueno, Pablo A. González

Front Immunol. 2021; 12: 764861. Published online 2022 Jan 5. doi: 10.3389/fimmu.2021.764861

PMCID:: PMC8766714

Abstract Article PDF–4.8M

Select item 87605229.

The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury

Jie Cai, Xiaoge Zhang, Peng Chen, Yang Li, Songzi Liu, Qian Liu, Hanyong Zhang, Zhuyin Wu, Ke Song, Jianmiao Liu, Bo Shan, Yong Liu

J Biol Chem. 2022 Jan; 298(1): 101532. Published online 2021 Dec 23. doi: 10.1016/j.jbc.2021.101532

PMCID:: PMC8760522

Abstract Article PDF–5.0M

Select item 865182910.

IRE1α-mediated monounsaturated fatty acid synthesis drives B cell differentiation and lupus-like autoimmune disease

Yana Zhang, Ming Gui, Yajun Wang, Nikita Mani, Shuvam Chaudhuri, Beixue Gao, Huabin Li, Yashpal S. Kanwar, Sarah A. Lewis, Sabrina N. Dumas, James M. Ntambi., Kezhong Zhang, Deyu Fang

Arthritis Rheumatol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Arthritis Rheumatol. 2021 Dec; 73(12): 2314–2326. Published online 2021 Nov 2. doi: 10.1002/art.41883

PMCID:: PMC8651829

Abstract Article PDF–3.0M

Select item 801069811.

Inflammation promotes adipocyte lipolysis via IRE1 kinase

Kevin P. Foley, Yong Chen, Nicole G. Barra, Mark Heal, Kieran Kwok, Akhilesh K. Tamrakar, Wendy Chi, Brittany M. Duggan, Brandyn D. Henriksbo, Yong Liu, Jonathan D. Schertzer

J Biol Chem. 2021 Jan-Jun; 296: 100440. Published online 2021 Feb 19. doi: 10.1016/j.jbc.2021.100440

PMCID:: PMC8010698

Abstract Article PDF–2.2M

Select item 724603712.

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

Amado Carreras-Sureda, Fabián Jaña, Hery Urra, Sylvere Durand, David E. Mortenson, Alfredo Sagredo, Galdo Bustos, Younis Hazari, Eva Ramos-Fernández, Maria L. Sassano, Philippe Pihán, Alexander R. van Vliet, Matías González-Quiroz, Angie K. Torres, Cheril Tapia-Rojas, Martijn Kerkhofs, Rubén Vicente, Randal J. Kaufman, Nibaldo C. Inestrosa, Christian Gonzalez-Billault, R. Luke Wiseman, Patrizia Agostinis, Geert Bultynck, Felipe A. Court, Guido Kroemer, J. César Cárdenas, Claudio Hetz

Nat Cell Biol. Author manuscript; available in PMC 2020 May 24.

Published in final edited form as: Nat Cell Biol. 2019 Jun; 21(6): 755–767. Published online 2019 May 20. doi: 10.1038/s41556-019-0329-y

Correction in:: Nat Cell Biol. 2019 Jul; 21(7): 913.

PMCID:: PMC7246037

Abstract Article PDF–3.1M

Select item 693217313.

Molecular Insight Into the IRE1α-Mediated Type I Interferon Response Induced by Proteasome Impairment in Myeloid Cells of the Brain

Maja Studencka-Turski, Gonca Çetin, Heike Junker, Frédéric Ebstein, Elke Krüger

Front Immunol. 2019; 10: 2900. Published online 2019 Dec 18. doi: 10.3389/fimmu.2019.02900

PMCID:: PMC6932173

Abstract Article PDF–1.7M

Select item 500801214.

Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure

Yuzhong Xiao, Tingting Xia, Junjie Yu, Yalan Deng, Hao Liu, Bin Liu, Shanghai Chen, Yong Liu, Feifan Guo

Open Biol. 2016 Aug; 6(8): 160131. Published online 2016 Aug 24. doi: 10.1098/rsob.160131

PMCID:: PMC5008012

Abstract Article PDF–1.0M

Select item 446347115.

The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis

Hai-Sheng Zhang, Ying Chen, Li Fan, Qiu-Lei Xi, Guo-Hao Wu, Xiu-Xiu Li, Tang-Long Yuan, Sheng-Qi He, Yue Yu, Meng-Le Shao, Yang Liu, Chen-Guang Bai, Zhi-Qiang Ling, Min Li, Yong Liu, Jing Fang

J Biol Chem. 2015 Jun 12; 290(24): 15327–15336. Published online 2015 Apr 29. doi: 10.1074/jbc.M114.633560

PMCID:: PMC4463471

Abstract Article PDF–3.1M

Select item 316244616.

A Conserved Structural Determinant Located at the Interdomain Region of Mammalian Inositol-requiring Enzyme 1α

Zhen Xue, Yin He, Kaixiong Ye, Zhenglong Gu, Yuxin Mao, Ling Qi

J Biol Chem. 2011 Sep 2; 286(35): 30859–30866. Published online 2011 Jul 13. doi: 10.1074/jbc.M111.273714

PMCID:: PMC3162446

Abstract Article PDF–2.3M

Select item 169852017.

Autophagy Is Activated for Cell Survival after Endoplasmic Reticulum Stress

Maiko Ogata, Shin-ichiro Hino, Atsushi Saito, Keisuke Morikawa, Shinichi Kondo, Soshi Kanemoto, Tomohiko Murakami, Manabu Taniguchi, Ichiro Tanii, Kazuya Yoshinaga, Sadao Shiosaka, James A. Hammarback, Fumihiko Urano, Kazunori Imaizumi

Mol Cell Biol. 2006 Dec; 26(24): 9220–9231. Published online 2006 Oct 9. doi: 10.1128/MCB.01453-06

PMCID:: PMC1698520

Abstract Article PDF–1.2M

Select item 54642118.

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

Kezhong Zhang, Hetty N. Wong, Benbo Song, Corey N. Miller, Donalyn Scheuner, Randal J. Kaufman

J Clin Invest. 2005 Feb 1; 115(2): 268–281. doi: 10.1172/JCI21848

PMCID:: PMC546421

Abstract Article PDF–1.2M

Select item 1109618419.

IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis

Dadi Jiang, Youming Guo, Tianyu Wang, Liang Wang, Yuelong Yan, Ling Xia, Rakesh Bam, Zhifen Yang, Hyemin Lee, Takao Iwawaki, Boyi Gan, Albert C. Koong

Nat Commun. 2024; 15: 4114. Published online 2024 May 15. doi: 10.1038/s41467-024-48330-0

PMCID:: PMC11096184

Abstract Article PDF–3.7M

Select item 1072114520.

Impaired T cell IRE1α/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction

Sasha Smolgovsky, Abraham L. Bayer, Kuljeet Kaur, Erin Sanders, Mark Aronovitz, Mallory E. Filipp, Edward B. Thorp, Gabriele G. Schiattarella, Joseph A. Hill, Robert M. Blanton, Juan R. Cubillos-Ruiz, Pilar Alcaide

J Clin Invest. 2023 Dec 15; 133(24): e171874. Published online 2023 Dec 15. doi: 10.1172/JCI171874

PMCID:: PMC10721145

Abstract Article PDF–10M

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