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Select item 109371121.

Jacob A. Klickstein, Michelle A. Johnson, Pantelis Antonoudiou, Jamie Maguire, Joao A. Paulo, Steve P. Gygi, Chris Weihl, Malavika Raman

Stem Cell Reports. 2024 Mar 12; 19(3): 366–382. Published online 2024 Feb 8. doi: 10.1016/j.stemcr.2024.01.002

PMCID:: PMC10937112

Abstract Article PDF–5.5M

Select item 109281542.

Bone scan findings of Paget’s disease of bone in patients with VCP Multisystem Proteinopathy 1

Rod Carlo Agram Columbres, Sarosh Din, Liliane Gibbs, Virginia Kimonis

Sci Rep. 2024; 14: 5917. Published online 2024 Mar 11. doi: 10.1038/s41598-024-54526-7

PMCID:: PMC10928154

Abstract Article PDF–1.4M

Select item 108489453.

p97/VCP Promotes the Recycling of Endocytic Cargo

Mona Kawan, Maria Körner, Andreas Schlosser, Alexander Buchberger

Mol Biol Cell. 2023 Dec 1; 34(13): ar126. Published online 2023 Nov 13. doi: 10.1091/mbc.E23-06-0237

PMCID:: PMC10848945

Abstract Article PDF–5.0M

Select item 106455654.

An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCP

Annelise Y. Mah-Som, Jil Daw, Diana Huynh, Mengcheng Wu, Benjamin C. Creekmore, William Burns, Steven A. Skinner, Øystein L. Holla, Marie F. Smeland, Marc Planes, Kevin Uguen, Sylvia Redon, Tatjana Bierhals, Tasja Scholz, Jonas Denecke, Martin A. Mensah, Henrike L. Sczakiel, Heidelis Tichy, Sarah Verheyen, Jasmin Blatterer, Elisabeth Schreiner, Jenny Thies, Christina Lam, Christine G. Spaeth, Loren Pena, Keri Ramsey, Vinodh Narayanan, Laurie H. Seaver, Diana Rodriguez, Alexandra Afenjar, Lydie Burglen, Edward B. Lee, Tsui-Fen Chou, Conrad C. Weihl, Marwan S. Shinawi

Am J Hum Genet. 2023 Nov 2; 110(11): 1959–1975. Published online 2023 Oct 25. doi: 10.1016/j.ajhg.2023.10.007

PMCID:: PMC10645565

Abstract Article PDF–3.4M

Select item 105760985.

Nuclear VCP drives colorectal cancer progression by promoting fatty acid oxidation

Youwei Huang, Fang Wang, Xi Lin, Qing Li, Yuli Lu, Jiayu Zhang, Xi Shen, Jingyi Tan, Zixi Qin, Jiahong Chen, Xueqin Chen, Guopeng Pan, Xiangyu Wang, Yuequan Zeng, Shangqi Yang, Jun Liu, Fan Xing, Kai Li, Haipeng Zhang

Proc Natl Acad Sci U S A. 2023 Oct 10; 120(41): e2221653120. Published online 2023 Oct 3. doi: 10.1073/pnas.2221653120

PMCID:: PMC10576098

Abstract Article PDF–9.9M

Select item 104054386.

Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases

Siwei Chu, Xinyi Xie, Carla Payan, Ursula Stochaj

Mol Neurodegener. 2023; 18: 52. Published online 2023 Aug 7. doi: 10.1186/s13024-023-00639-y

PMCID:: PMC10405438

Abstract Article PDF–7.3M

Select item 103372787.

Novel variants, muscle imaging, and myopathological changes in Chinese patients with VCP‐related multisystem proteinopathy

Yalan Wan, Qi Wang, Yiming Zheng, Meng Yu, Zhiying Xie, Chen Ling, Lingchao Meng, Jiaxi Yu, Yilei Zheng, Yikang Wang, Wenhao Zhang, Chang Liu, Yawen Zhao, Yun Yuan, Jianwen Deng, Qiang Gang, Zhaoxia Wang

Mol Genet Genomic Med. 2023 Jul; 11(7): e2176. Published online 2023 Mar 31. doi: 10.1002/mgg3.2176

PMCID:: PMC10337278

Abstract Article PDF–5.1M

Select item 100483438.

Novel Variants in the VCP Gene Causing Multisystem Proteinopathy 1

Rod Carlo Agram Columbres, Yue Chin, Sanjana Pratti, Colin Quinn, Luis F. Gonzalez-Cuyar, Michael Weiss, Fabiola Quintero-Rivera, Virginia Kimonis

Genes (Basel) 2023 Mar; 14(3): 676. Published online 2023 Mar 8. doi: 10.3390/genes14030676

PMCID:: PMC10048343

Abstract Article PDF–2.1M

Select item 92878629.

A clinicopathologic study of malignancy in VCP-associated multisystem proteinopathy

Alyaa Shmara, Mari Perez-Rosendahl, Kady Murphy, Ashley Kwon, Charles Smith, Virginia Kimonis

Orphanet J Rare Dis. 2022; 17: 272. Published online 2022 Jul 15. doi: 10.1186/s13023-022-02403-9

PMCID:: PMC9287862

Abstract Article PDF–2.3M

Select item 922286810.

Multisystem Proteinopathy Due to VCP Mutations: A Review of Clinical Heterogeneity and Genetic Diagnosis

Gerald Pfeffer, Grace Lee, Carly S. Pontifex, Roberto D. Fanganiello, Allison Peck, Conrad C. Weihl, Virginia Kimonis

Genes (Basel) 2022 Jun; 13(6): 963. Published online 2022 May 27. doi: 10.3390/genes13060963

PMCID:: PMC9222868

Abstract Article PDF–1.2M

Select item 910006111.

p97/UBXD1 Generate Ubiquitylated Proteins That Are Sequestered into Nuclear Envelope Herniations in Torsin-Deficient Cells

Sarah M. Prophet, Brigitte S. Naughton, Christian Schlieker

Int J Mol Sci. 2022 May; 23(9): 4627. Published online 2022 Apr 21. doi: 10.3390/ijms23094627

PMCID:: PMC9100061

Abstract Article PDF–2.4M

Select item 898600312.

VCP inhibition induces an unfolded protein response and apoptosis in human acute myeloid leukemia cells

Paweł P. Szczęśniak, Jan B. Heidelberger, Hubert Serve, Petra Beli, Sebastian A. Wagner

PLoS One. 2022; 17(4): e0266478. Published online 2022 Apr 6. doi: 10.1371/journal.pone.0266478

PMCID:: PMC8986003

Abstract Article PDF–2.7M

Select item 861620713.

Impacts of p97 on Proteome Changes in Human Cells during Coronaviral Replication

Kai-Wen Cheng, Shan Li, Feng Wang, Nallely M. Ruiz-Lopez, Nadia Houerbi, Tsui-Fen Chou

Cells. 2021 Nov; 10(11): 2953. Published online 2021 Oct 29. doi: 10.3390/cells10112953

PMCID:: PMC8616207

Abstract Article PDF–2.8M

Select item 854079314.

The Biogenesis of Dengue Virus Replication Organelles Requires the ATPase Activity of Valosin-Containing Protein

Clément Mazeaud, Anaïs Anton, Felix Pahmeier, Aïssatou Aïcha Sow, Berati Cerikan, Wesley Freppel, Mirko Cortese, Ralf Bartenschlager, Laurent Chatel-Chaix

Viruses. 2021 Oct; 13(10): 2092. Published online 2021 Oct 18. doi: 10.3390/v13102092

PMCID:: PMC8540793

Abstract Article PDF–5.8M

Select item 851785015.

AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation

Brian Caffrey, Xing Zhu, Alison Berezuk, Katharine Tuttle, Sagar Chittori, Sriram Subramaniam

J Biol Chem. 2021 Oct; 297(4): 101187. Published online 2021 Sep 11. doi: 10.1016/j.jbc.2021.101187

PMCID:: PMC8517850

Abstract Article PDF–3.3M

Select item 834798216.

Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes

Purbasha Nandi, Shan Li, Rod Carlo A. Columbres, Feng Wang, Dewight R. Williams, Yu-Ping Poh, Tsui-Fen Chou, Po-Lin Chiu

Int J Mol Sci. 2021 Aug; 22(15): 8079. Published online 2021 Jul 28. doi: 10.3390/ijms22158079

PMCID:: PMC8347982

Abstract Article PDF–2.9M

Select item 792500117.

Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities

Hongyang Shu, Yizhong Peng, Weijian Hang, Ning Zhou, Dao Wen Wang

Biochem Soc Trans. 2021 Feb 26; 49(1): 485–494. Published online 2021 Jan 13. doi: 10.1042/BST20200981

PMCID:: PMC7925001

Abstract Article PDF–2.8M

Select item 784658418.

Microthermal-induced subcellular-targeted protein damage in cells on plasmonic nanosilver-modified surfaces evokes a two-phase HSP-p97/VCP response

Martin Mistrik, Zdenek Skrott, Petr Muller, Ales Panacek, Lucie Hochvaldova, Katarina Chroma, Tereza Buchtova, Veronika Vandova, Libor Kvitek, Jiri Bartek

Nat Commun. 2021; 12: 713. Published online 2021 Jan 29. doi: 10.1038/s41467-021-20989-9

PMCID:: PMC7846584

Abstract Article PDF–9.5M

Select item 761118519.

A role for VCP/p97 in the processing of drug-stabilised TOP2-DNA covalent complexes

Rebecca L. Swan, Ian G. Cowell, Caroline A. Austin

Mol Pharmacol. Author manuscript; available in PMC 2021 Jul 12.

Published in final edited form as: Mol Pharmacol. 2021 Jul 1; 100(1): 57–62. Published online 2021 May 3. doi: 10.1124/molpharm.121.000262

PMCID:: PMC7611185

Abstract Article PDF–775K

Select item 731207820.

Valosin-Containing Protein, a Calcium-Associated ATPase Protein, in Endoplasmic Reticulum and Mitochondrial Function and Its Implications for Diseases

Xiaonan Sun, Hongyu Qiu

Int J Mol Sci. 2020 Jun; 21(11): 3842. Published online 2020 May 28. doi: 10.3390/ijms21113842

PMCID:: PMC7312078

Abstract Article PDF–981K

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