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Select item 102093421.

Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control

Zeliha Yalçin, Daniëlle Koot, Karel Bezstarosti, Daniel Salas-Lloret, Onno B. Bleijerveld, Vera Boersma, Mattia Falcone, Román González-Prieto, Maarten Altelaar, Jeroen A.A. Demmers, Jacqueline J.L. Jacobs

Mol Cell Proteomics. 2023 Jun; 22(6): 100548. Published online 2023 Apr 13. doi: 10.1016/j.mcpro.2023.100548

PMCID:: PMC10209342

Abstract Article PDF–2.4M

Select item 50780322.

UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo

Xiaojia Gao, Wenbo Wang, Hui Yang, Lin Wu, Zhongshi He, Shuliang Zhou, Hong Zhao, Zhenming Fu, Fuxiang Zhou, Yunfeng Zhou

Oncotarget. 2016 May 31; 7(22): 32543–32553. Published online 2016 Apr 20. doi: 10.18632/oncotarget.8869

PMCID:: PMC5078032

Abstract Article PDF–5.8M

Select item 28402843.

Identification of an unconventional E3 binding surface on the UbcH5 ∼ Ub conjugate recognized by a pathogenic bacterial E3 ligase.

Itay Levin, Catherine Eakin, Marie-Pierre Blanc, Rachel E. Klevit, Samuel I. Miller, Peter S. Brzovic

Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7): 2848–2853. Published online 2010 Feb 1. doi: 10.1073/pnas.0914821107

PMCID:: PMC2840284

Abstract Article PDF–455K

Select item 19244784.

RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells

Hidenori Hattori, Xueqing Zhang, Yonghui Jia, Kulandayan K. Subramanian, Hakryul Jo, Fabien Loison, Peter E. Newburger, Hongbo R. Luo

Blood. 2007 Jul 15; 110(2): 640–650. Prepublished online 2007 Apr 9. doi: 10.1182/blood-2006-11-059048

PMCID:: PMC1924478

Abstract Article

Select item 78392515.

N-terminal protein labeling with N-hydroxysuccinimide esters and microscale thermophoresis measurements of protein-protein interactions using labeled protein

Hanjie Jiang, Philip A. Cole

Curr Protoc. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: Curr Protoc. 2021 Jan; 1(1): e14. doi: 10.1002/cpz1.14

Correction in:: Curr Protoc. 2022 Aug; 2(8): e552.

PMCID:: PMC7839251

Abstract Article PDF–1.1M

Select item 78087526.

Development and characterisation of SMURF2-targeting modifiers

Dhanoop Manikoth Ayyathan, Gal Levy-Cohen, Moran Shubely, Sandy Boutros-Suleiman, Veronica Lepechkin-Zilbermintz, Michael Shokhen, Amnon Albeck, Arie Gruzman, Michael Blank

J Enzyme Inhib Med Chem. 2021; 36(1): 401–409. Published online 2021 Jan 12. doi: 10.1080/14756366.2020.1871337

PMCID:: PMC7808752

Abstract Article PDF–3.0M

Select item 59355477.

Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance

Murugendra Vanarotti, Benjamin J. Evison, Marcelo L. Actis, Akira Inoue, Ezelle T. McDonald, Youming Shao, Richard J. Heath, Naoaki Fujii

Bioorg Med Chem. Author manuscript; available in PMC 2019 May 15.

Published in final edited form as: Bioorg Med Chem. 2018 May 15; 26(9): 2345–2353. Published online 2018 Mar 19. doi: 10.1016/j.bmc.2018.03.028

PMCID:: PMC5935547

Abstract Article PDF–2.1M

Select item 58448328.

Biophysical and Biological Evaluation of Optimized Stapled Peptide Inhibitors of the Linear Ubiquitin Chain Assembly Complex (LUBAC)

Francisco Aguilar-Alonso, Amanda L. Whiting, Ye Joon Kim, Federico Bernal

Bioorg Med Chem. Author manuscript; available in PMC 2019 Mar 15.

Published in final edited form as: Bioorg Med Chem. 2018 Mar 15; 26(6): 1179–1188. Published online 2017 Dec 5. doi: 10.1016/j.bmc.2017.11.047

PMCID:: PMC5844832

Abstract Article PDF–1.7M

Select item 37638179.

Structure Based Design of Covalent Siah Inhibitors

John L. Stebbins, Eugenio Santelli, Yongmei Feng, Surya K. De, Angela Purves, Khatereh Motamedchaboki, Bainan Wu, Ze’ev A. Ronai, Robert C. Liddington, Maurizio Pellecchia

Chem Biol. Author manuscript; available in PMC 2014 Aug 22.

Published in final edited form as: Chem Biol. 2013 Aug 22; 20(8): 973–982. Published online 2013 Jul 25. doi: 10.1016/j.chembiol.2013.06.008

PMCID:: PMC3763817

Abstract Article PDF–3.0M

Select item 366617610.

Activation of UbcH5c~Ub is the result of a shift in inter-domain motions of the conjugate when bound to the U-box E3 ligase E4B

Sarah E. Soss, Rachel E. Klevit, Walter J Chazin

Biochemistry. Author manuscript; available in PMC 2014 Apr 30.

Published in final edited form as: Biochemistry. 2013 Apr 30; 52(17): 2991–2999. Published online 2013 Apr 15. doi: 10.1021/bi3015949

PMCID:: PMC3666176

Abstract Article PDF–1.8M

Select item 336646011.

Structural Insights into the Conformation and Oligomerization of E2~Ubiquitin Conjugates

Richard C. Page, Jonathan N. Pruneda, Joseph Amick, Rachel E. Klevit, Saurav Misra

Biochemistry. Author manuscript; available in PMC 2013 May 22.

Published in final edited form as: Biochemistry. 2012 May 22; 51(20): 4175–4187. Published online 2012 May 14. doi: 10.1021/bi300058m

PMCID:: PMC3366460

Abstract Article PDF–5.4M

Select item 305639312.

Ubiquitin in Motion: Structural studies of the E2~Ub conjugate

Jonathan N. Pruneda, Kate E. Stoll, Laura J. Bolton, Peter S. Brzovic, Rachel E. Klevit

Biochemistry. Author manuscript; available in PMC 2012 Mar 15.

Published in final edited form as: Biochemistry. 2011 Mar 15; 50(10): 1624–1633. Published online 2011 Feb 21. doi: 10.1021/bi101913m

PMCID:: PMC3056393

Abstract Article PDF–2.7M

Select item 260343613.

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

Latarsha J. Reid, Reena Shakya, Ami P. Modi, Maria Lokshin, Jiin-Tsuey Cheng, Maria Jasin, Richard Baer, Thomas Ludwig

Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52): 20876–20881. Published online 2008 Dec 16. doi: 10.1073/pnas.0811203106

PMCID:: PMC2603436

Abstract Article PDF–674K

Select item 258368314.

Biochemical Characterization of a Recombinant TRIM5α Protein That Restricts Human Immunodeficiency Virus Type 1 Replication

Charles R. Langelier, Virginie Sandrin, Debra M. Eckert, Devin E. Christensen, Viswanathan Chandrasekaran, Steven L. Alam, Christopher Aiken, John C. Olsen, Alak Kanti Kar, Joseph G. Sodroski, Wesley I. Sundquist

J Virol. 2008 Dec; 82(23): 11682–11694. Published online 2008 Sep 17. doi: 10.1128/JVI.01562-08

PMCID:: PMC2583683

Abstract Article PDF–1003K

Select item 122204115.

Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation.

C S Coleman, A E Pegg

Biochem J. 2001 Aug 15; 358(Pt 1): 137–145. doi: 10.1042/0264-6021:3580137

PMCID:: PMC1222041

Summary PDF–277K

Select item 108416416.

CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein

Shigeo Murata, Yasufumi Minami, Michiko Minami, Tomoki Chiba, Keiji Tanaka

EMBO Rep. 2001 Dec 15; 2(12): 1133–1138. doi: 10.1093/embo-reports/kve246

PMCID:: PMC1084164

Abstract Article PDF–355K

Select item 1115981117.

BRCA1 contributes to transcription‐coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein

Leizhen Wei, Li Lan, Akira Yasui, Kiyoji Tanaka, Masafumi Saijo, Ayako Matsuzawa, Risa Kashiwagi, Emiko Maseki, Yiheng Hu, Jeffrey D. Parvin, Chikashi Ishioka, Natsuko Chiba

Cancer Sci. 2011 Oct; 102(10): 1840–1847. Published online 2011 Aug 18. doi: 10.1111/j.1349-7006.2011.02037.x

PMCID:: PMC11159811

Abstract Article PDF–473K

Select item 1107245618.

The E3 ubiquitin ligase SMURF2 stabilizes RNA editase ADAR1p110 and promotes its adenosine-to-inosine (A-to-I) editing function

Praveen Koganti, Venkata Narasimha Kadali, Dhanoop Manikoth Ayyathan, Andrea Emanuelli, Biagio Paolini, Gal Levy-Cohen, Michael Blank

Cell Mol Life Sci. 2022 May; 79(5): 237. Published online 2022 Apr 11. doi: 10.1007/s00018-022-04272-8

PMCID:: PMC11072456

Abstract Article PDF–6.5M

Select item 989823819.

Lysine 222 in PPAR γ1 functions as the key site of MuRF2-mediated ubiquitination modification

Yucheng Fan, Fangjing Xu, Rui Wang, Jun He

Sci Rep. 2023; 13: 1999. Published online 2023 Feb 3. doi: 10.1038/s41598-023-28905-5

PMCID:: PMC9898238

Abstract Article PDF–2.2M

Select item 909746020.

The molecular basis of spinocerebellar ataxia type 48 caused by a de novo mutation in the ubiquitin ligase CHIP

A. Umano, K. Fang, Z. Qu, J.B. Scaglione, S. Altinok, C.J. Treadway, E.T. Wick, E. Paulakonis, C. Karunanayake, S. Chou, T.M. Bardakjian, P. Gonzalez-Alegre, R.C. Page, J.C. Schisler, N.G. Brown, D. Yan, K.M. Scaglione

J Biol Chem. 2022 May; 298(5): 101899. Published online 2022 Apr 7. doi: 10.1016/j.jbc.2022.101899