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Select item 105309161.

Endoplasmic Reticulum Stress-Related Ten-Biomarker Risk Classifier for Survival Evaluation in Epithelial Ovarian Cancer and TRPM2: A Potential Therapeutic Target of Ovarian Cancer

Minghai Zhang, Yingjie Wang, Shilin Xu, Shan Huang, Meixuan Wu, Guangquan Chen, Yu Wang

Int J Mol Sci. 2023 Sep; 24(18): 14010. Published online 2023 Sep 12. doi: 10.3390/ijms241814010

PMCID:: PMC10530916

Abstract Article PDF–15M

Select item 102783172.

TRPM2-mediated Ca²⁺ signaling as a potential therapeutic target in cancer treatment: an updated review of its role in survival and proliferation of cancer cells

Eunus S. Ali, Brototi Chakrabarty, Sarker Ramproshad, Banani Mondal, Neloy Kundu, Chandan Sarkar, Javad Sharifi-Rad, Daniela Calina, William C. Cho

Cell Commun Signal. 2023; 21: 145. Published online 2023 Jun 19. doi: 10.1186/s12964-023-01149-6

PMCID:: PMC10278317

Abstract Article PDF–1.3M

Select item 98128063.

TRPM2 facilitates tumor progression of clear cell renal cell carcinoma by relieving Endoplasmic Reticulum Stress

Hongwei Yuan, Weiquan Li, Ning Lou, Tiexi Yu, Xiangui Meng, Wen Xiao, Xiaoping Zhang

Int J Med Sci. 2023; 20(1): 57–69. Published online 2023 Jan 1. doi: 10.7150/ijms.77944

PMCID:: PMC9812806

Abstract Article PDF–26M

Select item 97090804.

The human ion channel TRPM2 modulates migration and invasion in neuroblastoma through regulation of integrin expression

Lei Bao, Fernanda Festa, Iwona Hirschler-Laszkiewicz, Kerry Keefer, Hong-Gang Wang, Joseph Y. Cheung, Barbara A. Miller

Sci Rep. 2022; 12: 20544. Published online 2022 Nov 29. doi: 10.1038/s41598-022-25138-w

PMCID:: PMC9709080

Abstract Article PDF–13M

Select item 89758295.

Role of TRPM2 in brain tumours and potential as a drug target

Delphine Ji, Zheng-wei Luo, Andrea Ovcjak, Rahmah Alanazi, Mei-Hua Bao, Zhong-Ping Feng, Hong-Shuo Sun

Acta Pharmacol Sin. 2022 Apr; 43(4): 759–770. Published online 2021 Jun 9. doi: 10.1038/s41401-021-00679-4

PMCID:: PMC8975829

Abstract Article PDF–2.1M

Select item 88341716.

A Systemic Review of the Integral Role of TRPM2 in Ischemic Stroke: From Upstream Risk Factors to Ultimate Neuronal Death

Pengyu Zong, Qiaoshan Lin, Jianlin Feng, Lixia Yue

Cells. 2022 Feb; 11(3): 491. Published online 2022 Jan 31. doi: 10.3390/cells11030491

PMCID:: PMC8834171

Abstract Article PDF–16M

Select item 86420467.

Effect of TRPM2-Mediated Calcium Signaling on Cell Proliferation and Apoptosis in Esophageal Squamous Cell Carcinoma

Xingbang Wang, Yong Xiao, Mingming Huang, Bing Shen, Haowei Xue, Kaile Wu

Technol Cancer Res Treat. 2021; 20: 15330338211045213. Published online 2021 Oct 4. doi: 10.1177/15330338211045213

PMCID:: PMC8642046

Abstract Article PDF–1.3M

Select item 83074398.

The Role of TRPM2 in Endothelial Function and Dysfunction

Wioletta Zielińska, Jan Zabrzyński, Maciej Gagat, Alina Grzanka

Int J Mol Sci. 2021 Jul; 22(14): 7635. Published online 2021 Jul 16. doi: 10.3390/ijms22147635

PMCID:: PMC8307439

Abstract Article PDF–906K

Select item 81849469.

TRPM2 promotes pancreatic cancer by PKC/MAPK pathway

Rui Lin, Xunxia Bao, Hui Wang, Sibo Zhu, Zhongyan Liu, Quanning Chen, Kaixing Ai, Baomin Shi

Cell Death Dis. 2021 Jun; 12(6): 585. Published online 2021 Jun 7. doi: 10.1038/s41419-021-03856-9

PMCID:: PMC8184946

Abstract Article PDF–2.0M

Select item 675935310.

Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

Yihe Huang, Becca Roth, Wei Lü, Juan Du

eLife. 2019; 8: e50175. Published online 2019 Sep 12. doi: 10.7554/eLife.50175

PMCID:: PMC6759353

Abstract Article PDF–3.7M

Select item 664679411.

Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2

Ellen Gattkowski, Anke Johnsen, Andreas Bauche, Franziska Möckl, Frederike Kulow, Maria Garcia Alai, Trevor J. Rutherford, Ralf Fliegert, Henning Tidow

Biochim Biophys Acta Mol Cell Res. 2019 Jul; 1866(7): 1162–1170. doi: 10.1016/j.bbamcr.2018.12.010

PMCID:: PMC6646794

Abstract Article

Select item 641462912.

TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway

Shekoufeh Almasi, Andra M. Sterea, Wasundara Fernando, Derek R. Clements, Paola Marcato, David W. Hoskin, Shashi Gujar, Yassine El Hiani

Sci Rep. 2019; 9: 4182. Published online 2019 Mar 12. doi: 10.1038/s41598-019-40330-1

PMCID:: PMC6414629

Abstract Article PDF–2.4M

Select item 598395313.

TRPM2 promotes the proliferation and invasion of pancreatic ductal adenocarcinoma

Rui Lin, Yufeng Wang, Quanning Chen, Zhongyan Liu, Shuai Xiao, Bingyi Wang, Baomin Shi

Mol Med Rep. 2018 Jun; 17(6): 7537–7544. Published online 2018 Mar 28. doi: 10.3892/mmr.2018.8816

PMCID:: PMC5983953

Abstract Article PDF–1.2M

Select item 584614614.

TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway

Shekoufeh Almasi, Barry E. Kennedy, Mariam El-Aghil, Andra M. Sterea, Shashi Gujar, Santiago Partida-Sánchez, Yassine El Hiani

J Biol Chem. 2018 Mar 9; 293(10): 3637–3650. Published online 2018 Jan 17. doi: 10.1074/jbc.M117.817635

PMCID:: PMC5846146

Abstract Article PDF–3.1M

Select item 518010015.

The overexpressed functional transient receptor potential channel TRPM2 in oral squamous cell carcinoma

Ling-Yan Zhao, Wan-Lin Xu, Zeng-Qi Xu, Cui Qi, Yang Li, Jie Cheng, Lai-Kui Liu, Yu-Nong Wu, Jun Gao, Jin-Hai Ye

Sci Rep. 2016; 6: 38471. Published online 2016 Dec 23. doi: 10.1038/srep38471

PMCID:: PMC5180100

Abstract Article PDF–1.6M

Select item 511440016.

Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics

Lei Bao, Shu-jen Chen, Kathleen Conrad, Kerry Keefer, Thomas Abraham, John P. Lee, JuFang Wang, Xue-Qian Zhang, Iwona Hirschler-Laszkiewicz, Hong-Gang Wang, Sinisa Dovat, Brian Gans, Muniswamy Madesh, Joseph Y. Cheung, Barbara A. Miller

J Biol Chem. 2016 Nov 18; 291(47): 24449–24464. Published online 2016 Sep 30. doi: 10.1074/jbc.M116.747147

PMCID:: PMC5114400

Abstract Article PDF–4.0M

Select item 496775817.

TRPM2 protects against tissue damage following oxidative stress and ischaemia–reperfusion

Barbara A. Miller, Joseph Y. Cheung

J Physiol. 2016 Aug 1; 594(15): 4181–4191. Published online 2015 Nov 11. doi: 10.1113/JP270934

PMCID:: PMC4967758

Abstract Article PDF–574K

Select item 473569718.

Enhanced cytotoxicity in triple-negative and estrogen receptor-positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel

DAVID W. KOH, DANIEL P. POWELL, STEVEN D. BLAKE, JOY L. HOFFMAN, MANDI M. HOPKINS, XIAOXING FENG

Oncol Rep. 2015 Sep; 34(3): 1589–1598. Published online 2015 Jul 14. doi: 10.3892/or.2015.4131

PMCID:: PMC4735697

Abstract Article PDF–727K

Select item 438302819.

Inhibition of the transient receptor potential melastatin-2 channel causes increased DNA damage and decreased proliferation in breast adenocarcinoma cells

MANDI M. HOPKINS, XIAOXING FENG, MENGWEI LIU, LAUREN P. PARKER, DAVID W. KOH

Int J Oncol. 2015 May; 46(5): 2267–2276. Published online 2015 Mar 6. doi: 10.3892/ijo.2015.2919

PMCID:: PMC4383028

Abstract Article PDF–769K

Select item 410626320.

Transient receptor potential melastatin 2: a novel target for treatment of gout

Zhenyu Zhong, Yougang Zhai, Liang Qiao

Expert Opin Ther Targets. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Expert Opin Ther Targets. 2013 Nov; 17(11): 1243–1247. Published online 2013 Sep 4. doi: 10.1517/14728222.2013.835399