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Select item 99436801.

Structures of human TR4_LBD–JAZF1 and TR4_DBD–DNA complexes reveal the molecular basis of transcriptional regulation

Yunlong Liu, Lulu Ma, Min Li, Zizi Tian, Meiting Yang, Xi Wu, Xue Wang, Guohui Shang, Mengjia Xie, Yiyun Chen, Xin Liu, Lun Jiang, Wei Wu, Chaoqun Xu, Liqun Xia, Gonghui Li, Shaodong Dai, Zhongzhou Chen

Nucleic Acids Res. 2023 Feb 22; 51(3): 1443–1457. Published online 2023 Jan 18. doi: 10.1093/nar/gkac1259

PMCID:: PMC9943680

Abstract Article PDF–8.8M

Select item 89736672.

Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment

Yuhan Wang, Li Zhao, DuoJun Qiu, Yonghong Shi, Huijun Duan

Bioengineered. 2022; 13(3): 5880–5891. Published online 2022 Feb 21. doi: 10.1080/21655979.2022.2040875

PMCID:: PMC8973667

Abstract Article PDF–2.9M

Select item 70441113.

Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression

Linyi Hu, Yin Sun, Jie Luo, Xiang He, Meihua Ye, Gonghui Li, Yong Zhang, Jian Bai, Dahong Zhang, Chawnshang Chang

Oncogene. 2020; 39(9): 1891–1903. Published online 2019 Nov 20. doi: 10.1038/s41388-019-1070-5

PMCID:: PMC7044111

Abstract Article PDF–3.9M

Select item 67269044.

TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform

Stephanie R Kehl, Brandy‐Lee A Soos, Bhaskar Saha, Seong Won Choi, Anthony W Herren, Terje Johansen, Michael A Mandell

EMBO Rep. 2019 Sep; 20(9): e46238. Published online 2019 Jul 25. doi: 10.15252/embr.201846238

PMCID:: PMC6726904

Abstract Article PDF–5.4M

Select item 65421805.

Enterohemorrhagic Escherichia coli Tir inhibits TAK1 activation and mediates immune evasion

Ruixue Zhou, Zijuan Chen, Doudou Hao, Yu Wang, Yihua Zhang, Xianfu Yi, Liang-Dong Lyu, Haipeng Liu, Quanming Zou, Yiwei Chu, Baoxue Ge, Dapeng Yan

Emerg Microbes Infect. 2019; 8(1): 734–748. Published online 2019 May 25. doi: 10.1080/22221751.2019.1620589

PMCID:: PMC6542180

Abstract Article PDF–3.9M

Select item 64864026.

TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance

Veenu Tripathi, Jee-Hye Shin, Christina H. Stuelten, Ying E. Zhang

Oncogene. Author manuscript; available in PMC 2019 Jul 9.

Published in final edited form as: Oncogene. 2019 Apr; 38(17): 3185–3200. Published online 2019 Jan 9. doi: 10.1038/s41388-018-0655-8

PMCID:: PMC6486402

Abstract Article PDF–1.7M

Select item 55121627.

Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction

Lihong Shi, Shuaiying Cui, James D Engel, Osamu Tanabe

Nat Med. Author manuscript; available in PMC 2017 Jul 17.

Published in final edited form as: Nat Med. 2013 Mar; 19(3): 291–294. Published online 2013 Feb 17. doi: 10.1038/nm.3101

PMCID:: PMC5512162

Abstract Article PDF–461K

Select item 45581598.

TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGFβR2/p-Smad3 signals

Xiaofu Qiu, Jin Zhu, Yin Sun, Kun Fan, Dong-Rong Yang, Gonghui Li, Guosheng Yang, Chawnshang Chang

Oncotarget. 2015 Jun 20; 6(17): 15397–15409. Published online 2015 Apr 27. doi: 10.18632/oncotarget.3778

PMCID:: PMC4558159

Abstract Article PDF–6.2M

Select item 44151179.

The Differential Effects of Anti-Diabetic Thiazolidinedione on Prostate Cancer Progression Are Linked to the TR4 Nuclear Receptor Expression Status

Shin-Jen Lin, Chang-Yi Lin, Dong-Rong Yang, Kouji Izumi, Emily Yan, Xiaodan Niu, Hong-Chiang Chang, Hiroshi Miyamoto, Nancy Wang, Gonghui Li, Chawnshang Chang

Neoplasia. 2015 Apr; 17(4): 339–347. Published online 2015 Apr 26. doi: 10.1016/j.neo.2015.02.005

PMCID:: PMC4415117

Abstract Article PDF–1.4M

Select item 401442410.

Biased, Non-equivalent Gene-Proximal and -Distal Binding Motifs of Orphan Nuclear Receptor TR4 in Primary Human Erythroid Cells

Lihong Shi, M. C. Sierant, Katherine Gurdziel, Fan Zhu, Shuaiying Cui, Katarzyna E. Kolodziej, John Strouboulis, Yuanfang Guan, Osamu Tanabe, Kim-Chew Lim, James Douglas Engel

PLoS Genet. 2014 May; 10(5): e1004339. Published online 2014 May 8. doi: 10.1371/journal.pgen.1004339

PMCID:: PMC4014424

Abstract Article PDF–1.6M

Select item 398426511.

TGF-β-Activated Kinase 1 (TAK1) Signaling Regulates TGF-β-Induced WNT-5A Expression in Airway Smooth Muscle Cells via Sp1 and β-Catenin

Kuldeep Kumawat, Mark H. Menzen, Ralph M. Slegtenhorst, Andrew J. Halayko, Martina Schmidt, Reinoud Gosens

PLoS One. 2014; 9(4): e94801. Published online 2014 Apr 11. doi: 10.1371/journal.pone.0094801

PMCID:: PMC3984265

Abstract Article PDF–1.9M

Select item 377805712.

TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy

Yihui Fan, Jin Cheng, Sanjeev A. Vasudevan, Roma H. Patel, Li Liang, Xin Xu, Yanling Zhao, Wei Jia, Fengmin Lu, Hong Zhang, Jed G. Nuchtern, Eugene S. Kim, Yang Jianhua

Apoptosis. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Apoptosis. 2013 Oct; 18(10): 1224–1234. doi: 10.1007/s10495-013-0864-0

PMCID:: PMC3778057

Abstract Article PDF–1.0M

Select item 373412913.

AMD-Associated Genes Encoding Stress-Activated MAPK Pathway Constituents Are Identified by Interval-Based Enrichment Analysis

John Paul SanGiovanni, Phil H. Lee

PLoS One. 2013; 8(8): e71239. Published online 2013 Aug 5. doi: 10.1371/journal.pone.0071239

PMCID:: PMC3734129

Abstract Article PDF–313K

Select item 359656714.

Recent advances in the study of testicular nuclear receptor 4

Xian-fan Ding, Shi-cheng Yu, Bi-de Chen, Shin-jen Lin, Chawnshang Chang, Gong-hui Li

J Zhejiang Univ Sci B. 2013 Mar; 14(3): 171–177. doi: 10.1631/jzus.B1200357

PMCID:: PMC3596567

Abstract Article PDF–291K

Select item 350837015.

TAK1 ubiquitination regulates Doxorubicin-induced NF-κB activation

Li Liang, Yihui Fan, Jin Cheng, Da Cheng, Yanling Zhao, Baoshan Cao, Liwen Ma, Lei An, Wei Jia, Xu Su, Jianhua Yang, Hong Zhang

Cell Signal. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Cell Signal. 2013 Jan; 25(1): 247–254. Published online 2012 Sep 7. doi: 10.1016/j.cellsig.2012.09.003

PMCID:: PMC3508370

Abstract Article PDF–1.9M

Select item 302478316.

The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor

X. Edward Zhou, Kelly M. Suino-Powell, Yong Xu, Cee-Wah Chan, Osamu Tanabe, Schoen W. Kruse, Ross Reynolds, James Douglas Engel, H. Eric Xu

J Biol Chem. 2011 Jan 28; 286(4): 2877–2885. Published online 2010 Nov 9. doi: 10.1074/jbc.M110.168740

PMCID:: PMC3024783

Abstract Article PDF–2.5M

Select item 301923117.

Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes

Henriette O'Geen, Yu-Hsuan Lin, Xiaoqin Xu, Lorigail Echipare, Vitalina M Komashko, Daniel He, Seth Frietze, Osamu Tanabe, Lihong Shi, Maureen A Sartor, James D Engel, Peggy J Farnham

BMC Genomics. 2010; 11: 689. Published online 2010 Dec 2. doi: 10.1186/1471-2164-11-689