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Select item 100417081.

Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer

Qijing Guo, Linglin Zhao, Nan Yan, Yan Li, Cuiping Guo, Shengyan Dang, Xianliang Shen, Jianfang Han, Yushuang Luo

Front Immunol. 2023; 14: 1148056. Published online 2023 Mar 13. doi: 10.3389/fimmu.2023.1148056

PMCID:: PMC10041708

Abstract Article PDF–15M

Select item 93068992.

A novel nonsense variant in TPM4 caused dominant macrothrombocytopenia, mild bleeding tendency and disrupted cytoskeleton remodeling

Ana Marín‐Quílez, Elena Vuelta, Lorena Díaz‐Ajenjo, Cristina Fernández‐Infante, Ignacio García‐Tuñón, Rocío Benito, Verónica Palma‐Barqueros, Jesús María Hernández‐Rivas, José Ramón González‐Porras, José Rivera, José María Bastida

J Thromb Haemost. 2022 May; 20(5): 1248–1255. Published online 2022 Feb 28. doi: 10.1111/jth.15672

PMCID:: PMC9306899

Abstract Article PDF–1018K

Select item 77389553.

The expression and clinical significance of TPM4 in hepatocellular carcinoma

Linjing Li, Tao Ye, Qingyan Zhang, Xin Li, Li Ma, Jing Yan

Int J Med Sci. 2021; 18(1): 169–175. Published online 2021 Jan 1. doi: 10.7150/ijms.49906

PMCID:: PMC7738955

Abstract Article PDF–822K

Select item 68950454.

Upregulation of tropomyosin alpha-4 chain in patients’ saliva with oral squamous cell carcinoma as demonstrated by Phage display

Paula Cristina Batista Faria, Ana Paula Carneiro, Renata Binato, Rafael Nascimento, Paula Souza Santos, Deborah Fagundes, Sindeval José da Silva, Adriano Mota Loyola, Eliana Abdelhay, Luiz Ricardo Goulart

Sci Rep. 2019; 9: 18399. Published online 2019 Dec 5. doi: 10.1038/s41598-019-54686-x

PMCID:: PMC6895045

Abstract Article PDF–1.9M

Select item 54648895.

Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling

SukYeong Jeong, SunYoung Lim, Galina Schevzov, Peter W. Gunning, David M. Helfman

Oncotarget. 2017 May 16; 8(20): 33544–33559. Published online 2017 Apr 4. doi: 10.18632/oncotarget.16825

PMCID:: PMC5464889

Abstract Article PDF–9.1M

Select item 47428006.

Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2

Nikolas Hundt, Walter Steffen, Salma Pathan-Chhatbar, Manuel H. Taft, Dietmar J. Manstein

Sci Rep. 2016; 6: 20554. Published online 2016 Feb 5. doi: 10.1038/srep20554

PMCID:: PMC4742800

Abstract Article PDF–1.4M

Select item 18501307.

TPM3-ALK and TPM4-ALK Oncogenes in Inflammatory Myofibroblastic Tumors

Brandon Lawrence, Antonio Perez-Atayde, Michele K. Hibbard, Brian P. Rubin, Paola Dal Cin, Jack L. Pinkus, Geraldine S. Pinkus, Sheng Xiao, Eunhee S. Yi, Christopher D. M. Fletcher, Jonathan A. Fletcher

Am J Pathol. 2000 Aug; 157(2): 377–384. doi: 10.1016/S0002-9440(10)64550-6

PMCID:: PMC1850130

Abstract Article PDF–557K

Select item 84723308.

The miR-133a, TPM4 and TAp63γ Role in Myocyte Differentiation Microfilament Remodelling and Colon Cancer Progression

Sabrina Caporali, Cosimo Calabrese, Marilena Minieri, Massimo Pieri, Umberto Tarantino, Mario Marini, Stefano D’Ottavio, Silvia Angeletti, Alessandro Mauriello, Claudio Cortese, Sergio Bernardini, Alessandro Terrinoni

Int J Mol Sci. 2021 Sep; 22(18): 9818. Published online 2021 Sep 10. doi: 10.3390/ijms22189818

PMCID:: PMC8472330

Abstract Article PDF–10M

Select item 53307619.

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia

Irina Pleines, Joanne Woods, Stephane Chappaz, Verity Kew, Nicola Foad, José Ballester-Beltrán, Katja Aurbach, Chiara Lincetto, Rachael M. Lane, Galina Schevzov, Warren S. Alexander, Douglas J. Hilton, William J. Astle, Kate Downes, Paquita Nurden, Sarah K. Westbury, Andrew D. Mumford, Samya G. Obaji, Peter W. Collins, NIHR BioResource, Fabien Delerue, Lars M. Ittner, Nicole S. Bryce, Mira Holliday, Christine A. Lucas, Edna C. Hardeman, Willem H. Ouwehand, Peter W. Gunning, Ernest Turro, Marloes R. Tijssen, Benjamin T. Kile

J Clin Invest. 2017 Mar 1; 127(3): 814–829. Published online 2017 Jan 30. doi: 10.1172/JCI86154

PMCID:: PMC5330761

Abstract Article PDF–3.8M

Select item 502994410.

Inflammatory Adipokines Decrease Expression of Two High Molecular Weight Isoforms of Tropomyosin Similar to the Change in Type 2 Diabetic Patients

Stuart A. Savill, Helen F. Leitch, John N. Harvey, Trevor H. Thomas

PLoS One. 2016; 11(9): e0162908. Published online 2016 Sep 20. doi: 10.1371/journal.pone.0162908

PMCID:: PMC5029944

Abstract Article PDF–2.7M

Select item 1027369811.

MicroRNA-5195-3p mediated malignant biological behaviour of insulin-resistant liver cancer cells via SOX9 and TPM4

Jing Yan, Bei Xie, Ye Tian, Wenqin An, Zhiheng Peng, Zhuan Liu, Jing Li, Linjing Li

BMC Cancer. 2023; 23: 557. Published online 2023 Jun 16. doi: 10.1186/s12885-023-11068-x

PMCID:: PMC10273698

Abstract Article PDF–7.7M

Select item 964065412.

LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation

Aoran Luo, Xiaoxiao Lan, Qiongzi Qiu, Qing Zhou, Jia Li, Mengting Wu, Pengyuan Liu, Honghe Zhang, Bingjian Lu, Yan Lu, Weiguo Lu

Cell Death Dis. 2022 Nov; 13(11): 936. Published online 2022 Nov 7. doi: 10.1038/s41419-022-05359-7

PMCID:: PMC9640654

Abstract Article PDF–6.2M

Select item 743932813.

Differential expression and diagnostic significance of P53, MutS homologs 2, tropomyosin‐4 in alpha‐fetoprotein‐negative hepatocellular carcinoma

Xuyang Gong, Ailong Huang

J Clin Lab Anal. 2020 Aug; 34(8): e23353. Published online 2020 May 3. doi: 10.1002/jcla.23353

PMCID:: PMC7439328

Abstract Article PDF–1.1M

Select item 39086414.

A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism.

A R MacLeod, C Houlker, F C Reinach, L B Smillie, K Talbot, G Modi, F S Walsh

Proc Natl Acad Sci U S A. 1985 Dec; 82(23): 7835–7839. doi: 10.1073/pnas.82.23.7835

PMCID:: PMC390864

Summary Page Browse PDF–1.0M

Select item 303982115.

Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value

M I Lomnytska, S Becker, I Bodin, A Olsson, K Hellman, A-C Hellström, M Mints, U Hellman, G Auer, S Andersson

Br J Cancer. 2011 Jan 4; 104(1): 110–119. Published online 2010 Nov 30. doi: 10.1038/sj.bjc.6605992

PMCID:: PMC3039821

Abstract Article PDF–703K

Select item 377913216.

Protein isoform-specific validation defines multiple chloride intracellular channel and tropomyosin isoforms as serological biomarkers of ovarian cancer

Hsin-Yao Tang, Lynn A. Beer, Janos L. Tanyi, Rugang Zhang, Qin Liu, David W. Speicher

J Proteomics. Author manuscript; available in PMC 2014 Aug 26.

Published in final edited form as: J Proteomics. 2013 Aug 26; 89: 165–178. Published online 2013 Jun 21. doi: 10.1016/j.jprot.2013.06.016

PMCID:: PMC3779132

Abstract Article PDF–3.6M

Select item 140591217.

H2-calponin is regulated by mechanical tension and modifies the function of actin cytoskeleton

M. Moazzem Hossain, James F. Crish, Richard L. Eckert, Jim J.-C. Lin, J.-P. Jin

J Biol Chem. Author manuscript; available in PMC 2006 Dec 23.

Published in final edited form as: J Biol Chem. 2005 Dec 23; 280(51): 42442–42453. Published online 2005 Oct 18. doi: 10.1074/jbc.M509952200

PMCID:: PMC1405912

Abstract Article PDF–2.3M

Select item 442613618.

A systematic nomenclature for mammalian tropomyosin isoforms

Michael A. Geeves, Sarah E. Hitchcock-DeGregori, Peter W. Gunning

J Muscle Res Cell Motil. 2015; 36(2): 147–153. Published online 2014 Nov 5. doi: 10.1007/s10974-014-9389-6

PMCID:: PMC4426136

Abstract Article PDF–2.8M

Select item 301030119.

Vimentin is a novel AKT1 target mediating motility and invasion

Quan-Sheng Zhu, Kevin Rosenblatt, Kai-Lieh Huang, Guy Lahat, Reynolds Brobey, Svetlana Bolshakov, Theresa Nguyen, Zhiyong Ding, Roman Belousov, Katelynn Bill, Xuemei Luo, Alexander Lazar, Adam Dicker, Gordon B. Mills, Mien-Chie Hung, Dina Lev

Oncogene. Author manuscript; available in PMC 2011 Jul 27.

Published in final edited form as: Oncogene. 2011 Jan 27; 30(4): 457–470. Published online 2010 Sep 20. doi: 10.1038/onc.2010.421

PMCID:: PMC3010301

Abstract Article PDF–1.1M

Select item 329919220.

A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans

Rehan Qayyum, Beverly M. Snively, Elad Ziv, Michael A. Nalls, Yongmei Liu, Weihong Tang, Lisa R. Yanek, Leslie Lange, Michele K. Evans, Santhi Ganesh, Melissa A. Austin, Guillaume Lettre, Diane M. Becker, Alan B. Zonderman, Andrew B. Singleton, Tamara B. Harris, Emile R. Mohler, Benjamin A. Logsdon, Charles Kooperberg, Aaron R. Folsom, James G. Wilson, Lewis C. Becker, Alexander P. Reiner

PLoS Genet. 2012 Mar; 8(3): e1002491. Published online 2012 Mar 8. doi: 10.1371/journal.pgen.1002491

PMCID:: PMC3299192

Abstract Article PDF–285K

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PMC Links for Gene (Select 7171) (114)
PMC
Homo sapiens acyl-CoA synthetase long chain family member 6 (ACSL6), transcript ...
Homo sapiens acyl-CoA synthetase long chain family member 6 (ACSL6), transcript variant 6, mRNA
gi|327412328|ref|NM_001205251.1|

Nucleotide
TPM4[gene] (36)
ClinVar
tropomyosin alpha-4 chain isoform 3 [Homo sapiens]
tropomyosin alpha-4 chain isoform 3 [Homo sapiens]
gi|1539091043|ref|NP_001354765.1|

Protein

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