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Select item 97792231.

Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin

Victoria V. Nefedova, Galina V. Kopylova, Daniil V. Shchepkin, Anastasia M. Kochurova, Olga I. Kechko, Vera A. Borzova, Natalia S. Ryabkova, Ivan A. Katrukha, Vladimir A. Mitkevich, Sergey Y. Bershitsky, Dmitrii I. Levitsky, Alexander M. Matyushenko

Int J Mol Sci. 2022 Dec; 23(24): 15723. Published online 2022 Dec 11. doi: 10.3390/ijms232415723

PMCID:: PMC9779223

Abstract Article PDF–2.8M

Select item 87580222.

Identification of a novel missense mutation in the TPM1 gene via exome sequencing in a Chinese family with dilated cardiomyopathy: A case report and literature review

Yilong Man, Changying Yi, Meili Fan, Tianyu Yang, Peng Liu, Shiguang Liu, Guangxin Wang

Medicine (Baltimore) 2022 Jan 14; 101(2): e28551. Published online 2022 Jan 14. doi: 10.1097/MD.0000000000028551

PMCID:: PMC8758022

Abstract Article PDF–387K

Select item 87290553.

The prognostic value of TPM1–4 in hepatocellular carcinoma

Zhihui Tian, Jian Zhao, Yusheng Wang

Cancer Med. 2022 Jan; 11(2): 433–446. Published online 2021 Nov 30. doi: 10.1002/cam4.4453

PMCID:: PMC8729055

Abstract Article PDF–2.3M

Select item 83218304.

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

Lorenzo R. Sewanan, Jinkyu Park, Michael J. Rynkiewicz, Alice W. Racca, Nikolaos Papoutsidakis, Jonas Schwan, Daniel L. Jacoby, Jeffrey R. Moore, William Lehman, Yibing Qyang, Stuart G. Campbell

J Gen Physiol. 2021 Sep 6; 153(9): e202012640. Published online 2021 Jul 28. doi: 10.1085/jgp.202012640

PMCID:: PMC8321830

Abstract Article PDF–4.9M

Select item 78638805.

M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end

Alice Ward Racca, Michael J. Rynkiewicz, Nicholas LaFave, Anita Ghosh, William Lehman, Jeffrey R. Moore

J Biol Chem. 2020 Dec 11; 295(50): 17128–17137. Published online 2020 Oct 5. doi: 10.1074/jbc.RA120.014713

PMCID:: PMC7863880

Abstract Article PDF–1.7M

Select item 78518536.

Dynamics of Tpm1.8 domains on actin filaments with single-molecule resolution

Ilina Bareja, Hugo Wioland, Miro Janco, Philip R. Nicovich, Antoine Jégou, Guillaume Romet-Lemonne, James Walsh, Till Böcking

Mol Biol Cell. 2020 Oct 15; 31(22): 2452–2462. doi: 10.1091/mbc.E19-10-0586

PMCID:: PMC7851853

Abstract Article PDF–1.5M

Select item 76989297.

Impact of A134 and E218 Amino Acid Residues of Tropomyosin on Its Flexibility and Function

Marina A. Marchenko, Victoria V. Nefedova, Daria S. Yampolskaya, Galina V. Kopylova, Daniil V. Shchepkin, Sergey Y. Bershitsky, Natalia A. Koubassova, Andrey K. Tsaturyan, Dmitrii I. Levitsky, Alexander M. Matyushenko

Int J Mol Sci. 2020 Nov; 21(22): 8720. Published online 2020 Nov 18. doi: 10.3390/ijms21228720

PMCID:: PMC7698929

Abstract Article PDF–5.1M

Select item 69463288.

Association of single nucleotide polymorphisms in the 3′UTR region of TPM1 gene with dilated cardiomyopathy: A case-control study

Qiang Yao, Wei Zhang, Tianjie Zhang

Medicine (Baltimore) 2019 Nov; 98(44): e17710. Published online 2019 Nov 1. doi: 10.1097/MD.0000000000017710

PMCID:: PMC6946328

Abstract Article PDF–586K

Select item 62313229.

Downregulated Expression of Tropomyosin 1 in Intrahepatic Cholangiocarcinoma: A Predictor of Recurrence and Prognosis

Yan Chen, Zhixian Hong, Shanshan Lu, Ning Zhang, Guanghua Rong, Xiujuan Chang, Ze Liu, Wenlin Bai, Zheng Dong, Xudong Gao, Zhen Zeng, Yinying Lu

Med Sci Monit. 2018; 24: 7875–7882. Published online 2018 Nov 3. doi: 10.12659/MSM.907340

PMCID:: PMC6231322

Abstract Article PDF–897K

Select item 608511810.

The impact of tropomyosins on actin filament assembly is isoform specific

Miro Janco, Teresa T. Bonello, Alex Byun, Adelle C. F. Coster, Helene Lebhar, Irina Dedova, Peter W. Gunning, Till Böcking

Bioarchitecture. 2016; 6(4): 61–75. Published online 2016 Jul 15. doi: 10.1080/19490992.2016.1201619

PMCID:: PMC6085118

Abstract Article PDF–714K

Select item 595861811.

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments

Gerrie P. Farman, Michael J. Rynkiewicz, Marek Orzechowski, William Lehman, Jeffrey R. Moore

Arch Biochem Biophys. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: Arch Biochem Biophys. 2018 Jun 1; 647: 84–92. Published online 2018 Apr 5. doi: 10.1016/j.abb.2018.04.002

PMCID:: PMC5958618

Abstract Article PDF–752K

Select item 577517412.

Structural destabilization of tropomyosin induced by the cardiomyopathy‐linked mutation R21H

Thu Ly, Inna Krieger, Dmitri Tolkatchev, Cheyenna Krone, Timothy Moural, Fadel A. Samatey, ChulHee Kang, Alla S. Kostyukova

Protein Sci. 2018 Feb; 27(2): 498–508. Published online 2017 Nov 21. doi: 10.1002/pro.3341

PMCID:: PMC5775174

Abstract Article PDF–883K

Select item 564499413.

Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge

Simon Brayford, Nicole S. Bryce, Galina Schevzov, Elizabeth M. Haynes, James E. Bear, Edna C. Hardeman, Peter W. Gunning

Curr Biol. Author manuscript; available in PMC 2017 Oct 17.

Published in final edited form as: Curr Biol. 2016 May 23; 26(10): 1312–1318. Published online 2016 Apr 21. doi: 10.1016/j.cub.2016.03.028

PMCID:: PMC5644994

Article PDF–1.1M

Select item 556849114.

The Cardiomyopathy-Associated K15N Mutation in Tropomyosin Alters Actin Filament Pointed End Dynamics

Mert Colpan, Thu Ly, Samantha Grover, Dmitri Tolkatchev, Alla S. Kostyukova

Arch Biochem Biophys. Author manuscript; available in PMC 2018 Sep 15.

Published in final edited form as: Arch Biochem Biophys. 2017 Sep 15; 630: 18–26. Published online 2017 Jul 18. doi: 10.1016/j.abb.2017.07.006

PMCID:: PMC5568491

Abstract Article PDF–1.3M

Select item 544118415.

Tropomyosin 1: Multiple roles in the developing heart and in the formation of congenital heart defects

Jennifer England, Javier Granados-Riveron, Luis Polo-Parada, Diji Kuriakose, Christopher Moore, J. David Brook, Catrin S. Rutland, Kerry Setchfield, Christopher Gell, Tushar K. Ghosh, Frances Bu'Lock, Christopher Thornborough, Elisabeth Ehler, Siobhan Loughna

J Mol Cell Cardiol. 2017 May; 106: 1–13. doi: 10.1016/j.yjmcc.2017.03.006

PMCID:: PMC5441184

Abstract Article PDF–2.1M

Select item 530022716.

Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma

Hao Pan, Liqun Gu, Binjie Liu, Yiping Li, Yuehong Wang, Xinna Bai, Long Li, Baisheng Wang, Qian Peng, Zhigang Yao, Zhangui Tang

PLoS One. 2017; 12(2): e0168900. Published online 2017 Feb 9. doi: 10.1371/journal.pone.0168900

PMCID:: PMC5300227

Abstract Article PDF–1.7M

Select item 462161317.

Stabilizing the Central Part of Tropomyosin Increases the Bending Stiffness of the Thin Filament

Salavat R. Nabiev, Denis A. Ovsyannikov, Galina V. Kopylova, Daniil V. Shchepkin, Alexander M. Matyushenko, Natalia A. Koubassova, Dmitrii I. Levitsky, Andrey K. Tsaturyan, Sergey Y. Bershitsky

Biophys J. 2015 Jul 21; 109(2): 373–379. Published online 2015 Jul 21. doi: 10.1016/j.bpj.2015.06.006

PMCID:: PMC4621613

Abstract Article PDF–525K

Select item 435812418.

Mechanistic Heterogeneity in Contractile Properties of α-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies

Tejas M. Gupte, Farah Haque, Binnu Gangadharan, Margaret S. Sunitha, Souhrid Mukherjee, Swetha Anandhan, Deepa Selvi Rani, Namita Mukundan, Amruta Jambekar, Kumarasamy Thangaraj, Ramanathan Sowdhamini, Ruth F. Sommese, Suman Nag, James A. Spudich, John A. Mercer

J Biol Chem. 2015 Mar 13; 290(11): 7003–7015. Published online 2014 Dec 29. doi: 10.1074/jbc.M114.596676

PMCID:: PMC4358124

Abstract Article PDF–2.1M

Select item 425843619.

Energy landscapes reveal the myopathic effects of tropomyosin mutations

Marek Orzechowski, Stefan Fischer, Jeffrey R. Moore, William Lehman, Gerrie P. Farman

Arch Biochem Biophys. Author manuscript; available in PMC 2015 Dec 15.

Published in final edited form as: Arch Biochem Biophys. 2014 Dec 15; 0: 89–99. Published online 2014 Sep 18. doi: 10.1016/j.abb.2014.09.007

PMCID:: PMC4258436

Abstract Article PDF–1.3M

Select item 345512920.

Familial hypertrophic cardiomyopathy related E180G mutation increases flexibility of human cardiac α-tropomyosin

Campion K. P. Loong, Huan-Xiang Zhou, P. Bryant Chase

FEBS Lett. Author manuscript; available in PMC 2013 Sep 21.

Published in final edited form as: FEBS Lett. 2012 Sep 21; 586(19): 3503–3507. Published online 2012 Aug 14. doi: 10.1016/j.febslet.2012.08.005

PMCID:: PMC3455129

Abstract Article PDF–1.7M

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PMC Links for Gene (Select 7168) (162)
PMC
Homo sapiens tropomyosin 1 (TPM1), transcript variant 18, mRNA
Homo sapiens tropomyosin 1 (TPM1), transcript variant 18, mRNA
gi|1677502093|ref|NM_001365781.2|

Nucleotide
Homo sapiens chromosome 15, clone RP11-244F12, complete sequence
Homo sapiens chromosome 15, clone RP11-244F12, complete sequence
gi|20986480|gnl|WIBR|L10908|gb|AC07 11|

Nucleotide
tropomyosin alpha-1 chain isoform Tpm1.9cy [Homo sapiens]
tropomyosin alpha-1 chain isoform Tpm1.9cy [Homo sapiens]
gi|1057867570|ref|NP_001317273.1|

Protein

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