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Select item 98829861.

Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget’s disease of bone

Xiangxiang Hu, Sing-Wai Wong, Kaixin Liang, Tai-Hsien Wu, Sheng Wang, Lufei Wang, Jie Liu, Mitsuo Yamauchi, Brian L. Foster, Jenny P.-Y. Ting, Baohong Zhao, Henry C. Tseng, Ching-Chang Ko

Sci Adv. 2023 Jan; 9(4): eade6998. Published online 2023 Jan 27. doi: 10.1126/sciadv.ade6998

PMCID:: PMC9882986

Abstract Article PDF–3.1M

Select item 91672782.

OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy

Yin Xu, Yun Liu, Xi Chen, Qia Xu, Liwei Liu, Hui Liu, Ruowen Guo, Yide Qin

Transl Psychiatry. 2022; 12: 230. Published online 2022 Jun 4. doi: 10.1038/s41398-022-02004-x

PMCID:: PMC9167278

Abstract Article PDF–3.8M

Select item 90160823.

Mingying Hou, Zhengbo Shao, Shiqi Zhang, Xinna Liu, Pan Fan, Menglu Jiang, Yutong Zhao, Rong Xiao, Huiping Yuan

Cell Death Dis. 2022 Apr; 13(4): 362. Published online 2022 Apr 18. doi: 10.1038/s41419-022-04836-3

PMCID:: PMC9016082

Abstract Article PDF–8.1M

Select item 84379524.

OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection

Joshua Ames, Tejabhiram Yadavalli, Rahul Suryawanshi, James Hopkins, Alexander Agelidis, Chandrashekhar Patil, Brian Fredericks, Henry Tseng, Tibor Valyi-Nagy, Deepak Shukla

Nat Commun. 2021; 12: 5401. Published online 2021 Sep 13. doi: 10.1038/s41467-021-25642-z

PMCID:: PMC8437952

Abstract Article PDF–8.7M

Select item 82036765.

Neuroprotective effects of bone marrow Sca-1⁺ cells against age-related retinal degeneration in OPTN E50K mice

Xinna Liu, Mingying Hou, Shiqi Zhang, Yutong Zhao, Qi Wang, Menglu Jiang, Mengxian Du, Zhengbo Shao, Huiping Yuan

Cell Death Dis. 2021 Jun; 12(6): 613. Published online 2021 Jun 15. doi: 10.1038/s41419-021-03851-0

PMCID:: PMC8203676

Abstract Article PDF–4.8M

Select item 81026406.

Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response

Peng Xue, Xiangxiang Hu, Emily Chang, Lufei Wang, Minghui Chen, Tai-Hsien Wu, Dong-Joon Lee, Brian L. Foster, Henry C. Tseng, Ching-Chang Ko

Exp Mol Med. 2021 Apr; 53(4): 667–680. Published online 2021 Apr 16. doi: 10.1038/s12276-021-00596-w

PMCID:: PMC8102640

Abstract Article PDF–2.3M

Select item 79607257.

The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro

Shiqi Zhang, Zhengbo Shao, Xinna Liu, Mingying Hou, Fang Cheng, Dawei Lei, Huiping Yuan

Cell Death Discov. 2021; 7: 49. Published online 2021 Mar 15. doi: 10.1038/s41420-021-00432-0

PMCID:: PMC7960725

Abstract Article PDF–4.0M

Select item 75301168.

Respiratory pathology in the Optn^−/− mouse model of Amyotrophic Lateral Sclerosis

Angela L. McCall, Justin S. Dhindsa, Logan A. Pucci, Amanda F. Kahn, Anna F. Fusco, Debolina D. Biswas, Laura M. Strickland, Henry C. Tseng, Mai K. ElMallah

Respir Physiol Neurobiol. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Respir Physiol Neurobiol. 2020 Nov; 282: 103525. Published online 2020 Aug 14. doi: 10.1016/j.resp.2020.103525

Correction in:: Respir Physiol Neurobiol. 2020 Nov 16 : 103570.

PMCID:: PMC7530116

Abstract Article PDF–1.0M

Select item 72059979.

Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease

Sing-Wai Wong, Bo-Wen Huang, Xiangxiang Hu, Eui Ho Kim, Joseph P. Kolb, Ricardo J. Padilla, Peng Xue, Lufei Wang, Thomas H. Oguin, III, Patricia A. Miguez, Henry C. Tseng, Ching-Chang Ko, Jennifer Martinez

Cell Death Differ. 2020 Jan; 27(1): 71–84. Published online 2019 May 10. doi: 10.1038/s41418-019-0341-6

Correction in:: Cell Death Differ. 2021 Feb; 28(2): 825–826.

PMCID:: PMC7205997

Abstract Article PDF–6.5M

Select item 464683810.

Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget’s Disease

Rami Obaid, Sachin E. Wani, Asim Azfer, Toby Hurd, Ruth Jones, Philip Cohen, Stuart H. Ralston, Omar M.E. Albagha

Cell Rep. 2015 Nov 10; 13(6): 1096–1102. Published online 2015 Oct 29. doi: 10.1016/j.celrep.2015.09.071

PMCID:: PMC4646838

Abstract Article

Select item 443360711.

Visual impairment in an optineurin mouse model of primary open angle glaucoma

Henry C. Tseng, Thorfinn T. Riday, Celia McKee, Catherine E Braine, Howard Bomze, Ian Barak, Carrie Marean-Reardon, Simon W.M. John, Benjamin D. Philpot, Michael D. Ehlers

Neurobiol Aging. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Neurobiol Aging. 2015 Jun; 36(6): 2201–2212. Published online 2015 Feb 27. doi: 10.1016/j.neurobiolaging.2015.02.012

PMCID:: PMC4433607

Abstract Article PDF–3.3M

Select item 1054919412.

Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia

Laura M. Meyer, Sebastian E. Koschade, Jonas B. Vischedyk, Marlyn Thoelken, Andrea Gubas, Martin Wegner, Marion Basoglu, Stefan Knapp, Manuel Kaulich, Stefan Eimer, Shabnam Shaid, Christian H. Brandts

Autophagy. 2023; 19(11): 2982–2996. Published online 2023 Jul 13. doi: 10.1080/15548627.2023.2230839

PMCID:: PMC10549194

Abstract Article PDF–2.3M

Select item 1028933213.

Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection

Masaya Fukushi, Ryosuke Ohsawa, Yasushi Okinaka, Daisuke Oikawa, Tohru Kiyono, Masaya Moriwaki, Takashi Irie, Kosuke Oda, Yasuhiro Kamei, Fuminori Tokunaga, Yusuke Sotomaru, Hirofumi Maruyama, Hideshi Kawakami, Takemasa Sakaguchi

PLoS One. 2023; 18(6): e0287545. Published online 2023 Jun 23. doi: 10.1371/journal.pone.0287545

PMCID:: PMC10289332

Abstract Article PDF–1.3M

Select item 908453314.

Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β

Xiao Chen Shi, Bo Xia, Jian Feng Zhang, Rui Xin Zhang, Dan Yang Zhang, Huan Liu, Bao Cai Xie, Yong Liang Wang, Jiang Wei Wu

PLoS Biol. 2022 Apr; 20(4): e3001619. Published online 2022 Apr 27. doi: 10.1371/journal.pbio.3001619

PMCID:: PMC9084533

Abstract Article PDF–5.6M

Select item 901568315.

Intrinsic antiviral activity of Optineurin prevents hyperproliferation of a primary herpes simplex virus type-2 infection

Chandrashekhar D Patil, Rahul Suryawanshi, Joshua Ames, Raghuram Koganti, Alex Agelidis, Divya Kapoor, Tejabhiram Yadavalli, Lulia Koujah, Henry C Tseng, Deepak Shukla

J Immunol. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: J Immunol. 2022 Jan 1; 208(1): 63–73. Published online 2021 Dec 8. doi: 10.4049/jimmunol.2100472

PMCID:: PMC9015683

Abstract Article PDF–1.8M

Select item 852604516.

Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3

Zheng-Zhao Liu, Chun-Gu Hong, Wen-Bao Hu, Meng-Lu Chen, Ran Duan, Hong-Ming Li, Tao Yue, Jia Cao, Zhen-Xing Wang, Chun-Yuan Chen, Xiong-Ke Hu, Ben Wu, Hao-Ming Liu, Yi-Juan Tan, Jiang-Hua Liu, Zhong-Wei Luo, Yan Zhang, Shan-Shan Rao, Ming-Jie Luo, Hao Yin, Yi-Yi Wang, Kun Xia, Lang Xu, Si-Yuan Tang, Rong-Gui Hu, Hui Xie

Autophagy. 2021; 17(10): 2766–2782. Published online 2020 Nov 4. doi: 10.1080/15548627.2020.1839286

PMCID:: PMC8526045

Abstract Article PDF–14M

Select item 802078517.

A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis

Lauren Mifflin, Zhirui Hu, Connor Dufort, Cynthia C. Hession, Alec J. Walker, Kongyan Niu, Hong Zhu, Nan Liu, Jun S. Liu, Joshua Z. Levin, Beth Stevens, Junying Yuan, Chengyu Zou

Proc Natl Acad Sci U S A. 2021 Mar 30; 118(13): e2025102118. Published online 2021 Mar 25. doi: 10.1073/pnas.2025102118