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Select item 101653641.

Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability

Direnis Erdinc, Alejandro Rodríguez‐Luis, Mahmoud R Fassad, Sarah Mackenzie, Christopher M Watson, Sebastian Valenzuela, Xie Xie, Katja E Menger, Kate Sergeant, Kate Craig, Sila Hopton, Gavin Falkous, Genomics England Research Consortium, Joanna Poulton, Hector Garcia‐Moreno, Paola Giunti, Carlos A de Moura Aschoff, Jonas A Morales Saute, Amelia J Kirby, Camilo Toro, Lynne Wolfe, Danica Novacic, Lior Greenbaum, Aviva Eliyahu, Ortal Barel, Yair Anikster, Robert McFarland, Gráinne S Gorman, Andrew M Schaefer, Claes M Gustafsson, Robert W Taylor, Maria Falkenberg, Thomas J Nicholls

EMBO Mol Med. 2023 May; 15(5): e16775. Published online 2023 Apr 4. doi: 10.15252/emmm.202216775

PMCID:: PMC10165364

Abstract Article PDF–2.9M

Select item 27329032.

The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells

Nassima Temime-Smaali, Lionel Guittat, Assitan Sidibe, Kazuo Shin-ya, Chantal Trentesaux, Jean-François Riou

PLoS One. 2009; 4(9): e6919. Published online 2009 Sep 9. doi: 10.1371/journal.pone.0006919

PMCID:: PMC2732903

Abstract Article PDF–1008K

Select item 23746643.

Expression of topoisomerase III α in normal and neoplastic tissues determined by immunohistochemistry using novel monoclonal antibody

A J Lodge, J J Anderson, S W Ng, F Fenwick, M Steward, B Haugk, C H W Horne, B Angus

Br J Cancer. 2000 Jul; 83(4): 498–505. Published online 2000 Jul 24. doi: 10.1054/bjoc.2000.1293

PMCID:: PMC2374664

Summary PDF–723K

Select item 1484464.

Purification and characterization of human DNA topoisomerase IIIalpha.

H Goulaouic, T Roulon, O Flamand, L Grondard, F Lavelle, J F Riou

Nucleic Acids Res. 1999 Jun 15; 27(12): 2443–2450. doi: 10.1093/nar/27.12.2443

PMCID:: PMC148446

Summary PDF–600K

Select item 1294075.

Dual localization of human DNA topoisomerase IIIα to mitochondria and nucleus

Yong Wang, Yi Lisa Lyu, James C. Wang

Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19): 12114–12119. Published online 2002 Sep 3. doi: 10.1073/pnas.192449499

PMCID:: PMC129407

Abstract Article PDF–243K

Select item 396666.

Human TOP3: a single-copy gene encoding DNA topoisomerase III.

R Hanai, P R Caron, J C Wang

Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8): 3653–3657. doi: 10.1073/pnas.93.8.3653

PMCID:: PMC39666

Summary Page Browse PDF–1.2M

Select item 207587.

Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype

Eberhard Fritz, Sarah H. Elsea, Pragna I. Patel, M. Stephen Meyn

Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9): 4538–4542. doi: 10.1073/pnas.94.9.4538

PMCID:: PMC20758

Abstract Article PDF–283K

Select item 96389428.

Two type I topoisomerases maintain DNA topology in human mitochondria

Katja E Menger, James Chapman, Héctor Díaz-Maldonado, Mushtaq M Khazeem, Dasha Deen, Direnis Erdinc, John W Casement, Valeria Di Leo, Angela Pyle, Alejandro Rodríguez-Luis, Ian G Cowell, Maria Falkenberg, Caroline A Austin, Thomas J Nicholls

Nucleic Acids Res. 2022 Oct 28; 50(19): 11154–11174. Published online 2022 Oct 10. doi: 10.1093/nar/gkac857

PMCID:: PMC9638942

Abstract Article PDF–10M

Select item 95497299.

TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT

Alexandre de Nonneville, Sébastien Salas, François Bertucci, Alexander P Sobinoff, José Adélaïde, Arnaud Guille, Pascal Finetti, Jane R Noble, Dimitri Churikov, Max Chaffanet, Elise Lavit, Hilda A Pickett, Corinne Bouvier, Daniel Birnbaum, Roger R Reddel, Vincent Géli

EMBO Mol Med. 2022 Oct; 14(10): e15859. Published online 2022 Aug 3. doi: 10.15252/emmm.202215859

PMCID:: PMC9549729

Abstract Article PDF–15M

Select item 608076610.

Mutations in TOP3A Cause a Bloom Syndrome-like Disorder

Carol-Anne Martin, Kata Sarlós, Clare V. Logan, Roshan Singh Thakur, David A. Parry, Anna H. Bizard, Andrea Leitch, Louise Cleal, Nadia Shaukat Ali, Mohammed A. Al-Owain, William Allen, Janine Altmüller, Miriam Aza-Carmona, Bushra A.Y. Barakat, Jimena Barraza-García, Amber Begtrup, Massimo Bogliolo, Megan T. Cho, Jaime Cruz-Rojo, Hassan Ali Mundi Dhahrabi, Nursel H. Elcioglu, GOSgene, Gráinne S. Gorman, Rebekah Jobling, Ian Kesterton, Yoshihito Kishita, Masakazu Kohda, Polona Le Quesne Stabej, Asam Jassim Malallah, Peter Nürnberg, Akira Ohtake, Yasushi Okazaki, Roser Pujol, Maria José Ramirez, Anya Revah-Politi, Masaru Shimura, Paul Stevens, Robert W. Taylor, Lesley Turner, Hywel Williams, Carolyn Wilson, Gökhan Yigit, Laura Zahavich, Fowzan S. Alkuraya, Jordi Surralles, Alejandro Iglesais, Kei Murayama, Bernd Wollnik, Mehul Dattani, Karen E. Heath, Ian D. Hickson, Andrew P. Jackson

Am J Hum Genet. 2018 Aug 2; 103(2): 221–231. Published online 2018 Jul 26. doi: 10.1016/j.ajhg.2018.07.001

Correction in:: Am J Hum Genet. 2018 Sep 6; 103(3): 456.

Correction in:: Am J Hum Genet. 2024 May 2; 111(5): 996.

PMCID:: PMC6080766

Abstract Article PDF–1.2M

Select item 593512011.

Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA

Thomas J. Nicholls, Cristina A. Nadalutti, Elisa Motori, Ewen W. Sommerville, Gráinne S. Gorman, Swaraj Basu, Emily Hoberg, Doug M. Turnbull, Patrick F. Chinnery, Nils-Göran Larsson, Erik Larsson, Maria Falkenberg, Robert W. Taylor, Jack D. Griffith, Claes M. Gustafsson

Mol Cell. Author manuscript; available in PMC 2019 Jan 4.

Published in final edited form as: Mol Cell. 2018 Jan 4; 69(1): 9–23.e6. Published online 2017 Dec 28. doi: 10.1016/j.molcel.2017.11.033

PMCID:: PMC5935120

Abstract Article PDF–1.2M

Select item 239639112.

Topoisomerase IIIα is required for normal proliferation and telomere stability in alternative lengthening of telomeres

Nassima Temime-Smaali, Lionel Guittat, Thomas Wenner, Emilie Bayart, Céline Douarre, Dennis Gomez, Marie-Josèphe Giraud-Panis, Arturo Londono-Vallejo, Eric Gilson, Mounira Amor-Guéret, Jean-François Riou

EMBO J. 2008 May 21; 27(10): 1513–1524. Published online 2008 Apr 17. doi: 10.1038/emboj.2008.74

PMCID:: PMC2396391

Abstract Article PDF–350K

Select item 13715913.

The Bloom’s syndrome helicase stimulates the activity of human topoisomerase IIIα

Leonard Wu, Ian D. Hickson

Nucleic Acids Res. 2002 Nov 15; 30(22): 4823–4829. doi: 10.1093/nar/gkf611

PMCID:: PMC137159

Abstract Article PDF–161K

Select item 997190614.

The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins

Michael M. Soniat, Giaochau Nguyen, Hung-Che Kuo, Ilya J. Finkelstein

J Biol Chem. 2023 Feb; 299(2): 102802. Published online 2022 Dec 16. doi: 10.1016/j.jbc.2022.102802

PMCID:: PMC9971906

Abstract Article PDF–2.0M

Select item 881393015.

The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loops

Gábor M. Harami, János Pálinkás, Yeonee Seol, Zoltán J. Kovács, Máté Gyimesi, Hajnalka Harami-Papp, Keir C. Neuman, Mihály Kovács

Nat Commun. 2022; 13: 654. Published online 2022 Feb 3. doi: 10.1038/s41467-022-28208-9

PMCID:: PMC8813930

Abstract Article PDF–1.7M

Select item 692019716.

Long interspersed element-1 ribonucleoprotein particles protect telomeric ends in alternative lengthening of telomeres dependent cells

Thomas Aschacher, Brigitte Wolf, Olivia Aschacher, Florian Enzmann, Viktoria Laszlo, Barbara Messner, Adrian Türkcan, Serge Weis, Sabine Spiegl-Kreinecker, Klaus Holzmann, Günther Laufer, Marek Ehrlich, Michael Bergmann

Neoplasia. 2020 Feb; 22(2): 61–75. Published online 2019 Dec 14. doi: 10.1016/j.neo.2019.11.002